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St. John's Wort 375 mg

Swanson Premium Brand
4.7
★ ★ ★ ★ ★
(8437 ratings)
St. John's Wort 375 mg
Product Image
Score79
Focused dosing is convenient, yet unstandardized potency and major medication interactions make careful selection essential.
How scoring works
Quantity:120 Capsule(s) • (120 servings)
Goals:
Mood Support
Stress Relief

Score 79

Focused dosing is convenient, yet unstandardized potency and major medication interactions make careful selection essential.
How scoring works

Also available as

1 option
60 servings St. John's Wort 375 mg • 60 Capsule(s) • 60 servings $4.29 ($0.07 per serving)
$4.89($0.04 per serving)
iHerb
$ 4.89
iHerb
$ 5.99
Amazon
$ 9.38
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Analysis

The 375 mg serving provides unstandardized whole herb in a focused capsule format. No unrelated active ingredients dilute the intended mood-support role.

No hypericin or hyperforin standardization is given, so different batches may not deliver identical active strength. The large herb weight does not by itself establish clinical potency.

Adults with mild mood concerns who take no interacting medicines are the clearest audience. The one capsule format is convenient, but suitability depends more on medication compatibility than ease of use.

Who is it for
  • Adults seeking focused St. John’s wort support
  • People who take no interacting medicines
  • Users who prefer a capsule
Best for
  • Focused mood-support supplementation
  • Whole-herb St. John’s wort use
  • one capsule daily use

Pros

  • Focused single-herb formula
  • Clearly states a 375 mg serving
  • one capsule format

Cons

  • Hypericin and hyperforin are not standardized
  • Extensive medication interactions restrict use
  • Whole-herb potency can vary

Warnings

  • St. John’s wort can sharply reduce the effectiveness of oral contraceptives, warfarin, transplant medicines, HIV medicines, and many other drugs by speeding their clearance.
  • Combining St. John’s wort with SSRIs, SNRIs, MAO inhibitors, triptans, tramadol, or dextromethorphan can cause dangerous serotonin excess.
  • St. John’s wort can increase sensitivity to sunlight, so strong sun or UV exposure may require extra skin and eye protection.

Nutrient quality

74 High impact

The single-herb formula fits mood support directly. Missing extract and active-marker details limit form quality despite a usable daily amount.

.

Ingredient transparency

75 High impact

The herb amount is clearly disclosed without a hidden blend. Active-marker strength, complete intake directions, and inactive ingredients are not supplied.

.

Customer satisfaction

71 High impact

The supplied average rating is strong. An exceptionally large rating base makes the average highly dependable, but no detailed experience evidence was supplied.

.

Value for money

97 Highest impact

Serving economics are highly favorable. Formula quality supports the asking price well.

.
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Goals

Mood Support
Mood Support
Impact
High effect
B+ Goal FitC+ Strength of SupportD- CoverageA Formula Quality

St. John's Wort 375 mg provides 375 mg per serving and uses a St. John's wort extract with incomplete active-marker detail, giving it direct but dose-dependent alignment with mood support.

Customer feedback averages 4.67 from 8352 reviews, while the published label carries medication-interaction cautions and a product-specific independent certification was not confirmed.

Study evidence
St. John's Wort Supportive 97 studies
Stress Relief
Stress Relief
Impact
Moderate effect
D- Goal FitD- Strength of SupportF CoverageA- Formula Quality

Swanson St. John's Wort 375 mg, 120 capsules supplies 375 mg of St. John's wort in an unstandardized whole-herb capsule, offering a focused but situational route to stress-related emotional balance.

Supplied feedback averages 4.67 across 8,352 reviews, while published safety information makes medication-interaction and photosensitivity review important before use.

Study evidence
St. John's Wort Mixed 6 studies

Ingredients

IngredientAmount per serving
St. John's Wort
375 mg
Adults 18–50
Report overview
St. John's Wort · 375 mg OverallScore58
F Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyA+ Value

Swanson Saint John's Wort 375 mg, 120 capsules provides 375 mg per serving and uses plain Saint John's wort without extract or marker details, producing a partial dosage fit under the collection rubric. Customer feedback averages 4.67 from 8352 reviews, while the published label includes a specific interaction warning.

View ingredientView products
Loading alternative details
84 Performance

Feeling Positive St. John's Wort 300 mg

Sundown
Marker standardization supports consistent extract quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; its extract quality and goal fit provide a clearer option when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Performance

Perika St. John's Wort

Nature's Way
The named extract supports consistent quality, though the daily amount is moderate; its extract quality and goal fit provide a clearer option when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort Extract

Swanson Superior Herbs
Marker standardization supports consistent extract quality, though the daily amount is moderate; it is among the lowest-cost eligible options, although it is not cheaper than the original when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
90 Budget

St. John's Wort 300 mg

NOW
Marker standardization supports consistent extract quality, though the daily amount is moderate; it is among the lowest-cost eligible options, although it is not cheaper than the original when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
89 Budget

St. John's Wort 300 mg

California Gold Nutrition EuroHerbs
A hypericin-standardized extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; it is among the lowest-cost eligible options, although it is not cheaper than the original when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
87 Value

St. John's Wort Extract 300 mg

Lake Avenue Nutrition
A hypericin-standardized aerial-parts extract gives useful potency clarity and focused mood support, though one serving may provide only a partial daily dose; the quality-to-cost balance is favorable when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
86 Value

St. John's Wort 300 mg

Nature's Bounty
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
83 Value

St. John's Wort

Paradise
Marker standardization supports consistent extract quality, though the daily amount is moderate; the quality-to-cost balance is favorable when the original has incomplete potency or marker detail. Saint John’s wort can weaken oral contraceptives and anticoagulants and can interact seriously with serotonergic antidepressants, so medication use needs clinician or pharmacist review.
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Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. St John's wort for major depression.
    Linde K; Berner MM; Kriston L · The Cochrane database of systematic reviews · 2009
    Systematic review5,489 participants29 studies pooledMood Support forSt. John's Wort
  2. Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
    Lecrubier Y; Clerc G; Didi R; Kieser M · The American journal of psychiatry · 2002
    Randomized trial375 participantsMood Support forSt. John's Wort
  3. A systematic review and meta-analysis of Hypericum perforatum in depression: a comprehensive clinical review.
    Whiskey E; Werneke U; Taylor D · International clinical psychopharmacology · 2002
    Meta-analysis22 studies pooledMood Support forSt. John's Wort
  4. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
    Kalb R; Trautmann-Sponsel RD; Kieser M · Pharmacopsychiatry · 2001
    Randomized trial72 participantsMood Support forSt. John's Wort
  5. Complementary therapies for clinical depression: an overview of systematic reviews.
    Haller H; Anheyer D; Cramer H; Dobos G · BMJ open · 2020
    Systematic review26 studies pooledMood Support forSt. John's Wort
  6. Comparison of St John's wort and imipramine for treating depression: randomised controlled trial.
    Woelk H · BMJ (Clinical research ed.) · 2000
    Randomized trial324 participantsStress Relief forSt. John's Wort
  7. Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John's wort.
    Friede M; Henneicke von Zepelin HH; Freudenstein J · Pharmacopsychiatry · 2002
    Randomized trial240 participantsStress Relief forSt. John's Wort
  8. Kava and St. John's Wort: current evidence for use in mood and anxiety disorders.
    Sarris J; Kavanagh DJ · Journal of alternative and complementary medicine (New York, N.Y.) · 2009
    Systematic reviewStress Relief forSt. John's Wort
  9. Do early changes in the HAM-D-17 anxiety/somatization factor items affect the treatment outcome among depressed outpatients? Comparison of two controlled trials of St John's wort (Hypericum perforatum) versus a SSRI.
    Bitran S; Farabaugh AH; Ameral VE; LaRocca RA; Clain AJ; Fava M; Mischoulon D · International clinical psychopharmacology · 2012
    Other475 participantsStress Relief forSt. John's Wort
  10. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.
    Lakhan SE; Vieira KF · Nutrition journal · 2011
    Systematic review2,619 participants24 studies pooledStress Relief forSt. John's Wort