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St. John's Wort

Oregon's Wild Harvest
4.4
★ ★ ★ ★ ★
(89 ratings)
St. John's Wort 1050 mg
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Score65

A substantial organic serving and named marker classes are positives. Undisclosed marker percentages, three capsules, and weak value hold it back.

How scoring works
Quantity:90 Capsule(s) • (30 servings)
Goals:
Mood Support

Score 65

A substantial organic serving and named marker classes are positives. Undisclosed marker percentages, three capsules, and weak value hold it back.

How scoring works
$26.36($0.87 per serving)
iHerb
$ 26.36
iHerb
$ 26.36
Vitacost
$ 26.36
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Analysis

The daily serving provides 1,050 mg of organic St. John’s wort and names hypericins and flavonoids. That level of identity is better than a generic herb label, but it does not show the amount of either marker group.

The formula provides focused single-herb depth for mood support. Missing standardization still prevents a clear comparison with extracts delivering a known 0.3% hypericin level.

Three capsules and relatively weak serving value reduce convenience for regular use. Users must also account for the herb’s broad interaction profile despite the natural-source positioning.

Who is it for
  • Adults seeking an organic high-weight St. John’s wort product
  • Users who have reviewed all medication interactions
Best for
  • Substantial whole-herb-oriented intake
  • People prioritizing organic sourcing

Pros

  • Organic St. John’s wort
  • Substantial daily herb weight
  • Names hypericins and flavonoids
  • Focused single-herb formula

Cons

  • Does not state marker percentages
  • Requires three capsules
  • Serving value is weak
  • Potency is harder to predict than a standardized extract

Warnings

  • Do not combine St. John’s wort with SSRI, SNRI, MAOI, or other serotonergic medicines because serotonin toxicity can occur.
  • St. John’s wort can reduce the effectiveness of oral contraceptives, warfarin, transplant medicines, some HIV medicines, and several seizure medicines.
  • The herb can increase sensitivity to sunlight, so extra sun protection may be needed.
  • People with bipolar disorder should avoid unsupervised use because St. John’s wort can trigger agitation or mania.

Nutrient quality

78 High impact

Named active markers and a substantial amount support ingredient quality, but missing percentages limit standardization confidence. Duplicate herb entries create dosing uncertainty even though the formula remains focused on mood support.

Ingredient transparency

65 Moderate impact

Duplicate entries for the same herb make the true active amount difficult to interpret, with no proprietary blend obscuring the main doses. Daily directions and a complete inactive-ingredient list are not supplied.

Customer satisfaction

63 Moderate impact

The supplied aggregate rating is favorable and supported by a moderate review volume. Detailed feedback is unavailable, so repeated complaints and fit with the intended use cannot be judged.

Value for money

51 Moderate impact

The formula provides weak practical value for its quality and serving profile. Secondary ingredients or quality gaps reduce its category competitiveness.

Report analysis

Goals

Mood Support
Mood Support
Impact
Highest effect
A- Goal FitB Strength of SupportC- CoverageA Formula Quality

Saint John’s wort is directly relevant to mood support, and named hypericins and flavonoids add useful identity. Absent marker percentages still limit comparison with standardized clinical extracts.

The single-herb formula provides strong depth but only one primary mood pathway. Saint John’s wort can reduce the effects of oral contraceptives and anticoagulants, and combining it with serotonergic antidepressants can cause a serious interaction.

Study evidence
St. John's Wort Supportive 97 studies

Ingredients

IngredientAmount per serving
organic St. John's Wort (Flavonoids, Hypericins)
 1050 mg
Gluten Free Adults 18–50 Dairy Free Women Organic
Report overview
St. John's Wort (Flavonoids, Hypericins) · 1050 mg OverallScore53
B- Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyF Value

Hypericins and flavonoids are identified, but their standardization percentages are not disclosed. The daily amount falls within the broad clinically relevant range. The cost for an equivalent clinical daily amount is above the preferred range. Saint John’s wort can reduce the effect of oral contraceptives and anticoagulants, and combining it with serotonergic antidepressants may cause a serious interaction.

View ingredientView products
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88 Performance

Full Spectrum St. John's Wort Extract 600 mg

Planetary Herbals
A standardized, substantial Saint John’s wort blend offers focused mood support with stronger potency clarity than nonstandardized options; its extract quality and goal fit provide a clearer option when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
84 Performance

Feeling Positive St. John's Wort 300 mg

Sundown
Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort Extract

Swanson Superior Herbs
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort 300 mg

NOW
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
89 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the lower serving cost improves economy when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

Nature's Bounty
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

Perika St. John's Wort

Nature's Way
The named extract supports consistent quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has a weak, secondary, or opaque Saint John’s wort contribution. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  2. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  3. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  4. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  5. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort