Men's Once Daily

Men's Once Daily

Format:Tablet Quantity: 60 Tablet(s) · 60 servings
Goals

Product analysis

51 out of 100

Men's Once Daily may help fill everyday nutrient gaps and support normal energy and immune functions. Its blends do not disclose all component details, making their added contribution difficult to judge.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality34

Food and yeast source descriptions do not establish superior nutrient quality. Vitamin K and selenium lack clear form identities, while much of the remaining form quality is uncertain.

Ingredient Transparency78

All listed amounts and nearly all source descriptions are disclosed. The blend components and some source proportions remain unclear, limiting a detailed comparison.

Value For Money40

Vitamin K is affordable at the serving cost, but the selenium portion is expensive for its amount. Value for most other nutrients is uncertain, so the food-blend description does not establish a price advantage.

Customer Satisfaction92

Customer ratings are very positive across thousands of reviews. The broad feedback reflects satisfaction without proving the nutritional benefits of the food blends.

Product Focus22

The nutrients may support everyday health and immune function when they fill dietary gaps. The unspecified blend makes the contribution of every active ingredient harder to establish.

Format
Tablet
Container
60 Tablet(s)
Per serving
$0.58
Customer rating
4.8 · 6,419 ratings
Report analysis

Goals

Everyday Health
Impact
Highest effect
A- Ingredient FitA+ PathwaysB+ EvidenceA+ Formulation Logic
Folate · 400 mcg DFEVitamin B12 · 7.2 mcgVitamin D · 25 mcgVitamin K · 120 mcgSelenium · 55 mcgZinc · 3.9 mgVitamin C · 90 mg
Study evidence
Folate Supportive 80 studies
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies
Vitamin D Supportive 115 studies
Vitamin K Supportive 34 studies
Zinc Supportive 60 studies
Immunity
Impact
High effect
C- Ingredient FitA- PathwaysA+ EvidenceA+ Formulation Logic
Vitamin C · 90 mgZinc · 3.9 mgVitamin A · 900 mcgVitamin D · 25 mcgSelenium · 55 mcg
Study evidence
Selenium Mixed 37 studies
Vitamin A Supportive 107 studies
Vitamin C Supportive 53 studies
Vitamin D Supportive 85 studies
Vitamin E Supportive 21 studies
Zinc Supportive 73 studies
Longevity
Impact
High effect
C- Ingredient FitD+ PathwaysB+ EvidenceA+ Formulation Logic
Folate · 400 mcg DFEVitamin B12 · 7.2 mcgVitamin K · 120 mcgVitamin D · 25 mcg
Study evidence
Folate Supportive 16 studies
Selenium Supportive 27 studies
Vitamin C Supportive 30 studies
Vitamin D Supportive 50 studies
Vitamin E Supportive 19 studies
Vitamin K Supportive 27 studies
Zinc Supportive 10 studies
Heart Health
Impact
High effect
D+ Ingredient FitD PathwaysA- EvidenceA+ Formulation Logic
Vitamin K · 120 mcgVitamin B12 · 7.2 mcgVitamin B6 · 8.5 mgFolate · 400 mcg DFEVitamin D · 25 mcg
Study evidence
Folate Supportive 116 studies
Niacin Supportive 105 studies
Selenium Mixed 89 studies
Vitamin B6 Supportive 44 studies
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
Cardiovascular Support
Impact
Moderate effect
D+ Ingredient FitD PathwaysB- EvidenceA+ Formulation Logic
Vitamin K · 120 mcgVitamin D · 25 mcgSelenium · 55 mcgVitamin B12 · 7.2 mcgVitamin B6 · 8.5 mgVitamin E · 15 mgFolate · 400 mcg DFENiacin · 18.4 mgVitamin C · 90 mg
Study evidence
Folate Supportive 93 studies
Niacin Supportive 136 studies
Selenium Supportive 107 studies
Vitamin B6 Supportive 35 studies
Vitamin C Supportive 101 studies
Vitamin D Mixed 170 studies
Vitamin E Mixed 79 studies
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per servingScore
Vitamin A (Beta-Carotene, Organic Food Blend)
900 mcg
Vitamin C (Organic Food Blend)
90 mg
Vitamin D (D3)
25 mcg
Vitamin E (Organic Food Blend)
15 mg
Vitamin K (Saccharomyces cerevisiae)
120 mcg 20
Thiamin (Organic Food Blend)
1.38 mg
Riboflavin (Organic Food Blend)
1.5 mg
Niacin (Organic Food Blend)
18.4 mg
Vitamin B6 (Organic Food Blend)
8.5 mg
Folate (Organic Food Blend)
400 mcg DFE
Vitamin B12 (Methylcobalamin, Saccharomyces cerevisiae)
7.2 mcg
Biotin (Organic Food Blend)
120 mcg
Pantothenic Acid (Organic Food Blend)
5 mg
Zinc (Organic Food Blend)
3.9 mg
Selenium (Organic Food Blend)
55 mcg 30
Manganese (Organic Food Blend)
0.8 mg
Chromium (Organic Food Blend)
35 mcg
Organic Food Blend
587 mg
Gluten Free Men 18–50 Vegan Kosher Dairy Free Organic Vegetarian
Report overview
F Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyF Value
55 mcg of selenium per serving contributes to daily intake. The cost is high relative to the selenium supplied. The selenium form is unspecified.
How this ingredient is rated

Active Ingredient Quality & Bioavailability0

The selenium form is unspecified. Its absorption cannot be determined from the form.
Selenium Chemical Form
The selenium form is unspecified.
Form Transparency & Isomer Specificity
Without the chemical form, its identity and absorption are unclear.

Dose, Safety & Label Transparency70

55 mcg of selenium per serving contributes to daily intake. The 55 mcg serving is below the 400 mcg adult upper limit, leaving room for selenium from food.
Dosage Efficacy Sweet Spot
55 mcg of selenium per serving contributes to daily intake.
Safety Margin & UL Adherence
The 55 mcg serving is below the 400 mcg adult upper limit, leaving room for selenium from food.

Value10

The cost is high relative to the selenium supplied.
Price per 200 mcg Serving
The cost is high relative to the selenium supplied.
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyA+ Value
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort.
    Zhang B; Dong H; Xu Y; Xu D; Sun H; Han L · European journal of clinical nutrition · 2023
    Cohort study115,664 participantsCardiovascular Support forFolate
  2. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke.
    Shi M; Zheng J; Liu Y; Mao X; Wu X; Chu M; Niu H; Sun L; Chang X; He Y; Liu Y; Guo D; Zhang Y; Zhu Z; Zhao J · Journal of the American Heart Association · 2024
    Cohort study3,530 participantsCardiovascular Support forFolate
  3. Effect of folic acid on endothelial function following acute myocardial infarction.
    Moens AL; Claeys MJ; Wuyts FL; Goovaerts I; Van Hertbruggen E; Wendelen LC; Van Hoof VO; Vrints CJ · The American journal of cardiology · 2007
    Randomized trial40 participantsCardiovascular Support forFolate
  4. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial.
    Mangoni AA; Sherwood RA; Swift CG; Jackson SH · Journal of internal medicine · 2003
    Randomized trial24 participantsCardiovascular Support forFolate
  5. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia.
    Verhaar MC; Wever RM; Kastelein JJ; van Dam T; Koomans HA; Rabelink TJ · Circulation · 1998
    Non-randomized trial20 participantsCardiovascular Support forFolate
  6. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.
    Lavigne PM; Karas RH · Journal of the American College of Cardiology · 2013
    Meta-analysis9,959 participants11 studies pooledCardiovascular Support forNiacin
  7. Effects of niacin on apo A1 and B levels: a systematic review and meta-analysis of randomised controlled trials.
    Saboori S; Yousefi Rad E; Tammam J; Thondre PS; Coe S · The British journal of nutrition · 2024
    Meta-analysis12 studies pooledCardiovascular Support forNiacin
  8. Effect of lipid-lowering therapies on lipoprotein(a) levels: a comprehensive meta-analysis of randomized controlled trials.
    Xie S; Galimberti F; Olmastroni E; Carugo S; Catapano AL; Casula M; META-LIPID Group · Atherosclerosis · 2025
    Meta-analysis145,314 participants147 studies pooledCardiovascular Support forNiacin
  9. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group.
    Guyton JR; Blazing MA; Hagar J; Kashyap ML; Knopp RH; McKenney JM; Nash DT; Nash SD · Archives of internal medicine · 2000
    Randomized trial173 participantsCardiovascular Support forNiacin
  10. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia.
    Knopp RH; Alagona P; Davidson M; Goldberg AC; Kafonek SD; Kashyap M; Sprecher D; Superko HR; Jenkins S; Marcovina S · Metabolism: clinical and experimental · 1998
    Randomized trial223 participantsCardiovascular Support forNiacin
  11. Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial.
    Rayman MP; Stranges S; Griffin BA; Pastor-Barriuso R; Guallar E · Annals of internal medicine · 2011
    Randomized trial501 participantsCardiovascular Support Heart Health forSelenium
  12. Association of selenium and cadmium with heart failure and mortality based on the National Health and Nutrition Examination Survey.
    Xing X; Xu M; Yang L; Shao C; Wang Y; Qi M; Niu X; Gao D · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2023
    Cohort study15,689 participantsCardiovascular Support forSelenium
  13. Higher serum selenium concentration is associated with lower risk of all-cause and cardiovascular mortality among individuals with chronic kidney disease: A population-based cohort study of NHANES.
    Zhu D; Zhong Q; Lin T; Song T · Frontiers in nutrition · 2023
    Cohort study3,063 participantsCardiovascular Support Heart Health forSelenium
  14. Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis.
    Kuria A; Tian H; Li M; Wang Y; Aaseth JO; Zang J; Cao Y · Critical reviews in food science and nutrition · 2021
    Meta-analysis13 studies pooledCardiovascular Support forSelenium
  15. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledCardiovascular Support Everyday Health forSelenium
  16. Vitamin B12 Status and Cardiovascular Risk: Novel Insights from NMR-Based Lipoprotein Profiling in 20,665 Adults.
    Eken Y; Tekin N; Şahin F; Tay İ; Yıldırım Saral N; Serteser M; Baykal AT · Journal of clinical medicine · 2026
    Cross-sectional study20,665 participantsCardiovascular Support Heart Health forVitamin B12
  17. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.
    Zhang M; Aris IM; Cardenas A; Rifas-Shiman SL; Lin PD; Ngo LH; Oken E; Hivert MF; Juraschek SP · Hypertension (Dallas, Tex. : 1979) · 2025
    Cohort study493 participantsCardiovascular Support forVitamin B12
  18. Vitamin B12 Deficiency, Hyperhomocysteinemia, and Diabetes as Metabolic Determinants of Cardiovascular Risk in Mexican Women.
    Ramirez-Villalobos MD; Monterrubio-Flores E; Marquez-Murillo M; Alcalde-Rabanal J; Shamah-Levy T; Perichart-Perera O; Macias-Morales N; Campos-Nonato I · Nutrients · 2025
    Cross-sectional study1,197 participantsCardiovascular Support forVitamin B12
  19. Impact of serum vitamin (Vitamin D, Vitamin B12) and trace element (Fe, Zn, Cu) levels on major adverse cardiovascular events and poor prognosis in STEMI patients undergoing primary PCI.
    Wang C; Liu D; Tang M; Liu J; Ma Y · Journal of clinical biochemistry and nutrition · 2026
    Cohort study202 participantsCardiovascular Support forVitamin B12
  20. Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.
    Datt V; Wadhhwa R; Sharma V; Virmani S; Minhas HS; Malik S · Journal of cardiac surgery · 2021
    Systematic reviewCardiovascular Support forVitamin B12