Vitamin D-3 25000 IU
Metabolic Maintenance
Vitamin D-3 25000 IU
4.8
★ ★ ★ ★ ★
(543 ratings)
Vitamin K 45 mcg
Score 50.0
A very high-dose Vitamin D3 supplement with a disproportionately low Vitamin K2 (MK-7) component, making it unsuitable for general bone and heart health and best used under medical guidance.
Quantity: 60 Capsule(s)Servings size: 1 Capsule(s) (60 servings)
Selected goals:
Other goals:
Bone Health
Heart Health
Cardiovascular Support
General Health
leaderboard Score 50.0
A very high-dose Vitamin D3 supplement with a disproportionately low Vitamin K2 (MK-7) component, making it unsuitable for general bone and heart health and best used under medical guidance.
insights Analysis
Metabolic Maintenance Vitamin D-3 25000 IU is a potent Vitamin D3 supplement, delivering a very high dose intended for individuals with severe deficiencies or specific medical requirements, always under professional guidance. While it includes Vitamin K2 as MK-7 (45 mcg), this dosage is relatively low compared to the massive Vitamin D3 amount. Nutritionists emphasize that high doses of Vitamin D should always be paired with adequate K2 to ensure calcium is directed to the bones and not deposited in soft tissues like arteries. The imbalance in this product, with a very high D3 and low K2, is a concern for general, unsupervised supplementation for bone and cardiovascular health. Its utility is highly specific to treating severe D3 deficiency rather than broad K-related goals.
- Provides an exceptionally high dose of Vitamin D3 (25000 IU) for severe deficiencies.
- Includes Vitamin K2 (MK-7), which is crucial when taking high doses of D3.
- The Vitamin D3 dose (25000 IU) is too high for regular, unsupervised supplementation for most individuals.
- The K2 (MK-7: 45 mcg) dose is disproportionately low relative to the massive D3 dose, creating an imbalanced ratio for optimal calcium distribution.
- Not designed for general bone or cardiovascular health maintenance due to its extreme potency.
- The very high Vitamin D3 dose requires consultation with a healthcare professional and regular monitoring of Vitamin D levels to avoid toxicity.
- Not recommended for general daily use without specific medical indication and supervision.
$36.00($0.60 per serving)
 Pure Formulas | $ 36.00 | |
 iHerb | $ 36.00 |
bolt Effectiveness for goals
Vitamin K is essential for proper blood clotting and plays a significant role in bone metabolism. It helps the body produce proteins necessary for these vital bodily functions.
Vitamin K activates proteins such as osteocalcin, which are crucial for incorporating calcium into the bone matrix. This mechanism supports bone mineralization and helps maintain bone density.
Vitamin K1 (phylloquinone) is primarily effective for blood coagulation and is abundant in green leafy vegetables. Vitamin K2 (menaquinones) is more involved in bone and cardiovascular health, found in fermented foods and animal products, and has different bioavailabilities.
Emerging research suggests that Vitamin K, particularly K2, may help prevent arterial calcification by activating matrix Gla protein. This protein helps inhibit calcium deposition in soft tissues, supporting arterial flexibility.
Vitamin K works synergistically with calcium by helping to direct calcium to the bones and away from soft tissues like arteries. It activates proteins like osteocalcin for bone binding and matrix Gla protein to inhibit soft tissue calcification.
schedule Dosage, timing & forms
Recommended dosages for Vitamin K vary by age and form (K1 vs K2). For adults, the Adequate Intake (AI) for Vitamin K is 120 mcg per day for men and 90 mcg per day for women. Specific supplemental dosages may differ depending on individual needs and health goals.
Yes, dosages can differ between Vitamin K1 and K2 due to their varying potencies and half-lives. While K1 is measured in micrograms (mcg) for general intake, K2 (especially MK-7) may be effective at lower microgram doses due to its longer half-life. It's important to check the specific form and dosage on the supplement label.
Yes, Vitamin K is a fat-soluble vitamin, meaning it is best absorbed when taken with a meal containing some dietary fat. This helps facilitate its absorption into the body.
The two main forms of Vitamin K found in supplements are Vitamin K1 (phylloquinone) and Vitamin K2 (menaquinone). Vitamin K2 further has various subtypes, with MK-4 and MK-7 being the most common in supplements. Each form may have distinct roles and bioavailability.
There is no established Upper Limit (UL) for Vitamin K from food or supplements, as toxicity is rare. However, high doses of synthetic Vitamin K (menadione, K3) can be toxic, though this form is not typically found in supplements. Always adhere to recommended dosages and consult a healthcare provider if you have concerns.
health_and_safety Safety & interactions
Vitamin K plays a crucial role in blood clotting, which is the opposite effect of anticoagulant medications such as warfarin. Consuming inconsistent amounts of Vitamin K can alter warfarin's effectiveness, potentially making the blood thinner less effective or increasing bleeding risk. Individuals taking warfarin should maintain a consistent intake of Vitamin K and consult their healthcare provider.
Individuals taking anticoagulant medications like warfarin should consult their doctor before taking Vitamin K supplements due to potential interactions. People with certain liver conditions or those with a G6PD deficiency should also seek medical advice before supplementation. Always discuss new supplements with a healthcare provider.
Vitamin K supplements are generally considered safe for most healthy individuals when taken at recommended dosages. Side effects are uncommon but can include upset stomach, diarrhea, or allergic reactions in sensitive individuals. High doses of synthetic Vitamin K (menadione, K3) can be toxic, but this form is rarely used in supplements.
Vitamin K is essential during pregnancy and breastfeeding, and adequate intake is important for both mother and child. However, supplementation during these periods should only be undertaken under the guidance of a healthcare professional. High doses are generally not recommended without specific medical advice.
There is currently no established Tolerable Upper Intake Level (UL) for Vitamin K from food or supplements due to its low potential for toxicity. However, excessive intake, especially of synthetic forms, could potentially have adverse effects. It is always best to adhere to recommended dosages on supplement labels or as advised by a healthcare professional.
Ingredients
| Ingredient | Amount per serving |
|---|---|
| Vitamin D3 (Cholecalciferol) | 625 mcg |
| Vitamin K2 (Menaquinone-7) | 45 mcg |
Categories
Vitamin K 55.0
While it contains MK-7, the K2 dosage is minimal relative to the D3, making it a less significant source of Vitamin K within the collection for targeted K benefits.
Goals
Bone Health 50.0
While D3 is vital for bones, the extreme dosage coupled with a relatively low K2 creates an imbalanced scenario, potentially leading to calcium mishandling if not properly monitored.
Heart Health 50.0
The disproportionate D3:K2 ratio raises concerns for heart health if used without guidance, as K2 is essential for directing calcium away from arterial walls, especially with high D3.
Due to the unbalanced high D3 and lower K2, its cardiovascular support is questionable for general use, and could potentially lead to issues if calcium is not properly regulated.
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