Clincally Advanced Hair Skin & Nails

Clincally Advanced Hair Skin & Nails

NOW Solutions4.7 (5,114 ratings)
Format:Capsule Quantity: 90 Capsule(s) · 30 servings
Goals

Product analysis

59 out of 100

Clincally Advanced Hair Skin & Nails may help support hair and nails when low zinc or biotin intake is a contributing factor. The keratin preparation is not clearly identified, making comparison with the preparations used in research difficult.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality38

Several vitamin and mineral preparations are named, including a well-identified copper form. Missing details for keratin and several other ingredients make their preparation quality harder to compare.

Ingredient Transparency86

All ingredient amounts are disclosed, making the serving easier to compare. Several forms, including keratin and biotin, are not specified.

Value For Money50

The keratin and riboflavin contributions come at an economical serving cost. Some other nutrients are less economical, and many ingredient-level comparisons remain uncertain.

Customer Satisfaction88

Customer feedback is very positive across a sizeable review base. That gives a broad picture of satisfaction.

Product Focus48

The formula supports hair and nail nutrition, particularly when zinc or biotin intake is low. Its many additional ingredients do not establish greater benefit, and several preparations do not clearly match those used in research.

Format
Capsule
Container
90 Capsule(s)
Per serving
$0.53
Customer rating
4.7 · 5,114 ratings
Report analysis

Goals

Hair Health
Impact
High effect
B Ingredient FitD- PathwaysA EvidenceA+ Formulation Logic
Biotin · 300 mcgZinc · 15 mgVitamin C · 60 mgKeratin · 500 mg
Study evidence
Biotin Supportive 4 studies
Copper Adverse 4 studies
Folate Mixed 15 studies
Horsetail Not classified

No linked studies yet.

Keratin Disputed 14 studies
Niacin Disputed 2 studies
Vitamin A Disputed 13 studies
Vitamin E No effect 3 studies
Zinc Supportive 22 studies
Impact
High effect
C- Ingredient FitC- PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 300 mcgHorsetail · 100 mgKeratin · 500 mg
Study evidence
Biotin Supportive 8 studies
Horsetail Not classified

No linked studies yet.

Keratin Adverse 7 studies
Vitamin C Supportive 1 study
Vitamin E Supportive 6 studies
Zinc No effect 1 study
Impact
Moderate effect
C+ Ingredient FitF PathwaysB+ EvidenceA+ Formulation Logic
Vitamin B5 · 14 mgRiboflavin · 10 mgThiamin · 10 mgVitamin B12 · 100 mcg
Study evidence
Thiamin Disputed 12 studies

Ingredients

IngredientAmount per servingScore
Vitamin A (Beta-Carotene)
1500 mcg
Vitamin C (Ascorbic Acid)
60 mg
Vitamin E (D-Alpha-Tocopheryl Succinate)
20 mg
Thiamine (Thiamine Hydrochloride)
10 mg 65
Riboflavin
10 mg 58
Niacin (Niacinamide)
18 mg
Vitamin B6 (Pyridoxine Hydrochloride)
2 mg
Folate
680 mcg DFE
Vitamin B12 (Methylcobalamin)
100 mcg
Biotin
300 mcg 59
Pantothenic Acid (Calcium Pantothenate)
14 mg
Choline (Choline Bitartrate)
25 mg 50
Zinc (Zinc Bisglycinate)
15 mg
Copper (Copper Bisglycinate)
2 mg 90
Cynatine HNS
500 mg 100
MSM
500 mg
Beef Gelatin
200 mg
L-Proline
100 mg 79
Horsetail
100 mg 29
Hyaluronic Acid (Sodium Hyaluronate)
50 mg
Inositol
25 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Keratin · 500 mg OverallScore100
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value
A+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyB+ Value
2 mg of copper per serving comes at a moderate cost per serving. The source is copper bisglycinate. The serving also has 15 mg of zinc, a 7.5:1 zinc-to-copper ratio.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The source is copper bisglycinate. The amount and source are stated.
Copper Form Bioavailability
The source is copper bisglycinate.
Elemental Copper Labeling Clarity
The label states the copper amount and its source.

Dose, Safety & Label Transparency85

The serving provides 2 mg of copper. The serving also has 15 mg of zinc, a 7.5:1 zinc-to-copper ratio.
Copper Dosage Safety & Efficacy
The serving provides 2 mg of copper.
Zinc-to-Copper Balance
The serving also has 15 mg of zinc, a 7.5:1 zinc-to-copper ratio.

Value80

The cost per serving is moderate.
Price Per Serving Efficiency
The cost per serving is moderate.
Proline · 100 mg OverallScore79
A+ Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyC Value
Each serving supplies 100 mg of L-Proline, with a moderate full product cost relative to the proline amount. It uses L-Proline.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

It uses L-Proline.
Proline Form & Source Purity
It uses L-Proline.

Dose, Safety & Label Transparency68

The serving states 100 mg of L-Proline.
Proline Dosage Strength
Each serving contains 100 mg of L-Proline.
Label Transparency & Disclosure
The proline amount per serving is stated.

Value60

The full product cost per 500 mg of proline is moderate.
Price Per 500mg of Proline
The full product cost per 500 mg of proline is moderate.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health Nail Health forBiotin
  17. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health forBiotin
  18. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  19. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  20. Menkes disease and response to copper histidine: An Indian case series.
    Yoganathan S; Sudhakar SV; Arunachal G; Thomas M; Subramanian A; George R; Danda S · Annals of Indian Academy of Neurology · 2022
    Case series4 participantsHair Health forCopper