5-HTP 100 mg

5-HTP 100 mg

Metabolic Maintenance4.7 (127 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals
$36.00 $0.60 per serving

Product analysis

48 out of 100

5-HTP 100 mg is intended for mood and relaxation, but noticeable everyday benefits remain uncertain.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality24

The vitamin C form is named, while the other ingredient forms are unspecified. Those gaps leave the preparation quality of the main ingredients uncertain.

Ingredient Transparency72

All listed amounts are disclosed, but only the vitamin C form is named. The main ingredient preparations are less clearly described.

Value For Money34

The serving price offers limited value for both 5-HTP and glycine. Value for the added vitamins remains uncertain, so their inclusion does not establish a better buy.

Customer Satisfaction72

Customer ratings are generally positive, with hundreds of opinions available. Ratings describe satisfaction without proving health benefits or safety.

Product Focus62

Mood and relaxation give the formula a recognizable purpose, but the expected effects remain uncertain. The small glycine amount adds little support for sleep quality.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.60
Customer rating
4.7 · 127 ratings
Report analysis

Goals

Mood Support
Impact
Highest effect
B+ Ingredient FitC- PathwaysA EvidenceA+ Formulation Logic
Vitamin B6 · 3 mg5-HTP · 100 mg
Study evidence
5-HTP Supportive 9 studies
Glycine Mixed 3 studies
Vitamin B6 Supportive 19 studies
Stress Relief
Impact
Moderate effect
A Ingredient FitD PathwaysC- EvidenceA+ Formulation Logic
Glycine · 440 mgVitamin B6 · 3 mgVitamin C · 100 mg
Study evidence
5-HTP Supportive 18 studies
Glycine Supportive 1 study
Vitamin C Supportive 11 studies
Impact
Moderate effect
B+ Ingredient FitC PathwaysC- EvidenceA+ Formulation Logic
Glycine · 440 mg
Study evidence
5-HTP Supportive 1 study
Glycine Supportive 3 studies
Impact
Moderate effect
D Ingredient FitF PathwaysC EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 5 studies

Ingredients

IngredientAmount per servingScore
Vitamin C (Ascorbic Acid)
100 mg
Vitamin B6
3 mg
5-HTP
100 mg 62
Glycine
440 mg 48
Gluten Free Adults 18–50 Dairy Free
Report overview
Glycine · 440 mg OverallScore48
C Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyF Value
The serving provides 440 mg of glycine, below the amount used for sleep quality. The product costs high relative to its glycine content, using the full serving price. A GMP manufacturing claim is recorded. Ordinary excipients or capsule materials are recorded.
How this ingredient is rated

Active Ingredient Quality & Bioavailability60

A GMP manufacturing claim is recorded.
Glycine Sourcing and Purity Standards
A GMP manufacturing claim is recorded.

Dose, Safety & Label Transparency46

The serving provides 440 mg of glycine, below the amount used for sleep quality. Ordinary excipients or capsule materials are recorded.
Clinically Relevant Dosage
The serving provides 440 mg of glycine, below the amount used for sleep quality.
Label Transparency and Yield Disclosure
The glycine amount per serving is stated.
Clean Label and Excipient Quality
Ordinary excipients or capsule materials are recorded.

Value30

The product cost per gram of glycine is high; this attributes the whole serving price to glycine.
Cost Efficiency per 1,000mg of Glycine
The product cost per gram of glycine is high; this attributes the whole serving price to glycine.
5-HTP · 100 mg OverallScore62
D- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
A serving provides 100 mg of 5-HTP, with a high product cost relative to the amount. The botanical source of the 5-HTP is not specified. The label includes a warning about serotonin-related medication interactions.
How this ingredient is rated

Active Ingredient Quality & Bioavailability40

The botanical source of the 5-HTP is not specified.
Botanical Source & Standardization
The botanical source of the 5-HTP is not specified.

Dose, Safety & Label Transparency100

A serving provides 100 mg of 5-HTP. The label includes a warning about serotonin-related medication interactions.
Dosage Potency & Range
A serving provides 100 mg of 5-HTP.
Safety Warnings & Label Clarity
The label includes a warning about serotonin-related medication interactions.

Value30

The product cost is high relative to its 5-HTP amount.
Price per 100mg 5-HTP
The product cost is high relative to its 5-HTP amount.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  2. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  6. [Augmentation of antipsychotics with glycine may ameliorate depressive and extrapyramidal symptoms in schizophrenic patients--a preliminary 10-week open-label study].
    Strzelecki D; Kropiwnicki P; Rabe-Jabłońska J · Psychiatria polska · 2014
    Single-arm trial29 participantsMood Support forGlycine
  7. Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls.
    Pålsson E; Jakobsson J; Södersten K; Fujita Y; Sellgren C; Ekman CJ; Ågren H; Hashimoto K; Landén M · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015
    Cross-sectional study327 participantsMood Support forGlycine
  8. Erythrocyte glycine in depressed, hypomanic, and euthymic bipolar patients treated with lithium carbonate.
    Peselow ED; Deutsch SI; Stanley M; Banay-Schwartz M; Virgilio J; Fieve RR · Psychopharmacology · 1983
    Cross-sectional study27 participantsMood Support forGlycine
  9. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  10. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support Stress Relief forVitamin B6
  11. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  12. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  13. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  14. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  15. The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.
    Soh J; Raventhiran S; Lee JH; Lim ZX; Goh J; Kennedy BK; Maier AB · GeroScience · 2024
    Systematic reviewSleep Support forGlycine
  16. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.
    Bannai M; Kawai N · Journal of pharmacological sciences · 2012
    Narrative reviewSleep Support forGlycine
  17. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.
    Bannai M; Kawai N; Ono K; Nakahara K; Murakami N · Frontiers in neurology · 2012
    Clinical trial7 participantsSleep Support forGlycine
  18. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  19. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  20. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6