$56.00 $0.93 per serving
Product analysis
R.E.M. Maintenance may help with sleep timing and falling asleep, with possible additional sleep-quality support from glycine and magnesium. The 5-HTP is relatively expensive for the amount provided.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality28
The vitamin C and mineral forms are named, while the sleep-related ingredient preparations are less clearly disclosed. Their relative form quality cannot be confidently compared.
Ingredient Transparency77
Ingredient amounts are disclosed and some forms are identified. Unspecified forms still limit like-for-like comparisons.
Value For Money38
Glycine offers reasonable value, but 5-HTP is relatively expensive for the amount provided. Other ingredient comparisons remain uncertain, leaving value uneven across the blend.
Customer Satisfaction64
Customer feedback is generally positive. The relatively small review pool limits how representative that feedback may be.
Product Focus72
Sleep is the clearest fit, with melatonin supporting timing and limited findings for other ingredients in poor sleepers. Wider mood, stress and weight-related claims are less certain, and the broad ingredient mix does not establish extra benefit across those purposes.
- Format
Powder - Container
- 360 Gram(s)
- Per serving
- $0.93
- Customer rating
- 4.4 · 46 ratings
Goals
Impact
Highest effect
Magnesium · 250 mgMelatonin · 1 mgGlycine · 3500 mg
Melatonin supports sleep timing and may shorten the time needed to fall asleep, with effects depending on when it is taken. Glycine may support sleep quality through bedtime temperature regulation, although studies are small. Magnesium has shown modest improvements in adults with poor sleep. The 5-HTP contribution rests on a small study in older adults, mainly poor sleepers, rather than a general sleep benefit.
How this product is rated for Sleep Support
Ingredient fit78
Melatonin, glycine and 5-HTP have substantial declared amounts; magnesium makes a smaller amount-related contribution.
Goal fit
The main relevant ingredients connect with sleep, with the saved findings also considering the formula’s broader uses.
Dose adequacy
Melatonin, glycine and 5-HTP have substantial declared amounts; magnesium makes a smaller amount-related contribution.
Pathways100
Melatonin primarily supports sleep timing. The saved findings also include calming, precursor-related processes and bedtime temperature regulation.
Depth
Melatonin primarily supports sleep timing.
Breadth
The saved findings also include calming, precursor-related processes and bedtime temperature regulation.
Evidence100
Melatonin has the strongest supplied support for timing and onset, though timing and population still matter. Preparation matches do not establish the effect of the full formula.
Evidence strength
Melatonin has the strongest supplied support for timing and onset, though timing and population still matter.
Studied preparation
The saved findings recognize studied preparations among the ingredients considered, without proving that every form or combination has the same effect.
Formulation logic100
No configured activating conflict was identified in the supplied findings. The ingredients considered do not require an additional partner.
Partner coverage
The ingredients considered can contribute independently or have their required partner; this does not establish extra benefit from combining them.
Conflicts
No configured activating conflict was identified in the supplied findings.
Effective doses
The ingredients counted by this finding clear its amount threshold; that does not establish a clinically effective dose.
Impact
Highest effect
Magnesium · 250 mg5-HTP · 100 mg
Magnesium can support normal mood when low intake or deficiency contributes to apathy or depressed mood. Glycine is more closely connected with sleep than directly measured emotional improvement. Although 5-HTP has a serotonin-precursor role, the supplied older-adult trial did not show a significant mood benefit over its control. The saved contributions therefore extend beyond what can confidently be described as routine mood improvement.
How this product is rated for Mood Support
Ingredient fit74
The mood-related contribution comes from the relevant ingredients at their declared serving amounts, with the ingredient-specific limits described above.
Goal fit
The contributing ingredients address mood-related roles within a broader formula containing ingredients intended for other purposes.
Dose adequacy
Declared serving amounts contribute to different extents; meeting the amount comparison does not establish an individual mood effect.
Pathways79
The ingredients represent the areas described below; these are ingredient relationships rather than proof that every mechanism produces a mood benefit.
Depth
The strongest represented area is monoamine signalling, reflecting the ingredients and amounts retained in the saved findings.
Breadth
The saved findings cover neural calming, monoamine signalling.
Evidence94
The retained evidence and preparation findings below must be interpreted alongside each ingredient’s direct mood outcomes and the populations studied.
Evidence strength
5-HTP provides the strongest retained evidence contribution, with the population and outcome limits described for that ingredient.
Studied preparation
The retained preparations meet the saved matching check; this does not remove the population or outcome limits of their supporting findings.
Formulation logic100
The supplied partner, conflict and minimum-amount checks are satisfied for the retained contributors, without establishing synergy or medication suitability.
Partner coverage
No contributing ingredient is missing a required partner in the supplied checks; this does not establish added benefit from combining ingredients.
Conflicts
No listed ingredient conflict was triggered by the supplied product facts; this check does not establish general medication compatibility.
Effective doses
All retained contributors meet the saved minimum amount threshold; that threshold is not a proven effective dose for improving mood.
Impact
High effect
Magnesium · 250 mgGlycine · 3500 mgVitamin C · 250 mg
Magnesium offers conditional stress support in low-magnesium or selected clinical settings, while 5-HTP has limited, situational anxiety findings rather than a reliable everyday calming effect. Melatonin’s relevance is confined to sleep-associated and procedural-anxiety contexts. Glycine’s supplied metabolic oxidative-stress evidence does not establish emotional stress relief. Vitamin C adds a possible acute stress-response contribution, with its modest amount and nutritional context limiting expectations.
How this product is rated for Stress Relief
Ingredient fit78
Relevant stress-related ingredients sit within a broader formula with other purposes.
Goal fit
Relevant stress-related ingredients sit within a broader formula with other purposes.
Dose adequacy
The declared amounts support the supplied exposure comparison, without establishing a proven stress-relief dose or daily regimen.
Pathways100
Sleep-related recovery is most represented; this does not establish a broad psychological-stress or cortisol effect.
Depth
Sleep-related recovery is most represented; this does not establish a broad psychological-stress or cortisol effect.
Breadth
Several stress-related areas are represented, but this does not establish that each produces a demonstrated clinical benefit.
Evidence76
Magnesium’s stress support is conditional on low status or selected clinical settings; broad lasting everyday relief remains uncertain.
Evidence strength
Magnesium’s stress support is conditional on low status or selected clinical settings; broad lasting everyday relief remains uncertain.
Studied preparation
The qualifying preparations are accepted in the supplied comparison; this does not establish equivalent effects across every formulation.
Formulation logic100
No required companion is missing for the qualifying ingredients, without establishing an extra benefit from combining them.
Partner coverage
No required companion is missing for the qualifying ingredients, without establishing an extra benefit from combining them.
Conflicts
No matching formulation conflict was identified in the supplied checks.
Effective doses
The qualifying ingredients meet the supplied minimum amount comparison; that threshold does not establish measured effectiveness.
Impact
Highest effect
Magnesium · 250 mgGlycine · 3500 mg
Vitamin C supports collagen formation; correcting low intake helps prevent skin fragility, without established extra anti-aging benefit when intake is adequate.
How this product is rated for Longevity
Ingredient fit70
The saved findings count a range of ingredients and compare their amounts with reference amounts. Ingredient presence and amount alone do not establish anti-aging effects.
Goal fit
The mixture includes many ingredients serving other purposes, limiting its concentration on this goal.
Dose adequacy
The counted amounts provide partial coverage of the saved references; that comparison does not establish a clinically effective anti-aging dose.
Pathways69
The strongest saved coverage is antioxidant defence. Mechanistic coverage does not demonstrate lifespan extension.
Depth
The strongest saved coverage concerns antioxidant defence, a mechanistic finding rather than evidence of slower human aging.
Breadth
Antioxidant defence and cellular repair reach the saved coverage threshold, without demonstrating whole-body rejuvenation.
Evidence100
Magnesium leads the saved evidence finding, but its functional study involved exercising older women and does not establish routine anti-aging efficacy.
Evidence strength
Magnesium leads the saved evidence finding, but its functional study involved exercising older women and does not establish routine anti-aging efficacy.
Studied preparation
The saved preparation check is satisfied for counted amounts; this does not extend trial findings to all aging outcomes.
Formulation logic100
The saved findings show partner coverage and no matched ingredient conflicts. Some amount or preparation limits may still restrict practical relevance.
Partner coverage
The counted ingredients have their required partners or work independently under the saved findings; this does not demonstrate added benefit from combining them.
Conflicts
No ingredient conflict was matched in the supplied findings.
Effective doses
All counted ingredients pass the saved minimum amount threshold, which does not establish a proven anti-aging dose.
Impact
High effect
Magnesium · 250 mgVitamin C · 250 mgGlycine · 3500 mg
Glycine is connected to glutathione-related biology, while magnesium and vitamin C support normal nutrient functions. The supplied glycine research tested a combination in older adults and did not isolate glycine's effect on toxin elimination. Magnesium's enzyme role and vitamin C's antioxidant function also do not establish general toxin clearance. The saved glutathione-related finding therefore should not be read as a demonstrated cleanse benefit.
How this product is rated for Liver & Detox
Ingredient fit63
Glycine, magnesium and vitamin C provide the saved connections within a broader formula.
Goal fit
Glycine, magnesium and vitamin C provide the saved connections within a broader formula.
Dose adequacy
The known amounts contribute to the saved range without establishing effective toxin-clearance doses.
Pathways60
Glutathione and conjugation dominate the saved findings.
Depth
Glutathione and conjugation dominate the saved findings.
Breadth
Glutathione and conjugation are the only substantially represented route.
Evidence94
Magnesium leads the saved evidence finding. The three credited ingredients receive the saved preparation finding; this does not establish routine toxin-clearance efficacy.
Evidence strength
Magnesium leads the saved evidence finding; the supplied context limits what can be concluded about routine toxin clearance.
Studied preparation
The three credited ingredients receive the saved preparation finding; this does not establish routine toxin-clearance efficacy.
Formulation logic100
All three credited ingredients meet the saved amount threshold. No configured conflict was identified.
Partner coverage
Every credited ingredient works alone or has its required partner in the saved findings.
Conflicts
No configured ingredient conflict was identified in the saved findings.
Effective doses
All three credited ingredients meet the saved amount threshold.
Impact
Moderate effect
Magnesium · 250 mg
5-HTP at 100 mg relates to appetite and fullness, but the supplied weight trials were small and used much larger daily amounts. Magnesium supports normal metabolic functions. Inositol's diagnosis-specific findings do not provide a reliable general-adult weight-loss expectation.
How this product is rated for Weight Loss
Ingredient fit52
2 ingredients relate to the goal, alongside 5 other actives that make the formula broader than weight management. The amounts provide partial support relative to the saved comparisons.
Goal fit
2 ingredients relate to the goal, alongside 5 other actives that make the formula broader than weight management.
Dose adequacy
The amounts provide partial support relative to the saved comparisons.
Pathways9
The clearest connection is appetite and satiety, with limited support in the saved findings.
Depth
The clearest connection is appetite and satiety, with limited support in the saved findings.
Breadth
The assessed contributions remain too limited to show meaningful breadth across weight-management pathways.
Evidence80
Magnesium provides the strongest evidence contribution in the saved assessment; normal nutrient functions or selected trial findings should not be read as assured weight loss. The ingredients contributing at assessed amounts meet the saved preparation criteria.
Evidence strength
Magnesium provides the strongest evidence contribution in the saved assessment; normal nutrient functions or selected trial findings should not be read as assured weight loss.
Studied preparation
The ingredients contributing at assessed amounts meet the saved preparation criteria.
Formulation logic100
The relevant ingredients can contribute alone or have the partners required by the saved findings. No conflict was identified in the supplied checks. 2 of 2 relevant ingredients meet the saved minimum amount criterion.
Partner coverage
The relevant ingredients can contribute alone or have the partners required by the saved findings.
Conflicts
No conflict was identified in the supplied checks.
Effective doses
2 of 2 relevant ingredients meet the saved minimum amount criterion.
Impact
High effect
Glycine · 3500 mgVitamin C · 250 mg
Magnesium can help correct low status associated with low-grade inflammation; added benefit in people with adequate status is not established. Glycine relates to cellular inflammatory signalling, but its mechanisms do not establish routine clinical benefit. Vitamin C supports antioxidant defenses, with an inflammation finding limited to elevated baseline CRP rather than the overall trial population.
How this product is rated for Inflammation
Ingredient fit63
The formula includes ingredients for other purposes, which reduces its focus on inflammation-related support. The counted amounts provide partial rather than complete exposure coverage; this is an amount comparison, not proof of benefit.
Goal fit
The formula includes ingredients for other purposes, which reduces its focus on inflammation-related support.
Dose adequacy
The counted amounts provide partial rather than complete exposure coverage; this is an amount comparison, not proof of benefit.
Pathways59
The strongest recorded connection is inflammatory gene signalling, with substantial coverage in the saved comparison. Coverage remains concentrated in one route.
Depth
The strongest recorded connection is inflammatory gene signalling, with substantial coverage in the saved comparison.
Breadth
One pathway reaches the saved coverage threshold; the formula does not provide broad coverage across the inflammation-related routes.
Evidence96
Glycine supplies the strongest recorded evidence contribution; its assigned strength does not establish a clinical benefit. The supplied scientific context limits how these recorded contributions translate into routine clinical benefit.
Evidence strength
Glycine supplies the strongest recorded evidence contribution; its assigned strength does not establish a clinical benefit.
Studied preparation
The counted preparations match those recognized in the saved comparison; this does not establish equivalent clinical results.
Formulation logic100
Partner requirements are met and no configured conflict was recorded. The counted ingredients reach the saved amount threshold.
Partner coverage
The counted ingredients can stand alone or have the partners required by the saved comparison; no added benefit from combining them is established.
Conflicts
No configured ingredient conflict was recorded; this finding is limited to the interactions checked.
Effective doses
The counted ingredients meet the saved minimum amount threshold; that threshold is not a proven effective dose.
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
Calories | 10 Calorie(s) | |
Vitamin C (Ascorbic Acid) | 250 mg | |
Magnesium (Magnesium Glycinate) | 250 mg | |
Potassium (Potassium Citrate) | 75 mg | |
Glycine | 3500 mg | |
Inositol | 500 mg | |
5-Hydroxytryptophan | 100 mg | |
Melatonin | 1 mg |
Glycine · 3500 mg OverallScore68
Each serving provides 3500 mg of glycine, an amount aligned with glycine’s use for sleep support. Based on the whole-product price, that works out to about $0.27 per gram of glycine.
How this ingredient is rated
Active Ingredient Quality & Bioavailability60
A manufacturing-practice claim is recorded, but it does not establish the glycine’s purity.
Glycine Sourcing and Purity Standards
A manufacturing-practice claim is recorded, but it does not establish the glycine’s purity.
Dose, Safety & Label Transparency80
3500 mg of glycine is disclosed per serving, an amount aligned with glycine’s use for sleep support.
Clinically Relevant Dosage
The serving provides 3500 mg of glycine, an amount aligned with glycine’s use for sleep support.
Label Transparency and Yield Disclosure
The saved information lists 3500 mg of glycine per serving.
Clean Label and Excipient Quality
The saved information does not establish which excipients covered by the evaluation are present; their absence cannot be assumed.
Value60
Based on the whole-product price, that works out to about $0.27 per gram of glycine.
Cost Efficiency per 1,000mg of Glycine
Based on the whole-product price, that works out to about $0.27 per gram of glycine.
5-HTP · 100 mg OverallScore56
Each powder serving provides 100 mg of 5-HTP, with no botanical source identified in the saved facts. The whole-product price is about $0.93 per serving, relatively high in this comparison.
How this ingredient is rated
Active Ingredient Quality & Bioavailability40
The saved facts name 5-HTP but do not identify its botanical source.
Botanical Source & Standardization
The saved facts name 5-HTP but do not identify its botanical source.
Dose, Safety & Label Transparency100
A serving provides 100 mg of 5-HTP. The saved evaluation records a warning about serotonin-affecting medicines.
Dosage Potency & Range
A serving provides 100 mg of 5-HTP.
Safety Warnings & Label Clarity
The saved evaluation records a warning about serotonin-affecting medicines.
Value0
At about $0.93 per 100 mg of 5-HTP, the whole-product price is high in this comparison.
Price per 100mg 5-HTP
The whole-product price works out to about $0.93 per 100 mg of 5-HTP.
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Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes.
- Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial.
- Subgingival air polishing (glycine powder) versus minocycline hydrochloride: efficacy in residual periodontal pockets following endoscope-assisted scaling and root planing.
- Long-term Implant Maintenance: A Systematic Review of Home and Professional Care Strategies in Supportive Implant Therapy.
- Analysis of the factors influencing the occurrence of peri-implantitis in patients with implant-supported restoration and study on the maintenance effect of subgingival sandblasting.
- Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review.
- Efficacy and safety of magnesium glycinate as add on therapy in hypomagnesemic asthma and chronic obstructive pulmonary disease patients: A randomised controlled study assessing inflammatory biomarkers.
- Magnesium Supplementation and the Effects on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: a Randomized, Double-Blind, Placebo-Controlled Trial.
- The effect of long-term magnesium intake on inflammatory markers in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.
- Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.
- Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
- The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
- The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
- Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
- Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
- The impact of obesity-associated glycine deficiency on the elimination of endogenous and exogenous metabolites via the glycine conjugation pathway.
- Metabolic impact of dietary glycine supplementation in individuals with severe obesity.
- Contribution towards a Metabolite Profile of the Detoxification of Benzoic Acid through Glycine Conjugation: An Intervention Study.
- Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function.
- The treatment of isovaleric acidemia with glycine supplement