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Adrenal Optimizer

Jarrow Formulas
4.6
★ ★ ★ ★ ★
(2115 ratings)
Vitamin B5 250 mg
Eleuthero 100 mg
Deanol 25 mg
Rhodiola
Ashwagandha 100 mg
Product Image
Score67
A low-cost, broad adaptogen formula with substantial vitamin B5, though unstandardized herbs and licorice-related safety issues reduce precision.
How scoring works
Quantity:120 Tablet(s) • (60 servings)
Goals:
Energy
Cognitive Support
Mental Focus

Score 67

A low-cost, broad adaptogen formula with substantial vitamin B5, though unstandardized herbs and licorice-related safety issues reduce precision.
How scoring works
$19.02($0.31 per serving)
Pure Formulas
$ 24.37
iHerb
$ 19.02
Daily Vita
$ 23.99
Daily Vita
$ 16.30
Amazon
$ 23.94
Daily Vita
$ 23.99
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Analysis

Pantothenic acid at 250 mg is the strongest clearly dosed nutrient, supported by vitamin C and several adaptogenic herbs. Ashwagandha, rhodiola, eleuthero, schizandra, gotu kola, chamomile, and shatavari cover both stimulating and calming pathways.

The major herbal extracts do not state active-marker standardization, so their practical strength is difficult to compare. DMAE is modest, and the combination of many herbs at 80 to 125 mg each favors breadth over depth.

The low serving cost is attractive for users seeking a balanced adaptogen blend. Licorice and the mixed calming-stimulating profile mean it is not a universally simple daily energy product.

Who is it for
  • Adults seeking broad adaptogen support
  • Users wanting high-dose pantothenic acid
  • People comfortable with a mixed calming and energizing formula
Best for
  • Stress-related energy support
  • Pantothenic acid intake
  • Broad adaptogen coverage

Pros

  • Provides 250 mg pantothenic acid
  • Includes several complementary adaptogens
  • Low serving cost
  • Balances calming and energizing herbs

Cons

  • Herbal active markers are not stated
  • Most herbs are modestly dosed
  • DMAE amount is low
  • Licorice limits broad suitability

Warnings

  • Licorice may raise blood pressure and lower potassium, especially with diuretics, digoxin, corticosteroids, or hypertension
  • Ashwagandha may affect thyroid function and may not suit people taking thyroid medicine
  • Rhodiola and eleuthero may feel stimulating and can interfere with sleep when taken late

Nutrient quality

55 Moderate impact

The adaptogen selection is coherent and covers both energy and calming support. Poor standardization, modest doses, high pantothenic acid, and licorice concerns weaken the formulation.

.

Ingredient transparency

71 High impact

The main active amounts are generally available and no broad proprietary blend obscures the formula. Complete usage directions and non-active ingredients are not supplied, while any noted duplicate or vague entries reduce clarity.

.

Customer satisfaction

70 High impact

Aggregate satisfaction is strong and supported by an extensive evidence base. No firsthand experience details are supplied, so recurring complaints and purpose alignment remain uncertain.

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Value for money

74 High impact

A long supply and coherent blend support good practical value. Weak extract standardization and modest core doses keep potency less certain.

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Report analysis

Goals

Energy
Energy
Impact
High effect
B Goal FitC Strength of SupportB- CoverageB- Formula Quality
Vitamin B5 · 250 mg

Rhodiola, eleuthero, ashwagandha, schisandra, and pantothenic acid provide a coherent stress-resilience approach to fatigue. The formula combines several adaptogens with a substantial pantothenic acid amount rather than relying on a stimulant.

Most botanical extracts are modest and lack active-marker standardization, making their practical potency uncertain. Licorice can raise blood pressure or lower potassium in susceptible users, especially with prolonged use or relevant medication.

Study evidence
Ashwagandha Supportive 9 studies
Eleuthero Disputed 3 studies
Rhodiola Supportive 18 studies
Cognitive Support
Cognitive Support
Impact
Moderate effect
C Goal FitD+ Strength of SupportC+ CoverageB Formula Quality
Ashwagandha · 100 mg

Rhodiola, eleuthero, ashwagandha, gotu kola, and DMAE create moderate relevance to stress-related cognition. Most amounts are supporting rather than clinically strong, and none of the botanical extracts provides marker standardization.

The adaptogen-centered design is coherent for mental fatigue but lacks direct cholinergic depth or a strong memory active. Licorice can raise blood pressure or lower potassium in susceptible users, especially with prolonged use or interacting medicines.

Study evidence
Ashwagandha Supportive 17 studies
Eleuthero No effect 1 study
Rhodiola Supportive 7 studies
Mental Focus
Mental Focus
Impact
Moderate effect
C- Goal FitD Strength of SupportD CoverageC- Formula Quality

Rhodiola, Ashwagandha, and Eleuthero create a sensible non-stimulant approach to stress-related mental fatigue. Their combined adaptogenic theme may suit people whose concentration falls during demanding periods.

Each extract is modestly dosed, and none includes active-marker standardization. The formula may offer gentle resilience support, but it is unlikely to provide a strong or immediate focus effect.

Study evidence
Ashwagandha Supportive 12 studies
Eleuthero Disputed 3 studies
Rhodiola Supportive 15 studies

Ingredients

IngredientAmount per serving
Vitamin C (Calcium Ascorbate)
 100 mg
Pantothenic Acid (Calcium D-Pantothenate, Vitamin B5)
 250 mg
Calcium (Calcium Ascorbate, Calcium D-Pantothenate, Calcium Phosphate)
 80 mg
Chamomile (Matricaria recutita)
 125 mg
Shatavari
100 mg
Gotu Kola
100 mg
Rhodiola rosea root extract
100 mg
Eleuthero root extract
100 mg
Licorice root extract
100 mg
Ashwagandha root extract
100 mg
Schizandra fruit and seed extract
80 mg
DMAE (DMAE Bitartrate)
 25 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
Vitamin B5 (Calcium D-Pantothenate) · 250 mg OverallScore70
B Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value

Calcium pantothenate is a stable, well-absorbed form, and the 250 mg dose provides strong support for energy and stress response. The source and amount are clear, but excipient purity cannot be verified without an Other Ingredients list. The normalized cost for the delivered B5 amount is high.

View ingredientView products
Eleuthero · 100 mg OverallScore64
D- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyB+ Value
The root-derived extract reaches the minimum useful amount and is fully quantified. Missing active-marker standardization leaves its concentration and consistency uncertain, while the dose remains below the preferred extract range. Even with those limits, the economical serving delivers reasonable value.
View ingredientView products
Deanol (DMAE Bitartrate) · 25 mg OverallScore58
B- Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyC Value
The label clearly identifies DMAE bitartrate, but it gives only the salt weight rather than active Deanol yield. After conversion from the salt weight, the active amount is very low. No Deanol-specific safety warning is included, while the two-tablet serving is practical and the broad formula supports neutral Deanol value.
View ingredientView products
Loading alternative details
73 Performance

HPA Adapt

Integrative Therapeutics
<p>Its label clearly provides 200 mg of Holy Basil (Ocimum sanctum) leaf extract as Ursolic Acid, making it a more clearly defined ashwagandha and rhodiola and eleuthero option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s vitamin b5 and deanol coverage.</p>
81 Performance

Adrenal Serenity

Natural Factors Stress-Relax
<p>Its label clearly provides 250 mg of Sensoril Ashwagandha extract, making it a more clearly defined ashwagandha and rhodiola and eleuthero option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s vitamin b5 and deanol coverage.</p>
79 Performance

Cortisol Calm

Pure Encapsulations
<p>Its label clearly provides 10 mcg of Vitamin D as Cholecalciferol, making it a more clearly defined ashwagandha and rhodiola option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s vitamin b5 and eleuthero and deanol coverage.</p>
78 Budget

Saffron

youtheory
<p>Its label clearly provides 350 mg of Rhodiola (root) extract, preserving relevant ashwagandha and rhodiola coverage. It is not lower-cost than the original, but it is the closest remaining eligible fit for this category; it does not retain the original product’s vitamin b5 and eleuthero and deanol coverage.</p>
79 Budget

Dual Ginseng Plus

Swanson Superior Herbs
<p>Its label clearly provides 200 mg of American Ginseng root extract as Ginsenosides, preserving relevant ashwagandha and eleuthero coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s vitamin b5 and rhodiola and deanol coverage.</p>
72 Budget

Adrenal Strength

MegaFood
<p>Its label clearly provides 100 mg of Vitamin C as organic Orange, preserving relevant vitamin b5 and ashwagandha and rhodiola coverage. It is not lower-cost than the original, but it is the closest remaining eligible fit for this category; it does not retain the original product’s eleuthero and deanol coverage.</p>
77 Value

Energy Xtra

Pure Encapsulations
<p>Its label clearly provides 200 mg of Ashwagandha (Withania somnifera) extract as Withanolides, keeping the formula relevant to rhodiola and eleuthero. Compared with the original, the somewhat higher serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s vitamin b5 and ashwagandha and deanol coverage.</p>
81 Value

AdrenaSense

Natural Factors WS WomenSense
<p>Its label clearly provides 200 mg of Rhodiola extract as Rosavins, keeping the formula relevant to ashwagandha and rhodiola and eleuthero. Compared with the original, the somewhat higher serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s vitamin b5 and deanol coverage.</p>
62 Value

Yohimbe-Plus Maximum Enhancement

Irwin Naturals
<p>Its label clearly provides 1 g of Total Fat and 4 mg of BioPerine Complex, keeping the formula relevant to ashwagandha and eleuthero. Compared with the original, the somewhat higher serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s vitamin b5 and rhodiola and deanol coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study.
    Kale S; Lopresti A; Suri R; Garg N; Langade D · Journal of psychoactive drugs · 2026
    Randomized trial120 participantsEnergy forAshwagandha
  2. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males.
    Lopresti AL; Drummond PD; Smith SJ · American journal of men's health · 2020
    Randomized trial57 participantsEnergy forAshwagandha
  3. Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trial.
    Punja S; Shamseer L; Olson K; Vohra S · PloS one · 2015
    Randomized trial48 participantsEnergy forRhodiola
  4. Rhodiola rosea for physical and mental fatigue: a systematic review.
    Ishaque S; Shamseer L; Bukutu C; Vohra S · BMC complementary and alternative medicine · 2013
    Systematic review11 studies pooledEnergy forRhodiola
  5. The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players.
    Wang J; Zhao H; Yu L; Zhao K; Jiang W; Liu S; Dai J; Xu L; Sun P; Yun H; Liu C · Nutrients · 2025
    Randomized trial48 participantsEnergy forRhodiola
  6. Scientific Opinion on the substantiation of a health claim related to Rhodiola rosea L. extract and reduction of mental fatigue pursuant to Article 13(5) of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusEnergy forRhodiola
  7. Randomized controlled trial of Siberian ginseng for chronic fatigue.
    Hartz AJ; Bentler S; Noyes R; Hoehns J; Logemann C; Sinift S; Butani Y; Wang W; Brake K; Ernst M; Kautzman H · Psychological medicine · 2004
    Randomized trial96 participantsEnergy forEleuthero
  8. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
    Panossian A; Wikman G · Current clinical pharmacology · 2009
    Narrative reviewEnergy Mental Focus forEleuthero Cognitive Support Mental Focus forRhodiola
  9. Effect of ashwagandha (Withania somnifera) extract with Sominone (Somin-On™) to improve memory in adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study.
    Rai HP; Mishra DN · Journal of psychopharmacology (Oxford, England) · 2025
    Randomized trial40 participantsCognitive Support Mental Focus forAshwagandha
  10. Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.
    Leonard M; Dickerson B; Estes L; Gonzalez DE; Jenkins V; Johnson S; Xing D; Yoo C; Ko J; Purpura M; Jäger R; Faries M; Kephart W; Sowinski R; Rasmussen CJ; Kreider RB · Nutrients · 2024
    Randomized trial59 participantsCognitive Support Energy forAshwagandha
  11. A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study.
    Majeed M; Nagabhushanam K; Mundkur L · Medicine · 2023
    Randomized trial54 participantsCognitive Support Mental Focus forAshwagandha
  12. Efficacy and safety of ashwagandha root extract in children and adolescents with mild attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled trial.
    Naik S; Muralidhar G; Rao BS; Agarwal S; Jain M · Journal of medicine and life · 2026
    Randomized trial58 participantsCognitive Support Mental Focus forAshwagandha
  13. Efficacy of Withania somnifera supplementation on adult's cognition and mood.
    Remenapp A; Coyle K; Orange T; Lynch T; Hooper D; Hooper S; Conway K; Hausenblas HA · Journal of Ayurveda and integrative medicine · 2022
    Randomized trial60 participantsCognitive Support forAshwagandha
  14. No benefit adding eleutherococcus senticosus to stress management training in stress-related fatigue/weakness, impaired work or concentration, a randomized controlled study.
    Schaffler K; Wolf OT; Burkart M · Pharmacopsychiatry · 2014
    Randomized trial144 participantsCognitive Support Mental Focus forEleuthero
  15. Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event-related potential dual task study.
    Koop T; Dienel A; Heldmann M; Münte TF · Phytotherapy research : PTR · 2021
    Single-arm trial50 participantsCognitive Support forRhodiola
  16. Central additive effect of Ginkgo biloba and Rhodiola rosea on psychomotor vigilance task and short-term working memory accuracy.
    Al-Kuraishy HM · Journal of intercultural ethnopharmacology · 2016
    Clinical trial112 participantsCognitive Support forRhodiola
  17. Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes.
    Łuszczak J; Kocki J · Annals of agricultural and environmental medicine : AAEM · 2026
    Systematic review19 studies pooledCognitive Support forRhodiola
  18. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
    Olsson EM; von Schéele B; Panossian AG · Planta medica · 2009
    Randomized trial60 participantsCognitive Support forRhodiola
  19. Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study.
    McKinney E; Stewart J; Kewalramani R; Singh S · Trials · 2026
    Randomized trial186 participantsEnergy forAshwagandha
  20. Efficacy and Safety of Low-Dose Ashwagandha Supplementation on Exercise Endurance: A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial.
    Prajapati H; Satia M; Shah D; Basera I; Shah T · Phytotherapy research : PTR · 2026
    Randomized trialEnergy forAshwagandha
  21. Enhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits.
    Vittal M; Vinciguerra M · Biogerontology · 2025
    Narrative reviewEnergy forAshwagandha
  22. The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human
    J Kuo, K W Chen, I S Cheng, P H Tsai, Y J Lu, N Y Lee · Chinese Journal of Physiology · 2010
    Randomized trial9 participantsEnergy forEleuthero
  23. Effects of Rhodiola rosea on Physical and Decision-Making Performance in Football Players: A Randomised Controlled Trial.
    Dou Y; Wang Y; Zhang W; Jiang Y; Zhang J; Yang T; Han Z; Li Y; Liu C; Ren D · Nutrients · 2026
    Randomized trial24 participantsEnergy Mental Focus forRhodiola
  24. Combined Effects of Rhodiola Rosea and Caffeine Supplementation on Straight Punch Explosive Power in Untrained and Trained Boxing Volunteers: A Synergistic Approach.
    Tao B; Sun H; Li H; Xu Z; Xu Y; Chen L; Ma C; Zhang X; Yu L; Bao S; Liu C · Metabolites · 2025
    Randomized trial96 participantsEnergy forRhodiola
  25. Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial.
    Lekomtseva Y; Zhukova I; Wacker A · Complementary medicine research · 2019
    Single-arm trial100 participantsEnergy forRhodiola
  26. Combined Rhodiola rosea and eccentric training boost endurance performance and lower-limb reactive strength in recreationally active women.
    Wang IL; Su Y; Zhang L; Tang M; Chen YM · Frontiers in physiology · 2025
    Randomized trial30 participantsEnergy forRhodiola
  27. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions.
    Choudhary D; Bhattacharyya S; Bose S · Journal of dietary supplements · 2018
    Randomized trial50 participantsMental Focus forAshwagandha
  28. A clinical assessment of the therapeutic effects of Ashwagandha root extract on cognitive performance, sleep, and fatigue in children aged 6-12 years.
    Saxena A; Lopresti A; Sharif M; Elon N; Suri R; Langade DK · Frontiers in nutrition · 2026
    Randomized trial85 participantsMental Focus forAshwagandha
  29. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration.
    Panossian A; Wagner H · Phytotherapy research : PTR · 2005
    Narrative reviewMental Focus forEleuthero
  30. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials.
    Hung SK; Perry R; Ernst E · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2012
    Systematic review11 studies pooledMental Focus forRhodiola
  31. Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study.
    Koozehchian MS; Newton AT; Mabrey G; Bonness FM; Rafajlovska R; Naderi A · Nutrients · 2025
    Randomized trial27 participantsMental Focus forRhodiola
  32. Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men.
    Jówko E; Sadowski J; Długołęcka B; Gierczuk D; Opaszowski B; Cieśliński I · Journal of sport and health science · 2022
    Randomized trial26 participantsMental Focus forRhodiola