Stress B-Complex

Stress B-Complex

Thorne4.8 (216 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals

Product analysis

63 out of 100

Stress B-Complex supplies B vitamins that help your body use food for normal energy metabolism. Its main benefit is filling low intake, so an added energy boost is less likely when you already get enough.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality50

The disclosed thiamin and vitamin B5 forms provide some reassurance about ingredient quality. Several other forms are omitted or cannot be assessed fully, so that reassurance does not cover the whole formula.

Ingredient Transparency83

All ingredient amounts are disclosed, which helps you compare serving sizes. Four omitted forms leave a less complete picture of ingredient identity.

Value For Money45

Value varies considerably across the formula, with riboflavin and B6 comparing more favourably than niacin, B5 and choline. Missing value information for folate, B12 and biotin limits a confident judgement of the full mix.

Customer Satisfaction76

Customers give strongly positive ratings, although the review base is relatively modest. Those ratings describe satisfaction and do not establish an energy or stress benefit.

Product Focus70

The formula centres on normal energy metabolism and addressing low B-vitamin intake. Its nine listed actives serve those related uses rather than establishing a broad energy or stress benefit.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.43
Customer rating
4.8 · 216 ratings
Report analysis

Goals

Impact
High effect
A Ingredient FitF PathwaysB EvidenceA+ Formulation Logic
Vitamin B5 · 250 mgRiboflavin · 28.6 mgThiamin · 50 mgVitamin B12 · 100 mcg
Study evidence
Thiamin Disputed 12 studies
Impact
High effect
A- Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Biotin · 80 mcgNiacin · 80 mgVitamin B12 · 100 mcgRiboflavin · 28.6 mgThiamin · 50 mgVitamin B5 · 250 mgVitamin B6 · 28.4 mg
Study evidence
Biotin Supportive 5 studies
Niacin Supportive 17 studies
Thiamin Supportive 11 studies
Vitamin B6 Supportive 16 studies

Ingredients

IngredientAmount per servingScore
Thiamine (Thiamine Hydrochloride)
50 mg 76
Riboflavin
28.6 mg 79
Niacin (Niacinamide)
80 mg 65
Vitamin B6
28.4 mg 79
Folate
334 mcg DFE
Vitamin B12 (Methylcobalamin)
100 mcg
Biotin
80 mcg
Pantothenic Acid (Calcium Pantothenate)
250 mg 75
Choline (Choline Citrate)
14 mg 50
Gluten Free Adults 18–50
Report overview
A- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyF Value
The serving provides 80 mg of niacin at a high cost per serving. It uses niacinamide. The practical effect of the amount is uncertain.
How this ingredient is rated

Active Ingredient Quality & Bioavailability86

Niacinamide is a standard form for general use. The niacinamide comes without an advanced cellular energy claim.
Niacin Form & Goal Alignment
Niacinamide is a standard form for general use.
Precursor Source Quality
The niacinamide comes without an advanced cellular energy claim.

Dose, Safety & Label Transparency67

The label names niacinamide as the form. Niacinamide is a non-flushing form, but no no-flush claim is available.
Clarity of Chemical Form
The label names niacinamide as the form.
Form-Specific Dosage Efficacy
The serving provides 80 mg of niacin; the practical effect of this amount for the named form or forms is uncertain.
Flush Risk & Safety Labeling
Niacinamide is a non-flushing form, but no no-flush claim is available.

Value20

The cost per serving is high.
Price Per Effective Serving
The cost per serving is high.
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value
Each serving provides 50 mg of thiamin per serving, a high amount, at a high cost for the thiamin. It uses Thiamine Hydrochloride, a standard water-soluble form. The listed information does not indicate the configured artificial colors or sweeteners.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

It uses Thiamine Hydrochloride, a standard water-soluble form. The listed information does not indicate the configured artificial colors or sweeteners.
Thiamin Chemical Form
It uses Thiamine Hydrochloride, a standard water-soluble form.
Excipient Purity
The listed information does not indicate the configured artificial colors or sweeteners.

Dose, Safety & Label Transparency100

The label states 50 mg of thiamin per serving, a high amount.
Thiamin Dosage Potency
The 50 mg of thiamin per serving is a high amount.
Label Transparency & Proprietary Blends
The label declares 50 mg of thiamin per serving.

Value40

The cost relative to the declared thiamin amount is high.
Price per Declared Dose
The cost relative to the declared thiamin amount is high.
A Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value
Each serving provides 250 mg of vitamin B5, a substantial amount, but the cost is high for that amount. It uses Calcium Pantothenate, a stable, well-absorbed form.
How this ingredient is rated

Active Ingredient Quality & Bioavailability90

Calcium Pantothenate is a stable, well-absorbed form of B5.
Vitamin B5 Chemical Form
Calcium Pantothenate is a stable, well-absorbed form of B5.

Dose, Safety & Label Transparency88

A serving provides 250 mg of B5. The amount and source are both named.
Dosage Potency and Efficacy
A serving provides 250 mg of B5, a substantial amount.
Label Transparency & Source Clarity
The label states the B5 amount and names Calcium Pantothenate as its source.

Value20

The cost is high for the amount of B5 provided.
Price per 500mg Vitamin B5
The cost is high for the amount of B5 provided.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  2. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  3. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  4. Metabolic features of chronic fatigue syndrome.
    Naviaux RK; Naviaux JC; Li K; Bright AT; Alaynick WA; Wang L; Baxter A; Nathan N; Anderson W; Gordon E · Proceedings of the National Academy of Sciences of the United States of America · 2024
    Case-control study84 participantsEnergy forRiboflavin
  5. Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review
    Bregje Jaeger, Nina N Stolwijk, Femke Aaldering, Charlotte A Ruys, Marije Smits, Nicole I Wolf, Carla E M Hollak, Annet M Bosch · Journal of Inherited Metabolic Disease · 2026
    Systematic review381 studies pooledEnergy Metabolism Support forRiboflavin
  6. Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamin deficiency.
    Smidt LJ; Cremin FM; Grivetti LE; Clifford AJ · Journal of gerontology · 1991
    Randomized trial80 participantsEnergy forThiamin
  7. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Alimentary pharmacology & therapeutics · 2021
    Randomized trial40 participantsEnergy forThiamin
  8. Dietary reference values for thiamin.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Turck D; Bresson JL; Burlingame B; Dean T; Fairweather-Tait S; Heinonen M; Hirsch-Ernst KI; Mangelsdorf I; McArdle HJ; Naska A; Nowicka G; Pentieva K; Sanz Y; Siani A; Sjödin A; Stern M; Tomé D; Van Loveren H; Vinceti M; Willatts P; Lamberg-Allardt C; Przyrembel H; Tetens I; Gudelj Rakic J; Ioannidou S; de Sesmaisons-Lecarré A; Forss AC; Neuhäuser-Berthold M · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forThiamin
  9. Effects of thiamine supplementation on exercise-induced fatigue.
    Suzuki M; Itokawa Y · Metabolic brain disease · 1996
    Randomized trial16 participantsEnergy forThiamin
  10. Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the TARIF study.
    Bager P; Hvas CL; Rud CL; Dahlerup JF · Scandinavian journal of gastroenterology · 2022
    Randomized trialEnergy forThiamin
  11. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review.
    Dułak NA; Rytlewska M; Jaskólska M; Chmielewski M · Rheumatology international · 2024
    Case series3 participantsEnergy forVitamin B12
  12. Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression.
    Markun S; Gravestock I; Jäger L; Rosemann T; Pichierri G; Burgstaller JM · Nutrients · 2021
    Meta-analysis6,276 participants16 studies pooledEnergy forVitamin B12
  13. Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
    Zubair AS; Saab L; Scharer K; Khokhar B · Brain circulation · 2024
    Qualitative study5 participantsEnergy forVitamin B12
  14. Cobalamin deficiency: clinical picture and radiological findings.
    Briani C; Dalla Torre C; Citton V; Manara R; Pompanin S; Binotto G; Adami F · Nutrients · 2014
    Narrative reviewEnergy forVitamin B12
  15. Vitamin B12 Deficiency: Common Questions and Answers.
    Patel H; McGuirk R · American family physician · 2025
    Narrative reviewEnergy forVitamin B12
  16. Biotin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusMetabolism Support forBiotin
  17. Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
    Perry CA; West AA; Gayle A; Lucas LK; Yan J; Jiang X; Malysheva O; Caudill MA · The Journal of nutrition · 2015
    Clinical trial75 participantsMetabolism Support forBiotin
  18. Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in kermanshah in iran (2008-2009)
    Hemmati M, Babaei H, Abdolsalehei M · Oman Medical Journal · 2013
    Randomized trial70 participantsMetabolism Support forBiotin
  19. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes
    César A Albarracin, Bobby C Fuqua, James L Evans, Ira D Goldfine · Diabetes/Metabolism Research and Reviews · 2008
    Randomized trial348 participantsMetabolism Support forBiotin
  20. Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia
    Cristina Revilla-Monsalve, Iván Zendejas-Ruiz, Sergio Islas-Andrade, Armida Báez-Saldaña, Miguel Angel Palomino-Garibay, Pedro Martín Hernández-Quiróz, Cristina Fernandez-Mejia · Biomedicine & Pharmacotherapy · 2006
    Randomized trial33 participantsMetabolism Support forBiotin