Product Image

Hair Skin & Nails

Futurebiotics
4.5
★ ★ ★ ★ ★
(2823 ratings)
Iodine 225 mcg
Phosphorus 300 mg
Calcium 600 mg
PABA 50 mg
Flavonoid 50 mg
Methionine
Cysteine 150 mg
Product Image
Score64
Broad beauty-nutrient coverage is offset by weaker mineral forms, high manganese and niacin, and many lightly dosed extras.
How scoring works
Quantity:135 Tablet(s) • (45 servings)
Goals:
Hair Health
Bone Health
Energy
Skin Health

Score 64

Broad beauty-nutrient coverage is offset by weaker mineral forms, high manganese and niacin, and many lightly dosed extras.
How scoring works
$16.77($0.37 per serving)
Pure Formulas
$ 16.77
Vitacost
$ 19.23
Vitacost
$ 19.23
Amazon
$ 18.34
iHerb
$ 17.47
Report prices

Analysis

Biotin, cysteine, methionine, choline, vitamin C, zinc, iodine, and gelatin provide a plausible hair-and-skin nutrient foundation. The formula also supplies substantial calcium and several B vitamins.

Magnesium oxide and calcium carbonate are weaker forms, while manganese and niacin are high. Numerous botanicals, enzymes, and specialty compounds appear in small amounts that add clutter more than targeted value.

It fits adults who want a broad beauty multinutrient and are comfortable with animal-derived gelatin. The three-tablet serving and crowded formula make it less suitable for users who prefer focused supplementation.

Who is it for
  • Adults seeking a broad hair, skin, and nail multinutrient
  • Users comfortable with beef gelatin
Best for
  • Biotin and sulfur-amino-acid coverage
  • Consolidating beauty nutrients into one formula

Pros

  • Includes cysteine and methionine
  • Provides biotin, vitamin C, zinc, and iodine
  • Accessible serving value

Cons

  • Uses magnesium oxide and calcium carbonate
  • Many supporting ingredients are lightly dosed
  • Requires three tablets per serving

Warnings

  • Biotin can interfere with thyroid, hormone, and cardiac laboratory tests; stop it before testing when instructed.
  • The high manganese amount may be unsuitable for prolonged use in people with impaired liver function or manganese clearance.
  • Niacin may cause flushing, itching, or digestive discomfort, while iodine may not suit thyroid-sensitive users.

Nutrient quality

55 Moderate impact

Several hair-relevant nutrients are useful, but magnesium oxide, calcium carbonate, and conventional vitamin forms lower absorption quality. The broad profile includes meaningful core nutrients alongside aggressive vitamin A and manganese amounts.

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Ingredient transparency

76 High impact

Most active amounts are shown, but several forms and extract standardizations remain unspecified. Complete non-active ingredient details are not included in the supplied label data.

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Customer satisfaction

69 High impact

The supplied average rating is favorable. Detailed firsthand feedback is unavailable, so recurring complaints and purpose fit cannot be assessed.

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Value for money

57 Moderate impact

Broad coverage supports reasonable value, but mixed forms and dose-balance concerns reduce quality. Numerous low-dose extras inflate the label without clearly improving the core result.

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Report analysis

Goals

Hair Health
Hair Health
Impact
High effect
A- Goal FitC+ Strength of SupportB+ CoverageB+ Formula Quality
Biotin · 1500 mcgVitamin D · 5 mcgZinc · 15 mgIron · 6 mgMethionine · 100 mgVitamin C · 120 mg

Biotin, cysteine, methionine, zinc, low-dose iron, vitamin C, horsetail, and iodine cover structural and nutritional hair pathways. The sulfur amino acids are useful supporting amounts, while horsetail lacks silica standardization and active yield.

The formula is clearly hair-focused, though several ingredients provide moderate rather than strong depth. Biotin can interfere with thyroid, hormone, and cardiac blood tests, so use should be disclosed before laboratory testing.

Study evidence
Biotin Supportive 4 studies
Horsetail Not classified

No linked studies yet.

Iodine No effect 1 study
Iron Disputed 25 studies
Vitamin C Mixed 5 studies
Zinc Supportive 22 studies
Bone Health
Bone Health
Impact
High effect
B- Goal FitC Strength of SupportB- CoverageC- Formula Quality
Phosphorus · 300 mgMagnesium · 200 mgCalcium · 600 mgVitamin D · 5 mcgManganese · 10 mgZinc · 15 mgVitamin C · 120 mg

Calcium, phosphorus, magnesium, vitamin D3, manganese, and gelatin provide both mineral and limited matrix support. Evidence is strongest for the structural minerals, while the hair-focused botanicals have little proven skeletal value.

Calcium and phosphorus are meaningfully supplied, but vitamin D3 is small and magnesium oxide is poorly absorbed. Calcium carbonate, dicalcium phosphate, and magnesium oxide are less favorable than chelated or citrate forms.

Study evidence
Calcium Supportive 144 studies
Magnesium Supportive 48 studies
Manganese Adverse 12 studies
Phosphorus Supportive 44 studies
Vitamin D Supportive 202 studies
Energy
Energy
Impact
Moderate effect
C+ Goal FitC Strength of SupportC- CoverageC+ Formula Quality
Iodine · 225 mcgVitamin D · 5 mcgVitamin B5 · 30 mgMagnesium · 200 mgRiboflavin · 10 mgThiamin · 10 mgVitamin B12 · 16 mcgIron · 6 mg

B vitamins, choline, iron, and magnesium offer some metabolic support within a hair, skin, and nails formula. The B12 amount is low, and magnesium oxide weakens the apparent strength of the mineral contribution.

The formula lacks an acute alertness, mitochondrial, or adaptogen pathway, so energy coverage remains narrow. Additional beauty-oriented ingredients broaden the label without materially improving fatigue or stamina support.

Study evidence
Iron Supportive 74 studies
Magnesium Supportive 4 studies
Skin Health
Skin Health
Impact
Moderate effect
C- Goal FitD+ Strength of SupportC CoverageD- Formula Quality
Zinc · 15 mgVitamin C · 120 mgSelenium · 25 mcgVitamin E · 20 mg

The beauty formula covers several skin-supporting nutrients but relies on broad, lightly targeted ingredients. Vitamin A, vitamin C, vitamin E, zinc, selenium, horsetail, gelatin, and sulfur amino acids address turnover, antioxidants, and matrix support.

Gelatin and horsetail are not standardized as high-quality skin actives, and no ceramide or hydration ingredient is present. The extensive blend offers general beauty nutrition rather than strong evidence for visible skin outcomes.

Study evidence
Selenium Supportive 22 studies
Vitamin A Supportive 106 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Zinc Supportive 66 studies

Ingredients

IngredientAmount per serving
Vitamin A (Beta-Carotene)
 6000 mcg RAE
Vitamin C (Ascorbic Acid)
 120 mg
Vitamin D (Cholecalciferol)
 5 mcg
Vitamin E (Mixed Tocopherols)
 20 mg
Thiamine (Thiamine Mononitrate, Vitamin B1)
 10 mg
Riboflavin (Vitamin B2)
 10 mg
Niacin (Niacinamide)
 50 mg NE
Vitamin B6 (Pyridoxine Hydrochloride)
 10 mg
Folate
666.4 mcg DFE
Vitamin B12 (Cyanocobalamin)
 16 mcg
Biotin
1500 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 30 mg
Choline (Choline Bitartrate)
 150 mg
Calcium (Calcium Carbonate, Dicalcium Phosphate)
 600 mg
Iron (Iron Amino Acid Chelate)
 6 mg
Phosphorus (Dicalcium Phosphate)
 300 mg
Iodine (Potassium Iodide)
 225 mcg
Magnesium (Magnesium Oxide)
 200 mg
Zinc (Zinc Gluconate)
 15 mg
Selenium (Selenium Amino Acid Complex)
 25 mcg
Manganese
10 mg
Horsetail Leaf Extract
71 mg
Gelatin (Beef)
 250 mg
L-Cysteine Hydrochloride
150 mg
Methionine (L-Methionine)
 100 mg
Oat Straw
75 mg
Echinacea angustifolia
75 mg
Inositol
60 mg
Ribonucleic Acid
60 mg
Betaine (Betaine Hydrochloride)
 50 mg
Para-Aminobenzoic Acid
50 mg
Citrus Bioflavonoids
50 mg
Papain
50 mg
Asparagus racemosus
50 mg
Rutin
25 mg
Adults 18–50 Women
Report overview
Iodine (Potassium Iodide) · 225 mcg OverallScore95
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

Potassium iodide provides a stable and readily absorbed iodine source. The 225 mcg amount is clearly disclosed and fits daily thyroid maintenance. The moderate serving cost shapes the trade-off, while its nonmarine form avoids a seaweed-specific contamination concern.

View ingredientView products
Phosphorus (Dicalcium Phosphate) · 300 mg OverallScore90
B Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Dicalcium phosphate is a reliable bone-mineral source delivered at the upper edge of the targeted range. The exact amount is clear, although three tablets are needed for the serving. A low serving cost supports strong value.

View ingredientView products
Calcium (Calcium Carbonate, Dicalcium Phosphate) · 600 mg OverallScore82
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value

Calcium carbonate and dicalcium phosphate are common forms that generally absorb less readily than citrate or chelates. The 600 mg elemental calcium serving sits within the preferred per-dose absorption range. No concerning additives are disclosed, and the serving cost is competitive.

View ingredientView products
Loading alternative details
70 Performance

Body Hair Skin & Nails

Mason Natural
Biotin, zinc, choline, iron, and antioxidant vitamins provide broad hair and nail coverage with less extreme vitamin A than the original. Basic nutrient forms, high manganese, and poorly absorbed magnesium oxide remain important limitations.
69 Performance

Extra Strength Hair Skin & Nails

21st Century
D-biotin, vitamin D3, vitamin C, and zinc create a simpler and more focused beauty formula than the original’s crowded blend. Structural additions such as collagen and horsetail are token doses, and concentrated biotin may interfere with laboratory tests.
68 Performance

Hair Skin & Nails

Sundown
D-biotin and core vitamins provide a more streamlined beauty-support option with fewer aggressively dosed minerals. Collagen, horsetail, choline, and several antioxidants are present only in token amounts, while biotin may interfere with laboratory tests.
70 Budget

Body Hair Skin & Nails

Mason Natural
Biotin, iron, zinc, choline, and antioxidant vitamins provide broad hair and nail nutrition at a similar serving value. Basic forms, high manganese, magnesium oxide, and included iron limit routine suitability, but vitamin A is less aggressive than in the original.
69 Budget

Extra Strength Hair Skin & Nails

21st Century
High-dose D-biotin, vitamin D3, vitamin C, and zinc provide a simpler beauty-support base at a lower serving cost. Collagen, horsetail, and choline are token additions, while the biotin amount may interfere with some laboratory tests.
68 Budget

Hair Skin & Nails

Sundown
High-dose D-biotin and several vitamins provide an economical beauty-nutrient base. Collagen, horsetail, choline, and antioxidants are token amounts, and the biotin dose may interfere with some laboratory tests.
70 Value

Body Hair Skin & Nails

Mason Natural
Broad biotin, iron, zinc, choline, and antioxidant coverage offers competitive value for hair and nail nutrition. Users without an identified iron need may prefer another option, and high manganese plus magnesium oxide reduce quality.
69 Value

Extra Strength Hair Skin & Nails

21st Century
A focused combination of D-biotin, vitamin D3, vitamin C, and zinc offers strong serving value without the original’s very high vitamin A. Token collagen and horsetail provide little structural depth, and biotin can affect laboratory tests.
68 Value

Hair Skin & Nails

Sundown
The affordable formula centers on D-biotin and core vitamins rather than a long list of assertive minerals. Several accessory ingredients are token doses, basic forms reduce quality, and high biotin can affect laboratory tests.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Association between serum phosphorus levels and pelvic bone mineral density in U.S. adults aged 18-59 years.
    Jiang T; Pan Y; Xu J; Ge J; Ji S; Li T; Zhang Y · BMC musculoskeletal disorders · 2025
    Cross-sectional study5,589 participantsBone Health forPhosphorus
  2. Interventions for infantile seborrhoeic dermatitis (including cradle cap).
    Victoire A; Magin P; Coughlan J; van Driel ML · The Cochrane database of systematic reviews · 2019
    Systematic review35 participants2 studies pooledSkin Health forBiotin
  3. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  4. Assessment of the feed additives calcium d-pantothenate and d-panthenol for all animal species for the renewal of their authorisation (DSM Nutritional products Ltd).
    EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP); Villa RE; Azimonti G; Bonos E; Christensen H; Durjava M; Dusemund B; Gehring R; Glandorf B; Kouba M; López-Alonso M; Marcon F; Nebbia C; Pechová A; Prieto-Maradona M; Röhe I; Theodoridou K; Galobart J; Holczknecht O; Pizzo F; Radovnikovic A; Vettori MV; Amaduzzi A · EFSA journal. European Food Safety Authority · 2025
    Guideline / consensusSkin Health forVitamin B5
  5. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa.
    Capo-chichi CD; Guéant JL; Lefebvre E; Bennani N; Lorentz E; Vidailhet C; Vidailhet M · The American journal of clinical nutrition · 1999
    Clinical trial34 participantsMetabolism Boost forRiboflavin
  6. Vitamin B status in patients with chronic fatigue syndrome.
    Heap LC; Peters TJ; Wessely S · Journal of the Royal Society of Medicine · 1999
    Case-control study30 participantsEnergy forRiboflavin
  7. [Evaluation of the role of dietary intake in the occurrence of alopecia].
    El Fékih N; Kamoun H; Fazaa B; El Ati J; Zouari B; Kamoun MR; Gaigi S · Revue medicale de Liege · 2010
    Case-control study272 participantsHair Health forIodine
  8. Declining serum bone turnover markers are associated with the short-term positive change of lumbar spine bone mineral density in postmenopausal women.
    Zhao S; Mo X; Wen Z; Liu M; Chen Z; Lin W; Huang Z; Chen B · Menopause (New York, N.Y.) · 2022
    Cohort study135 participantsBone Health forPhosphorus
  9. Anti-pollution cosmetic-based one-step formation of w/o/w multiple emulsion containing D-biotin for skin protection: fabrication and in vitro and in vivo evaluation.
    Ali A; Iqbal S; Ilyas A; Khan H; Asad MHHB; Fatima N; Akhtar N · Drug delivery and translational research · 2020
    Non-randomized trial15 participantsSkin Health forBiotin
  10. Panthenol Allergic Contact Dermatitis: Sources of Exposure, Reported Cases, and a Call for More Frequent Testing.
    Weber B; Hylwa S · Dermatitis : contact, atopic, occupational, drug · 2025
    Narrative reviewSkin Health forVitamin B5
  11. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  12. Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on job fatigue among Egyptian construction workers.
    Fouad S; Ibrahim GE; Hussein AMS; Ibrahim FA; El Gendy A · Heliyon · 2021
    Non-randomized trialEnergy forRiboflavin
  13. Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies.
    Mereis M; Wanders RJA; Schoonen M; Dercksen M; Smuts I; van der Westhuizen FH · The international journal of biochemistry & cell biology · 2024
    Systematic reviewMetabolism Boost forRiboflavin
  14. The association between dietary mineral intake and bone mineral density: a cross-sectional study.
    Wei M; Wei J; Huang S · Journal of health, population, and nutrition · 2025
    Cross-sectional study11,520 participantsBone Health forPhosphorus
  15. Biotinidase deficiency: the enzymatic defect in late-onset multiple carboxylase deficiency.
    Wolf B; Grier RE; Allen RJ; Goodman SI; Kien CL · Clinica chimica acta; international journal of clinical chemistry · 1983
    Case series5 participantsSkin Health forBiotin
  16. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation.
    Proksch E; Nissen HP · The Journal of dermatological treatment · 2009
    Randomized trialSkin Health forVitamin B5
  17. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsSkin Health Hair Health forBiotin
  18. Anaemia during pregnancy: could riboflavin deficiency be implicated?
    Duffy B; McNulty H; Ward M; Pentieva K · The Proceedings of the Nutrition Society · 2026
    Narrative reviewMetabolism Boost forRiboflavin
  19. B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue treated with high dose oral thiamine.
    Bager P; Hvas CL; Hansen MM; Ueland P; Dahlerup JF · Molecular medicine (Cambridge, Mass.) · 2023
    Observational studyEnergy forRiboflavin
  20. Dairy product consumption, eating habits, sedentary behaviour and physical activity association with bone mineral density among adolescent boys: a cross-sectional observational study.
    Kopiczko A; Czapla M; Juárez-Vela R; Ross C; Uchmanowicz B · BMC pediatrics · 2024
    Cross-sectional study115 participantsBone Health forPhosphorus
  21. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
    Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS · International journal of dermatology · 2021
    Non-randomized trial60 participantsSkin Health forBiotin
  22. Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: a pilot study.
    Udompataikul M; Limpa-o-vart D · Journal of drugs in dermatology : JDD · 2012
    Non-randomized trial30 participantsSkin Health forVitamin B5
  23. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsSkin Health Hair Health forBiotin
  24. Generalized seborrhoeic dermatitis. Clinical and therapeutic data of 25 patients.
    Messaritakis J; Kattamis C; Karabula C; Matsaniotis N · Archives of disease in childhood · 1976
    Non-randomized trial25 participantsSkin Health forBiotin
  25. Phosphate Metabolism in Health and Disease.
    Peacock M · Calcified tissue international · 2021
    Narrative reviewBone Health forPhosphorus
  26. Dexpanthenol modulates gene expression in skin wound healing in vivo.
    Heise R; Skazik C; Marquardt Y; Czaja K; Sebastian K; Kurschat P; Gan L; Denecke B; Ekanayake-Bohlig S; Wilhelm KP; Merk HF; Baron JM · Skin pharmacology and physiology · 2013
    Clinical trialSkin Health forVitamin B5
  27. Association between phosphorus intake and bone health in the NHANES population.
    Lee AW; Cho SS · Nutrition journal · 2016
    Cross-sectional studyBone Health forPhosphorus
  28. Panthenyl triacetate transformation, stimulation of metabolic pathways, and wound-healing properties in the human skin.
    Dell'Acqua G; Schweikert K · Journal of cosmetic science · 2012
    Randomized trialSkin Health forVitamin B5
  29. Expert consensus on clinical management of metabolic bone disease of prematurity (2021).
    Yan-Mei C; Xin-Zhu L; Rong Z; Xi-Hong L; Xiao-Mei T; Ping-Yang C; Zhi-Chun F; Nutritional Committee of Neonatology Branch of Chinese Medical Doctor Association; Neonatal Nutrition and Health Management Group, Professional Committee of Child Health, Chinese Medical Doctor Association; Editorial Committee of Chinese Journal of Contemporary Pediatrics. · Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
    Guideline / consensusBone Health forPhosphorus
  30. A randomized, double-blind, placebo-controlled study of a novel pantothenic Acid-based dietary supplement in subjects with mild to moderate facial acne.
    Yang M; Moclair B; Hatcher V; Kaminetsky J; Mekas M; Chapas A; Capodice J · Dermatology and therapy · 2014
    Randomized trial48 participantsSkin Health forVitamin B5
  31. Management of Hyperphosphatemia in End-Stage Renal Disease: A New Paradigm.
    Rastogi A; Bhatt N; Rossetti S; Beto J · Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2021
    Systematic reviewBone Health forPhosphorus
  32. Holocarboxylase synthetase deficiency: novel clinical and molecular findings.
    Tammachote R; Janklat S; Tongkobpetch S; Suphapeetiporn K; Shotelersuk V · Clinical genetics · 2010
    Case series4 participantsSkin Health forBiotin
  33. Biochemical and clinical study of calcium pantetheine-S-sulfonate.
    Hayakawa R; Matsunaga K; Ukei C; Ohiwa K · Acta vitaminologica et enzymologica · 1985
    Clinical trial50 participantsSkin Health forVitamin B5
  34. Dietary calcium, phosphorus, and osteosarcopenic adiposity in Korean adults aged 50 years and older.
    Choi MK; Bae YJ · Archives of osteoporosis · 2021
    Cross-sectional study7,007 participantsBone Health forPhosphorus
  35. Partial biotinidase deficiency: clinical and biochemical features.
    McVoy JR; Levy HL; Lawler M; Schmidt MA; Ebers DD; Hart PS; Pettit DD; Blitzer MG; Wolf B · The Journal of pediatrics · 1990
    Case seriesSkin Health forBiotin
  36. Effectiveness, safety, and pharmacokinetics of burosumab in Chinese children with X-linked hypophosphatemia: an open-label, single-arm phase 4 study.
    Wu W; Jiang Y; Zhang Z; Liu L; Qiu W; Ji Y; Sugimoto M; Yung C; Qiu C; Kuriki M; Luo X; Xia W · JBMR plus · 2026
    Single-arm trial28 participantsBone Health forPhosphorus
  37. Final report on the safety assessment of biotin.
    Fiume MZ; Cosmetic Ingredient Review Expert Panel · International journal of toxicology · 2002
    Narrative reviewSkin Health forBiotin
  38. What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.
    Manoj P; Derwin R; George S · International journal of older people nursing · 2023
    Meta-analysis12,620 participants7 studies pooledBone Health forCalcium
  39. Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial.
    Storm D; Eslin R; Porter ES; Musgrave K; Vereault D; Patton C; Kessenich C; Mohan S; Chen T; Holick MF; Rosen CJ · The Journal of clinical endocrinology and metabolism · 1998
    Randomized trial60 participantsBone Health forCalcium
  40. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women.
    Prince R; Devine A; Dick I; Criddle A; Kerr D; Kent N; Price R; Randell A · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1995
    Randomized trial168 participantsBone Health forCalcium
  41. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.
    Rajatanavin R; Chailurkit L; Saetung S; Thakkinstian A; Nimitphong H · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial404 participantsBone Health forCalcium
  42. Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
    Bonjour JP; Carrie AL; Ferrari S; Clavien H; Slosman D; Theintz G; Rizzoli R · The Journal of clinical investigation · 1997
    Randomized trial149 participantsBone Health forCalcium
  43. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies.
    Dominguez LJ; Veronese N; Ciriminna S; Pérez-Albela JL; Vásquez-López VF; Rodas-Regalado S; Di Bella G; Parisi A; Tagliaferri F; Barbagallo M · Nutrients · 2023
    Meta-analysis119,755 participants4 studies pooledBone Health forMagnesium
  44. Bioabsorbable Magnesium-Based Materials Potential and Safety in Bone Surgery: A Systematic Review.
    Hung CH; Kwok YC; Yip J; Wong HH; Leung YY · Craniomaxillofacial trauma & reconstruction · 2025
    Systematic review386 participants8 studies pooledBone Health forMagnesium
  45. Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head.
    Zhao D; Huang S; Lu F; Wang B; Yang L; Qin L; Yang K; Li Y; Li W; Wang W; Tian S; Zhang X; Gao W; Wang Z; Zhang Y; Xie X; Wang J; Li J · Biomaterials · 2016
    Randomized trial48 participantsBone Health forMagnesium
  46. An update on magnesium and bone health.
    Rondanelli M; Faliva MA; Tartara A; Gasparri C; Perna S; Infantino V; Riva A; Petrangolini G; Peroni G · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Narrative reviewBone Health forMagnesium
  47. Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
    Wang B; Tan X; Yao X; Zhu Z · Endocrine connections · 2025
    Cross-sectional study1,343 participantsBone Health forMagnesium
  48. Risk of Environmental Chemicals on Bone Fractures Is Independent of Low Bone Mass in US Adults: Insights from 2017 to 2018 NHANES.
    Ling R; Ai Y; Chen C; Zhang J; Zou Z; Cheng S; Li C; Li X; Wang B · Metabolites · 2023
    Cross-sectional study2,640 participantsBone Health forManganese
  49. The Manganese-Bone Connection: Investigating the Role of Manganese in Bone Health.
    Taskozhina G; Batyrova G; Umarova G; Issanguzhina Z; Kereyeva N · Journal of clinical medicine · 2024
    Narrative reviewBone Health forManganese
  50. Associations of multiple metals with bone mineral density: A population-based study in US adults.
    Wei MH; Cui Y; Zhou HL; Song WJ; Di DS; Zhang RY; Huang Q; Liu JA; Wang Q · Chemosphere · 2021
    Cross-sectional studyBone Health forManganese
  51. Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017-2020) analysis.
    Li H; Li G; Yi M; Zhou J; Deng Y; Huang Y; He S; Meng X; Liu L · Frontiers in public health · 2024
    Cross-sectional study31 participantsBone Health forManganese
  52. Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study.
    Wang C; Zhu Y; Long H; Ou M; Zhao S · PloS one · 2022
    Cross-sectional study9,732 participantsBone Health forManganese
  53. Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X-Linked Hypophosphatemia: A Phase 3, Single-Arm, International Trial.
    Insogna KL; Rauch F; Kamenický P; Ito N; Kubota T; Nakamura A; Zhang L; Mealiffe M; San Martin J; Portale AA · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Single-arm trial14 participantsBone Health forPhosphorus
  54. Early high calcium and phosphorus intake by parenteral nutrition prevents short-term bone strength decline in preterm infants.
    Pereira-da-Silva L; Costa A; Pereira L; Filipe A; Virella D; Leal E; Moreira A; Rosa M; Mendes L; Serelha M · Journal of pediatric gastroenterology and nutrition · 2011
    Randomized trialBone Health forPhosphorus
  55. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  56. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  57. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  58. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  59. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  60. Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial.
    Van Wyck DB; Mangione A; Morrison J; Hadley PE; Jehle JA; Goodnough LT · Transfusion · 2010
    Randomized trial477 participantsEnergy forIron
  61. The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.
    Macher S; Herster C; Holter M; Moritz M; Matzhold EM; Stojakovic T; Pieber TR; Schlenke P; Drexler C; Amrein K · Nutrients · 2021
    Randomized trial176 participantsEnergy forIron
  62. Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP).
    Breymann C; Milman N; Mezzacasa A; Bernard R; Dudenhausen J; FER-ASAP investigators · Journal of perinatal medicine · 2018
    Randomized trial252 participantsEnergy forIron
  63. Effect of iron therapy on fatigue symptoms in non-anaemic iron deficient women of reproductive age- A Randomized Controlled Trial.
    Sultana N; Bajwa FA; Sikandar MZ; Haider MM; Majeed T · JPMA. The Journal of the Pakistan Medical Association · 2026
    Randomized trial164 participantsEnergy forIron
  64. Intravenous iron isomaltoside treatment of women suffering from severe fatigue after postpartum hemorrhage.
    Holm C; Thomsen LL; Langhoff-Roos J · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
    Randomized trial85 participantsEnergy forIron
  65. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.
    Hausenblas HA; Lynch T; Hooper S; Shrestha A; Rosendale D; Gu J · Sleep medicine: X · 2025
    Randomized trial80 participantsEnergy forMagnesium
  66. Total magnesium intake and risk of frailty in older women.
    Struijk EA; Fung TT; Bischoff-Ferrari HA; Willett WC; Lopez-Garcia E · Journal of cachexia, sarcopenia and muscle · 2024
    Cohort study81,524 participantsEnergy forMagnesium
  67. Red blood cell magnesium and chronic fatigue syndrome.
    Cox IM; Campbell MJ; Dowson D · Lancet (London, England) · 1991
    Randomized trial32 participantsEnergy forMagnesium
  68. Exercise, magnesium and immune function.
    Laires MJ; Monteiro C · Magnesium research · 2008
    Narrative reviewEnergy forMagnesium
  69. The Association Between Alopecia Areata and Iron Deficiency Anemia: A Large-Scale Population-Based Case-Control Study.
    Davidovici B; Drutin Y; Ben-Tov A; Mimouni D; Wohl Y · Journal of personalized medicine · 2026
    Case-control study100,203 participantsHair Health forIron
  70. Iron Deficiency and Nonscarring Alopecia in Women: Systematic Review and Meta-Analysis.
    Treister-Goltzman Y; Yarza S; Peleg R · Skin appendage disorders · 2022
    Meta-analysis10,029 participants36 studies pooledHair Health forIron
  71. Comparative Analysis of Postoperative Hair Loss and Micronutrient Deficiencies After One-Anastomosis Gastric Bypass Versus Sleeve Gastrectomy.
    Chinisaz F; Maleki T; Najjari K; Miratashi Yazdi SA · Obesity surgery · 2026
    Cohort study261 participantsHair Health forIron
  72. Assessment of Serum Ferritin Levels in Female Patients With Telogen Effluvium.
    Thamotharan N; Harikumar MV; Sundaram M; Swaminathan A; Rangarajan S · Cureus · 2026
    Cross-sectional study100 participantsHair Health forIron
  73. Diagnosis and treatment of female alopecia: Focusing on the iron deficiency-related alopecia.
    Lin CS; Chan LY; Wang JH; Chang CH · Tzu chi medical journal · 2023
    Cohort study155 participantsHair Health forIron
  74. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  75. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  76. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  77. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  78. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  79. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  80. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  81. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  82. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  83. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  84. Comparative clinical trial of bifonazole solution versus selenium sulphide shampoo in the treatment of pityriasis versicolor.
    Chu AC · Dermatologica · 1985
    Randomized trial38 participantsSkin Health forSelenium
  85. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial.
    Duffield-Lillico AJ; Slate EH; Reid ME; Turnbull BW; Wilkins PA; Combs GF; Park HK; Gross EG; Graham GF; Stratton MS; Marshall JR; Clark LC; Nutritional Prevention of Cancer Study Group · Journal of the National Cancer Institute · 2003
    Randomized trial1,312 participantsSkin Health forSelenium
  86. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forSelenium Skin Health forVitamin E Skin Health forZinc
  87. A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh.
    Verret WJ; Chen Y; Ahmed A; Islam T; Parvez F; Kibriya MG; Graziano JH; Ahsan H · Journal of occupational and environmental medicine · 2006
    Randomized trial121 participantsSkin Health forSelenium
  88. The Whitening, Moisturizing, Anti-aging Activities, and Skincare Evaluation of Selenium-Enriched Mung Bean Fermentation Broth.
    Wei K; Guo C; Zhu J; Wei Y; Wu M; Huang X; Zhang M; Li J; Wang X; Wang Y; Wei X · Frontiers in nutrition · 2022
    Clinical trial31 participantsSkin Health forSelenium
  89. Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.
    Farris P; Berson D; Bhatia N; Goldberg D; Lain E; Mariwalla K; Zeichner J; Miller D; McGuire T; Kizoulis M · Journal of drugs in dermatology : JDD · 2024
    Meta-analysis471 participants6 studies pooledSkin Health forVitamin A
  90. Tensile properties and contours of aging facial skin. A controlled double-blind comparative study of the effects of retinol, melibiose-lactose and their association.
    Piérard-Franchimont C; Castelli D; Cromphaut IV; Bertin C; Ries G; Cauwenbergh G; Piérard GE · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2016
    Randomized trial120 participantsSkin Health forVitamin A
  91. Antiaging action of retinol: from molecular to clinical.
    Bellemère G; Stamatas GN; Bruère V; Bertin C; Issachar N; Oddos T · Skin pharmacology and physiology · 2009
    Randomized trial48 participantsSkin Health forVitamin A
  92. An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer.
    Balado-Simó P; Morgado-Carrasco D; Gómez-Armayones S; López-Ferrer A; Barco D; Ferrándiz-Pulido C; Podlipnik S · Journal of clinical medicine · 2025
    Narrative reviewSkin Health forVitamin A
  93. Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
    Chang H; Tao K; Yang Y; Wang Y; Ge M; Wang X; Tang S; Yu H · Journal of cosmetic dermatology · 2025
    Randomized trialSkin Health forVitamin A
  94. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  95. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  96. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  97. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  98. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  99. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
    Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
    Randomized trial45 participantsSkin Health forVitamin E
  100. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
    Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
    Meta-analysis20 studies pooledSkin Health forVitamin E
  101. Effects of tocotrienol on aging skin: A systematic review.
    Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
    Systematic reviewSkin Health forVitamin E
  102. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
    Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
    Randomized trialSkin Health forVitamin E
  103. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  104. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  105. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  106. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc