5-HTP 100 mg

5-HTP 100 mg

California Gold Nutrition4.7 (3,810 ratings)
Format:Capsule Quantity: 90 Capsule(s) · 90 servings
Goals
$24.51 $0.27 per serving

About this product

A standard 100 mg 5-HTP serving gives the formula a clear and focused role in serotonin-related mood and sleep support. The amount matches the practical middle ground represented in the supplied goal analyses without pushing into a high-strength serving.

Griffonia simplicifolia is identified as the source, although no active standardization percentage is supplied. The capsule(s) format is convenient, but it does not add a disclosed release or absorption feature.

The simple design makes the active easy to judge, although it covers only one main pathway. Cost efficiency is a clear strength for the disclosed amount. It best fits adults seeking a straightforward middle-dose option for mood or sleep support.

Who is it for
  • Adults seeking a standard 5-HTP amount
  • People focused on mood or sleep support
  • Users who prefer a simple capsule or tablet routine
Best for
  • Focused serotonin-pathway mood support
  • Indirect sleep support through serotonin and melatonin pathways
  • Stress accompanied by low mood or disrupted sleep

Pros

  • Clearly discloses 100 mg of 5-HTP
  • Capsule(s) format is easy to use
  • Names Griffonia simplicifolia as the botanical source
  • Focused formula is easy to assess
  • Good value for the disclosed active amount

Cons

  • No 5-HTP standardization percentage is provided
  • No controlled-release or enteric delivery feature is disclosed
  • Single-pathway formula offers limited support beyond serotonin production

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, or other serotonin-raising medicines because serotonin toxicity can occur.
  • The 100 mg 5-HTP serving may cause nausea or digestive upset.
  • Avoid stacking it with other serotonin-focused supplements such as tryptophan or SAMe unless a qualified clinician has reviewed the combination.

Product analysis

81 out of 100
100 mg of 5-HTP provides standard serotonin-pathway support in a convenient format. The named Griffonia source helps, but missing standardization limits quality detail.

AI assessment of the formula, label and price. How scoring works

Nutrient quality85

Griffonia simplicifolia identifies the botanical source, but no active standardization percentage is supplied. The 5-HTP amount matches a common standard serving, while missing extract standardization limits source-potency confidence.

Ingredient transparency81

Every listed active amount is disclosed, and no proprietary blend hides dosing. Complete directions, inactive ingredients, and some source or standardization details remain unavailable.

Customer satisfaction70

The aggregate rating is favorable, and the very large review count makes it stable. No detailed feedback is supplied, so repeated complaints and purpose fit cannot be judged.

Value for money89

A standard amount and plant source provide good practical value. Missing extract standardization prevents stronger quality confidence.

Format
Capsule
Container
90 Capsule(s)
Per serving
$0.27
Customer rating
4.7 · 3,810 ratings
Report analysis

Goals

Mood Support
Impact
Highest effect
A Ingredient FitC- PathwaysA EvidenceA+ Formulation Logic
5-HTP · 100 mg
Study evidence
5-HTP Supportive 9 studies
Stress Relief
Impact
Moderate effect
A Ingredient FitD PathwaysC- EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 18 studies
Weight Loss
Impact
Moderate effect
B- Ingredient FitF PathwaysC EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 5 studies
Sleep Support
Impact
Moderate effect
A Ingredient FitC PathwaysC- EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 1 study

Ingredients

IngredientAmount per servingScore
5-HTP (Griffonia simplicifolia seed extract)
100 mg 85
Gluten Free Adults 18–50 Dairy Free
Report overview
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyA- Value
This capsule provides 100 mg of 5-HTP from Griffonia simplicifolia, but the label doesn't give a standardization percentage. It includes a specific warning about interactions with serotonin medicines. The cost per 100 mg is below the collection's typical price, making it a relatively economical option for this amount.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

A botanical source is identified, though the extract's 5-HTP concentration isn't stated.
Botanical Source & Standardization
Griffonia simplicifolia is identified, but no percentage of 5-HTP in the extract is given.

Dose, Safety & Label Transparency100

Each serving provides 100 mg and carries a specific drug-interaction warning.
Dosage Potency & Range
The serving contains 100 mg of 5-HTP.
Safety Warnings & Label Clarity
The label specifically warns about use with SSRIs or other serotonin-modulating medicines.

Value85

The cost for a standard 100 mg amount is below the collection's typical price.
Price per 100mg 5-HTP
Its cost per 100 mg is below the collection's typical price.
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Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  2. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  3. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  4. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  5. Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic review.
    Baraldi S; Hepgul N; Mondelli V; Pariante CM · Journal of clinical psychopharmacology · 2012
    Systematic review64 studies pooledMood Support for5-HTP
  6. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  7. Serotonin precursors in the treatment of depression.
    van Praag HM · Advances in biochemical psychopharmacology · 1982
    Narrative reviewMood Support for5-HTP
  8. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  9. Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
    Takahashi S; Takahashi R; Masumura I; Miike A · Folia psychiatrica et neurologica japonica · 1977
    Single-arm trial14 participantsMood Support for5-HTP
  10. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  11. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  12. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  13. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  14. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  15. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  16. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  17. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  18. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  19. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  20. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP