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Vitamin K2 as MK-7 100 mcg

Healthy Origins
4.7
★ ★ ★ ★ ★
(762 ratings)
Vitamin K 100 mcg
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Score87
Best suited to long-term users seeking a simple economical MK-7 softgel; source and carrier details are missing, but the long supply gives it favorable practical value.
How scoring works
Quantity:180 Softgel(s) • (180 servings)
Goals:
Bone Health
Cardiovascular Support
General Health
Anti-Aging
Heart Health

Score 87

Best suited to long-term users seeking a simple economical MK-7 softgel; source and carrier details are missing, but the long supply gives it favorable practical value.
How scoring works
$27.99($0.15 per serving)
Vitacost
$ 27.99
iHerb
$ 27.99
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Analysis

A 100 mcg MK-7 softgel offers focused, long-acting vitamin K2 support in a large-count bottle. The label provides enough detail to judge the central vitamin strategy.

Source and carrier details are missing, but the long supply gives it favorable practical value. Format, dose, and companion nutrients determine whether it is appropriate for daily use.

The best fit is long-term users seeking a simple economical MK-7 softgel. Vitamin K and vitamin D support normal physiology, but the practical benefit depends on baseline intake and individual need.

Who is it for
  • Long-term users seeking a simple economical MK-7 softgel
  • Adults whose current vitamin intake matches the listed potency
  • Users able to account for vitamin K medication interactions
Best for
  • Long-acting MK-7
  • Useful daily amount
  • Users who accept that mk-7 source is not disclosed

Pros

  • Long-acting MK-7
  • Useful daily amount
  • Softgel delivery
  • Large 180-serving supply

Cons

  • MK-7 source is not disclosed
  • Carrier oil is not identified
  • No companion vitamin D
  • Inactive ingredients are not supplied

Warnings

  • The 100 mcg vitamin K serving can counteract warfarin and related vitamin K antagonist anticoagulants.
  • Bile-acid sequestrants and orlistat can reduce absorption of fat-soluble vitamin K, which may make this softgel less reliable.
  • People with fat-malabsorption conditions may not absorb the listed vitamin K consistently and should use an individualized plan.

Nutrient quality

96 Highest impact

MK-7 is a long-acting vitamin K2 form, and the softgel suits a fat-soluble nutrient, and the 100 mcg MK-7 amount is meaningful for daily vitamin K2 support. The vitamin K2 amount is not obviously excessive for general supplementation, while the single active is tightly focused on vitamin K2 support without mismatched additions.

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Ingredient transparency

84 Highest impact

Every listed active ingredient has a specific amount, and no proprietary blend hides the dose of a listed active ingredient. Serving count is supplied, but complete daily-use directions are not provided, while inactive ingredients and excipients are not included in the supplied label details.

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Customer satisfaction

72 High impact

The supplied average rating is strong, and moderate review volume provides a reasonable evidence base. Specific review themes are unavailable, so repeated negatives and real-world fit remain uncertain.

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Value for money

93 Highest impact

The ingredient forms and dosing generally justify the product positioning, and the very low serving cost provides excellent practical value. The focused active profile is not inflated by low-value additions, while the formula and serving value compare well with similar products.

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Goals

Bone Health
Bone Health
Impact
Highest effect
A- Goal FitA Strength of SupportC CoverageA- Formula Quality
Vitamin K · 100 mcg

MK-7 directly supports activation of proteins that guide calcium into bone. Its evidence and dose make it a strong targeted option, though it does not supply structural minerals.

The amount falls in a commonly used range and the long-lasting K2 form is clearly named. People using warfarin or another vitamin K antagonist need consistent intake because MK-7 can oppose the medicine’s effect.

Study evidence
Vitamin K Supportive 78 studies
Cardiovascular Support
Cardiovascular Support
Impact
Highest effect
A- Goal FitA Strength of SupportD+ CoverageA+ Formula Quality
Vitamin K · 100 mcg

MK-7 provides focused support for proteins that help direct calcium away from soft tissues and into bone. The disclosed amount and softgel delivery are well aligned with routine K2 use.

The product addresses one specialized vascular pathway rather than broader cardiovascular needs. Vitamin K can oppose warfarin and related vitamin K antagonists, so users of those medicines need consistent intake and clinician-guided dosing.

Study evidence
Vitamin K Supportive 40 studies
General Health
General Health
Impact
Highest effect
A- Goal FitA Strength of SupportC- CoverageA Formula Quality
Vitamin K · 100 mcg

Vitamin K2 supports normal calcium handling in bone and vascular tissues, making it relevant to foundational health. The single nutrient remains narrower than a broad daily wellness formula.

MK-7 is a long-lasting form and the disclosed amount falls in a useful supplemental range. Vitamin K can oppose warfarin and related vitamin K antagonists, so people using those medicines need clinician-guided, consistent intake.

Study evidence
Vitamin K Supportive 34 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
B+ Goal FitA Strength of SupportC- CoverageA+ Formula Quality
Vitamin K · 100 mcg

MK-7 supports bone and vascular protein activation, giving the product a focused connection to healthy aging. Human evidence is useful for vitamin K status and related markers, but broader longevity effects remain uncertain.

The clearly disclosed amount falls in a practical daily range, while the generic source lacks all-trans or branded purity detail. Vitamin K can oppose warfarin and related vitamin K antagonists, so users of those medicines need consistent intake and clinical guidance.

Study evidence
Vitamin K Supportive 27 studies
Heart Health
Heart Health
Impact
Highest effect
B Goal FitA- Strength of SupportC- CoverageA Formula Quality
Vitamin K · 100 mcg

MK-7 is the long-lasting vitamin K2 form used to support normal calcium handling in blood vessels. The 100 mcg serving is clearly disclosed and sits in a practical daily range.

Support is limited to arterial calcium regulation rather than broad cardiovascular coverage. Vitamin K2 can interfere with warfarin and similar vitamin K antagonists, so users of those medicines need clinician-guided consistency.

Study evidence
Vitamin K Mixed 62 studies

Ingredients

IngredientAmount per serving
Vitamin K2 (Menaquinone-7)
 100 mcg
Gluten Free Adults 18–50 Dairy Free Vegetarian
Report overview
Vitamin K (Menaquinone-7) · 100 mcg OverallScore90
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA+ Value

Generic MK-7 provides the preferred long-lasting vitamin K2 form, but no branded or all-trans source is disclosed. 100 mcg falls in the preferred MK-7 range for bone and cardiovascular support; the clinical dose is delivered at a low serving cost. Vitamin K can oppose warfarin and related vitamin K antagonists, so users of those medicines need consistent intake and clinician guidance.

View ingredientView products
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87 Performance

Vitamin K2 100 mcg

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86 Performance

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<p>The formula provides 90 mcg of Vitamin K2 (Menaquinone-7), which may be a better fit than the original’s 100 mcg of Vitamin K2 (Menaquinone-7) when its specific vitamin K form and companion nutrients are preferred. Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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<p>The formula provides 100 mcg of Vitamin K2 (MenaQ7 Menaquinone), which may be a better fit than the original’s 100 mcg of Vitamin K2 (Menaquinone-7) when its specific vitamin K form and companion nutrients are preferred. Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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<p>At a lower recurring cost, the formula provides 100 mcg of Vitamin K (Menaquinone-7), making it a practical budget alternative to the original’s 100 mcg of Vitamin K2 (Menaquinone-7). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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Liquid D-3 & MK-7

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<p>At a lower recurring cost, the formula provides 100 mcg of Vitamin K-2 (Menaquinone-7) and 62.50 mcg of Vitamin D-3 (Lanolin), making it a practical budget alternative to the original’s 100 mcg of Vitamin K2 (Menaquinone-7). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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Vitamin K2 MenaQ7 100 mcg

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<p>At a lower recurring cost, the formula provides 100 mcg of Vitamin K2 (Natto), making it a practical budget alternative to the original’s 100 mcg of Vitamin K2 (Menaquinone-7). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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<p>The formula combines 100 mcg of Vitamin K2 (Menaquinone-7) with favorable serving value, which may offer a better quality-to-cost balance than the original’s 100 mcg of Vitamin K2 (Menaquinone-7). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
86 Value

Vitamins D3 2500 IU (62.5 mcg) & K2 120 mcg

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<p>The formula combines 120 mcg of Vitamin K2 (Menaquinone-7) and 62.50 mcg of Vitamin D3 (Cholecalciferol) with favorable serving value, which may offer a better quality-to-cost balance than the original’s 100 mcg of Vitamin K2 (Menaquinone-7). Vitamin K may interfere with warfarin-type anticoagulants, so people using them need clinician-directed intake.</p>
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Vitamin K2 100 mcg + Vitamin D3 125 mcg

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<p>The formula combines 100 mcg of Vitamin K (Menaquinone-7) and 125 mcg of Vitamin D (Cholecalciferol) with favorable serving value, which may offer a better quality-to-cost balance than the original’s 100 mcg of Vitamin K2 (Menaquinone-7). The high vitamin D amount warrants attention to total intake, and vitamin K may interfere with warfarin-type anticoagulants.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study.
    Bellinge JW; Dalgaard F; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Sim M; Croft KD; Gislason G; Torp-Pedersen C; Tjønneland A; Overvad K; Hodgson JM; Schultz C; Bondonno NP · Journal of the American Heart Association · 2021
    Cohort study53,372 participantsHeart Health Cardiovascular Support forVitamin K
  2. Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials.
    Vlasschaert C; Goss CJ; Pilkey NG; McKeown S; Holden RM · Nutrients · 2021
    Systematic review9 studies pooledHeart Health forVitamin K
  3. Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial.
    Witham MD; Lees JS; White M; Band M; Bell S; Chantler DJ; Ford I; Fulton RL; Kennedy G; Littleford RC; McCrea IV; McGlynn D; Panarelli M; Ralston MR; Rutherford E; Severn A; Thomson N; Traynor JP; Struthers AD; Wetherall K; Mark PB · Journal of the American Society of Nephrology : JASN · 2021
    Randomized trial159 participantsHeart Health forVitamin K
  4. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
    Knapen MH; Drummen NE; Smit E; Vermeer C; Theuwissen E · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Randomized trial244 participantsBone Health forVitamin K
  5. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials.
    Huang ZB; Wan SL; Lu YJ; Ning L; Liu C; Fan SW · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Meta-analysis6,759 participants19 studies pooledBone Health forVitamin K
  6. Investigating the interrelationship of vitamin K and vitamin D status on bone density: results from the VITamin D and OmegA-3 TriaL.
    Chou SH; Booth SL; Cook NR; Kim E; Kotler G; Fu X; Buring JE; Manson JE; LeBoff MS · JBMR plus · 2026
    Randomized trial771 participantsBone Health forVitamin K
  7. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.
    Knapen MH; Braam LA; Drummen NE; Bekers O; Hoeks AP; Vermeer C · Thrombosis and haemostasis · 2016
    Randomized trial244 participantsCardiovascular Support Heart Health forVitamin K
  8. The relationship between vitamin K and peripheral arterial disease.
    Vissers LET; Dalmeijer GW; Boer JMA; Verschuren WMM; van der Schouw YT; Beulens JWJ · Atherosclerosis · 2017
    Cohort study36,629 participantsCardiovascular Support forVitamin K
  9. Interventions to Attenuate Cardiovascular Calcification Progression: A Systematic Review of Randomized Clinical Trials.
    Murali S; Smith ER; Tiong MK; Tan SJ; Toussaint ND · Journal of the American Heart Association · 2024
    Systematic review9,901 participants49 studies pooledCardiovascular Support forVitamin K
  10. Vitamin K status, cardiovascular disease, and all-cause mortality: a participant-level meta-analysis of 3 US cohorts.
    Shea MK; Barger K; Booth SL; Matuszek G; Cushman M; Benjamin EJ; Kritchevsky SB; Weiner DE · The American journal of clinical nutrition · 2020
    Meta-analysis3,891 participants3 studies pooledAnti-Aging General Health forVitamin K
  11. Topical Menaquinone‑7 (Vitamin K2, MK-7) as a Mitochondrial Bioenergetic Activator for Skin Anti-Aging: Mechanistic Evidence in Skin Cells and a Randomized Split-Face/Neck Study.
    Huang H; Wei R; Xu C; Liu C; Zhao S; Li Y; Wang M · ACS omega · 2026
    Randomized trial30 participantsAnti-Aging forVitamin K
  12. Vitamin K status and cognitive function in healthy older adults.
    Presse N; Belleville S; Gaudreau P; Greenwood CE; Kergoat MJ; Morais JA; Payette H; Shatenstein B; Ferland G · Neurobiology of aging · 2014
    Cross-sectional study320 participantsAnti-Aging forVitamin K
  13. High dephospho-uncarboxylated matrix Gla protein concentrations, a plasma biomarker of vitamin K, in relation to frailty: the Longitudinal Aging Study Amsterdam.
    Machado-Fragua MD; Hoogendijk EO; Struijk EA; Rodriguez-Artalejo F; Lopez-Garcia E; Beulens JW; van Ballegooijen AJ · European journal of nutrition · 2021
    Cohort study644 participantsAnti-Aging forVitamin K
  14. Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study.
    Alisi L; Cafolla C; Gentili A; Tartaglione S; Curini R; Cafolla A · Journal of aging research · 2022
    Cross-sectional study85 participantsAnti-Aging forVitamin K
  15. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
    Cockayne S; Adamson J; Lanham-New S; Shearer MJ; Gilbody S; Torgerson DJ · Archives of internal medicine · 2006
    Meta-analysis13 studies pooledBone Health forVitamin K
  16. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.
    Iwamoto J; Takeda T; Ichimura S · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2001
    Randomized trial92 participantsBone Health forVitamin K
  17. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
    Zhou M; Han S; Zhang W; Wu D · Journal of bone and mineral metabolism · 2022
    Meta-analysis6,853 participants9 studies pooledBone Health forVitamin K
  18. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.
    Koitaya N; Sekiguchi M; Tousen Y; Nishide Y; Morita A; Yamauchi J; Gando Y; Miyachi M; Aoki M; Komatsu M; Watanabe F; Morishita K; Ishimi Y · Journal of bone and mineral metabolism · 2015
    Randomized trial48 participantsBone Health forVitamin K
  19. Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women.
    de Vries F; Bittner R; Maresz K; Machuron F; Gåserød O; Jeanne JF; Schurgers LJ · Nutrients · 2025
    Randomized trial165 participantsCardiovascular Support forVitamin K
  20. Dietary Vitamin K1 Intake and Incident Aortic Valve Stenosis.
    Schultz CJ; Dalgaard F; Bellinge JW; Murray K; Sim M; Connolly E; Blekkenhorst LC; Bondonno CP; Lewis JR; Gislason GH; Tjønneland A; Overvad K; Hodgson JM; Bondonno NP · Arteriosclerosis, thrombosis, and vascular biology · 2024
    Cohort study55,545 participantsCardiovascular Support Heart Health forVitamin K
  21. Association between vitamin K1 intake and mortality in the Danish Diet, Cancer, and Health cohort.
    Palmer CR; Bellinge JW; Dalgaard F; Sim M; Murray K; Connolly E; Blekkenhorst LC; Bondonno CP; Croft KD; Gislason G; Tjønneland A; Overvad K; Schultz C; Lewis JR; Hodgson JM; Bondonno NP · European journal of epidemiology · 2021
    Cohort study56,048 participantsCardiovascular Support Heart Health forVitamin K
  22. Dietary vitamin K intake associates with reduced all-cause mortality in non-alcoholic fatty liver disease patients.
    Huang Y; Zhu X; Han L; Hu H · Scientific reports · 2025
    Cohort study7,857 participantsGeneral Health forVitamin K
  23. The Effect of Topical Vitamin K1 on the Treatment of Cetuximab-Induced Skin Rashes in Metastatic Colorectal Cancer Patients.
    Roayaei M; Rezaei M; Najafizade N · Advanced biomedical research · 2024
    Randomized trial49 participantsGeneral Health forVitamin K
  24. Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis.
    Sun Z; Zhu K; Liang G; Yan F; Chao S; Jia L; Niu Y · Experimental and therapeutic medicine · 2023
    Meta-analysis7 studies pooledGeneral Health forVitamin K
  25. Vitamin K1 intake is associated with lower risk for all-cause and cardiovascular disease mortality in community-dwelling older Australian women.
    Dupuy M; Radavelli-Bagatini S; Zhong L; Dalla Via J; Zhu K; Blekkenhorst LC; Bondonno NP; Linneberg A; Bellinge JW; Schultz C; Courtney W; Prince RL; Hodgson JM; Lewis JR; Sim M · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024
    Cohort study1,436 participantsGeneral Health forVitamin K
  26. The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial.
    Bellinge JW; Francis RJ; Lee SC; Bondonno NP; Sim M; Lewis JR; Watts GF; Schultz CJ · The American journal of clinical nutrition · 2022
    Randomized trial149 participantsHeart Health forVitamin K