Methylfolate B Complex
Codeage
Methylfolate B Complex
4.8
★ ★ ★ ★ ★
(538 ratings)
Vitamin B12 1000 mcg
Riboflavin 30 mg
Vitamin B6 15 mg
Score 90.0
A premium B vitamin complex with active forms of B12, B6, and Riboflavin for enhanced absorption, but it's expensive and the name may be misleading regarding folate content.
Quantity: 120 Capsule(s)Servings size: 2 Capsule(s) (60 servings)
Selected goals:
Other goals:
Fitness
Muscle Gain
Cardiovascular Support
Energy
Brain Health
leaderboard Score 90.0
A premium B vitamin complex with active forms of B12, B6, and Riboflavin for enhanced absorption, but it's expensive and the name may be misleading regarding folate content.
insights Analysis
The Codeage Methylfolate B Complex is formulated with active, coenzyme forms of Vitamin B12 (Methylcobalamin), Vitamin B6 (Pyridoxal 5-Phosphate), and Riboflavin (Riboflavin 5-Phosphate). This advanced formulation bypasses the need for the body to convert these vitamins, making them immediately available for biological processes crucial for energy metabolism, nervous system health, and cognitive function. The slightly higher Riboflavin dosage in its active form is a positive. Despite its 'Methylfolate' name, the absence of folate in the provided ingredient list means its primary benefit, as analyzed, comes from the other highly absorbable B vitamins.
- All specified B vitamins (B12, B6, Riboflavin) are in their active, coenzyme forms, optimizing absorption and utilization by the body.
- Contains Riboflavin 5-Phosphate at a good dosage (30mg), which is a superior form for vision and cellular health compared to standard Riboflavin.
- Offers a comprehensive spectrum of highly bioavailable B vitamins known to support energy, brain, and metabolic health efficiently.
- It is the most expensive product per serving (59 cents) among the analyzed group, making it less accessible for some budgets.
- The product name 'Methylfolate B Complex' implies the inclusion of Methylfolate (B9), which is not listed in the provided ingredients, potentially leading to unmet expectations for consumers seeking folate.
- With a lower review count compared to established brands like Life Extension or NOW, it may not have as broad a user validation despite its strong ingredient profile.
$35.99($0.59 per serving)
 BodyBuilding.com | $ 35.99 | |
 Pure Formulas | $ 35.99 | |
 iHerb | $ 35.99 | |
| BodyBuilding.com | $ 35.99 |
bolt Effectiveness for goals
B vitamins are essential cofactors for numerous enzymatic reactions throughout the body. They play critical roles in cellular metabolism, energy production, and the proper functioning of the nervous system. Each B vitamin has unique functions but often works synergistically to support various physiological processes.
Active forms like Methylcobalamin (B12) and Quatrefolic (folate) are already in a biologically usable state. This means the body does not need to convert them, potentially leading to more efficient absorption and utilization. This can be particularly beneficial for individuals with genetic variations affecting nutrient conversion pathways.
Folate and vitamin B12 are intimately linked in the methylation cycle, a crucial metabolic pathway. B12 is required for an enzyme that regenerates a specific form of folate, and both are necessary for the synthesis of DNA and red blood cell formation. Their synergistic action is vital for cell growth, nerve function, and homocysteine metabolism.
Betaine, or Trimethylglycine (TMG), is involved in methylation processes by donating methyl groups. It works alongside B vitamins like folate and B12 to support the healthy metabolism of homocysteine. This interaction is important for cardiovascular health and various metabolic functions.
Vitamin B6 is a coenzyme involved in over 100 enzymatic reactions, including amino acid metabolism and neurotransmitter synthesis. When combined with other B vitamins, it further supports energy production, homocysteine regulation, and nervous system function. This active form ensures broader metabolic support.
schedule Dosage, timing & forms
Yes, 600 mg of Betaine (Trimethylglycine or TMG) is a common daily dosage found in many supplements targeting methylation support and cardiovascular health. This amount is often chosen to effectively contribute to homocysteine metabolism. Individual needs may vary, so always refer to product labels.
Many individuals prefer taking B vitamins in the morning, often with food, due to their role in energy metabolism throughout the day. Taking them with a meal can also help minimize any potential stomach upset. Since B vitamins are water-soluble, they are not stored in the body for long periods.
Yes, taking B vitamin supplements with food is generally recommended. This can enhance their absorption and reduce the likelihood of gastrointestinal discomfort. Eating a meal helps with the digestive process and can improve nutrient uptake.
Most supplements containing active B vitamins and Betaine (TMG) are formulated for daily consumption, typically once per day. This consistency ensures a steady supply of these water-soluble nutrients. Always adhere to the specific dosing instructions provided on the supplement's label.
1360 mcg DFE (Dietary Folate Equivalents) of Quatrefolic folate is a higher daily dosage, equivalent to 800 mcg of L-methylfolate. This amount is often selected to provide robust support for methylation processes. It exceeds the standard Recommended Daily Allowance for adults, reflecting a targeted approach.
health_and_safety Safety & interactions
B vitamins are water-soluble, meaning excess amounts are typically excreted through urine. While generally safe, very high doses of certain B vitamins, like B6 (pyridoxine), can uncommonly lead to sensory neuropathy over time. The forms included are generally well-tolerated.
Folate can interact with certain medications, including methotrexate, some anti-epileptic drugs (like phenytoin), and sulfasalazine. These interactions may affect the efficacy of the medication or the metabolism of folate in the body. It is advisable to consult a healthcare professional regarding potential interactions.
Yes, taking high doses of folate (especially folic acid, but also methylfolate) without adequate B12 can potentially mask the neurological symptoms of a B12 deficiency. This product includes both methylfolate and methylcobalamin, aiming to address both nutrient needs simultaneously. Regular monitoring of B12 levels is still important if a deficiency is suspected.
Betaine primarily functions in homocysteine metabolism. While it is not typically associated with direct interactions with blood pressure medications, high doses might have an effect on cholesterol levels in some individuals. It's always best to discuss with a healthcare provider, especially if you are on prescribed medications.
Individuals with pre-existing kidney conditions should exercise caution with certain supplements, including B vitamins. While water-soluble, high doses might be a concern depending on the severity of kidney impairment. Consulting a healthcare professional before use is crucial to determine suitability and appropriate dosage.
Ingredients
| Ingredient | Amount per serving |
|---|---|
Riboflavin | 30 mg |
Vitamin B6 | 15 mg |
Folate | 1360 mcg DFE |
Vitamin B12 | 1000 mcg |
Betaine | 600 mg |
Categories
Vitamin B12 95.0
Methylcobalamin at 1000mcg is an excellent, highly absorbable form of B12, ensuring optimal cellular uptake and utilization.
Vitamin B6 95.0
The use of Pyridoxal 5-Phosphate (P-5-P) for B6 means it's in its active, ready-to-use form, leading to superior efficacy in various metabolic pathways.
Riboflavin 95.0
Riboflavin 5-Phosphate is the active, coenzyme form of Riboflavin, providing superior bioavailability and effectiveness, especially at the 30mg dose, for cellular energy.
Goals
Energy 94.0
The active forms of B12, B6, and Riboflavin are directly involved in energy metabolism, providing highly efficient support for energy levels and combating fatigue.
Brain Health 94.0
The bioavailable B6 and B12 forms are crucial for neurotransmitter production and maintaining healthy nervous system function, strongly supporting brain health and neural communication.
Mood Support 94.0
Active B vitamins facilitate the synthesis of key neurotransmitters like serotonin and dopamine, which are essential for mood regulation and emotional stability.
Recommended Alternatives
88 Value 
Activated B-Complex High Bioavailability
Swanson
4.9
★★★★★
(1190 ratings)
This Swanson complex offers all three B vitamins (B12, B6, Riboflavin) in their active forms for 20 cents per serving, making it an excellent balance of high quality and significant cost savings compared to the original's 59 cents.
80 Value 
Homocysteine Resist
Life Extension
4.8
★★★★★
(5258 ratings)
Providing active B12 and B6, and standard Riboflavin, for 32 cents per serving, this product offers a strong quality profile at a substantially lower price point, presenting a compelling value proposition for effective B vitamin support.
70 Value 
B-100
NOW
4.8
★★★★★
(9362 ratings)
For general high-potency B vitamin needs, NOW's B-100 offers robust doses of standard B vitamins (100mg B6/Riboflavin, 100mcg B12) for just 12 cents per serving, providing excellent bang for the buck for broad spectrum support without the premium active forms.
92 Performance 
HomocysteX Plus
Seeking Health
4.8
★★★★★
(1721 ratings)
While very similar in ingredient quality, Seeking Health's product uses MecobalActive, a branded, highly refined form of Methylcobalamin, which slightly edges out generic Methylcobalamin for those seeking the absolute purest and most research-backed forms, despite the higher price.
94 Performance 
Mega B-150 Balanced B-Complex
NaturesPlus
4.7
★★★★★
(325 ratings)
This alternative offers remarkably high dosages (150mg for B6 and Riboflavin, 150mcg active B12), providing a more potent and comprehensive B vitamin profile, which could be beneficial for those with higher needs or severe deficiencies, despite some standard forms.
90 Performance 
Migra-Eeze
Life Extension
4.5
★★★★★
(651 ratings)
For individuals with specific needs for high-dose, active Riboflavin, this product delivers an impressive 400mg of Riboflavin 5-Phosphate, making it a superior targeted solution if that particular B vitamin is the primary health concern.
88 Budget
Activated B-Complex High Bioavailability
Swanson
4.9
★★★★★
(1190 ratings)
This Swanson product offers all three B vitamins (B12, B6, Riboflavin) in their active forms (Methylcobalamin, P-5-P, Riboflavin 5-Phosphate) for 20 cents per serving, significantly undercutting the original's 59 cents while maintaining high quality.
80 Budget
Homocysteine Resist
Life Extension
4.8
★★★★★
(5258 ratings)
At 32 cents per serving, this Life Extension product provides active B12 and B6 forms at a much more accessible price, making it a good value alternative despite using standard Riboflavin for some components.
65 Budget 
B 100 Complex
Spring Valley
4.7
★★★★★
(401 ratings)
For extreme budget consciousness, this B-complex provides high doses of B6 and Riboflavin (100mg each) and B12 for only 9 cents per serving, though it uses standard, less bioavailable forms.
88 Value
Activated B-Complex High Bioavailability
Swanson
4.9
★★★★★
(1190 ratings)
This Swanson complex offers all three B vitamins (B12, B6, Riboflavin) in their active forms for 20 cents per serving, making it an excellent balance of high quality and significant cost savings compared to the original's 59 cents.
80 Value
Homocysteine Resist
Life Extension
4.8
★★★★★
(5258 ratings)
Providing active B12 and B6, and standard Riboflavin, for 32 cents per serving, this product offers a strong quality profile at a substantially lower price point, presenting a compelling value proposition for effective B vitamin support.
70 Value
B-100
NOW
4.8
★★★★★
(9362 ratings)
For general high-potency B vitamin needs, NOW's B-100 offers robust doses of standard B vitamins (100mg B6/Riboflavin, 100mcg B12) for just 12 cents per serving, providing excellent bang for the buck for broad spectrum support without the premium active forms.
92 Performance
HomocysteX Plus
Seeking Health
4.8
★★★★★
(1721 ratings)
While very similar in ingredient quality, Seeking Health's product uses MecobalActive, a branded, highly refined form of Methylcobalamin, which slightly edges out generic Methylcobalamin for those seeking the absolute purest and most research-backed forms, despite the higher price.
94 Performance
Mega B-150 Balanced B-Complex
NaturesPlus
4.7
★★★★★
(325 ratings)
This alternative offers remarkably high dosages (150mg for B6 and Riboflavin, 150mcg active B12), providing a more potent and comprehensive B vitamin profile, which could be beneficial for those with higher needs or severe deficiencies, despite some standard forms.
90 Performance
Migra-Eeze
Life Extension
4.5
★★★★★
(651 ratings)
For individuals with specific needs for high-dose, active Riboflavin, this product delivers an impressive 400mg of Riboflavin 5-Phosphate, making it a superior targeted solution if that particular B vitamin is the primary health concern.