$46.00 $0.38 per serving
Product analysis
5-HTP 100 mg may offer limited sleep-quality support for people who sleep poorly, while dependable mood and everyday stress benefits remain uncertain.
AI assessment of the formula, label and price. How scoring works
Nutrient Quality24
Most ingredient forms are not specified, making their quality difficult to compare. Naming the vitamin C form does not resolve the uncertainty across the rest of the blend.
Ingredient Transparency72
All ingredient amounts are listed, helping you compare servings. Only the vitamin C form is specified, leaving the main ingredient forms unclear.
Value For Money46
The 5-HTP contribution offers reasonable value, while glycine offers limited value at the full serving cost. The value of the vitamin contributions remains uncertain.
Customer Satisfaction74
Customer ratings are very positive. The smaller review base limits confidence in how widely that satisfaction is shared.
Product Focus62
The combination has limited evidence for sleep quality in people who already sleep poorly. Routine mood, stress and weight-loss benefits remain uncertain, and the small glycine amount adds little confidence in sleep benefits.
- Format
Capsule - Container
- 120 Capsule(s)
- Per serving
- $0.38
- Customer rating
- 4.7 · 256 ratings
Goals
Impact
Highest effect
Vitamin B6 · 3 mg5-HTP · 100 mg
Impact
Moderate effect
Glycine · 300 mg
Impact
Moderate effect
Glycine · 300 mgVitamin B6 · 3 mgVitamin C · 100 mg
Impact
Moderate effect
Ingredients
| Ingredient | Amount per serving | Score |
|---|---|---|
Vitamin C (Ascorbic Acid) | 100 mg | |
Vitamin B6 | 3 mg | |
5-Hydroxytryptophan | 100 mg | |
Glycine | 300 mg |
5-HTP · 100 mg OverallScore68
Each serving supplies 100 mg of 5-HTP; its estimated cost per 100 mg is somewhat high. Its botanical source is unclear. The label includes a medication interaction warning.
How this ingredient is rated
Active Ingredient Quality & Bioavailability40
5-HTP is named, but its botanical source is not specified.
Botanical Source & Standardization
5-HTP is named, but its botanical source is not specified.
Dose, Safety & Label Transparency100
Each serving provides 100 mg of 5-HTP. The label includes a warning about serotonin-related medication interactions.
Dosage Potency & Range
Each serving provides 100 mg of 5-HTP.
Safety Warnings & Label Clarity
The label includes a warning about serotonin-related medication interactions.
Value60
The estimated cost per 100 mg of 5-HTP is somewhat high.
Price per 100mg 5-HTP
The estimated cost per 100 mg of 5-HTP is somewhat high.
Glycine · 300 mg OverallScore48
The serving provides 300 mg of glycine, with a high estimated cost per gram based on the full serving price. The amount is below that associated with sleep quality. GMP manufacturing is claimed. Ordinary excipients are indicated, but their identities are unspecified.
How this ingredient is rated
Active Ingredient Quality & Bioavailability60
Glycine is listed and GMP manufacturing is claimed.
Glycine Sourcing and Purity Standards
Glycine is listed and GMP manufacturing is claimed.
Dose, Safety & Label Transparency46
The stated 300 mg of glycine per serving is below the amount associated with sleep quality in the supplied context. Ordinary excipients are indicated, but their identities are unspecified.
Clinically Relevant Dosage
The stated 300 mg of glycine per serving is below the amount associated with sleep quality in the supplied context.
Label Transparency and Yield Disclosure
The glycine amount is stated as 300 mg per serving.
Clean Label and Excipient Quality
Ordinary excipients are indicated, but their identities are unspecified.
Value30
The estimated cost per gram of glycine is high, using the full serving price.
Cost Efficiency per 1,000mg of Glycine
The estimated cost per gram of glycine is high, using the full serving price.
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Sources
Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
- The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
- Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
- Tryptophan and 5-hydroxytryptophan for depression.
- 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
- [Augmentation of antipsychotics with glycine may ameliorate depressive and extrapyramidal symptoms in schizophrenic patients--a preliminary 10-week open-label study].
- Markers of glutamate signaling in cerebrospinal fluid and serum from patients with bipolar disorder and healthy controls.
- Erythrocyte glycine in depressed, hypomanic, and euthymic bipolar patients treated with lithium carbonate.
- High Dose Vitamin B6 Reduces Depression Symptoms.
- Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
- Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
- Associations of dietary B vitamins intakes with depression in adults.
- Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
- The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
- The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review.
- New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.
- The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers.
- Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
- Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
- Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.