B-Complex #6

B-Complex #6

Thorne4.7 (4,822 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals

Product analysis

65 out of 100

B-Complex #6 may help address nutrient gaps that contribute to tiredness and support normal energy use from food. Its nutritional role is clearest when intake is low.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality49

Thiamin, vitamin B5 and choline use reasonable to favorable forms, while niacin is clearly identified. Missing form details for several other B vitamins limit a complete quality comparison.

Ingredient Transparency83

All ingredient amounts are disclosed, making quantities easy to compare. Several B-vitamin forms are still unspecified.

Value For Money48

Riboflavin and vitamin B6 offer more favorable value than several other ingredients. Niacin, vitamin B5 and choline appear relatively expensive for their contributions, leaving a mixed value picture.

Customer Satisfaction89

Buyer ratings are positive across a large number of reviews. That supports a positive picture of satisfaction, while reviews do not establish health benefits.

Product Focus70

The B-vitamin emphasis fits nutritional support for normal energy metabolism. Larger amounts do not establish extra energy or faster calorie burning once nutritional needs are met.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.43
Customer rating
4.7 · 4,822 ratings
Report analysis

Goals

Impact
High effect
A Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Vitamin B5 · 45 mgRiboflavin · 30 mgThiamin · 40 mgVitamin B12 · 100 mcg
Study evidence
Thiamin Disputed 12 studies
Impact
High effect
A- Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 80 mcgNiacin · 80 mgVitamin B12 · 100 mcgRiboflavin · 30 mgThiamin · 40 mgVitamin B5 · 45 mgVitamin B6 · 100 mg
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per servingScore
Thiamine (Thiamine Hydrochloride)
40 mg 65
Riboflavin
30 mg 79
Niacin (Niacinamide)
80 mg 65
Vitamin B6
100 mg 72
Folate
334 mcg DFE
Vitamin B12 (Methylcobalamin)
100 mcg
Biotin
80 mcg
Pantothenic Acid (Calcium Pantothenate)
45 mg 61
Choline (Choline Citrate)
14 mg 50
Gluten Free Adults 18–50
Report overview
A- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value
Each serving provides 80 mg of niacin. The price per serving is high for the niacin form. It uses niacinamide, a non-flushing form of niacin.
How this ingredient is rated

Active Ingredient Quality & Bioavailability86

It uses niacinamide, a non-flushing form of niacin.
Niacin Form & Goal Alignment
It uses niacinamide, a non-flushing form of niacin.
Precursor Source Quality
Niacinamide is the named form.

Dose, Safety & Label Transparency67

Each serving provides 80 mg of niacin. Niacinamide is a non-flushing form; no no-flush claim is recorded.
Clarity of Chemical Form
The label names niacinamide.
Form-Specific Dosage Efficacy
Each serving provides 80 mg of niacin.
Flush Risk & Safety Labeling
Niacinamide is a non-flushing form; no no-flush claim is recorded.

Value20

The price per serving is high for the niacin form.
Price Per Effective Serving
The price per serving is high for the niacin form.
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value
The serving provides 40 mg of thiamin as thiamine hydrochloride, at a high cost relative to the thiamin amount. It uses a standard water-soluble form.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Thiamine Hydrochloride is a standard water-soluble form. No configured artificial sweetener or color was flagged, though other excipients may be present.
Thiamin Chemical Form
Thiamine Hydrochloride is a standard water-soluble form of thiamin.
Excipient Purity
No configured artificial sweetener or color was flagged, though other excipients may be present.

Dose, Safety & Label Transparency72

The serving provides 40 mg of thiamin, a moderate amount.
Thiamin Dosage Potency
The serving provides 40 mg of thiamin, a moderate amount.
Label Transparency & Proprietary Blends
The thiamin amount is stated as 40 mg per serving.

Value40

The cost is high relative to the amount of thiamin provided.
Price per Declared Dose
The cost is high relative to the amount of thiamin provided.
A Active Ingredient Quality & BioavailabilityD+ Dose, Safety & Label TransparencyF Value
45 mg of vitamin B5 per 1 capsule comes at a high cost for the amount of B5. The label names Calcium Pantothenate, a stable form of B5.
How this ingredient is rated

Active Ingredient Quality & Bioavailability90

Calcium Pantothenate is a stable form of vitamin B5.
Vitamin B5 Chemical Form
Calcium Pantothenate is a stable form of vitamin B5.

Dose, Safety & Label Transparency52

Each 1 capsule provides 45 mg of vitamin B5. The label names Calcium Pantothenate as the B5 source.
Dosage Potency and Efficacy
Each 1 capsule provides 45 mg of vitamin B5.
Label Transparency & Source Clarity
The label names Calcium Pantothenate as the B5 source.

Value20

The cost is high for the amount of vitamin B5 provided.
Price per 500mg Vitamin B5
The cost is high for the amount of vitamin B5 provided.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Biotin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Support forBiotin
  17. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
    Perry CA; West AA; Gayle A; Lucas LK; Yan J; Jiang X; Malysheva O; Caudill MA · The Journal of nutrition · 2015
    Clinical trial75 participantsMetabolism Support forBiotin
  18. Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in kermanshah in iran (2008-2009)
    Hemmati M, Babaei H, Abdolsalehei M · Oman Medical Journal · 2013
    Randomized trial70 participantsMetabolism Support forBiotin
  19. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes
    César A Albarracin, Bobby C Fuqua, James L Evans, Ira D Goldfine · Diabetes/Metabolism Research and Reviews · 2008
    Randomized trial348 participantsMetabolism Support forBiotin
  20. Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia
    Cristina Revilla-Monsalve, Iván Zendejas-Ruiz, Sergio Islas-Andrade, Armida Báez-Saldaña, Miguel Angel Palomino-Garibay, Pedro Martín Hernández-Quiróz, Cristina Fernandez-Mejia · Biomedicine & Pharmacotherapy · 2006
    Randomized trial33 participantsMetabolism Support forBiotin