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Neurobion USA High Potency Formula

OTC Pharmaceutical Products
4.9
★ ★ ★ ★ ★
(70 ratings)
Thiamin 100 mg
Vitamin B6 100 mg
Vitamin B12 200 mcg
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Score71
A simple high-potency trio with useful thiamine, but the 100 mg pyridoxine amount makes routine use hard to justify.
How scoring works
Quantity:50 Tablet(s) • (50 servings)
Goals:
General Health

Score 71

A simple high-potency trio with useful thiamine, but the 100 mg pyridoxine amount makes routine use hard to justify.
How scoring works
$12.70($0.25 per serving)
Walmart
$ 12.70
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Analysis

The tablet provides 100 mg of thiamine hydrochloride, 100 mg of pyridoxine hydrochloride, and 200 mcg of cyanocobalamin. The thiamine amount is substantial, but all three nutrients use conventional forms.

The B6 amount reaches a level that is poorly suited to routine long-term use. No riboflavin is present to support conversion of pyridoxine, and the B12 amount is modest for a swallowed cyanocobalamin tablet.

One-tablet convenience is the main practical strength. Adults seeking general B-vitamin support can find broader formulas with much lower B6 exposure and better B12 forms.

Who is it for
  • Adults with a specific reason for high-dose thiamine
  • Short-term users under informed guidance
  • People who prefer one-tablet formulas
Best for
  • High-potency thiamine
  • Simple three-vitamin dosing
  • Limited-duration use

Pros

  • Substantial thiamine amount
  • Clear active labeling
  • One-tablet serving

Cons

  • Contains 100 mg pyridoxine
  • Uses cyanocobalamin
  • No riboflavin cofactor

Warnings

  • Prolonged use of 100 mg vitamin B6 may cause peripheral nerve symptoms
  • Stop and seek medical advice if numbness, tingling, or balance changes develop
  • Do not combine with other vitamin B6 supplements

Nutrient quality

65 High impact

Pyridoxine, folic acid or unspecified folate, and cyanocobalamin are conventional rather than metabolically direct forms. The main B vitamins and supporting nutrients are present at purposeful amounts.

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Ingredient transparency

83 Highest impact

Every listed active has a specific amount. A complete excipient list is not available in the supplied data.

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Customer satisfaction

69 High impact

The average rating is very strong. The modest rating volume limits confidence.

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Value for money

62 Moderate impact

The supply provides weak value per effective serving. The formula is not inflated by low-value extras.

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Goals

General Health
Daily Energy Vitality
General Health
Impact
Moderate effect
C+ Goal FitD- Strength of SupportD- CoverageB- Formula Quality
Vitamin B12 · 200 mcg

Three B vitamins support energy metabolism and nervous-system function, but the formula covers only a narrow part of general health. Cyanocobalamin is a basic B12 form, and the 100 mg vitamin B6 amount is unnecessarily high for routine long-term use.

Every active amount is clearly listed and the design avoids filler ingredients. The high B6 dose may raise neuropathy risk with sustained use, so the label directions and total intake from other products matter.

Study evidence
Vitamin B12 Adverse 66 studies

Ingredients

IngredientAmount per serving
Vitamin B1 (Thiamine Hydrochloride)
 100 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 100 mg
Vitamin B12 (Cyanocobalamin)
 200 mcg
Adults 18–50
Report overview
Thiamin (Thiamine Hydrochloride) · 100 mg OverallScore76
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD- Value

Thiamine hydrochloride is a standard water-soluble form with reliable basic availability. The 100 mg dose is well suited to high-potency use and clearly disclosed. Cost per active dose is high for thiamin within a high-potency B-vitamin formula.

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Vitamin B6 (Pyridoxine Hydrochloride) · 100 mg OverallScore58
D+ Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyB- Value

The 100 mg pyridoxine dose reaches the chronic-use safety ceiling without a riboflavin cofactor. One-tablet delivery is convenient and clearly labeled. Long-term use deserves caution because sustained high vitamin B6 intake can cause peripheral neuropathy.

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Vitamin B12 (Cyanocobalamin) · 200 mcg OverallScore27
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

Cyanocobalamin is the only disclosed form, while the 200 mcg amount is geared mainly to maintenance. The tablet uses conventional oral delivery rather than a format specifically designed for absorption difficulties. Cost efficiency is weak because the B12 delivered is limited relative to the product cost.

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Loading alternative details
82 Performance

BioActive Vitamin B

Terry Naturally
<p>P-5-P, methylcobalamin, and methylfolate offer a clear form upgrade and reduce vitamin B6 from the original’s extreme amount. The formula is still concentrated, but it is more coherent for targeted B-vitamin use.</p>
81 Performance

Activated Homocysteine

Swanson
<p>Active B6, methylfolate, methylcobalamin, and betaine provide stronger forms and a clear methylation focus. Vitamin B6 is still aggressive for routine long-term use, though it is substantially lower than the original.</p>
78 Performance

Methylfolate B Complex

Codeage
<p>Active riboflavin, B6, methylfolate, and methylcobalamin provide broader and higher-quality nutrient coverage. Concentrated folate and B12 make the formula more suitable for targeted use than basic maintenance.</p>
81 Budget

Tri-B

Carlson
<p>The very low serving cost preserves B6, folate, and B12 in a simple cardiovascular-support formula. Conventional forms, high folate, and elevated pyridoxine remain concerns, though the B6 amount is less extreme than the original.</p>
81 Budget

Folic Acid B6 & B12

Mason Natural
<p>The inexpensive three-vitamin formula adds folate while retaining B6 and B12. Older forms and an aggressive pyridoxine amount limit quality, but it avoids the original’s 100 mg B6 dose.</p>
70 Budget

Kyolic GABA Vitamin B1 B6 & B12

Kyolic
<p>The lower-cost formula retains B1, B6, and B12 while adding aged garlic and modest GABA. Unspecified vitamin forms, elevated pyridoxine, and possible bleeding interactions with aged garlic are trade-offs.</p>
78 Value

Homocysteine Defense

Source Naturals
<p>Betaine and added folate create a more coherent cardiovascular and methylation formula at favorable serving value. Older vitamin forms and elevated pyridoxine still limit long-term fit.</p>
79 Value

Homocysteine Modulators

Solgar
<p>Betaine and a small active B6 addition broaden the formula while maintaining strong serving value. Most vitamins still use older forms, and total B6 remains aggressive for prolonged use.</p>
78 Value

Homocysteine Resist

Life Extension
<p>Active B6, methylfolate, and methylcobalamin provide a focused form upgrade with solid practical value. Very high folate and B6 at a chronic-use threshold still require caution, but the B6 exposure is lower than the original.</p>
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsGeneral Health forVitamin B12
  2. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsGeneral Health forVitamin B12
  3. Relationship between serum B12 concentrations and mortality: experience in NHANES.
    Wolffenbuttel BHR; Heiner-Fokkema MR; Green R; Gans ROB · BMC medicine · 2021
    Cohort study24,262 participantsGeneral Health forVitamin B12
  4. Holo-transcobalamin is not associated with the risk of all-cause mortality in the general population.
    Stürmer P; Strathmann EA; Rimbach G; Weber KS; Lieb W · Clinical nutrition ESPEN · 2024
    Cohort study862 participantsGeneral Health forVitamin B12
  5. The origin of vitamin B12 levels and risk of all-cause, cardiovascular and cancer specific mortality: A systematic review and dose-response meta-analysis.
    Liu K; Yang Z; Lu X; Zheng B; Wu S; Kang J; Sun S; Zhao J · Archives of gerontology and geriatrics · 2024
    Meta-analysis92,346 participants22 studies pooledGeneral Health forVitamin B12
  6. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsGeneral Health forVitamin B12
  7. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsGeneral Health forVitamin B12
  8. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsGeneral Health forVitamin B12