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Daily Gentle Cleanse

Irwin Naturals
4.4
★ ★ ★ ★ ★
(889 ratings)
Ginger
Milk Thistle 200 mg
Omega-3 322 mg
Fish Oil 1073 mg
Product Image
Score62
Standardized milk thistle gives this broad liver-digestive blend a useful anchor. Low supporting doses, opaque subcomponents, and medication complexity are the trade-offs.
How scoring works
Quantity:60 Liquid(s) • (30 servings)
Goals:
Detoxification
Anti-Inflammatory Support

Score 62

Standardized milk thistle gives this broad liver-digestive blend a useful anchor. Low supporting doses, opaque subcomponents, and medication complexity are the trade-offs.
How scoring works
$19.60($0.65 per serving)
iHerb
$ 19.99
Pure Formulas
$ 19.99
Amazon
$ 19.60
Vitacost
$ 19.99
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Analysis

The clearest strength is a milk thistle extract paired with a separately stated silymarin amount. Artichoke, dandelion, triphala, marshmallow, ginger, and black pepper cover digestive, bile-flow, and antioxidant pathways.

The supporting herbs are often modest, and some triphala components or BioPerine ingredients have no individual amounts. Fish oil provides only a limited total omega-3 amount and does not disclose EPA and DHA separately.

The softgel oil base and black pepper may improve delivery of some botanicals. It fits users seeking broad liver-digestive support, but people using several medicines may prefer a simpler formula with fewer interaction variables.

Who is it for
  • Adults seeking broad liver and digestive support
  • Users comfortable with fish oil and multiple herbs
  • People who can review medication interactions
Best for
  • Milk thistle-centered routines
  • Broad digestive and bile-flow support
  • Users preferring multi-herb softgels

Pros

  • Silymarin amount is clearly disclosed
  • Covers several liver and digestive pathways
  • Oil base and black pepper may aid delivery

Cons

  • Many supporting herbs are modestly dosed
  • EPA and DHA are not separated
  • Several blend subcomponents lack individual amounts

Warnings

  • Fish oil from anchovy and sardine makes the product unsuitable for people with a fish allergy.
  • Milk thistle, ginger, and BioPerine may alter the handling or effects of some medicines, especially in complex regimens.
  • Triphala and dandelion may loosen stools or increase digestive activity in sensitive users.
  • Fish oil and ginger may add to bleeding risk with anticoagulant or antiplatelet medicine.

Nutrient quality

68 High impact

Silymarin anchors a broad liver and digestive formula with complementary artichoke, dandelion, triphala, ginger, and omega-three fats. Several supporting doses are modest or hidden, and the crowded combination creates interaction uncertainty.

Ingredient transparency

54 Moderate impact

Several botanical markers and main totals are disclosed, but EPA, DHA, triphala component amounts, and BioPerine details remain hidden. Complete directions and softgel excipients are also absent.

Customer satisfaction

67 High impact

The good average rating and substantial review count make the aggregate satisfaction signal reasonably dependable. No detailed review text was provided, so recurring complaints and purpose alignment cannot be assessed.

Value for money

60 Moderate impact

Meaningful silymarin and broad digestive support provide fair value at a moderate serving cost. Hidden omega-three and botanical details plus low-dose padding weaken competitiveness.

Report analysis

Goals

Detoxification
Detoxification
Impact
High effect
B+ Goal FitB+ Strength of SupportB+ CoverageC Formula Quality
Milk Thistle · 200 mgOmega-3 · 322 mg

Disclosed silymarin anchors a broad liver-support formula with artichoke, dandelion, triphala, and antioxidant botanicals. The oil-based softgel and black pepper may improve delivery of some poorly soluble compounds.

Many supporting herbs are modestly dosed, while omega-3 content is low and its EPA and DHA profile is absent. The formula offers breadth across liver protection, bile flow, digestion, and antioxidant pathways but includes substantial low-dose padding.

Study evidence
Milk Thistle Supportive 46 studies
Omega-3 Supportive 19 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B- Goal FitC- Strength of SupportB- CoverageC- Formula Quality
Fish Oil · 1073 mg

Fish oil, silymarin, artichoke, dandelion, and ginger provide several plausible antioxidant and inflammatory pathways. Evidence is useful for omega-3 fats and some standardized botanicals, but several included herbs have limited systemic inflammation data.

The 322 mg omega-3 amount and 1 mg gingerols are modest, while 160 mg silymarin provides the clearest botanical depth. Several markers are disclosed, but the triphala components and proprietary BioPerine complex lack individual amounts. The fish oil comes from anchovy and sardine and may not be suitable for people with a fish allergy.

Study evidence
Fish Oil Supportive 68 studies
Ginger Supportive 30 studies

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Total Fat
1 Gram(s)
Cholesterol
5 mg
Total Carbohydrates
1 Gram(s)
Protein
1 Gram(s)
Fish Oil
1073 mg
Omega-3 Fatty Acids
322 mg
Triphala, Powder
600 mg
Amla fruit extract
0 NP
Belleric Myrobalan, Powder
0 NP
Chebulic Myrobalan fruit extract
0 NP
Milk Thistle seed extract
200 mg
Silymarin
160 mg
Artichoke leaf extract
100 mg
Cynarin
2.5 mg
Dandelion leaf extract
100 mg
Vitexin
3 mg
Marshmallow root extract
80 mg
Ginger rhizome extract
20 mg
Gingerols
1 mg
BioPerine Complex
12 mg
BioPerine
0 NP
Ginger Rhizome Extract
0 NP
Adults 18–50 Women
Report overview
Ginger · 20 mg OverallScore52
C Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyD+ Value

The ginger amount is too low for a strong targeted effect. The active-marker disclosure strengthens potency transparency, but the extraction method remains unclear. Value is moderate because cost and ginger potency are only partly aligned.

View ingredientView products
Milk Thistle · 200 mg OverallScore28
C Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

A 200 mg seed extract is supplied in an oil-based softgel that may improve solubility. The active silymarin yield is not disclosed, so dose adequacy remains uncertain. The serving cost is above the collection norm.

View ingredientView products
Omega-3 · 322 mg OverallScore24
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The fish-oil molecular form is not specified, and no antioxidant protection is listed. Only total omega-3 is disclosed, with a low concentration relative to the oil and no independent purity standard. The small active amount produces poor omega-3 cost efficiency.

View ingredientView products
Loading alternative details
78 Performance

Fish Oil 1000 mg

Spring Valley
Triglyceride-form fish oil with a clearly stated combined EPA-and-DHA amount improves absorption detail over the original. The active dose is modest and the formula does not address the original’s detoxification ingredients.
77 Performance

Milk Thistle 525 mg

Natrol
Milk thistle leads a coherent liver-oriented blend and ginger preserves part of the original botanical profile. Silymarin standardization is missing, and the product does not supply fish oil or omega-3s.
70 Performance

Mini Fish Oil 1290 mg

Nature's Bounty
The focused fish-oil formula aligns well with cardiovascular and anti-inflammatory use and is easier to assess than the original’s sprawling blend. It lacks separate EPA and DHA amounts and does not retain milk thistle or the other detoxification botanicals.
66 Budget

Fish Oil 1000 mg

Sundown
The simple fish-oil formula offers basic omega-3 support at a much lower serving cost. It does not replace milk thistle, ginger, triphala, artichoke, or the original’s broader detox-oriented blend.
65 Budget

Fish Oil 1200 mg

Nature's Bounty
A low-cost fish-oil serving preserves basic cardiovascular and anti-inflammatory intent. Missing EPA and DHA amounts reduce transparency, and the formula provides none of the original liver-oriented botanicals.
70 Budget

Fish Oil 1200 mg

Nature's Bounty
Named small-fish sources and a long supply make this a low-cost alternative for the marine-oil portion of the original. EPA and DHA are not separated, and milk thistle, ginger, triphala, and artichoke are absent.
69 Value

Fish Oil 1000 mg

Nature's Bounty
A low serving cost and simple fish-oil profile offer practical value for the original’s omega-3 role. Modest concentration, missing EPA and DHA amounts, and loss of the liver-support ingredients limit the comparison.
68 Value

Fish Oil + D3

Nature's Bounty
Fish oil plus vitamin D3 offers an inexpensive, compact nutritional formula with some cardiovascular and anti-inflammatory relevance. The omega-3 details are incomplete and none of the original milk-thistle, ginger, triphala, or artichoke support remains.
67 Value

Fish Oil 2400 mg

Nature's Bounty
A larger fish-oil amount and low serving cost create reasonable value for basic omega-fat support. Its modest active concentration and missing EPA and DHA disclosure make it less complete than the original for ingredient transparency.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.
    Shahsavari K; Ardekani SS; Ardekani MRS; Esfahani MM; Kazemizadeh H; Jamialahmadi T; Iranshahi M; Khanavi M; Hasanpour M · BMC complementary medicine and therapies · 2025
    Meta-analysis3,545 participants55 studies pooledDetoxification forMilk Thistle
  2. Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
    Calderon Martinez E; Herrera D; Mogan S; Hameed Z; Jangda AA; Khan TJ; Mroke P; Sajid S; Shah YR; Baig I · Cureus · 2023
    Systematic review3,846 participants29 studies pooledDetoxification forMilk Thistle
  3. The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial.
    Mirnezami M; Jafarimanesh H; Rezagholizamenjany M; Alimoradian A; Ranjbaran M · Dermatologic therapy · 2021
    Randomized trial74 participantsDetoxification forMilk Thistle
  4. A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury.
    Luangchosiri C; Thakkinstian A; Chitphuk S; Stitchantrakul W; Petraksa S; Sobhonslidsuk A · BMC complementary and alternative medicine · 2016
    Randomized trial55 participantsDetoxification forMilk Thistle
  5. Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery.
    Mirhashemi SH; Hakakzadeh A; Yeganeh FE; Oshidari B; Rezaee SP · Metabolism open · 2022
    Observational studyDetoxification forMilk Thistle
  6. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
    El-Kamary SS; Shardell MD; Abdel-Hamid M; Ismail S; El-Ateek M; Metwally M; Mikhail N; Hashem M; Mousa A; Aboul-Fotouh A; El-Kassas M; Esmat G; Strickland GT · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2009
    Randomized trial105 participantsDetoxification forMilk Thistle
  7. Evaluation of Hepatoprotective Effect of Silymarin Among Under Treatment Tuberculosis Patients: A Randomized Clinical Trial.
    Marjani M; Baghaei P; Kazempour Dizaji M; Gorji Bayani P; Fahimi F; Tabarsi P; Velayati AA · Iranian journal of pharmaceutical research : IJPR · 2016
    Randomized trial70 participantsDetoxification forMilk Thistle
  8. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: a randomized, placebo-controlled trial.
    Erfanian SS; Ansari H; Javanmard SH; Amini Z; Hajigholami A · BMC complementary medicine and therapies · 2024
    Randomized trial100 participantsDetoxification forMilk Thistle
  9. A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine.
    Moayedi B; Gharagozloo M; Esmaeil N; Maracy MR; Hoorfar H; Jalaeikar M · European journal of haematology · 2013
    Randomized trial97 participantsDetoxification forMilk Thistle
  10. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.
    Ghalandari K; Shabani M; Khajehlandi A; Mohammadi A · Archives of physiology and biochemistry · 2023
    Randomized trial60 participantsDetoxification forMilk Thistle
  11. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial.
    Song J; Hu M; Li C; Yang B; Ding Q; Wang C; Mao L · Food & function · 2018
    Randomized trial201 participantsAnti-Inflammatory Support forFish Oil
  12. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.
    Lin YL; Wang CL; Chiang TI · Frontiers in nephrology · 2024
    Randomized trial60 participantsAnti-Inflammatory Support forFish Oil
  13. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.
    Yang B; Ren XL; Li ZH; Shi MQ; Ding F; Su KP; Guo XJ; Li D · Food & function · 2020
    Randomized trial77 participantsAnti-Inflammatory Support forFish Oil
  14. The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.
    Meng Z; Dong Y; Gao H; Yao D; Gong Y; Meng Q; Zheng T; Cui X; Su X; Tian Y · The Journal of international medical research · 2019
    Randomized trial174 participantsAnti-Inflammatory Support forFish Oil
  15. Effects of Omega-3 Fatty Acid Intake in Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Liu R; Jiang J; Fu Z; Liu C; Yao L; Quan H · Journal of the American Nutrition Association · 2022
    Meta-analysis49 studies pooledAnti-Inflammatory Support forFish Oil
  16. The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis.
    Mazidi M; Gao HK; Rezaie P; Ferns GA · Food & nutrition research · 2022
    Meta-analysis9 studies pooledAnti-Inflammatory Support forGinger
  17. Ginger supplementation and metabolic health: an umbrella review of meta-analyses of randomized trials.
    Musazadeh V; Morvaridi M; Hosseini-Roknabadi SM; Mahmoudinezhad M; Jafari A; Shidfar F · Diabetology & metabolic syndrome · 2026
    Meta-analysis43,570 participants36 studies pooledAnti-Inflammatory Support forGinger
  18. Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial.
    Mozaffari-Khosravi H; Naderi Z; Dehghan A; Nadjarzadeh A; Fallah Huseini H · Journal of nutrition in gerontology and geriatrics · 2017
    Randomized trial120 participantsAnti-Inflammatory Support forGinger
  19. Effects of Ginger Supplementation on Markers of Inflammation and Functional Capacity in Individuals with Mild to Moderate Joint Pain.
    Broeckel J; Estes L; Leonard M; Dickerson BL; Gonzalez DE; Purpura M; Jäger R; Sowinski RJ; Rasmussen CJ; Kreider RB · Nutrients · 2025
    Randomized trial30 participantsAnti-Inflammatory Support forGinger
  20. The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis.
    Aryaeian N; Shahram F; Mahmoudi M; Tavakoli H; Yousefi B; Arablou T; Jafari Karegar S · Gene · 2019
    Randomized trial70 participantsAnti-Inflammatory Support forGinger
  21. Impact of silymarin-supplemented cookies on liver enzyme and inflammatory markers in non-alcoholic fatty liver disease patients.
    Jaffar HM; Bader Ul Ain H; Tufail T; Hanif A; Malik T · Food science & nutrition · 2024
    Clinical trial64 participantsDetoxification forMilk Thistle
  22. Systematic review and meta-analysis of controlled intervention studies on the effectiveness of long-chain omega-3 fatty acids in patients with nonalcoholic fatty liver disease.
    Musa-Veloso K; Venditti C; Lee HY; Darch M; Floyd S; West S; Simon R · Nutrition reviews · 2019
    Meta-analysis18 studies pooledDetoxification forOmega-3
  23. Omega-3 polyunsaturated fatty acids in the treatment of non-alcoholic fatty liver disease: An umbrella systematic review and meta-analysis.
    Musazadeh V; Karimi A; Malekahmadi M; Ahrabi SS; Dehghan P · Clinical and experimental pharmacology & physiology · 2023
    Meta-analysis6,561 participants8 studies pooledDetoxification forOmega-3
  24. Effectiveness of ω-3 Polyunsaturated Fatty Acids Based Lipid Emulsions for Treatment of Patients after Hepatectomy: A Prospective Clinical Trial.
    Gong Y; Liu Z; Liao Y; Mai C; Chen T; Tang H; Tang Y · Nutrients · 2017
    Randomized trial119 participantsDetoxification forOmega-3
  25. Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis.
    Parker HM; Johnson NA; Burdon CA; Cohn JS; O'Connor HT; George J · Journal of hepatology · 2012
    Meta-analysis355 participants9 studies pooledDetoxification forOmega-3
  26. Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.
    Aziz T; Niraj MK; Kumar S; Kumar R; Parveen H · Cureus · 2024
    Meta-analysis15 studies pooledDetoxification forOmega-3