5-HTP

5-HTP

Integrative Therapeutics4.4 (14 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals
$24.00 $0.40 per serving
Pure Formulas$24.00

About this product

A cautious 50 mg 5-HTP serving gives the formula a clear and focused role in serotonin-related mood and sleep support. The amount works as a conservative starting level but may be modest for someone seeking a pronounced standalone effect.

Griffonia simplicifolia is identified as the source, although no active standardization percentage is supplied. The capsule(s) format is convenient, but it does not add a disclosed release or absorption feature.

The simple design makes the active easy to judge, although it covers only one main pathway. Value is weak relative to the amount and formulation detail provided. It best fits people seeking a cautious starting amount or gradual dose adjustment.

Who is it for
  • Adults new to 5-HTP
  • People who prefer a cautious starting amount
  • Users seeking focused mood or sleep support
Best for
  • Focused serotonin-pathway mood support
  • Indirect sleep support through serotonin and melatonin pathways
  • Stress accompanied by low mood or disrupted sleep

Pros

  • Clearly discloses 50 mg of 5-HTP
  • Capsule(s) format is easy to use
  • Names Griffonia simplicifolia as the botanical source
  • Focused formula is easy to assess

Cons

  • No 5-HTP standardization percentage is provided
  • No controlled-release or enteric delivery feature is disclosed
  • Lower amount may be too modest for some users

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonin-raising medicines because serotonin toxicity can occur.
  • The 50 mg 5-HTP serving may cause nausea or digestive upset.
  • Avoid stacking it with other serotonin-focused supplements such as tryptophan or SAMe unless a qualified clinician has reviewed the combination.

Product analysis

70 out of 100
50 mg of 5-HTP provides cautious serotonin-pathway support in a convenient format. The named Griffonia source helps, but missing standardization limits quality detail.

AI assessment of the formula, label and price. How scoring works

Nutrient quality79

Griffonia simplicifolia identifies the botanical source, but no active standardization percentage is supplied. The 5-HTP amount suits cautious starting use but is modest for a standard serving, while missing extract standardization limits source-potency confidence.

Ingredient transparency81

Every listed active amount is disclosed, and no proprietary blend hides dosing. Complete directions, inactive ingredients, and some source or standardization details remain unavailable.

Customer satisfaction52

The aggregate rating is favorable, but the limited review count weakens confidence. No detailed feedback is supplied, so repeated complaints and purpose fit cannot be judged.

Value for money60

A cautious starting amount and plant source provide basic quality. A costly serving for the low amount produces weak category value.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.40
Customer rating
4.4 · 14 ratings
Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
B Ingredient FitF PathwaysA EvidenceA+ Formulation Logic
5-HTP · 50 mg
Study evidence
5-HTP Supportive 9 studies
Sleep Support
Sleep Support
Impact
Moderate effect
B Ingredient FitD- PathwaysC- EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 1 study
Stress Relief
Stress Relief
Impact
Moderate effect
B Ingredient FitF PathwaysC- EvidenceA+ Formulation Logic

Ingredients

IngredientAmount per servingScore
L-5-Hydroxytryptophan (Griffonia simplicifolia)
 50 mg 60
Gluten Free Adults 18–50 Vegan Dairy Free Women Vegetarian
Report overview
5-HTP (Griffonia simplicifolia) · 50 mg OverallScore60
B- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value
The 5-HTP capsule provides 50 mg and identifies Griffonia as its source, though no standardization percentage is given. A specific medication-interaction warning is included. The amount matches the starting range described in the supplied guidance, but the cost per 100 mg is high.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

Griffonia is named as the source, but no extract standardization is stated.
Botanical Source & Standardization
It names Griffonia simplicifolia but doesn't state a standardization percentage.

Dose, Safety & Label Transparency79

The amount matches the starting range, and a specific medication warning is included.
Dosage Potency & Range
It provides 50 mg, the starting amount described in the supplied guidance.
Safety Warnings & Label Clarity
A specific warning about interactions with serotonin-modulating medicines is included.

Value0

The cost is high relative to the standard amount.
Price per 100mg 5-HTP
The cost per 100 mg of 5-HTP is high.
View ingredientView products
Loading alternative details
85 Performance

5-HTP 100 mg

NOW
Clearer botanical sourcing makes this a stronger quality alternative. The 100 mg 5-HTP serving gives the alternative a clearer dosing role than the original blend. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP 100 mg Extra Strength

Swanson
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. The 100 mg 5-HTP serving gives the alternative a clearer dosing role than the original blend. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. The 100 mg 5-HTP serving gives the alternative a clearer dosing role than the original blend. The same serious interaction caution with serotonin-raising medicines applies.
84 Budget

5-HTP 50 mg

NOW
The lower recurring cost makes this a more economical eligible choice. The 50 mg 5-HTP serving gives the alternative a clearer dosing role than the original blend. The same serious interaction caution with serotonin-raising medicines applies.
85 Budget

5-HTP 100 mg

Doctor's Best
The lower recurring cost makes this a more economical eligible choice. The 100 mg 5-HTP serving gives the alternative a clearer dosing role than the original blend. The same serious interaction caution with serotonin-raising medicines applies.
82 Budget

5-HTP 50 mg

Swanson Premium Brand
The lower recurring cost makes this a more economical eligible choice. The 50 mg 5-HTP serving gives the alternative a clearer dosing role than the original blend. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP 200mg

Best Naturals
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP with Vitamin B6 & Vitamin C

Lake Avenue Nutrition
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. The active amount is disclosed, but botanical-source detail remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
82 Value

5-HTP 200 mg Maximum Strength

Swanson
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  2. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  5. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  6. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  7. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP