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St. John's Wort 300 mg

NOW
4.6
★ ★ ★ ★ ★
(33 ratings)
St. John's Wort 300 mg
Product Image
Score84
A defined extract and simple dosing improve potency clarity, but incomplete marker detail and extensive drug interactions remain important limits.
How scoring works
Quantity:100 Capsule(s) • (100 servings)
Goals:
Mood Support

Score 84

A defined extract and simple dosing improve potency clarity, but incomplete marker detail and extensive drug interactions remain important limits.
How scoring works
$9.90($0.09 per serving)
Daily Vita
$ 9.90
Walmart
$ 12.19
Vitacost
$ 11.03
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Analysis

The 300 mg serving uses a defined St. John’s wort extract linked to hypericin. That is easier to assess than a raw-herb weight alone.

The supplied data does not state a precise hypericin percentage or yield, so exact potency comparison remains limited. A full medication review is essential because the herb strongly changes drug metabolism.

Adults with mild mood concerns who take no interacting medicines are the clearest audience. The one capsule format is convenient, but suitability depends more on medication compatibility than ease of use.

Who is it for
  • Adults seeking focused St. John’s wort support
  • People who take no interacting medicines
  • Users who prefer a capsule
Best for
  • Focused mood-support supplementation
  • Defined St. John’s wort extract intake
  • one capsule daily use

Pros

  • Uses a hypericin extract
  • Clearly states a 300 mg serving
  • one capsule format

Cons

  • Marker percentage is not fully disclosed
  • Extensive medication interactions restrict use
  • No supporting nutrients are included

Warnings

  • St. John’s wort can sharply reduce the effectiveness of oral contraceptives, warfarin, transplant medicines, HIV medicines, and many other drugs by speeding their clearance.
  • Combining St. John’s wort with SSRIs, SNRIs, MAO inhibitors, triptans, tramadol, or dextromethorphan can cause dangerous serotonin excess.
  • St. John’s wort can increase sensitivity to sunlight, so strong sun or UV exposure may require extra skin and eye protection.

Nutrient quality

89 Highest impact

A marker-standardized extract provides strong form quality for mood support. The daily amount is useful but may require multiple servings to match common researched use.

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Ingredient transparency

83 Highest impact

The active amount and marker standardization are clearly disclosed without a hidden blend. Complete intake directions and inactive ingredients are not supplied.

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Customer satisfaction

62 Moderate impact

The supplied average rating is strong. The rating base is modest and limits confidence in the average, but no detailed experience evidence was supplied.

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Value for money

98 Highest impact

Serving economics are highly favorable. Formula quality supports the asking price well.

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Report analysis

Goals

Mood Support
Mood Support
Impact
High effect
A Goal FitC- Strength of SupportC CoverageA+ Formula Quality

St. John’s wort directly targets mood-regulating pathways and has substantial human evidence for mild depressive symptoms. The simple capsule avoids unrelated ingredients.

The 300 mg serving is below a typical full daily clinical regimen, and hypericin standardization is not quantified. It can reduce the effectiveness of oral contraceptives and anticoagulants, while combining it with serotonergic antidepressants can cause a serious interaction.

Study evidence
St. John's Wort Supportive 97 studies

Ingredients

IngredientAmount per serving
St. John's Wort extract (Hypericin)
 300 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Women Vegetarian
Report overview
St. John's Wort (Hypericin) · 300 mg OverallScore58
B- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyA+ Value

The extract identifies hypericin but does not state its standardization percentage. The daily amount reaches the lower supplemental tier but not the preferred clinical range. The cost for an equivalent clinical daily amount is exceptionally low. Saint John’s wort can reduce the effect of oral contraceptives and anticoagulants, and combining it with serotonergic antidepressants may cause a serious interaction.

View ingredientView products
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88 Performance

Full Spectrum St. John's Wort Extract 600 mg

Planetary Herbals
A standardized, substantial Saint John’s wort blend offers focused mood support with stronger potency clarity than nonstandardized options; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
84 Performance

Feeling Positive St. John's Wort 300 mg

Sundown
Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort Extract

Swanson Superior Herbs
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort 300 mg

NOW
Marker standardization supports consistent extract quality, though the daily amount is moderate; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
89 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the lower serving cost improves economy when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

Nature's Bounty
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

Perika St. John's Wort

Nature's Way
The named extract supports consistent quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original already has a credible Saint John’s wort profile. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  2. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  3. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  4. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  5. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort