Twice Daily Multi

Twice Daily Multi

Designs for Health4.7 (41 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 60 servings
Goals
$62.49 $1.04 per serving

Product analysis

54 out of 100

Twice Daily Multi brings together nutrients that support normal skin and eye function, particularly when dietary intake is low. Undisclosed proportions in its vitamin blends make the exact mix harder to compare.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality42

The natural vitamin E forms and the boron form are favorable features. Quality across the other nutrients remains uncertain, so these strengths do not establish the quality of the entire mix.

Ingredient Transparency79

Amounts and nearly all forms are stated, which helps with checking the label. The proportions within the vitamin A and vitamin E mixtures are not disclosed.

Value For Money39

The vitamin A and boron contributions are relatively costly, while the vitamin E offers limited value. Value for most of the other nutrients cannot be judged reliably.

Customer Satisfaction69

The available ratings are highly positive. The small number of responses leaves a less settled picture of customer satisfaction.

Product Focus48

The clearest nutritional fit is support for normal skin and eye function. The broad formula does not establish extra cosmetic benefits or improved vision in someone whose intake is already adequate.

Format
Capsule
Container
120 Capsule(s)
Per serving
$1.04
Customer rating
4.7 · 41 ratings
Report analysis

Goals

Skin Health
Impact
High effect
C- Ingredient FitD- PathwaysA+ EvidenceA Formulation Logic
Zinc · 15 mgVitamin C · 500 mgSelenium · 200 mcgVitamin E · 158 mg
Study evidence
Biotin Supportive 10 studies
Niacin Supportive 61 studies
Selenium Supportive 22 studies
Vitamin A Supportive 106 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Zinc Supportive 66 studies
Impact
High effect
D+ Ingredient FitC PathwaysB+ EvidenceA Formulation Logic
Zinc · 15 mgVitamin E · 158 mgVitamin C · 500 mgVitamin A · 3200 IU
Study evidence
Riboflavin Supportive 69 studies
Selenium Supportive 15 studies
Vitamin A Supportive 65 studies
Vitamin C Disputed 24 studies
Vitamin D Disputed 35 studies
Vitamin E Disputed 35 studies
Zinc Supportive 39 studies

Ingredients

IngredientAmount per servingScore
Vitamin A (Mixed Carotenoids, Vitamin A Palmitate)
3200 IU 63
Vitamin C (Ascorbic Acid)
500 mg
Vitamin D (Cholecalciferol)
500 IU
Vitamin E (D-Alpha-Tocopherol)
24 IU 58
Thiamine (Thiamine Hydrochloride)
50 mg
Riboflavin
30 mg
Niacin (Niacinamide)
30 mg
Vitamin B6 (Pyridoxine Hydrochloride)
50 mg
NatureFolate Blend
400 mcg
Vitamin B12 (Methylcobalamin)
500 mcg
Biotin (D-Biotin)
300 mcg
Pantothenic Acid (D-Calcium Pantothenate)
50 mg
Iodine (Potassium Iodide)
75 mcg
Zinc (TRAACS Zinc Glycinate Chelate)
15 mg
Selenium (Selenium Glycinate)
200 mcg
Manganese (TRAACS Manganese Glycinate Chelate)
3 mg
Chromium (TRAACS Chromium Nicotinate Glycinate Chelate)
400 mcg
Molybdenum (TRAACS Molybdenum Glycinate Chelate)
100 mcg
Mixed Tocopherols (D-Alpha-Tocopherol, D-Beta-Tocopherol, D-Delta-Tocopherol, D-Gamma-Tocopherol)
158 mg 58
Alpha Lipoic Acid
20 mg
Boron (Bororganic Glycine)
2 mg 74
Gluten Free Adults 18–50
Report overview
B Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyD- Value
Each serving provides 24 IU of vitamin E. That is a relatively small amount. The cost per serving is high. The blend includes several tocopherols, but their amounts are unknown.
How this ingredient is rated

Active Ingredient Quality & Bioavailability77

The blend includes natural d-alpha, d-beta, d-gamma and d-delta tocopherols; their proportions are unknown. No tocotrienols are listed.
Natural (d-alpha) vs. Synthetic (dl-alpha)
The blend includes natural d-alpha, d-beta, d-gamma and d-delta tocopherols; their proportions are unknown.
Mixed Tocopherol Isomer Diversity
The blend includes alpha, beta, gamma and delta tocopherols.
Tocotrienol Complex Inclusion
No tocotrienols are listed.

Dose, Safety & Label Transparency48

Each serving provides 24 IU of vitamin E. That is a relatively small amount. Individual tocopherol amounts are not specified.
Therapeutic Dosage Range
Each serving provides 24 IU of vitamin E. That is a relatively small amount.
Label Transparency and Isomer Specificity
Individual tocopherol amounts are not specified.

Value40

The cost per serving is high.
Cost per Natural-Form Therapeutic Serving
The cost per serving is high.
A+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value
A serving provides 2 mg of boron, with a high cost for the amount supplied. The amount is in a maintenance range, below amounts commonly used for bone health. It uses Bororganic Glycine.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

It uses Bororganic Glycine. Bororganic Glycine is a named branded source.
Boron Form & Bioavailability
It uses Bororganic Glycine.
Trademarked & High-Purity Sources
Bororganic Glycine is a named branded source.

Dose, Safety & Label Transparency80

The label lists 2 mg of boron per serving. The amount is in a maintenance range, below amounts commonly used for bone health.
Elemental Dose Transparency
The elemental boron amount is stated.
Dosage Efficacy & Safety Margin
The amount is in a maintenance range, below amounts commonly used for bone health.

Value10

The cost is high for a 3 mg equivalent of boron.
Price per 3mg Elemental Boron
The cost is high for a 3 mg equivalent of boron.
C+ Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyF Value
A serving provides 3,200 IU of vitamin A at a high cost for the vitamin A amount. The sources are mixed carotenoids and retinyl palmitate. Their proportions are unknown.
How this ingredient is rated

Active Ingredient Quality & Bioavailability65

The sources are mixed carotenoids and retinyl palmitate. Their proportions are unknown.
Vitamin A Chemical Form & Source
The sources are mixed carotenoids and retinyl palmitate. Their proportions are unknown.

Dose, Safety & Label Transparency82

A serving provides 3,200 IU of vitamin A. The sources are mixed carotenoids and retinyl palmitate. Their proportions are unknown.
Dosage Efficacy & Safety Thresholds
A serving provides 3,200 IU of vitamin A.
Label Transparency of Specific Forms
The sources are mixed carotenoids and retinyl palmitate. Their proportions are unknown.

Value20

The cost for the vitamin A amount is high.
Price per 5,000 IU Dose
The cost for the vitamin A amount is high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. U.S. Multicenter Clinical Trial of Corneal Collagen Crosslinking for Treatment of Corneal Ectasia after Refractive Surgery.
    Hersh PS; Stulting RD; Muller D; Durrie DS; Rajpal RK; U.S. Crosslinking Study Group · Ophthalmology · 2017
    Randomized trial179 participantsEye Health forRiboflavin
  2. United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment.
    Hersh PS; Stulting RD; Muller D; Durrie DS; Rajpal RK; United States Crosslinking Study Group · Ophthalmology · 2017
    Randomized trial205 participantsEye Health forRiboflavin
  3. EpiSmart Crosslinking for Keratoconus: A Phase 2 Study.
    Epstein RJ; Belin MW; Gravemann D; Littner R; Rubinfeld RS · Cornea · 2023
    Randomized trial2,228 participantsEye Health forRiboflavin
  4. Prospective Randomized Trial of Corneal Cross-linking Riboflavin Dosing Frequencies for Treatment of Keratoconus and Corneal Ectasia.
    Price MO; Fairchild K; Feng MT; Price FW · Ophthalmology · 2019
    Randomized trial510 participantsEye Health forRiboflavin
  5. Corneal collagen cross-linking for keratoconus: results of 3-year follow-up in Pakistani population.
    Khan WA; Zaheer N; Khan S · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2015
    Non-randomized trial66 participantsEye Health forRiboflavin
  6. Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction: A vehicle-controlled, randomized clinical trial.
    Watson SL; Jones LW; Stapleton F; Hinds M; Ng A; Tan J; Alster Y; Bosworth C; Rafaeli O; DePuy V; CELESTIAL STUDY Group · The ocular surface · 2026
    Randomized trial245 participantsEye Health forSelenium
  7. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledEye Health forSelenium
  8. Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction over six months of treatment: A Phase 2, vehicle-controlled, randomized extension trial.
    Downie LE; Craig JP; Stapleton F; Tan J; Jones LW; Ng A; Hinds M; Bosworth C; Alster Y · The ocular surface · 2025
    Randomized trial245 participantsEye Health forSelenium
  9. AZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial.
    Stapleton F; Hinds M; Tan J; Jones L; Chalmers R; Bosworth C; Alster Y · The ocular surface · 2025
    Randomized trial67 participantsEye Health forSelenium
  10. The effect of a biweekly novel selenium sulfide-containing topical treatment in symptomatic contact lens wearers: An exploratory study.
    Stapleton F; Jia T; DePuy V; Bosworth C; Gleeson M; Tan J · The ocular surface · 2025
    Randomized trial14 participantsEye Health forSelenium
  11. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa.
    Berson EL; Rosner B; Sandberg MA; Hayes KC; Nicholson BW; Weigel-DiFranco C; Willett W · Archives of ophthalmology (Chicago, Ill. : 1960) · 1993
    Randomized trial601 participantsEye Health forVitamin A
  12. Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial.
    Toshida H; Funaki T; Ono K; Tabuchi N; Watanabe S; Seki T; Otake H; Kato T; Ebihara N; Murakami A · Drug design, development and therapy · 2018
    Randomized trial66 participantsEye Health forVitamin A
  13. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.
    Imdad A; Mayo-Wilson E; Haykal MR; Regan A; Sidhu J; Smith A; Bhutta ZA · The Cochrane database of systematic reviews · 2022
    Meta-analysis1,223,856 participants47 studies pooledEye Health forVitamin A
  14. Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity.
    Mactier H; McCulloch DL; Hamilton R; Galloway P; Bradnam MS; Young D; Lavy T; Farrell L; Weaver LT · The Journal of pediatrics · 2012
    Randomized trial89 participantsEye Health forVitamin A
  15. Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy.
    Owsley C; McGwin G; Jackson GR; Heimburger DC; Piyathilake CJ; Klein R; White MF; Kallies K · Investigative ophthalmology & visual science · 2006
    Randomized trial104 participantsEye Health forVitamin A
  16. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsEye Health forVitamin C
  17. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyEye Health forVitamin C
  18. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewEye Health forVitamin C
  19. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsEye Health forVitamin C Eye Health forVitamin E
  20. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsEye Health forVitamin C