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ProOmega Lemon 650 EPA/450 DHA

Nordic Naturals
4.9
★ ★ ★ ★ ★
(516 ratings)
Omega-3 1280 mg
Product Image
Score79
A concentrated EPA-and-DHA softgel with clear active amounts and good dose value. Source, form, freshness, and purity disclosure remain incomplete.
How scoring works
Quantity:120 Softgel(s) • (60 servings)
Goals:
Skin Health
Joint Health
Metabolism Boost

Score 79

A concentrated EPA-and-DHA softgel with clear active amounts and good dose value. Source, form, freshness, and purity disclosure remain incomplete.
How scoring works

Also available as

1 option
60 servings Omega-3 1280 mg • 60 Soft Gel(s) • 30 servings $30.70 ($1.02 per serving)
$47.01($0.78 per serving)
iHerb
$ 55.30
Pure Formulas
$ 47.01
Report prices

Analysis

The title identifies 650 mg EPA and 450 mg DHA within 1,280 mg total omega-3. That balance provides clear dose information for broad skin, joint, and metabolic support.

Softgel delivery is practical, but the supplied facts do not identify the source oil or molecular form. Freshness protection and independent purity evidence are also not disclosed.

It fits adults who want a strong, clearly split EPA and DHA dose without the highest serving cost in the group. Buyers requiring fully documented sourcing and oxidation control need more label detail.

Who is it for
  • Adults seeking concentrated EPA and DHA
  • Users wanting clear fatty-acid amounts
  • Value-conscious high-dose softgel users
Best for
  • Broad omega-3 supplementation
  • Joint and skin support
  • A balanced EPA and DHA routine

Pros

  • Clearly identifies 650 mg EPA
  • Clearly identifies 450 mg DHA
  • Concentrated 1,280 mg total
  • Softgel delivery
  • Competitive dose value

Cons

  • Oil source is not stated
  • Molecular form is missing
  • Freshness protection is not disclosed
  • Purity verification is not provided

Warnings

  • The high omega-3 intake may increase bruising or bleeding with anticoagulant or antiplatelet medicines
  • Fish-derived oil may be unsuitable for people with a fish allergy; verify the source when it is not stated
  • Fish oil can cause reflux, nausea, or loose stools in some users

Nutrient quality

85 Highest impact

The stated omega-3 amount is substantial. EPA and DHA are identifiable, giving the active omega-3 amount useful clarity.

Ingredient transparency

74 High impact

EPA and DHA are identifiable, giving the active omega-3 amount useful clarity. Complete usage, inactive-ingredient, molecular-form, and purity details remain unavailable.

Customer satisfaction

72 High impact

The supplied aggregate rating and review volume provide a useful satisfaction signal. Specific comments are unavailable, so recurring complaints and purpose-specific experiences cannot be assessed.

Value for money

85 Highest impact

The active amount and accessible cost support formula value despite incomplete quality detail. The product compares favorably on stated dose and serving value.

Report analysis

Goals

Skin Health
Skin Health
Impact
High effect
B- Goal FitB+ Strength of SupportC CoverageA+ Formula Quality
Omega-3 · 1280 mg

EPA and DHA in a concentrated marine-oil serving may support the skin barrier and help regulate inflammatory signaling. The disclosed fatty-acid amount provides useful systemic lipid support.

The formula does not include collagen, ceramides, or a dedicated hydration active. Missing molecular-form, antioxidant-protection, or purity details limit confidence in oil quality.

Study evidence
Omega-3 Supportive 35 studies
Joint Health
Joint Health
Impact
High effect
B+ Goal FitB Strength of SupportC- CoverageA- Formula Quality
Omega-3 · 1280 mg

Omega-3 fatty acids support inflammatory balance and may reduce stiffness in inflammatory joint conditions. Human evidence supports EPA and DHA for inflammatory pathways, though joint benefits are less consistent than their cardiovascular effects.

The 1,280 mg total omega-3 amount is meaningful for anti-inflammatory support. Total omega-3 is disclosed, but the ingredient data do not clearly separate EPA and DHA or identify molecular form and purity testing.

Study evidence
Omega-3 Supportive 40 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
B- Goal FitB- Strength of SupportD+ CoverageA Formula Quality
Omega-3 · 1280 mg

EPA and DHA may support insulin signaling and metabolic inflammation without directly stimulating thermogenesis. The named fatty-acid amounts provide useful depth in this pathway.

Molecular form, fish source, oxidation protection, and purity testing remain unclear. The focused formula avoids padding but does not cover thyroid or thermogenic mechanisms.

Study evidence
Omega-3 Supportive 42 studies

Ingredients

IngredientAmount per serving
Calories
20 Calorie(s)
Total Fat
2 Gram(s)
Total Omega-3 Fatty Acids
1280 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Omega-3 · 1280 mg OverallScore51
F Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB+ Value

The separately stated EPA and DHA amounts provide clear active-dose information and a moderate concentration. The molecular form, fish source, antioxidant protection, and independent purity verification remain undisclosed. Cost efficiency is competitive for the amount of EPA and DHA delivered.

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Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of Omega-3 Fatty Acids Intake on Lipid Metabolism and Plaque Volume in Patients With Coronary Heart Disease: A Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials.
    Zhang C; Xie Y; Zhou J; Zhang C; Xiang Q; Zhong Y; Xiao J; Feng J; Liao B; Chen X; Deng L · Food science & nutrition · 2025
    Meta-analysis2,061 participants23 studies pooledMetabolism Boost forOmega-3
  2. Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. The ENRGISE Pilot Randomized Clinical Trial.
    Pahor M; Anton SD; Beavers DP; Cauley JA; Fielding RA; Kritchevsky SB; Leeuwenburgh C; Lewis KH; Liu CK; Lovato LC; Lu J; Manini TM; McDermott MM; Miller ME; Newman AB; Radziszewska B; Stowe CL; Tracy RP; Walkup MP; Wu SS; Ambrosius WT · The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Randomized trial289 participantsJoint Health forOmega-3
  3. The Effects of α-Linolenic Acid Intake on Skin and Blood Vessel Health and Subjective Fatigue in Middle-Aged Japanese Females: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparative Trial.
    Ando N; Nosaka N; Arai C; Kato K · The Journal of nutrition · 2025
    Randomized trial120 participantsSkin Health forOmega-3
  4. Omega-3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a meta-analysis.
    Lee YH; Bae SC; Song GG · Archives of medical research · 2013
    Meta-analysis10 studies pooledJoint Health forOmega-3
  5. Dietary supplementation with very long-chain n-3 fatty acids in patients with atopic dermatitis. A double-blind, multicentre study.
    Søyland E; Funk J; Rajka G; Sandberg M; Thune P; Rustad L; Helland S; Middelfart K; Odu S; Falk ES · The British journal of dermatology · 1994
    Randomized trial145 participantsSkin Health forOmega-3
  6. The association of organophosphate flame retardants (OPFRs) exposure on omega-3 fatty acids metabolism: evidence derived from the United States general population.
    Hsu TH; Pan HY; Tsai KF; Kung CT; Huang WT; You HL; Li SH; Wang CC; Lee WC; Cheng FJ · Toxicology research · 2025
    Cross-sectional study1,350 participantsMetabolism Boost forOmega-3
  7. Prenatal Omega-3 Supplementation and Eczema Risk among Offspring at Age 36 Months.
    Berman D; Clinton C; Limb R; Somers EC; Romero V; Mozurkewich E · Insights in allergy, asthma & bronchitis · 2020
    Randomized trial84 participantsSkin Health forOmega-3
  8. Dietary fats and prevention of type 2 diabetes.
    Risérus U; Willett WC; Hu FB · Progress in lipid research · 2010
    Narrative reviewMetabolism Boost forOmega-3
  9. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial.
    Stonehouse W; Benassi-Evans B; Bednarz J; Vincent AD; Hall S; Hill CL · The American journal of clinical nutrition · 2022
    Randomized trial235 participantsJoint Health forOmega-3
  10. Effects of omega-3 supplementation on glucose and lipid metabolism in patients with gestational diabetes: A meta-analysis of randomized controlled trials.
    Liu W; Gao M; Yang S; Sun C; Bi Y; Li Y; Wang J; Yuan X · Journal of diabetes and its complications · 2023
    Meta-analysis331 participants6 studies pooledMetabolism Boost forOmega-3
  11. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
    Wang W; Xu Y; Zhou J; Zang Y · Clinical rheumatology · 2024
    Meta-analysis1,018 participants18 studies pooledJoint Health forOmega-3
  12. Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial.
    Miura K; Vail A; Chambers D; Hopkins PM; Ferguson L; Grant M; Rhodes LE; Green AC · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019
    Randomized trial49 participantsSkin Health forOmega-3
  13. Supplementation of fish oil and olive oil in patients with rheumatoid arthritis.
    Berbert AA; Kondo CR; Almendra CL; Matsuo T; Dichi I · Nutrition (Burbank, Los Angeles County, Calif.) · 2005
    Randomized trial43 participantsJoint Health forOmega-3
  14. Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis.
    Gao H; Geng T; Huang T; Zhao Q · Lipids in health and disease · 2018
    Meta-analysis672 participants17 studies pooledMetabolism Boost forOmega-3
  15. Randomized controlled trial of oral omega-3 PUFA in solar-simulated radiation-induced suppression of human cutaneous immune responses.
    Pilkington SM; Massey KA; Bennett SP; Al-Aasswad NM; Roshdy K; Gibbs NK; Friedmann PS; Nicolaou A; Rhodes LE · The American journal of clinical nutrition · 2013
    Randomized trial79 participantsSkin Health forOmega-3
  16. Improvement in Glycolipid Metabolism Parameters After Supplementing Fish Oil-Derived Omega-3 Fatty Acids Is Associated with Gut Microbiota and Lipid Metabolites in Type 2 Diabetes Mellitus.
    Xia J; Yin S; Yu J; Wang J; Jin X; Wang Y; Liu H; Sun G · Nutrients · 2024
    Randomized trial110 participantsMetabolism Boost forOmega-3
  17. Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis.
    Sigaux J; Mathieu S; Nguyen Y; Sanchez P; Letarouilly JG; Soubrier M; Czernichow S; Flipo RM; Sellam J; Daïen C · Arthritis research & therapy · 2022
    Meta-analysis1,420 participants30 studies pooledJoint Health forOmega-3
  18. Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
    Soleimani Z; Hashemdokht F; Bahmani F; Taghizadeh M; Memarzadeh MR; Asemi Z · Journal of diabetes and its complications · 2018
    Randomized trial60 participantsSkin Health Metabolism Boost forOmega-3
  19. Fish oil in knee osteoarthritis: a randomised clinical trial of low dose versus high dose.
    Hill CL; March LM; Aitken D; Lester SE; Battersby R; Hynes K; Fedorova T; Proudman SM; James M; Cleland LG; Jones G · Annals of the rheumatic diseases · 2016
    Randomized trial202 participantsJoint Health forOmega-3
  20. Dietetic intervention in psoriatic arthritis: the DIETA trial.
    Leite BF; Morimoto MA; Gomes CMF; Klemz BNC; Genaro PS; Shivappa N; Hébert JR; Damasceno NRT; Pinheiro MM · Advances in rheumatology (London, England) · 2022
    Randomized trial97 participantsSkin Health forOmega-3
  21. Oils Rich in α-Linolenic Acid or Docosahexaenoic Acid Have Distinct Effects on Plasma Oxylipin and Adiponectin Concentrations and on Monocyte Bioenergetics in Women with Obesity.
    Pauls SD; Rodway LR; Sidhu KK; Winter T; Sidhu N; Aukema HM; Zahradka P; Taylor CG · The Journal of nutrition · 2022
    Randomized trialMetabolism Boost forOmega-3
  22. Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women's Health Initiative.
    Krok-Schoen JL; Brasky TM; Hunt RP; Rohan TE; Baker TA; Li W; Carbone L; Mackey RH; Snetselaar L; Lustberg MB; Neuhouser ML · Journal of the Academy of Nutrition and Dietetics · 2019
    Cohort study80,551 participantsJoint Health forOmega-3
  23. Treatment of hard-to-heal wounds in ischaemic lower extremities with a novel fish skin-derived matrix.
    Lee YJ; Han HJ; Shim HS · Journal of wound care · 2024
    Randomized trial50 participantsSkin Health forOmega-3
  24. The consumption of omega-3 polyunsaturated fatty acids improves clinical outcomes and prognosis in pancreatic cancer patients: a systematic evaluation.
    Ma YJ; Yu J; Xiao J; Cao BW · Nutrition and cancer · 2015
    Meta-analysis11 studies pooledMetabolism Boost forOmega-3
  25. Effect of long-term omega-3 supplementation and a lifestyle multidomain intervention on intrinsic capacity among community-dwelling older adults: Secondary analysis of a randomized, placebo-controlled trial (MAPT study).
    Giudici KV; de Souto Barreto P; Beard J; Cantet C; Araujo de Carvalho I; Rolland Y; Vellas B; MAPT DSA group · Maturitas · 2020
    Randomized trial1,445 participantsJoint Health forOmega-3
  26. Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers.
    Rhodes LE; Shahbakhti H; Azurdia RM; Moison RM; Steenwinkel MJ; Homburg MI; Dean MP; McArdle F; Beijersbergen van Henegouwen GM; Epe B; Vink AA · Carcinogenesis · 2003
    Randomized trial42 participantsSkin Health forOmega-3
  27. Effect of isotretinoin and omega-3 fatty acid combination on lipid metabolism in patients with acne vulgaris: a randomized controlled trial.
    Du P; Huang Y; Hu J; Xiong X; Deng Y · Lipids in health and disease · 2026
    Randomized trial66 participantsMetabolism Boost forOmega-3
  28. Beneficial effect of n-3 polyunsaturated fatty acids on inflammation and analgesic use in psoriatic arthritis: a randomized, double blind, placebo-controlled trial.
    Kristensen S; Schmidt EB; Schlemmer A; Rasmussen C; Johansen MB; Christensen JH · Scandinavian journal of rheumatology · 2018
    Randomized trial145 participantsJoint Health forOmega-3
  29. Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation.
    Furuhjelm C; Warstedt K; Fagerås M; Fälth-Magnusson K; Larsson J; Fredriksson M; Duchén K · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2011
    Randomized trial145 participantsSkin Health forOmega-3
  30. Supplementation with n-3 fatty acids reduces triglycerides but increases PAI-1 in non-insulin-dependent diabetes mellitus.
    Boberg M; Pollare T; Siegbahn A; Vessby B · European journal of clinical investigation · 1993
    Randomized trial14 participantsMetabolism Boost forOmega-3
  31. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain.
    Goldberg RJ; Katz J · Pain · 2007
    Meta-analysis17 studies pooledJoint Health forOmega-3
  32. Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism.
    Green CJ; Pramfalk C; Charlton CA; Gunn PJ; Cornfield T; Pavlides M; Karpe F; Hodson L · BMJ open diabetes research & care · 2021
    Randomized trial38 participantsMetabolism Boost forOmega-3
  33. The Effects of Flaxseed Oil Omega-3 Fatty Acids Supplementation on Metabolic Status of Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Mirmasoumi G; Fazilati M; Foroozanfard F; Vahedpoor Z; Mahmoodi S; Taghizadeh M; Esfeh NK; Mohseni M; Karbassizadeh H; Asemi Z · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2018
    Randomized trial60 participantsMetabolism Boost forOmega-3
  34. A combination of omega-3 and plant sterols regulate glucose and lipid metabolism in individuals with impaired glucose regulation: a randomized and controlled clinical trial.
    Wang JF; Zhang HM; Li YY; Xia S; Wei Y; Yang L; Wang D; Ye JJ; Li HX; Yuan J; Pan RR · Lipids in health and disease · 2019
    Randomized trial200 participantsMetabolism Boost forOmega-3