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PQQ CoQ-10

Solaray
4.8
★ ★ ★ ★ ★
(1548 ratings)
Coenzyme Q-10 100 mg
Gluthathione 250 mg
Product Image
Score74
A coherent mitochondrial and antioxidant blend has meaningful actives, but generic forms and dry delivery limit absorption confidence.
How scoring works
Quantity:30 VegCap(s) • (30 servings)
Goals:
Energy
Anti-Aging
Heart Health
Cardiovascular Support
Anti-Inflammatory Support
Metabolism Boost

Score 74

A coherent mitochondrial and antioxidant blend has meaningful actives, but generic forms and dry delivery limit absorption confidence.
How scoring works
$37.01($1.23 per serving)
iHerb
$ 43.59
Pure Formulas
$ 43.59
Amazon
$ 37.01
Vitacost
$ 43.59
Report prices

Analysis

The four-active capsule combines mitochondrial support from CoQ10 and PQQ with NAC and direct glutathione. Each amount is disclosed, and the formula avoids unrelated vitamin padding.

CoQ10 is not identified as ubiquinol or ubiquinone and has no oil carrier in the dry capsule. Glutathione is not labeled as reduced, acetylated, or liposomal, so its oral delivery is also uncertain.

The formula best fits adults seeking a compact energy and antioxidant blend. It is more convincing as a multi-pathway combination than as a premium standalone CoQ10 or glutathione product.

Who is it for
  • Adults seeking combined mitochondrial and antioxidant support
  • People who prefer a compact capsule formula
Best for
  • Cellular energy support
  • Multi-pathway antioxidant coverage

Pros

  • CoQ10 and PQQ form a logical pair
  • NAC complements direct glutathione
  • All four active amounts are disclosed

Cons

  • CoQ10 molecular form is unspecified
  • Dry capsule lacks a lipid carrier
  • Glutathione form is not characterized

Warnings

  • CoQ10 may reduce the response to warfarin, so anticoagulation monitoring may need adjustment
  • NAC may intensify headache or low blood pressure when combined with nitrate medicines

Nutrient quality

79 High impact

The four-actives design offers coherent mitochondrial and antioxidant coverage at generally useful amounts. Dry delivery and unspecified CoQ10 and glutathione forms limit absorption confidence.

Ingredient transparency

77 High impact

Active amounts are clearly disclosed and no proprietary blend hides key doses. Daily directions and a complete inactive-ingredient list are not available in the supplied data.

Customer satisfaction

74 High impact

The aggregate satisfaction measure is favorable, with response volume determining how much confidence it deserves. Comment-level evidence is absent, so recurring complaints and purpose fit cannot be verified.

Value for money

64 Moderate impact

The coherent four-active blend adds utility, but its premium serving cost is difficult to justify without better form and delivery evidence. No active is mere decoration, yet category value remains only moderate.

Report analysis

Goals

Energy
Energy
Impact
Highest effect
A Goal FitB+ Strength of SupportB+ CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 and PQQ target mitochondrial energy production, while NAC and glutathione add antioxidant protection. The combination covers both ATP-related function and oxidative stress around mitochondria.

CoQ10 lacks a stated ubiquinone or ubiquinol form and the dry capsule has no lipid carrier. All principal amounts are disclosed, giving the formula meaningful depth despite those absorption limits.

Study evidence
Coenzyme Q-10 Supportive 32 studies
Anti-Aging
Anti-Aging
Impact
Highest effect
A- Goal FitC Strength of SupportA- CoverageA+ Formula Quality
Coenzyme Q-10 · 100 mg

PQQ and CoQ10 target mitochondrial energy, while NAC and glutathione support antioxidant defense. The combination covers important longevity pathways, but CoQ10 and glutathione forms are not identified and several amounts are only moderate.

Every active amount is disclosed in one capsule, yet dry delivery limits absorption confidence for CoQ10 and glutathione. The compact four-active design is coherent and avoids generic vitamin padding.

Study evidence
Coenzyme Q-10 Supportive 6 studies
Gluthathione Adverse 8 studies
Heart Health
Heart Health
Impact
Highest effect
A- Goal FitB Strength of SupportB CoverageA- Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 directly supports cardiac cellular energy, while PQQ, NAC, and glutathione add mitochondrial and antioxidant pathways. The combination is strongly heart relevant, though the CoQ10 molecular form and absorption strategy are not disclosed.

The main actives have meaningful amounts and complementary functions without an oversized ingredient list. CoQ10 can alter warfarin response, so anticoagulation management may need closer monitoring when starting or stopping it.

Study evidence
Coenzyme Q-10 Supportive 114 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
B+ Goal FitB Strength of SupportC+ CoverageB Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 is supplied at a meaningful amount for cardiac energy support, with PQQ, NAC, and glutathione adding mitochondrial and antioxidant coverage. The formula is relevant and reasonably deep, although CoQ10 is not identified as ubiquinol and no lipid carrier is disclosed.

The combination covers cardiac energy and oxidative defense but not lipids, vascular tone, or nitric-oxide signaling. CoQ10 may reduce warfarin response, so people using vitamin K antagonist therapy should discuss consistent use with their clinician.

Study evidence
Coenzyme Q-10 Supportive 89 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
B- Goal FitC+ Strength of SupportB- CoverageA- Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10, NAC, glutathione, and PQQ provide complementary mitochondrial and antioxidant support. This may help oxidative inflammatory stress, although direct clinical evidence for the full combination is limited.

The individual amounts are disclosed, but the CoQ10 molecular form is not named. Dry capsule delivery may also limit CoQ10 absorption.

Study evidence
Coenzyme Q-10 Supportive 46 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
C+ Goal FitC+ Strength of SupportC+ CoverageA Formula Quality
Coenzyme Q-10 · 100 mg

CoQ10 and PQQ form a clear mitochondrial energy pair, while NAC and glutathione add antioxidant support. The formula may support cellular energy efficiency but is not designed for direct thermogenesis.

The CoQ10 and PQQ amounts suit general support, though the dry capsule lacks a disclosed lipid carrier or absorption enhancer. Missing CoQ10 form details and modest evidence for PQQ-driven metabolic change limit certainty.

Study evidence
Coenzyme Q-10 Disputed 11 studies

Ingredients

IngredientAmount per serving
Pyrroloquinoline Quinone Disodium Salt
10 mg
Coenzyme Q-10
100 mg
NAC
255 mg
L-Glutathione
250 mg
Adults 18–50
Report overview
Coenzyme Q-10 · 100 mg OverallScore50
F Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyC Value

The CoQ10 amount suits general maintenance, but the label does not identify its molecular form. A dry capsule without a lipid carrier or absorption enhancer may limit uptake. PQQ, NAC, and glutathione add useful co-factors, though the serving remains costly.

View ingredientView products
Gluthathione · 250 mg OverallScore24
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value

The formula provides 250 mg of glutathione, but the label does not identify it as reduced, acetylated, or liposomal, so absorption and potency are uncertain. NAC may support the body's own glutathione production, but it does not replace a clearly identified direct form. The serving is costly for generic glutathione without a disclosed purity grade or advanced delivery system.

View ingredientView products
Loading alternative details
87 Performance

Extra Strength Ubiquinol 200 mg

NOW
<p>Its label clearly provides 200 mg of Ubiquinol as CoQ10, making it a more clearly defined CoQ10 option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s glutathione coverage.</p>
85 Performance

Mega Ubiquinol CoQ10 100 mg

Qunol
<p>Its label clearly provides 100 mg of Ubiquinol as Coenzyme Q10, making it a more clearly defined CoQ10 option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s glutathione coverage.</p>
87 Performance

QH-absorb 100 mg

Jarrow Formulas
<p>Its label clearly provides 100 mg of Ubiquinol, making it a more clearly defined CoQ10 option. Compared with the original, its ingredient and goal alignment is stronger, although it does not retain the original product’s glutathione coverage.</p>
79 Budget

Ubiquinol 100 mg

Qunol
<p>Its label clearly provides 100 mg of Kaneka Ubiquinol as Ubiquinol, preserving relevant CoQ10 coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s glutathione coverage.</p>
84 Budget

CoQ10 200 mg

Nature Made
<p>Its label clearly provides 200 mg of Coenzyme Q10 as Ubidecarenone, preserving relevant CoQ10 coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s glutathione coverage.</p>
84 Budget

High Absorption CoQ10 200 mg

Doctor's Best
<p>Its label clearly provides 200 mg of Coenzyme Q10 as Ubiquinone and 5 mg of Black Pepper ext. as Piperine, preserving relevant CoQ10 coverage. Compared with the original, it lowers the serving cost, although it does not retain the original product’s glutathione coverage.</p>
87 Value

Mega CoQ10 Ubiquinol 100 mg

Qunol
<p>Its label clearly provides 100 mg of Ubiquinol, keeping the formula relevant to CoQ10. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s glutathione coverage.</p>
86 Value

Ubiquinol 100 mg

NOW
<p>Its label clearly provides 100 mg of Ubiquinol as CoQ10, keeping the formula relevant to CoQ10. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s glutathione coverage.</p>
87 Value

CoQ10 200 mg

California Gold Nutrition
<p>Its label clearly provides 200 mg of Coenzyme Q-10 as Ubiquinone, keeping the formula relevant to CoQ10. Compared with the original, the lower serving cost and ingredient detail create a useful quality-to-cost balance, although it does not retain the original product’s glutathione coverage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.
    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A · Complementary therapies in medicine · 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  2. Coenzyme Q10 supplementation increases blood concentrations but shows limited and inconsistent effects on exercise performance: a systematic review and meta-analysis.
    Deng H; Song T; Yin M; Xu K; Zhong Y; Mohd NB; Naharudin MNB; Yusof A; Fan X · The British journal of nutrition · 2026
    Meta-analysis24 studies pooledEnergy forCoenzyme Q-10
  3. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer.
    Lesser GJ; Case D; Stark N; Williford S; Giguere J; Garino LA; Naughton MJ; Vitolins MZ; Lively MO; Shaw EG; Wake Forest University Community Clinical Oncology Program Research Base · The journal of supportive oncology · 2013
    Randomized trial236 participantsEnergy forCoenzyme Q-10
  4. Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview.
    Mantle D; Hargreaves I · Antioxidants (Basel, Switzerland) · 2020
    Narrative reviewAnti-Aging forCoenzyme Q-10
  5. Coenzyme Q10 Supplementation in Aging and Disease.
    Hernández-Camacho JD; Bernier M; López-Lluch G; Navas P · Frontiers in physiology · 2022
    Narrative reviewAnti-Aging forCoenzyme Q-10
  6. Coenzyme Q10, a cutaneous antioxidant and energizer.
    Hoppe U; Bergemann J; Diembeck W; Ennen J; Gohla S; Harris I; Jacob J; Kielholz J; Mei W; Pollet D; Schachtschabel D; Sauermann G; Schreiner V; Stäb F; Steckel F · BioFactors (Oxford, England) · 1999
    Clinical trialAnti-Aging forCoenzyme Q-10
  7. Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals.
    Pabis K; Wang W; Selvarajoo K; Budovskaya YV; Sorrentino V; Gruber J; Kennedy BK · Aging cell · 2026
    Cross-sectional study4,260 participantsAnti-Aging forCoenzyme Q-10
  8. Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults.
    Schmücker M; Tranberg C; Borch J; Kaae MK; Damgaard M; Flensted-Jensen M; Blom I; Morosetti M; Barbarossa S; Orlando P; Tiano L; Dela F; Helge JW; Larsen S · GeroScience · 2026
    Randomized trial40 participantsAnti-Aging forCoenzyme Q-10
  9. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation.
    Sekhar RV; Patel SG; Guthikonda AP; Reid M; Balasubramanyam A; Taffet GE; Jahoor F · The American journal of clinical nutrition · 2011
    Clinical trial16 participantsAnti-Aging forGluthathione
  10. Changes in levels of the antioxidant glutathione in brain and blood across the age span of healthy adults: A systematic review.
    Detcheverry F; Senthil S; Narayanan S; Badhwar A · NeuroImage. Clinical · 2023
    Systematic review35 studies pooledAnti-Aging forGluthathione
  11. Do glutathione levels decline in aging human brain?
    Tong J; Fitzmaurice PS; Moszczynska A; Mattina K; Ang LC; Boileau I; Furukawa Y; Sailasuta N; Kish SJ · Free radical biology & medicine · 2016
    Cross-sectional study74 participantsAnti-Aging forGluthathione
  12. Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study.
    Hajjar I; Hayek SS; Goldstein FC; Martin G; Jones DP; Quyyumi A · Journal of neuroinflammation · 2019
    Cohort study511 participantsAnti-Aging forGluthathione
  13. Changes in the intracellular homocysteine and glutathione content associated with aging.
    Hernanz A; Fernández-Vivancos E; Montiel C; Vazquez JJ; Arnalich F · Life sciences · 2000
    Cross-sectional study70 participantsAnti-Aging forGluthathione
  14. The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.
    Taghizadeh S; Izadi A; Shirazi S; Parizad M; Pourghassem Gargari B · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2021
    Randomized trial43 participantsAnti-Inflammatory Support forCoenzyme Q-10
  15. The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome.
    Karamali M; Gholizadeh M · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
    Randomized trial55 participantsAnti-Inflammatory Support forCoenzyme Q-10
  16. Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.
    Hou S; Tian Z; Zhao D; Liang Y; Dai S; Ji Q; Fan Z; Liu Z; Liu M; Yang Y · Molecular nutrition & food research · 2023
    Meta-analysis1,517 participants31 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  17. Can coenzyme Q10 supplementation effectively reduce human tumor necrosis factor-α and interleukin-6 levels in chronic inflammatory diseases? A systematic review and meta-analysis of randomized controlled trials.
    Farsi F; Heshmati J; Keshtkar A; Irandoost P; Alamdari NM; Akbari A; Janani L; Morshedzadeh N; Vafa M · Pharmacological research · 2020
    Meta-analysis509 participants9 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  18. Promising efficacy of coenzyme Q10 supplementation as adjunctive therapy in juvenile idiopathic arthritis: a randomized-controlled pilot study.
    Elsherif N; Shousha G; Sabri NA; Shawki MA · Immunopharmacology and immunotoxicology · 2026
    Randomized trial58 participantsAnti-Inflammatory Support forCoenzyme Q-10
  19. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.
    Liu Z; Tian Z; Zhao D; Liang Y; Dai S; Liu M; Hou S; Dong X; Zhaxinima; Yang Y · The Journal of clinical endocrinology and metabolism · 2022
    Meta-analysis2,794 participants50 studies pooledCardiovascular Support Heart Health forCoenzyme Q-10
  20. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
    Vrentzos E; Ikonomidis I; Pavlidis G; Katogiannis K; Korakas E; Kountouri A; Pliouta L; Michalopoulou E; Pelekanou E; Boumpas D; Lambadiari V · Cardiovascular diabetology · 2024
    Randomized trial60 participantsCardiovascular Support forCoenzyme Q-10
  21. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
    Mortensen SA; Rosenfeldt F; Kumar A; Dolliner P; Filipiak KJ; Pella D; Alehagen U; Steurer G; Littarru GP; Q-SYMBIO Study Investigators · JACC. Heart failure · 2015
    Randomized trial420 participantsCardiovascular Support forCoenzyme Q-10
  22. [Coenzyme Q-10 in the treatment of patients with chronic heart failure and reduced left ventricular ejection fraction: systematic review and meta-analysis].
    Mareev VY; Mareev YV; Begrambekova YL · Kardiologiia · 2022
    Meta-analysis1,139 participants6 studies pooledCardiovascular Support forCoenzyme Q-10
  23. Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.
    Mortensen AL; Rosenfeldt F; Filipiak KJ · Cardiology journal · 2020
    Randomized trialCardiovascular Support forCoenzyme Q-10
  24. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ · Journal of the American Heart Association · 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  25. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigò LP · Nutrients · 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  26. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV · Frontiers in pharmacology · 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  27. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y · Nutrition (Burbank, Los Angeles County, Calif.) · 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
  28. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial.
    Sabbatinelli J; Orlando P; Galeazzi R; Silvestri S; Cirilli I; Marcheggiani F; Dludla PV; Giuliani A; Bonfigli AR; Mazzanti L; Olivieri F; Antonicelli R; Tiano L · Nutrients · 2021
    Randomized trial51 participantsHeart Health forCoenzyme Q-10
  29. Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Zhao D; Liang Y; Dai S; Hou S; Liu Z; Liu M; Dong X; Zhan Y; Tian Z; Yang Y · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis1,831 participants26 studies pooledHeart Health forCoenzyme Q-10
  30. Effects of Coenzyme Q10 on Lipid, Glycemic, and Inflammatory Markers in Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Zhang Z; Liu Z; Geng Y; Huang Y; Hu R; Li F; Song Y; Zhang M · Journal of diabetes research · 2026
    Meta-analysis3,422 participants64 studies pooledHeart Health Metabolism Boost forCoenzyme Q-10
  31. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals.
    Zhang P; Yang C; Guo H; Wang J; Lin S; Li H; Yang Y; Ling W · Journal of clinical lipidology · 2019
    Randomized trial101 participantsHeart Health forCoenzyme Q-10
  32. Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial.
    Zhang P; Chen K; He T; Guo H; Chen X · Nutrition & metabolism · 2022
    Randomized trial101 participantsMetabolism Boost forCoenzyme Q-10
  33. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
    Meta-analysis2,362 participants41 studies pooledMetabolism Boost forCoenzyme Q-10
  34. Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise.
    Diaz-Castro J; Mira-Rufino PJ; Moreno-Fernandez J; Chirosa I; Chirosa JL; Guisado R; Ochoa JJ · Food & function · 2021
    Randomized trial100 participantsMetabolism Boost forCoenzyme Q-10
  35. The effect of coenzyme Q10 intake on metabolic profiles in women candidates for in-vitro fertilization: a randomised trial.
    Ahmadi Asouri S; Asemi R; Aghadavod E; Jamilian M · Annals of medicine and surgery (2012) · 2024
    Randomized trial40 participantsMetabolism Boost forCoenzyme Q-10