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Vitamins D3 2500 IU (62.5 mcg) & K2 120 mcg

NaturesPlus
4.8
★ ★ ★ ★ ★
(4174 ratings)
Vitamin K 120 mcg
Product Image
Score86
A transparent, well-dosed D3 and MK-7 tablet with strong practical value. Its substantial vitamin D amount requires attention when stacking supplements.
How scoring works
Quantity:90 Tablet(s) • (90 servings)
Goals:
Anti-Aging
General Health
Bone Health
Heart Health
Cardiovascular Support

Score 86

A transparent, well-dosed D3 and MK-7 tablet with strong practical value. Its substantial vitamin D amount requires attention when stacking supplements.
How scoring works
$14.24($0.15 per serving)
Vitacost
$ 14.35
Vitacost
$ 14.35
Pure Formulas
$ 14.24
iHerb
$ 14.24
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Analysis

Vitamin D3 and MK-7 vitamin K2 form a coherent combination for normal bone maintenance and calcium handling. Both amounts are clearly disclosed and fall within commonly used supplemental ranges.

The simple two-active tablet avoids proprietary blends and unnecessary extras. A dry tablet has no stated fat carrier, so taking it with a meal containing fat may improve absorption.

The 62.5 mcg D3 amount is substantial and should be added to vitamin D from other supplements. The formula is a strong fit for users who want focused dosing and already understand their total vitamin D plan.

Who is it for
  • Adults seeking focused D3 and K2
  • Users who want a simple tablet
  • People tracking their total vitamin D intake
Best for
  • Bone and calcium-handling support
  • Vitamin D3-K2 maintenance
  • Efficient two-nutrient dosing

Pros

  • Target-range 120 mcg MK-7
  • Substantial 62.5 mcg D3
  • Simple transparent formula

Cons

  • No lipid carrier
  • D3 amount may duplicate other products
  • No calcium or magnesium

Warnings

  • MK-7 can interfere with warfarin and other vitamin K antagonist anticoagulants; intake should remain clinician-guided and consistent.
  • Count the 62.5 mcg D3 alongside multivitamins and other vitamin D products to avoid unnecessary high total intake.

Nutrient quality

91 Highest impact

Well-regarded vitamin D3 and MK-7 forms provide focused support at meaningful amounts. The simple dry format is balanced but lacks a lipid carrier.

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Ingredient transparency

83 Highest impact

Most active ingredients and their amounts are clearly listed. Daily directions and a complete other-ingredients panel are not included in the supplied data.

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Customer satisfaction

72 High impact

The aggregate rating is favorable and supported by large feedback volume. Complaint-level experiences are unavailable, so repeated drawbacks and purpose fit remain uncertain.

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Value for money

98 Highest impact

Meaningful actives and a low serving cost provide strong practical value. Minor form limitations do not outweigh the economy.

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Report analysis

Goals

Anti-Aging
Impact
Highest effect
A- Goal FitA+ Strength of SupportB- CoverageA+ Formula Quality
Vitamin K · 120 mcgVitamin D · 62.5 mcg

MK-7 vitamin K2 at 120 mcg supports proteins that help keep calcium in bones and out of soft tissues. A substantial vitamin D3 amount adds complementary support, while the dry tablet relies on food fat for optimal absorption.

The formula focuses on vascular and skeletal aging rather than mitochondrial, neurological, or glycation pathways. Vitamin K2 can oppose warfarin-type anticoagulants and requires prescriber guidance for users of those medicines.

Study evidence
Vitamin D Supportive 50 studies
Vitamin K Supportive 27 studies
General Health
Impact
Highest effect
A Goal FitA Strength of SupportC+ CoverageA+ Formula Quality
Vitamin D · 62.5 mcgVitamin K · 120 mcg

Vitamin D3 and MK-7 form a strong foundational pair for calcium handling, bone maintenance, and related physiological functions. Both forms are well chosen and fully quantified.

The formula provides meaningful depth in one linked pathway but does not cover broader daily nutrition. Vitamin K2 can oppose warfarin and similar anticoagulants, so people using those medicines need clinician-guided intake.

Study evidence
Vitamin K Supportive 34 studies
Bone Health
Impact
Highest effect
A- Goal FitA- Strength of SupportC+ CoverageA Formula Quality
Vitamin K · 120 mcgVitamin D · 62.5 mcg

The combination of vitamin D3 and MK-7 directly supports calcium absorption and activation of calcium-binding proteins in bone. Both amounts are substantial, making the formula useful when dietary mineral intake is already adequate.

The dry tablet clearly identifies the active forms but does not provide calcium, magnesium, collagen, or a lipid carrier. Vitamin K2 can alter warfarin control, so people using a vitamin K antagonist need clinician-guided consistency before changing intake.

Study evidence
Vitamin D Supportive 202 studies
Vitamin K Supportive 78 studies
Heart Health
Impact
Highest effect
B+ Goal FitA+ Strength of SupportC+ CoverageA+ Formula Quality
Vitamin K · 120 mcgVitamin D · 62.5 mcg

Vitamin D3 and K2 as MK-7 form a targeted pair for calcium handling and vascular support. The lean combination is focused on calcium regulation rather than broad lipid or cardiac-energy support.

Both vitamins use favorable forms and are supplied at meaningful amounts. Vitamin K2 can interfere with warfarin dosing and requires clinician-guided consistency during anticoagulation.

Study evidence
Vitamin D Mixed 164 studies
Vitamin K Mixed 62 studies
Cardiovascular Support
Impact
Highest effect
B- Goal FitA+ Strength of SupportC- CoverageA+ Formula Quality
Vitamin K · 120 mcgVitamin D · 62.5 mcg

Vitamin K2 as MK-7 and vitamin D3 form a targeted pair for directing calcium toward bone rather than soft tissue. That mechanism is relevant to vascular health, although evidence for direct cardiovascular outcome improvement is less established than for lipid or blood-pressure interventions.

Both forms and amounts are clearly disclosed, and the K2 dose is substantial. Vitamin K2 can interfere with warfarin and related vitamin K antagonist therapy, so the combination requires clinician-guided consistency in that setting.

Study evidence
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Vitamin D3 (Cholecalciferol)
62.5 mcg
Vitamin K2 (Menaquinone-7)
120 mcg
Gluten Free Adults 18–50 No Allergies Vegetarian
Report overview
C+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

The 120 mcg MK-7 dose is clearly disclosed and fits the targeted range for bone and cardiovascular support. The very low serving cost and added vitamin D3 provide strong value, though the dry tablet lacks lipid-based absorption support. The MK-7 dose can affect warfarin control, so people using vitamin K antagonist anticoagulants need clinician-guided consistency.

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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsHeart Health Cardiovascular Support forVitamin K
  2. Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials.
    Vlasschaert C; Goss CJ; Pilkey NG; McKeown S; Holden RM · Nutrients · 2021
    Systematic review9 studies pooledHeart Health forVitamin K
  3. Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial.
    Witham MD; Lees JS; White M; Band M; Bell S; Chantler DJ; Ford I; Fulton RL; Kennedy G; Littleford RC; McCrea IV; McGlynn D; Panarelli M; Ralston MR; Rutherford E; Severn A; Thomson N; Traynor JP; Struthers AD; Wetherall K; Mark PB · Journal of the American Society of Nephrology : JASN · 2021
    Randomized trial159 participantsHeart Health forVitamin K
  4. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  5. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  6. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
    Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Meta-analysis6,759 participants19 studies pooledBone Health forVitamin K
  7. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  8. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  9. The relationship between vitamin K and peripheral arterial disease.
    Vissers LET; Dalmeijer GW; Boer JMA; Verschuren WMM; van der Schouw YT; Beulens JWJ · Atherosclerosis · 2017
    Cohort study36,629 participantsCardiovascular Support forVitamin K
  10. Interventions to Attenuate Cardiovascular Calcification Progression: A Systematic Review of Randomized Clinical Trials.
    Murali S; Smith ER; Tiong MK; Tan SJ; Toussaint ND · Journal of the American Heart Association · 2024
    Systematic review9,901 participants49 studies pooledCardiovascular Support forVitamin K
  11. Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.
    Pan Z; Zeng J; Chen Z; Chen S; Yang J; Li H; Wang S; Wang J; Li N; Gong Y; Liu M; Li C · The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Cohort study389,217 participantsAnti-Aging forVitamin D
  12. Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels.
    Schöttker B; Hagen L; Zhang Y; Gào X; Holleczek B; Gao X; Brenner H · The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Cohort study9,940 participantsAnti-Aging forVitamin D
  13. Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study.
    Song S; Lim JY; Kim M; Won CW; Park HY · The journal of nutrition, health & aging · 2025
    Cohort study1,292 participantsAnti-Aging forVitamin D
  14. Vitamin D deficit is associated with accelerated brain aging in the general population.
    Terock J; Bonk S; Frenzel S; Wittfeld K; Garvert L; Hosten N; Nauck M; Völzke H; Van der Auwera S; Grabe HJ · Psychiatry research. Neuroimaging · 2022
    Cross-sectional study1,865 participantsAnti-Aging forVitamin D
  15. Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
    Zhao C; Tsapanou A; Manly J; Schupf N; Brickman AM; Gu Y · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Cohort study1,759 participantsAnti-Aging forVitamin D
  16. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  17. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  18. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  19. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  20. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  21. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial.
    Moon RJ; D' Angelo S; Curtis EM; Ward KA; Crozier SR; Schoenmakers I; Javaid MK; Bishop NJ; Godfrey KM; Cooper C; Harvey NC; MAVIDOS Trial Group · The American journal of clinical nutrition · 2024
    Randomized trial454 participantsBone Health forVitamin D
  22. Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol.
    Matsumoto T; Takano T; Saito H; Takahashi F · BoneKEy reports · 2014
    Narrative reviewBone Health forVitamin D
  23. Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.
    Tangestani H; Djafarian K; Emamat H; Arabzadegan N; Shab-Bidar S · Critical reviews in food science and nutrition · 2020
    Meta-analysis1,786 participants20 studies pooledBone Health forVitamin D
  24. Cholecalciferol Supplementation Attenuates Bone Loss in Incident Kidney Transplant Recipients: A Prespecified Secondary Endpoint Analysis of a Randomized Controlled Trial.
    Tsujita M; Doi Y; Obi Y; Hamano T; Tomosugi T; Futamura K; Okada M; Hiramitsu T; Goto N; Isaka Y; Takeda A; Narumi S; Watarai Y · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Randomized trial193 participantsBone Health forVitamin D
  25. Vitamin D supplementation and bone health in post-menopausal women: a 24-month randomized controlled intervention with enhanced bioavailability formulations.
    Rasool N; Munir Y · European journal of clinical nutrition · 2026
    Randomized trial612 participantsBone Health forVitamin D
  26. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  27. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  28. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  29. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  30. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  31. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  32. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  33. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  34. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  35. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  36. Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.
    Yin WJ; Wang P; Ma SS; Tao RX; Hu HL; Jiang XM; Zhang Y; Tao FB; Zhu P · European journal of nutrition · 2024
    Randomized trial1,537 participantsHeart Health forVitamin D
  37. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsHeart Health forVitamin D
  38. Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
    Mirhosseini N; Rainsbury J; Kimball SM · Frontiers in cardiovascular medicine · 2020
    Meta-analysis81 studies pooledHeart Health forVitamin D
  39. Does vitamin D supplementation modulate metabolic risk factors of cardiovascular disease? A systematic review and meta-analysis of clinical trials.
    Abumweis S; Alqadi S; Al Tarteer A; Alrefai W; Alzoughool F; Jew S; Qudah T · Asia Pacific journal of clinical nutrition · 2026
    Meta-analysis45 studies pooledHeart Health forVitamin D
  40. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisHeart Health forVitamin D
  41. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K