Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.
- The Effects of Combined Exercise with Citrulline Supplementation on Body Composition and Lower Limb Function of Overweight Older Adults: A Systematic Review and Meta-Analysis.
Xie S; Li S; Shaharudin S · Journal of sports science & medicine · 2023
Meta-analysis303 participants7 studies pooledflagFitness forscienceCitrulline
- Effect of isolated and combined ingestion of caffeine and citrulline malate on resistance exercise and jumping performance: a randomized double-blind placebo-controlled crossover study.
Haugen ME; Vårvik FT; Grgic J; Studsrud H; Austheim E; Zimmermann EM; Falch HN; Larsen S; van den Tillaar R; Bjørnsen T · European journal of nutrition · 2023
Randomized trial35 participantsflagFitness forscienceCitrulline
- Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.
Luo P; Chen J; Liu K; Zhang J · Clinical nutrition ESPEN · 2025
Meta-analysis415 participants15 studies pooledflagCardiovascular Support forscienceCitrulline
- Micronutrient Supplementation to Reduce Cardiovascular Risk.
An P; Wan S; Luo Y; Luo J; Zhang X; Zhou S; Xu T; He J; Mechanick JI; Wu WC; Ren F; Liu S · Journal of the American College of Cardiology · 2022
Meta-analysis883,627 participants884 studies pooledflagCardiovascular Support forscienceCitrulline
- l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.
Bailey SJ; Blackwell JR; Lord T; Vanhatalo A; Winyard PG; Jones AM · Journal of applied physiology (Bethesda, Md. : 1985) · 2016
Randomized trial10 participantsflagCardiovascular Support forscienceCitrulline
- Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.
Maharaj A; Fischer SM; Dillon KN; Kang Y; Martinez MA; Figueroa A · Nutrients · 2022
Randomized trial25 participantsflagCardiovascular Support flagHeart Health forscienceCitrulline
- Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men.
Ochiai M; Hayashi T; Morita M; Ina K; Maeda M; Watanabe F; Morishita K · International journal of cardiology · 2012
Randomized trial15 participantsflagCardiovascular Support forscienceCitrulline
- Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis.
Rozemeijer S; Hemilä H; van Baaren M; de Man AME · BMC cardiovascular disorders · 2023
Meta-analysis872 participants7 studies pooledflagCardiovascular Support forscienceVitamin C
- Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.
Taddei S; Virdis A; Ghiadoni L; Magagna A; Salvetti A · Circulation · 1998
Clinical trial49 participantsflagCardiovascular Support forscienceVitamin C
- Vitamin C supplementation improves blood pressure and oxidative stress after acute exercise in patients with poorly controlled type 2 diabetes mellitus: A randomized, placebo-controlled, cross-over study.
Boonthongkaew C; Tong-Un T; Kanpetta Y; Chaungchot N; Leelayuwat C; Leelayuwat N · The Chinese journal of physiology · 2021
Randomized trial24 participantsflagCardiovascular Support forscienceVitamin C
- Vascular benefits of vitamin C supplementation against fine particulate air pollution in healthy adults: A double-blind randomised crossover trial.
Ren J; Liang J; Wang J; Yin B; Zhang F; Li X; Zhu S; Tian H; Cui Q; Song J; Liu G; Ling W; Ma Y · Ecotoxicology and environmental safety · 2022
Randomized trial58 participantsflagCardiovascular Support forscienceVitamin C
- Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes.
Mullan BA; Young IS; Fee H; McCance DR · Hypertension (Dallas, Tex. : 1979) · 2003
Randomized trial30 participantsflagCardiovascular Support forscienceVitamin C
- Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis.
Vårvik FT; Bjørnsen T; Gonzalez AM · International journal of sport nutrition and exercise metabolism · 2021
Meta-analysis137 participants8 studies pooledflagEnergy forscienceCitrulline
- Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study.
Suzuki T; Morita M; Kobayashi Y; Kamimura A · Journal of the International Society of Sports Nutrition · 2016
Randomized trial22 participantsflagEnergy forscienceCitrulline
- Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.
Pérez-Guisado J; Jakeman PM · Journal of strength and conditioning research · 2010
Randomized trial41 participantsflagEnergy forscienceCitrulline
- Citrulline/malate promotes aerobic energy production in human exercising muscle.
Bendahan D; Mattei JP; Ghattas B; Confort-Gouny S; Le Guern ME; Cozzone PJ · British journal of sports medicine · 2002
Single-arm trial18 participantsflagEnergy forscienceCitrulline
- The Effect of Citrulline Malate Supplementation on Muscle Fatigue Among Healthy Participants.
Farney TM; Bliss MV; Hearon CM; Salazar DA · Journal of strength and conditioning research · 2019
Randomized trial12 participantsflagEnergy forscienceCitrulline
- Effect of High-Intensity Interval Training Combined with L-Citrulline Supplementation on Functional Capacities and Muscle Function in Dynapenic-Obese Older Adults.
Buckinx F; Gouspillou G; Carvalho LP; Marcangeli V; El Hajj Boutros G; Dulac M; Noirez P; Morais JA; Gaudreau P; Aubertin-Leheudre M · Journal of clinical medicine · 2020
Randomized trial56 participantsflagFitness flagMuscle Gain forscienceCitrulline
- Initial Dietary Protein Intake Influence Muscle Function Adaptations in Older Men and Women Following High-Intensity Interval Training Combined with Citrulline.
Buckinx F; Marcangeli V; Pinheiro Carvalho L; Dulac M; Hajj Boutros G; Gouspillou G; Gaudreau P; Morais J; Noirez P; Aubertin-Leheudre M · Nutrients · 2020
Randomized trial73 participantsflagFitness forscienceCitrulline
- Effects of Citrulline alone or combined with exercise on muscle mass, muscle strength, and physical performance among older adults: a systematic review.
Aubertin-Leheudre M; Buckinx F · Current opinion in clinical nutrition and metabolic care · 2021
Systematic review250 participants6 studies pooledflagFitness flagMuscle Gain forscienceCitrulline
- Combined Vs. Single Supplementation of L-Citrulline and Sodium Bicarbonate During Sprint Interval Training in Basketball Players: Effects on Physical Performance and Hormonal Adaptations.
Wang Y; Wang Y; Qian K · Journal of sports science & medicine · 2025
Randomized trial40 participantsflagFitness forscienceCitrulline
- Inter-individual variability in redox and performance responses after antioxidant supplementation: A randomized double blind crossover study.
Margaritelis NV; Nastos GG; Vasileiadou O; Chatzinikolaou PN; Theodorou AA; Paschalis V; Vrabas IS; Kyparos A; Fatouros IG; Nikolaidis MG · Acta physiologica (Oxford, England) · 2023
Randomized trial44 participantsflagFitness forscienceVitamin C
- Antioxidant supplementation, redox deficiencies and exercise performance: A falsification design.
Margaritelis NV; Paschalis V; Theodorou AA; Kyparos A; Nikolaidis MG · Free radical biology & medicine · 2021
Randomized trial73 participantsflagFitness forscienceVitamin C
- A significant relationship between plasma vitamin C concentration and physical performance among Japanese elderly women.
Saito K; Yokoyama T; Yoshida H; Kim H; Shimada H; Yoshida Y; Iwasa H; Shimizu Y; Kondo Y; Handa S; Maruyama N; Ishigami A; Suzuki T · The journals of gerontology. Series A, Biological sciences and medical sciences · 2012
Cross-sectional study655 participantsflagFitness forscienceVitamin C
- Low vitamin C values are linked with decreased physical performance and increased oxidative stress: reversal by vitamin C supplementation.
Paschalis V; Theodorou AA; Kyparos A; Dipla K; Zafeiridis A; Panayiotou G; Vrabas IS; Nikolaidis MG · European journal of nutrition · 2016
Clinical trial20 participantsflagFitness forscienceVitamin C
- Low dietary vitamin C intake is associated with low muscle strength among elderly Korean women.
Park CY; Shin S · Nutrition research (New York, N.Y.) · 2024
Cross-sectional study14,844 participantsflagFitness forscienceVitamin C
- Effect of oral L-citrulline on brachial and aortic blood pressure defined by resting status: evidence from randomized controlled trials.
Yang HH; Li XL; Zhang WG; Figueroa A; Chen LH; Qin LQ · Nutrition & metabolism · 2022
Meta-analysis8 studies pooledflagHeart Health forscienceCitrulline
- Impact of L-Citrulline Supplementation and HIIT on Lipid Profile, Arterial Stiffness, and Fat Mass in Obese Adolescents with Metabolic-Dysfunction-Associated Fatty Liver Disease: A Randomized Clinical Trial.
Rodríguez-Carrillo AA; Espinoza-Vargas MR; Vargas-Ortiz K; Ibarra-Reynoso LDR; Olvera-Juárez M; Gómez-Ojeda A; Garay-Sevilla ME; Figueroa A · Nutrients · 2025
Randomized trial44 participantsflagHeart Health forscienceCitrulline
- Vascular effects of l-citrulline supplementation in healthy adults are largely influenced by the prehypertensive range of blood pressure: A double-blind, randomized, placebo-controlled, parallel-group study.
Nogimura D; Nagaoka K; Ogino K; Ogino N; Moriyasu K; Morita M · Nutrition research (New York, N.Y.) · 2026
Randomized trial66 participantsflagHeart Health forscienceCitrulline
- The Assessment of short-term effect of L-Citrulline on endothelial function via FMD to NMD ratio in known CAD patients: A randomized, cross-over clinical trial (Clinical trial number: NCT02638727).
Safi M; Mahjoob MP; Nateghi S; Khaheshi I; Akbarzadeh MA; Naderian M · Romanian journal of internal medicine = Revue roumaine de medecine interne · 2017
Randomized trial30 participantsflagHeart Health forscienceCitrulline
- Impact of L-citrulline supplementation and whole-body vibration training on arterial stiffness and leg muscle function in obese postmenopausal women with high blood pressure.
Figueroa A; Alvarez-Alvarado S; Ormsbee MJ; Madzima TA; Campbell JC; Wong A · Experimental gerontology · 2015
Randomized trial41 participantsflagMuscle Gain forscienceCitrulline
- Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes.
Figueroa A; Dillon KN; Levitt DE; Kang Y · Nutrients · 2025
Randomized trial16 participantsflagMuscle Gain forscienceCitrulline
- Citrulline stimulates muscle protein synthesis in the post-absorptive state in healthy people fed a low-protein diet - A pilot study.
Jourdan M; Nair KS; Carter RE; Schimke J; Ford GC; Marc J; Aussel C; Cynober L · Clinical nutrition (Edinburgh, Scotland) · 2016
Randomized trial8 participantsflagMuscle Gain forscienceCitrulline
- Effects of Citrulline Supplementation on Body Weight in Patients With Hepatobiliary Pancreatic Surgery.
Yang JA; Lee KE; Park JH; Yee J; Kim JY; Gwak HS · Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2020
Cohort study138 participantsflagWeight Gain forscienceCitrulline
- Impact of high-intensity interval training with or without l-citrulline on physical performance, skeletal muscle, and adipose tissue in obese older adults.
Marcangeli V; Youssef L; Dulac M; Carvalho LP; Hajj-Boutros G; Reynaud O; Guegan B; Buckinx F; Gaudreau P; Morais JA; Mauriège P; Noirez P; Aubertin-Leheudre M; Gouspillou G · Journal of cachexia, sarcopenia and muscle · 2022
Clinical trial81 participantsflagWeight Gain forscienceCitrulline
- Synergistic effect of long-term L-citruline supplementation combined with exercise on body composition in adults: A systematic review and meta-analysis of randomized controlled trials.
Wang W; Cai S; Liu K; Luo P · Complementary therapies in medicine · 2026
Meta-analysis9 studies pooledflagWeight Gain forscienceCitrulline
- Effects of Citrulline or Watermelon Supplementation on Body Composition: A Systematic Review and Dose-Response Meta-Analysis.
Ashtary-Larky D; Mohammadi S; Mousavi SAH; Hajizadeh L; Candow DG; Forbes SC; Afrisham R; Farrokhi V; Antonio J; Suzuki K · Nutrients · 2025
Meta-analysis21 studies pooledflagWeight Gain forscienceCitrulline
- Impact of 3-week citrulline supplementation on postprandial protein metabolism in malnourished older patients: The Ciproage randomized controlled trial.
Bouillanne O; Melchior JC; Faure C; Paul M; Canouï-Poitrine F; Boirie Y; Chevenne D; Forasassi C; Guery E; Herbaud S; Le Corvoisier P; Neveux N; Nivet-Antoine V; Astier A; Raynaud-Simon A; Walrand S; Cynober L; Aussel C · Clinical nutrition (Edinburgh, Scotland) · 2020
Randomized trial24 participantsflagWeight Gain forscienceCitrulline