B-Complex #12

B-Complex #12

Thorne4.8 (12,458 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals

Product analysis

63 out of 100

B-Complex #12 combines B vitamins and choline for broad nutritional support. Some vitamin forms are not clearly disclosed, making precise comparisons with other B complexes harder.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality46

Several forms are clearly identified, including niacinamide and calcium pantothenate. Missing form details for other B vitamins leave the quality of the whole combination less certain.

Ingredient Transparency83

Ingredient amounts are disclosed, but only some forms are named. The incomplete detail makes a close comparison harder.

Value For Money44

Riboflavin and vitamin B6 offer good value, while niacin, vitamin B5 and choline are less economical. The value therefore varies meaningfully across the formula.

Customer Satisfaction92

Customer feedback is favorable across a substantial number of ratings. Those opinions describe satisfaction, rather than proving health benefits or safety.

Product Focus66

The formula has useful support across a broad range of goals. That wide reach makes it less focused on any single nutritional need.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.43
Customer rating
4.8 · 12,458 ratings
Report analysis

Goals

Impact
High effect
B+ Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin B5 · 45 mgRiboflavin · 28.6 mgThiamin · 40 mgVitamin B12 · 600 mcg

B12, folate and B6 help fill nutritional gaps that can cause anaemia and fatigue. Riboflavin, niacin and pantothenic acid also contribute to normal nutritional functions relevant to tiredness. Larger amounts and the declared vitamin forms do not establish extra energy when intake is adequate.

How this product is rated for Energy

Ingredient fit84

The B vitamins have a relevant nutritional or fatigue-related connection, but the amount comparison cannot establish clinical benefit.
Goal fit
The B vitamins provide the relevant connection, while the product's wider purposes affect its focus on energy.
Dose adequacy
The known quantities make a partial combined contribution to the saved comparison, rather than establishing a fatigue-treatment dose.

Pathways0

No contribution was recorded for the configured energy pathways; correction of nutrient-related fatigue is a separate role.
Depth
No contribution was recorded for the configured energy pathways; correction of nutrient-related fatigue is a separate role.
Breadth
None of the configured alertness, exercise-energy or stress-fatigue pathways received coverage.

Evidence81

B12 leads the saved evidence finding; its nutritional fatigue role is conditional on low intake or deficiency.
Evidence strength
B12 leads the saved evidence finding; its nutritional fatigue role is conditional on low intake or deficiency.
Studied preparation
The declared nutrient preparations are accepted in the saved finding; this does not show the complete product was clinically tested for fatigue.

Formulation logic100

The included ingredients require no additional partner in the saved findings, and no matching conflict was identified. Their minimum amount check is satisfied.
Partner coverage
No additional partner is required for the included ingredients under the saved findings.
Conflicts
No matching conflict was identified by the supplied checks.
Effective doses
All ingredients included in this check meet its minimum amount threshold; that finding does not prove routine fatigue relief.
Study evidence
Thiamin Disputed 12 studies
Impact
Highest effect
A Ingredient FitB+ PathwaysB+ EvidenceA+ Formulation Logic
Folate · 667 mcg DFEVitamin B12 · 600 mcg

B vitamins supply nutrients used in normal energy metabolism, while folate and B12 contribute to blood formation and one-carbon metabolism. Their general-health value lies in filling dietary gaps. Large amounts and particular forms do not establish improved energy or additional benefit when intake is already adequate.

How this product is rated for Everyday Health

Ingredient fit91

Seven B vitamins supply a focused nutritional contribution.
Goal fit
Seven B vitamins supply a focused nutritional contribution.
Dose adequacy
The counted B-vitamin amounts reach their comparison ranges.

Pathways80

Energy metabolism receives the strongest saved coverage. Energy metabolism and blood formation describe the breadth of the supplied findings.
Depth
Energy metabolism receives the strongest saved coverage.
Breadth
Energy metabolism and blood formation describe the breadth of the supplied findings.

Evidence82

Folate anchors the nutritional evidence; this does not establish added benefit above adequate intake.
Evidence strength
Folate anchors the nutritional evidence; this does not establish added benefit above adequate intake.
Studied preparation
The counted preparations with substantial known amounts are accepted in the saved findings; no form superiority is established.

Formulation logic100

The counted ingredients can contribute independently or have their required partner.
Partner coverage
The counted ingredients can contribute independently or have their required partner.
Conflicts
No configured ingredient conflict was found.
Effective doses
All 7 counted ingredients provide meaningful amount under the saved criteria.
Study evidence
Folate Supportive 80 studies
Impact
High effect
A- Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 80 mcgNiacin · 80 mgVitamin B12 · 600 mcgRiboflavin · 28.6 mgThiamin · 40 mgVitamin B5 · 45 mgVitamin B6 · 23.4 mg
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies
Hair Health
Impact
High effect
A- Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Biotin · 80 mcg
Study evidence
Biotin Supportive 4 studies
Folate Mixed 15 studies
Niacin Disputed 2 studies

Ingredients

IngredientAmount per servingScore
Thiamine (Thiamine Hydrochloride)
40 mg 65
Riboflavin
28.6 mg 79
Niacin (Niacinamide)
80 mg 65
Vitamin B6
23.4 mg 80
Folate
667 mcg DFE
Vitamin B12 (Methylcobalamin)
600 mcg 76
Biotin
80 mcg
Pantothenic Acid (Calcium Pantothenate)
45 mg 61
Choline (Choline Citrate)
14 mg 50
Gluten Free Adults 18–50
Report overview
A- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value
A serving provides 80 mg of niacin as niacinamide at a high cost per serving. Niacinamide is a non-flushing form, and the amount and source are stated.
How this ingredient is rated

Active Ingredient Quality & Bioavailability86

Niacinamide provides a standard form of niacin.
Niacin Form & Goal Alignment
Niacinamide is a form used for general niacin support.
Precursor Source Quality
The niacin source is niacinamide.

Dose, Safety & Label Transparency67

The serving contains 80 mg of niacin. The niacinamide form is non-flushing.
Clarity of Chemical Form
Both the niacin amount and niacinamide form are stated.
Form-Specific Dosage Efficacy
The serving contains 80 mg of niacin.
Flush Risk & Safety Labeling
Niacinamide is a non-flushing form.

Value20

The cost per serving is high for the niacin contribution.
Price Per Effective Serving
The cost per serving is high for the niacin contribution.
A+ Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value
Each serving provides 600 mcg of B12, with a high cost per 1,000 mcg. It uses Methylcobalamin, a bioactive form of B12. The label specifies both the amount and form.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

It uses Methylcobalamin, a bioactive form of B12.
Bioactive B12 Form Selection
It uses Methylcobalamin, a bioactive form of B12.

Dose, Safety & Label Transparency79

The serving provides 600 mcg of B12. The amount and form are clearly stated.
Therapeutic Dosage Level
Each serving provides 600 mcg of B12. It falls below the amount considered meaningful for people with higher needs.
Label and Form Transparency
The label states the amount and identifies Methylcobalamin as the B12 source.

Value20

The cost per 1,000 mcg of B12 is high.
Price per 1,000 mcg B12
The cost per 1,000 mcg of B12 is high.
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyD- Value
The serving provides 40 mg of thiamin, a moderate amount, at a high cost relative to the amount. Thiamine Hydrochloride is a named form of thiamin.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Thiamine Hydrochloride is a named form of thiamin. No specified artificial sweeteners or colors are recorded.
Thiamin Chemical Form
Thiamine Hydrochloride is a named form of thiamin.
Excipient Purity
No specified artificial sweeteners or colors are recorded.

Dose, Safety & Label Transparency72

The label states 40 mg per serving, a moderate amount.
Thiamin Dosage Potency
The 40 mg per serving is a moderate amount.
Label Transparency & Proprietary Blends
The label states 40 mg of thiamin per serving.

Value40

The cost is high relative to the declared thiamin amount.
Price per Declared Dose
The cost is high relative to the declared thiamin amount.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsEveryday Health forFolate
  17. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsEveryday Health forFolate
  18. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsEveryday Health forFolate
  19. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewEveryday Health forFolate
  20. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledEveryday Health forFolate