Homocysteine Modulators
Solgar
Score 70
A homocysteine-focused formula combining B6 (mixed forms), unspecified folate, Cyanocobalamin B12, and a strong dose of TMG.
Score 70
A homocysteine-focused formula combining B6 (mixed forms), unspecified folate, Cyanocobalamin B12, and a strong dose of TMG.
Analysis
Solgar's Homocysteine Modulators is specifically formulated to support healthy homocysteine levels, featuring a blend of Vitamin B6 (both Pyridoxine Hydrochloride and Pyridoxal 5-Phosphate), Folate, Vitamin B12 (Cyanocobalamin), and Trimethylglycine (TMG). The inclusion of TMG at a robust dose of 1000mg, alongside B vitamins, is a strong point for targeting homocysteine metabolism.
However, while it includes some P-5-P, the primary B6 form is Pyridoxine Hydrochloride, and B12 is provided as Cyanocobalamin. These are common forms that require conversion in the body, which might be less efficient for some individuals compared to directly active forms like methylcobalamin or methylfolate. The folate form is also not specified as an active form.
This product is well-suited for individuals looking for a targeted supplement to support cardiovascular health through homocysteine regulation. It offers a solid foundation of B vitamins, but some form choices could be more optimal for maximum bioavailability and impact.
Pros
- Contains a significant dose of Trimethylglycine (TMG) for homocysteine support
- Includes both Pyridoxine HCl and some P-5-P for Vitamin B6
- Provides a good dose of B vitamins (B6, Folate, B12)
- Offers a high quantity of servings per bottle (120 capsules, 60 servings)
Cons
- Uses Cyanocobalamin for Vitamin B12, which requires conversion
- Primary Vitamin B6 form is Pyridoxine Hydrochloride, which needs conversion (though P-5-P is also present)
- Folate form is not specified as an active L-methylfolate
- Contains calories and some fat, though minimal
Warnings
- Individuals with a history of sensitivity to B vitamins should start with a lower dose if concerned.
- B vitamins can cause a harmless yellowish discoloration of urine.
- Consult a healthcare professional if pregnant, nursing, or taking other medications that affect homocysteine levels.
$15.79($0.26 per serving)
 Vitacost | $ 15.79 | |
 iHerb | $ 16.99 | |
 Pure Formulas | $ 17.99 | |
 Amazon | $ 17.99 | |
 Daily Vita | $ 19.80 |
Goals
Impact
Highest effect
This product is specifically designed to modulate homocysteine levels, a key factor in maintaining cardiovascular health, making it highly relevant for this goal.
Impact
Highest effect
The formulation is targeted at healthy homocysteine metabolism, which is a significant factor in maintaining a healthy heart and overall circulatory system.
Impact
Highest effect
This formula specifically addresses homocysteine, a biomarker for heart health, with a blend of B vitamins and TMG that work together to maintain cardiovascular wellness.
Impact
Highest effect
With a specific focus on homocysteine modulation through B vitamins and TMG, this product offers very good support for maintaining the health of the heart and blood vessels.
Impact
High effect
This formula provides foundational B vitamins and TMG, supporting a wide array of metabolic and cellular functions crucial for general well-being.
Impact
High effect
B vitamins are essential coenzymes for various metabolic pathways, including energy production and nutrient utilization, supporting an efficient metabolism.
Impact
High effect
The B vitamins present are integral to the conversion of carbohydrates, fats, and proteins into energy, thereby enhancing metabolic efficiency.
Impact
High effect
B vitamins are indispensable for cellular energy production. This formulation supports metabolic efficiency, which can contribute to overall energy levels.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Calories | 5 Calorie(s) |
Vitamin B6 | 50 mg |
Folate | 666 mcg DFE |
Vitamin B12 | 500 mcg |
Trimethylglycine | 1000 mg |
Pyridoxal 5-Phosphate | 6 mg |
Vitamin B6 75
It contains both Pyridoxine Hydrochloride and Pyridoxal 5-Phosphate (P-5-P). While P-5-P is excellent, the presence of Pyridoxine HCl means it's not exclusively using the active form.
Vitamin B12 60
The product uses Cyanocobalamin, a common but less active form of Vitamin B12, requiring conversion in the body for utilization. This is less optimal than active forms like methylcobalamin.
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Sublingual Methylcobalamin 1000 mcg
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HomocysteX Plus
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Features superior, active forms of B vitamins (P5P B6, Quatrefolic Folate, MecobalActive B12) and TMG, offering a highly bioavailable and targeted solution for comprehensive homocysteine support.
92 Performance
Fully Active B Complex with Quatrefolic
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This comprehensive B-complex provides active forms of B6 (P5P), Folate (Quatrefolic), and B12 (Methylcobalamin), which are all excellent for homocysteine metabolism and offer broad support for energy and brain health.
93 Performance
PureGenomics B-Complex
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A premium, full-spectrum B-complex that delivers a wide array of highly active and well-utilized B vitamin forms, providing superior support for metabolism, nerve function, and overall vitality.