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Vitamin K2 MenaQ7 100 mcg

AN Amazing Nutrition Amazing Formulas
4.8
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(347 ratings)
Vitamin K 100 mcg
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Score85
A clean, clearly dosed natto-derived MK-7 capsule with strong value. It is a focused K2 option rather than a complete bone formula.
How scoring works
Quantity:120 Capsule(s) • (120 servings)
Goals:
Bone Health
General Health
Heart Health
Anti-Aging
Cardiovascular Support

Score 85

A clean, clearly dosed natto-derived MK-7 capsule with strong value. It is a focused K2 option rather than a complete bone formula.
How scoring works
$17.99($0.14 per serving)
Pure Formulas
$ 17.99
Vitacost
$ 21.13
iHerb
$ 19.79
Report prices

Analysis

A single active supplies 100 mcg of vitamin K2 from natto. MK-7 is a long-lasting form suited to daily support for calcium-regulating proteins in bone and vascular tissue.

The label is unusually simple and makes the active amount easy to assess. No vitamin D, calcium, or other cofactor is included, so the product works best when those needs are handled separately.

One capsule per serving and low ongoing cost make it practical for focused K2 use. It fits adults seeking MK-7 alone rather than a broader bone or cardiovascular blend.

Who is it for
  • Adults seeking standalone MK-7
  • People who already manage vitamin D and calcium separately
  • Users wanting one-capsule vitamin K2
Best for
  • Focused vitamin K2 supplementation
  • Bone calcium-management support
  • Simple long-term MK-7 use

Pros

  • Provides 100 mcg of MK-7
  • Clearly identifies the natto source
  • Uses a simple single-active formula
  • Requires one capsule daily

Cons

  • Does not include vitamin D
  • Does not include calcium or magnesium
  • Natto source may concern soy-allergic users
  • Provides no added source-purity details

Warnings

  • Vitamin K2 can oppose warfarin and related vitamin K antagonists, so intake should remain consistent with prescriber guidance.
  • People with soy allergy should verify whether the natto-derived ingredient retains clinically relevant soy proteins.

Nutrient quality

93 Highest impact

Menaquinone-7 is a well-regarded, longer-acting vitamin K2 form. The vitamin K amount is meaningful for routine supplementation.

Ingredient transparency

82 Highest impact

Every active ingredient has a specific amount. Inactive ingredients are not supplied.

Customer satisfaction

68 High impact

The supplied average indicates very strong aggregate satisfaction. No detailed experience reports are available to identify repeated complaints or confirm perceived benefits.

Value for money

96 Highest impact

The focused, well-formed ingredient provides strong value for the cost. Serving value appears favorable for a simple vitamin K supplement.

Report analysis

Goals

Bone Health
Bone Health
Impact
Highest effect
A- Goal FitA Strength of SupportC+ CoverageA+ Formula Quality
Vitamin K · 100 mcg

Natto-derived vitamin K2 directly supports osteocalcin activation and calcium incorporation into bone. The 100 mcg amount is clearly disclosed and substantial for targeted K2 use.

The focused design does not provide calcium, magnesium, vitamin D, or a protein-matrix ingredient. Vitamin K2 can oppose warfarin and other vitamin K antagonists, so people using those medicines should not add it without prescriber guidance.

Study evidence
Vitamin K Supportive 78 studies
General Health
General Health
Impact
Highest effect
A- Goal FitA Strength of SupportC+ CoverageA- Formula Quality
Vitamin K · 100 mcg

Vitamin K2 from natto provides a targeted nutrient for normal calcium handling and bone maintenance. The MenaQ7 labeling and 100 mcg amount give useful source and dose clarity.

The single-nutrient design is focused, although it does not include vitamin D or other foundational nutrients. Vitamin K2 can oppose warfarin and related vitamin K antagonists, so people using those medicines need prescriber guidance before taking it.

Study evidence
Vitamin K Supportive 34 studies
Heart Health
Heart Health
Impact
Highest effect
A- Goal FitA Strength of SupportC+ CoverageA+ Formula Quality
Vitamin K · 100 mcg

Vitamin K2 directly supports calcium placement and arterial health. The single vitamin is focused on one vascular pathway and does not address lipids, blood flow, or cardiac energy.

The natto-derived amount is clearly disclosed and aligns with common MK-7 use. Vitamin K2 can counteract warfarin, so people using that anticoagulant need prescriber guidance before changing intake.

Study evidence
Vitamin K Mixed 62 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
B Goal FitA Strength of SupportC+ CoverageA+ Formula Quality
Vitamin K · 100 mcg

MK-7 supports vitamin K-dependent proteins involved in bone maintenance and arterial calcium handling. The amount is well aligned with daily use, although it addresses only one part of biological aging.

The active form and amount are clearly disclosed in a simple one-unit serving. MK-7 can oppose warfarin and other vitamin K antagonists, so intake changes require supervision from the prescriber managing that medicine.

Study evidence
Vitamin K Supportive 27 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B Goal FitA- Strength of SupportD+ CoverageA Formula Quality
Vitamin K · 100 mcg

Vitamin K2 supports activation of proteins that help direct calcium away from arteries and into bone. Evidence for cardiovascular outcomes is promising but less definitive than evidence for established lipid or blood-pressure interventions.

The natto-derived K2 amount is clearly disclosed, but the exact menaquinone subtype is not stated. Vitamin K can reduce warfarin’s anticoagulant effect and requires stable intake under warfarin management.

Study evidence
Vitamin K Supportive 40 studies

Ingredients

IngredientAmount per serving
Vitamin K2 (Natto)
 100 mcg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Vitamin K (Natto) · 100 mcg OverallScore92
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Menaquinone-7 provides the preferred long-lasting vitamin K2 form. The 100 mcg MK-7 dose falls within the preferred clinical range. Vitamin K can reduce warfarin's anticoagulant effect, so users of this medicine need clinician-guided dosing.

View ingredientView products
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<p>The formula provides 100 mcg of Vitamin K2 (Menaquinone-7), which may be a better fit than the original’s 100 mcg of Vitamin K2 (Natto) when its specific vitamin K form and companion nutrients are preferred. Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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<p>The formula provides 90 mcg of Vitamin K2 (Menaquinone-7), which may be a better fit than the original’s 100 mcg of Vitamin K2 (Natto) when its specific vitamin K form and companion nutrients are preferred. Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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<p>The formula provides 100 mcg of Vitamin K2 (MenaQ7 Menaquinone), which may be a better fit than the original’s 100 mcg of Vitamin K2 (Natto) when its specific vitamin K form and companion nutrients are preferred. Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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<p>At a lower recurring cost, the formula provides 100 mcg of Vitamin K (Menaquinone-7), making it a practical budget alternative to the original’s 100 mcg of Vitamin K2 (Natto). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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<p>At a lower recurring cost, the formula provides 100 mcg of Vitamin K-2 (Menaquinone-7) and 62.50 mcg of Vitamin D-3 (Lanolin), making it a practical budget alternative to the original’s 100 mcg of Vitamin K2 (Natto). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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<p>Although it is not strictly cheaper per serving, this is among the lowest-cost eligible options and provides 100 mcg of Vitamin K2 (Menaquinone-7) as an alternative to 100 mcg of Vitamin K2 (Natto). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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<p>The formula combines 100 mcg of Vitamin K2 (Menaquinone-7) with favorable serving value, which may offer a better quality-to-cost balance than the original’s 100 mcg of Vitamin K2 (Natto). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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Vitamins D3 2500 IU (62.5 mcg) & K2 120 mcg

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<p>The formula combines 120 mcg of Vitamin K2 (Menaquinone-7) and 62.50 mcg of Vitamin D3 (Cholecalciferol) with favorable serving value, which may offer a better quality-to-cost balance than the original’s 100 mcg of Vitamin K2 (Natto). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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Vitamin K2 100 mcg + Vitamin D3 125 mcg

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<p>The formula combines 100 mcg of Vitamin K (Menaquinone-7) and 125 mcg of Vitamin D (Cholecalciferol) with favorable serving value, which may offer a better quality-to-cost balance than the original’s 100 mcg of Vitamin K2 (Natto). The high vitamin D amount warrants attention to total intake, and vitamin K may interfere with warfarin-type anticoagulants.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  2. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
    Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Meta-analysis6,759 participants19 studies pooledBone Health forVitamin K
  3. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  4. Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03.
    Tanaka S; Miyazaki T; Uemura Y; Miyakawa N; Gorai I; Nakamura T; Fukunaga M; Ohashi Y; Ohta H; Mori S; Hagino H; Hosoi T; Sugimoto T; Itoi E; Orimo H; Shiraki M · Journal of bone and mineral metabolism · 2018
    Randomized trial1,874 participantsBone Health forVitamin K
  5. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  6. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  7. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  8. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsCardiovascular Support Heart Health forVitamin K
  9. Interventions to Attenuate Cardiovascular Calcification Progression: A Systematic Review of Randomized Clinical Trials.
    Murali S; Smith ER; Tiong MK; Tan SJ; Toussaint ND · Journal of the American Heart Association · 2024
    Systematic review9,901 participants49 studies pooledCardiovascular Support forVitamin K
  10. Intake of dietary phylloquinone and menaquinones and risk of stroke.
    Vissers LE; Dalmeijer GW; Boer JM; Monique Verschuren WM; van der Schouw YT; Beulens JW · Journal of the American Heart Association · 2014
    Cohort study35,476 participantsCardiovascular Support forVitamin K
  11. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease.
    van den Heuvel EG; van Schoor NM; Lips P; Magdeleyns EJ; Deeg DJ; Vermeer C; den Heijer M · Maturitas · 2014
    Cohort study577 participantsCardiovascular Support forVitamin K
  12. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  13. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  14. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  15. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  16. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  17. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  18. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  19. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  20. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  21. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  22. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  23. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  24. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  25. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  26. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K