B-100 Complex with B2 Coenzyme

B-100 Complex with B2 Coenzyme

Nature's Way4.7 (1,094 ratings)
Format:Capsule Quantity: 100 Capsule(s) · 100 servings
Goals

Product analysis

65 out of 100

B-100 Complex with B2 Coenzyme supplies B vitamins for normal energy metabolism and to help fill dietary gaps. The combination has several clearly identified forms, but missing folate and biotin forms limit a full comparison.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality57

Riboflavin and B5 have favorable form-quality support, while niacin and B6 forms are clearly identified. Missing forms and unresolved findings for other ingredients limit a firm judgment across the whole combination.

Ingredient Transparency71

All amounts and most forms are stated, making the nutrient contributions easy to check. Several forms and the proportions of the B6 mixture are missing.

Value For Money54

Riboflavin and B6 offer favorable value, while B5 and choline look costly at the full serving price. Other comparisons are moderate or unresolved, leaving the combination with uneven value.

Customer Satisfaction81

Customer ratings are favorable across more than a thousand reviews. The feedback gives a useful satisfaction picture without proving energy or heart benefits.

Product Focus69

The clearest purpose is helping fill low B-vitamin intake for normal metabolism. Larger amounts and coenzyme wording do not establish extra energy, weight loss or protection from heart events.

Format
Capsule
Container
100 Capsule(s)
Per serving
$0.23
Customer rating
4.7 · 1,094 ratings
Report analysis

Goals

Impact
High effect
A- Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Vitamin B5 · 100 mgRiboflavin · 100 mgThiamin · 100 mgVitamin B12 · 100 mcg

Folate, niacin, riboflavin and vitamins B5 and B6 help address tiredness when low intake causes a deficiency. Their metabolic roles do not establish extra energy once nutritional needs are met. High amounts and coenzyme or methylated forms do not establish a stronger fatigue effect. Vitamin B12 is below the saved inclusion comparison.

How this product is rated for Energy

Ingredient fit87

Vitamin B2 (Riboflavin) anchors this product’s saved energy connection. The declared amounts reach the saved comparison levels; this does not make them validated fatigue-treatment doses.
Goal fit
Vitamin B2 (Riboflavin) contributes to the energy findings within a formula that also serves other purposes.
Dose adequacy
The declared amounts reach the saved comparison levels; this does not make them validated fatigue-treatment doses.

Pathways0

No direct alertness, exercise-energy or stress-fatigue pathway contribution was recorded. Deficiency-related fatigue can still be nutritionally relevant.
Depth
No direct alertness, exercise-energy or stress-fatigue pathway contribution was recorded.
Breadth
No direct energy area reaches the saved coverage threshold; nutritional relevance and routine energy enhancement remain different questions.

Evidence78

Vitamin B2 (Riboflavin) is relevant to deficiency-related fatigue, without establishing extra energy at adequate intake.
Evidence strength
Vitamin B2 (Riboflavin) is relevant to deficiency-related fatigue, without establishing extra energy at adequate intake.
Studied preparation
The preparation qualifies in the saved findings, although population and treatment limits still govern how its effects can be described.

Formulation logic100

No missing partner or specified conflict was identified. The included amounts meet the saved minimum comparisons, without establishing a routine energy benefit.
Partner coverage
The included ingredients do not require a missing partner for the roles described.
Conflicts
No specified ingredient conflict was identified in the supplied findings.
Effective doses
The included ingredients meet the saved minimum amount comparisons; these are not proven fatigue-treatment thresholds.
Study evidence
Thiamin Disputed 12 studies
Impact
High effect
B+ Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 100 mcgNiacin · 100 mgVitamin B12 · 100 mcgRiboflavin · 100 mgThiamin · 100 mgVitamin B5 · 100 mgVitamin B6 · 50 mg

B vitamins help normal energy-yielding metabolism, but those essential functions do not establish a higher metabolic rate when intake is adequate. Thiamin, riboflavin and the other declared vitamins receive substantial amount consideration, but more coenzyme supply does not demonstrate thermogenesis. Their physiological roles do not establish persistent extra calorie expenditure or weight loss.

How this product is rated for Metabolism Support

Ingredient fit81

B vitamins dominate the formula and receive substantial but partial overall amount consideration.
Goal fit
B vitamins dominate the formula and receive substantial but partial overall amount consideration..
Dose adequacy
The credited amounts receive partial overall consideration; the comparison range is not a proven thermogenic dose-response.

Pathways0

The saved findings show no coverage of the listed thermogenic categories, despite recognizing normal nutrient roles.
Depth
No listed thermogenic category receives coverage from the credited nutrient roles.
Breadth
No category reaches the saved breadth threshold.

Evidence100

Thiamin leads the saved evidence finding, although normal carbohydrate metabolism does not establish a metabolism-rate boost.
Evidence strength
Thiamin leads the saved evidence finding, although normal carbohydrate metabolism does not establish a metabolism-rate boost.
Studied preparation
The credited nutrients receive preparation recognition in the saved findings; this does not establish a clinically effective metabolism-boosting preparation.

Formulation logic100

No missing required partner or configured conflict was identified, and every credited ingredient passes the saved minimum-amount threshold.
Partner coverage
The credited ingredients can stand alone or have their required partner; no extra combination benefit is established.
Conflicts
No configured conflict was identified from the supplied ingredients and amounts.
Effective doses
All credited ingredients pass the saved minimum-amount threshold, without proving increased energy expenditure.
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per servingScore
Thiamine
100 mg 56
Riboflavin (Riboflavin 5-Phosphate)
100 mg 100
Niacin (Niacinamide)
100 mg 83
Vitamin B6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride)
50 mg 75
Folate
666 mcg DFE
Vitamin B12 (Cyanocobalamin)
100 mcg 21
Biotin
100 mcg
Pantothenic Acid (Calcium D-Pantothenate)
100 mg 70
Choline (Choline Bitartrate)
25 mg 50
Inositol
100 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
A- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyC Value
The saved facts record 100 mg of niacin per serving as niacinamide. Niacinamide generally does not cause the flushing associated with nicotinic acid.
How this ingredient is rated

Active Ingredient Quality & Bioavailability86

Niacinamide is a standard form of vitamin B3, rather than a specialized niacin precursor.
Niacin Form & Goal Alignment
Niacinamide is the identified form of vitamin B3.
Precursor Source Quality
Niacinamide is a standard B3 form; the saved facts do not identify a specialized precursor.

Dose, Safety & Label Transparency92

The saved facts record 100 mg of niacin per serving as niacinamide, a form generally associated with less flushing than nicotinic acid.
Clarity of Chemical Form
Niacinamide is identified as the niacin form.
Form-Specific Dosage Efficacy
The saved niacin amount is 100 mg per serving.
Flush Risk & Safety Labeling
Niacinamide generally does not cause the flushing associated with nicotinic acid.

Value60

The whole-product price is about $0.23 per serving.
Price Per Effective Serving
The whole-product price is about $0.23 per serving.
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
Each serving provides 100 mg of riboflavin from riboflavin 5-phosphate, a form favored in the evaluation. The whole-product serving costs about $0.23.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The identified source is riboflavin 5-phosphate, a phosphate form favored in the evaluation.
Riboflavin Form Quality
Riboflavin 5-phosphate is the identified phosphate form, which the evaluation favors.

Dose, Safety & Label Transparency100

The serving provides 100 mg of riboflavin, and the saved facts identify the riboflavin amount from its phosphate source.
Dosage for Energy & Metabolism
Each serving contains 100 mg of riboflavin, a comparatively large amount in this comparison.
R5P Elemental Yield Transparency
The riboflavin amount from the phosphate source is identified as 100 mg per serving.
Additive Purity
No artificial dyes or synthetic sweeteners were flagged in the available ingredient information.

Value100

A whole-product serving costs about $0.23, a relatively low serving price in the evaluation.
Price per Serving Value
The whole-product serving costs about $0.23; the evaluation considers its serving price relatively low.
A+ Ingredient Form & Label QualityF Dose, Safety & Label TransparencyA+ Value
The 50 mg of vitamin B6 per serving exceeds the European adult daily upper limit. It comes from Pyridoxal 5-Phosphate and Pyridoxine Hydrochloride, and the proportions are undisclosed.
How this ingredient is rated

Ingredient Form & Label Quality100

The B6 sources are Pyridoxal 5-Phosphate and Pyridoxine Hydrochloride, with undisclosed proportions. The saved additive check flagged no artificial dyes, titanium dioxide or talc.
Vitamin B6 Form Identification
The B6 sources are identified as Pyridoxal 5-Phosphate and Pyridoxine Hydrochloride; their proportions are undisclosed.
Clean Label and Excipient Purity
The saved additive check flagged no artificial dyes, titanium dioxide or talc.

Dose, Safety & Label Transparency37

Each serving supplies 50 mg of B6, exceeding the European adult daily upper limit. Total daily intake is unknown.
Vitamin B6 Dose & Safety Policy
The 50 mg per serving exceeds the European adult daily upper limit; total daily intake is unknown.
Label Transparency
The B6 chemical sources are identified as Pyridoxal 5-Phosphate and Pyridoxine Hydrochloride.

Value100

The whole-product serving price works out to about $0.005 per mg of B6, a relatively low cost in this ingredient comparison.
Vitamin B6 Price Efficiency
The whole-product serving price works out to about $0.005 per mg of B6, a relatively low cost in this ingredient comparison.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Biotin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Support forBiotin
  17. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
    Perry CA; West AA; Gayle A; Lucas LK; Yan J; Jiang X; Malysheva O; Caudill MA · The Journal of nutrition · 2015
    Clinical trial75 participantsMetabolism Support forBiotin
  18. Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in kermanshah in iran (2008-2009)
    Hemmati M, Babaei H, Abdolsalehei M · Oman Medical Journal · 2013
    Randomized trial70 participantsMetabolism Support forBiotin
  19. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes
    César A Albarracin, Bobby C Fuqua, James L Evans, Ira D Goldfine · Diabetes/Metabolism Research and Reviews · 2008
    Randomized trial348 participantsMetabolism Support forBiotin
  20. Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia
    Cristina Revilla-Monsalve, Iván Zendejas-Ruiz, Sergio Islas-Andrade, Armida Báez-Saldaña, Miguel Angel Palomino-Garibay, Pedro Martín Hernández-Quiróz, Cristina Fernandez-Mejia · Biomedicine & Pharmacotherapy · 2006
    Randomized trial33 participantsMetabolism Support forBiotin