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Timed Release Super Bio Vitamin C

Solaray
4.7
★ ★ ★ ★ ★
(12411 ratings)
Vitamin C 1000 mg
Rutin 100 mg
Flavonoid (mixture) 500 mg
Product Image
Score77
A high-potency timed-release vitamin C and flavonoid blend with substantial supporting amounts, limited by unclear source accounting and an unbuffered core.
How scoring works
Quantity:100 VegCap(s) • (50 servings)
Goals:
General Health
Skin Health
Immunity
Anti-Inflammatory Support
Vision Support

Score 77

A high-potency timed-release vitamin C and flavonoid blend with substantial supporting amounts, limited by unclear source accounting and an unbuffered core.
How scoring works
$17.09($0.34 per serving)
Pure Formulas
$ 17.09
iHerb
$ 17.09
Vitacost
$ 17.09
iHerb
$ 17.09
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Analysis

A high vitamin C amount supports antioxidant defenses, collagen production, and normal immune function. Lemon bioflavonoids, rutin, and hesperidin add meaningful complementary flavonoid weights.

Timed release may spread exposure across the day, but the supplied data do not independently clarify the release design. Repeated vitamin C entries tied to acerola, ascorbic acid, and rose hip also make each source's true contribution hard to interpret.

The formula suits people seeking a high-potency antioxidant blend rather than a buffered vitamin C product. It offers useful depth in one pathway but lacks the carotenoids, minerals, and lipids needed for comprehensive vision or skin support.

Who is it for
  • Adults seeking high-potency vitamin C
  • Users wanting substantial citrus flavonoids
  • People who tolerate unbuffered ascorbic acid
Best for
  • Layered antioxidant support
  • Collagen formation support
  • Focused immune nutrition

Pros

  • Substantial vitamin C amount
  • Meaningful rutin and hesperidin
  • Timed-release delivery is listed

Cons

  • Vitamin C source contributions are ambiguous
  • Ascorbic acid is not buffered
  • Flavonoid concentrates lack marker percentages

Warnings

  • The high vitamin C amount may cause stomach upset or loose stools
  • People prone to oxalate kidney stones should seek advice before sustained high intake
  • Unbuffered ascorbic acid may be uncomfortable for acid-sensitive users
  • Avoid duplicate high-dose vitamin C from other supplements

Nutrient quality

85 Highest impact

Timed release improves delivery, but the main ascorbic acid remains unbuffered. Vitamin C and citrus bioflavonoids are substantial, with useful rutin and hesperidin support.

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Ingredient transparency

75 High impact

The major active amounts are listed, though source contribution to total vitamin C is not fully separated. The supplied data does not include a complete inactive ingredient list.

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Customer satisfaction

71 High impact

The aggregate satisfaction measure is strong enough to support a favorable first impression. Missing feedback themes leave repeat complaints and purpose fit uncertain despite adequate volume.

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Value for money

74 High impact

The price is reasonable for timed release and substantial flavonoid support. Each serving offers fair value, though it costs more than basic vitamin C.

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Goals

General Health
General Health
Impact
Highest effect
A Goal FitA+ Strength of SupportB+ CoverageA Formula Quality
Vitamin C · 1000 mg

A 1,000 mg vitamin C serving supplies strong antioxidant and collagen support, while rutin, hesperidin, and citrus compounds add complementary flavonoids. The timed-release design may spread delivery across the day.

The exact contribution from acerola, rose hip, and ascorbic acid is not separated, which limits form-level clarity. The formula still provides focused and meaningful support rather than trying to cover unrelated wellness claims.

Study evidence
Vitamin C Supportive 56 studies
Skin Health
Skin Health
Impact
Highest effect
A- Goal FitA Strength of SupportC+ CoverageA- Formula Quality
Vitamin C · 1000 mg

Vitamin C directly supports collagen synthesis and antioxidant protection in skin. The listed 1,000 mg amount provides strong depth, while substantial bioflavonoids, rutin, and hesperidin add complementary antioxidant support.

Timed release may spread delivery, but repeated 1,000 mg entries across acerola, ascorbic acid, and rose hip make the total source contribution ambiguous. The formula does not add collagen peptides or barrier lipids.

Study evidence
Vitamin C Supportive 53 studies
Immunity
Immunity
Impact
Highest effect
A- Goal FitA- Strength of SupportB- CoverageB Formula Quality
Vitamin C · 1000 mg

A high vitamin C amount provides focused antioxidant and immune-cell support. Bioflavonoids, rutin, and hesperidin add related plant compounds around that core nutrient.

Repeated vitamin C source lines make the contribution of each source unclear, and the supplied data do not verify the timed-release mechanism. The vitamin C amount may cause stomach upset and may be unsuitable for people prone to certain kidney stones.

Study evidence
Vitamin C Supportive 53 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B Goal FitB+ Strength of SupportB- CoverageB+ Formula Quality
Vitamin C · 1000 mg

Vitamin C, citrus flavonoids, rutin, and hesperidin provide layered antioxidant support relevant to inflammatory balance. The vitamin C and flavonoid amounts are substantial, and timed release may spread delivery across the day.

The formula emphasizes oxidative stress rather than directly targeting major inflammatory enzymes. Marker percentages and source details for the flavonoid concentrates are not supplied.

Study evidence
Rutin Supportive 6 studies
Vitamin C Supportive 50 studies
Vision Support
Vision Support
Impact
High effect
D Goal FitA- Strength of SupportD+ CoverageB- Formula Quality
Vitamin C · 1000 mg

Vitamin C contributes antioxidant support used within established multi-nutrient vision formulas. Timed-release capsules provides a substantial amount, but vitamin C alone has limited evidence for broad vision support.

Rutin, hesperidin, and lemon bioflavonoids provide secondary antioxidant support, though the formula still lacks macular pigments and omega-3 fats. The product is better viewed as general antioxidant support than a complete eye formula.

Study evidence
Rutin Not classified 1 study
Vitamin C Disputed 24 studies

Ingredients

IngredientAmount per serving
Vitamin C (Acerola Cherry, Ascorbic Acid, Rose Hip)
 1000 mg
Lemon Bioflavonoids concentrate
500 mg
Rutin concentrate
100 mg
Hesperidin concentrate
100 mg
Citrus Pectin
30 mg
Adults 18–50
Report overview
Vitamin C (Acerola Cherry, Ascorbic Acid, Rose Hip) · 1000 mg OverallScore75
C Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

A 1,000 mg vitamin C serving uses timed release and includes acerola, rose hip, citrus bioflavonoids, rutin, and hesperidin. Timed release improves delivery quality, although the ascorbic acid is not described as buffered. Cost efficiency is average for the active amount and added plant compounds.

View ingredientView products
Rutin · 100 mg OverallScore58
D- Active Ingredient Quality & BioavailabilityC+ Dose, Safety & Label TransparencyB Value

The clearly stated rutin concentrate provides a moderate supporting amount within a vitamin C formula. Its botanical source and purity percentage are missing, so the concentrate quality cannot be fully judged. Cost efficiency is good for the rutin delivered, though the dose remains below a targeted level.

View ingredientView products
Loading alternative details
87 Performance

Ester-C with Citrus Bioflavonoids

American Health
<p>Buffered vitamin C and a substantial citrus bioflavonoid amount improve form quality over the original’s unbuffered core. It gives up timed release and separately quantified rutin and hesperidin, but the focused formula may be easier to tolerate.</p>
86 Performance

Ester-C Plus 1000 mg Vitamin C

Solgar
<p>A substantial buffered vitamin C amount and citrus bioflavonoids provide a simpler, more stomach-friendly alternative. The original has broader measured flavonoids and timed release, while this option emphasizes core form quality.</p>
86 Performance

C

Swanson
<p>Fully buffered calcium ascorbate matches the main vitamin C amount with a clearly disclosed bioflavonoid addition. It improves expected stomach comfort, although timed release, rutin, hesperidin, and citrus pectin are absent.</p>
80 Budget

Supreme C Complex

Swanson Premium Brand
<p>Vitamin C, substantial citrus bioflavonoids, and measured rutin provide the same main collections at much lower serving cost. The vitamin C amount is smaller and unbuffered, and timed release is not provided.</p>
84 Budget

Ester-C 500 mg With Citrus Bioflavoinds

American Health
<p>Buffered vitamin C and citrus bioflavonoids offer much better value with stronger stomach-comfort potential than the original’s unbuffered ascorbic acid. It does not provide the same clearly measured rutin and hesperidin amounts or timed release.</p>
84 Budget

Ester-C 24 Hour Immune Support 1000 mg

NatureSmart
<p>A substantial buffered vitamin C serving with citrus bioflavonoids costs less to use and may suit sensitive stomachs better. The simpler formula omits separately measured rutin, hesperidin, and citrus pectin.</p>
80 Value

AlphaSorb-C 500

NOW
<p>Buffered calcium ascorbate, citrus bioflavonoids, rutin, acerola, and rose hips preserve broad antioxidant support at a much lower serving cost. The vitamin C and rutin amounts are smaller, but stomach comfort and everyday value improve.</p>
79 Value

Buffered Vitamin C 500 mg

Bluebonnet
<p>Buffered calcium ascorbate and a meaningful citrus bioflavonoid amount provide a lower-cost, stomach-friendly daily option. Potency, rutin, and flavonoid breadth are reduced compared with the original.</p>
82 Value

Ester-C Plus 1000 mg Vitamin C

Solgar
<p>Buffered vitamin C matches the original’s main potency and adds bioflavonoids, acerola, rose hips, and rutin at stronger serving value. Timed release and separately measured hesperidin are absent, but the core form may be gentler.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis.
    Bjelakovic G; Nikolova D; Gluud LL; Simonetti RG; Gluud C · JAMA · 2007
    Meta-analysis232,606 participants68 studies pooledGeneral Health forVitamin C
  2. Vitamin C intake and multiple health outcomes: an umbrella review of systematic reviews and meta-analyses.
    Xu K; Peng R; Zou Y; Jiang X; Sun Q; Song C · International journal of food sciences and nutrition · 2022
    Meta-analysis76 studies pooledGeneral Health forVitamin C
  3. Vitamin C supplementation in kidney failure: effect on uraemic symptoms.
    Singer RF · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2011
    Randomized trial99 participantsGeneral Health forVitamin C
  4. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  5. Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic Review and Meta-Analysis.
    Keya TA; Leela A; Fernandez K; Habib N; Rashid M · Current reviews in clinical and experimental pharmacology · 2022
    Meta-analysis10 studies pooledImmunity forVitamin C
  6. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  7. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  8. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage.
    Fitzpatrick RE; Rostan EF · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2002
    Non-randomized trial10 participantsSkin Health forVitamin C
  9. Vitamin C and postoperative outcomes following mandibular third molar extraction: a randomized split-mouth study.
    Demirel M; Aktas A; Kizil M; Yalcin N · Oral surgery, oral medicine, oral pathology and oral radiology · 2026
    Randomized trial56 participantsSkin Health forVitamin C
  10. The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial.
    Bazyar H; Moradi L; Zaman F; Zare Javid A · Phytotherapy research : PTR · 2023
    Randomized trial50 participantsAnti-Inflammatory Support forRutin
  11. Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature.
    Muvhulawa N; Dludla PV; Ziqubu K; Mthembu SXH; Mthiyane F; Nkambule BB; Mazibuko-Mbeje SE · Pharmacological research · 2022
    Systematic reviewAnti-Inflammatory Support forRutin
  12. Rutin-loaded chitosan microspheres: Characterization and evaluation of the anti-inflammatory activity.
    Cosco D; Failla P; Costa N; Pullano S; Fiorillo A; Mollace V; Fresta M; Paolino D · Carbohydrate polymers · 2018
    OtherAnti-Inflammatory Support forRutin
  13. Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial.
    Henrotin Y; Pap T; Lieten S; Badot V; Dubuc JE; Urbin-Choffray D; von Eynatten M; Johansen OE; Rau S; Brabants K · RMD open · 2025
    Randomized trial45 participantsAnti-Inflammatory Support forRutin
  14. The Impact of the Combination of Proteolytic Enzyme and Rutin on the Post-operative Management of Inflammation: A Randomized, Controlled, Double-Blind, Comparative Clinical Trial
    Rathi PC, Rathi CL, Risbud SP, Ganu GP · Cureus · 2024
    Randomized trial65 participantsAnti-Inflammatory Support forRutin
  15. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  16. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  17. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  18. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  19. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  20. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  21. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  22. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  23. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  24. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  25. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  26. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  27. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  28. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  29. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  30. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  31. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  32. A randomized, double-masked study on the treatment of retinal vein occlusion with troxerutin
    Glacet-Bernard A, Coscas G, Chabanel A, Zourdani A, Lelong F, Samama MM · American Journal of Ophthalmology · 1994
    Randomized trial53 participantsVision Support forRutin
  33. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  34. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  35. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  36. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  37. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C