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ACES

Carlson
4.8
★ ★ ★ ★ ★
(2840 ratings)
Selenium 100 mcg
Vitamin C 1000 mg
Product Image
Score75
A well-disclosed, concentrated antioxidant blend with good vitamin C and selenium forms, but high beta-carotene and vitamin E make user fit important.
How scoring works
Quantity:50 Softgel(s) • (25 servings)
Goals:
Immunity
Skin Health
Anti-Inflammatory Support
Vision Support
General Health

Score 75

A well-disclosed, concentrated antioxidant blend with good vitamin C and selenium forms, but high beta-carotene and vitamin E make user fit important.
How scoring works

Also available as

2 options
200 servings C 1000 mg, Selenium 100 mcg • 200 Softgel(s) • 100 servings $52.70 ($0.52 per serving) 90 servings C 1000 mg, Selenium 100 mcg • 90 Softgel(s) • 45 servings $25.42 ($0.56 per serving)
$15.22($0.60 per serving)
iHerb
$ 15.22
iHerb
$ 15.22
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Analysis

Calcium ascorbate provides 1,000 mg vitamin C in a buffered form, while natural vitamin E and L-selenomethionine add complementary fat-soluble and enzyme-based antioxidant support. The combination also has meaningful relevance to normal immune function, collagen formation, and ocular antioxidant defenses.

Every main active is named with an amount, and the selenium form is especially well chosen. The formula is still narrow rather than comprehensive because it does not add lutein, zeaxanthin, omega-3 fats, zinc, or structural skin and nail ingredients.

The large vitamin E and beta-carotene servings may be unnecessary for people already taking a multivitamin or antioxidant blend. It fits users seeking a concentrated antioxidant stack, provided the beta-carotene and bleeding-related cautions do not apply.

Who is it for
  • Non-smokers seeking a concentrated antioxidant combination
  • Adults who prefer buffered vitamin C
  • People wanting vitamin C, natural vitamin E, and selenium in one formula
Best for
  • Broad water- and fat-soluble antioxidant coverage
  • Immune and collagen-supporting micronutrients
  • Clearly disclosed vitamin and selenium forms

Pros

  • Uses buffered calcium ascorbate for the vitamin C serving
  • Provides natural d-alpha-tocopherol vitamin E
  • Uses well-absorbed L-selenomethionine
  • Discloses all main active amounts

Cons

  • High vitamin E may be excessive for routine use
  • Beta-carotene sharply narrows the suitable audience
  • Lacks lutein and zeaxanthin for more complete vision support
  • Does not provide direct structural ingredients for nails or skin hydration

Warnings

  • Current or former smokers should avoid the 3,000 mcg RAE supplemental beta-carotene because high-dose beta-carotene can raise lung-cancer risk in these groups.
  • The 268 mg vitamin E amount may increase bleeding tendency with anticoagulant or antiplatelet medicines and around surgery.
  • Avoid stacking it with other high-dose vitamin A, vitamin E, or selenium supplements without checking the combined intake.

Nutrient quality

83 Highest impact

Calcium ascorbate, natural vitamin E, and selenomethionine are well-regarded nutrient forms. Vitamin E and beta-carotene are aggressive for a routine general supplement.

Ingredient transparency

85 Highest impact

Listed active amounts are clear and no proprietary blend hides a key dose. Complete directions and inactive-ingredient details remain incomplete.

Customer satisfaction

73 High impact

The aggregate rating and its volume provide a favorable top-level signal. Missing experience details prevent assessment of repeated complaints or purpose-specific satisfaction.

Value for money

53 Moderate impact

The smaller package provides weak value despite good nutrient forms. Comparable products can provide similar core support more efficiently.

Report analysis

Goals

Immunity
Immunity
Impact
Highest effect
A Goal FitA+ Strength of SupportA+ CoverageA+ Formula Quality
Vitamin C · 1000 mgVitamin A · 3000 mcg RAESelenium · 100 mcg

Vitamins A, C, and E with selenium cover barrier integrity and antioxidant defenses that support normal immune function. The formula provides strong amounts and uses clearly identified nutrient forms.

Buffered vitamin C and organic selenium strengthen the core, while natural vitamin E fits the antioxidant theme. The 268 mg vitamin E amount may increase bleeding tendency in people using anticoagulant or antiplatelet medicines.

Study evidence
Selenium Mixed 37 studies
Vitamin A Supportive 107 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 21 studies
Skin Health
Skin Health
Impact
Highest effect
A- Goal FitA Strength of SupportB CoverageA- Formula Quality
Vitamin C · 1000 mgSelenium · 100 mcgVitamin E · 268 mg

Vitamin C, natural vitamin E, beta-carotene, and selenium provide strong antioxidant coverage, while vitamin C also supports collagen synthesis. The amounts and forms are clearly disclosed, including well-absorbed selenomethionine.

The formula supports collagen production and oxidative defense but does not directly address hydration or barrier lipids. Its vitamin E amount is high, so people using anticoagulant or antiplatelet medicines should consider the increased bleeding risk before routine use.

Study evidence
Selenium Supportive 22 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Highest effect
B- Goal FitA Strength of SupportB+ CoverageA Formula Quality
Vitamin E · 268 mgVitamin C · 1000 mg

Vitamin C, natural vitamin E, beta-carotene, and L-selenomethionine provide broad antioxidant support at meaningful amounts. The formula can help control oxidative stress linked to inflammation, but it does not directly inhibit major inflammatory enzymes.

Its antioxidant pathways are complementary and well dosed rather than superficially broad. The substantial vitamin E amount may increase bleeding tendency when combined with anticoagulant or antiplatelet medicines.

Study evidence
Selenium Supportive 34 studies
Vitamin C Supportive 50 studies
Vitamin E Supportive 20 studies
Vision Support
Vision Support
Impact
Highest effect
B Goal FitA Strength of SupportB CoverageA- Formula Quality
Vitamin E · 268 mgVitamin C · 1000 mgVitamin A · 3000 mcg RAE

Vitamins A, C, and E plus selenium provide substantial antioxidant support for ocular tissues. The formula lacks lutein, zeaxanthin, zinc, copper, and omega-3s needed for broader pathway coverage.

Forms and amounts are clearly disclosed, including natural vitamin E and selenomethionine. Its antioxidant depth is strong despite incomplete alignment with established comprehensive formulas.

Study evidence
Selenium Supportive 15 studies
Vitamin A Supportive 65 studies
Vitamin C Disputed 24 studies
Vitamin E Disputed 35 studies
General Health
General Health
Impact
Highest effect
B Goal FitA- Strength of SupportC+ CoverageA- Formula Quality
Selenium · 100 mcgVitamin C · 1000 mg

The antioxidant combination provides substantial vitamin C and E with beta-carotene and selenium. These nutrients support cellular antioxidant defenses, while their disclosed forms and amounts make the formula easy to assess.

The blend covers only part of daily nutrition and relies on doses that may exceed what many people need routinely. The high vitamin E amount can increase bleeding tendency when combined with anticoagulant or antiplatelet medicines.

Study evidence
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies
Nail Health
Nail Health
Impact
Moderate effect
D+ Goal FitB+ Strength of SupportD CoverageC Formula Quality

Vitamin E, vitamin C, selenium, and beta-carotene offer antioxidant support that may help protect the nail matrix. The formula lacks direct keratin building blocks, biotin, collagen, silicon, iron, and zinc.

Antioxidant amounts are substantial and clearly disclosed with generally suitable forms. High-dose vitamin E can increase bleeding tendency with anticoagulant or antiplatelet medicines.

Study evidence
Selenium Adverse 1 study
Vitamin C Supportive 1 study
Vitamin E Supportive 6 studies

Ingredients

IngredientAmount per serving
Calories
15 Calorie(s)
Total Fat
0.5 Gram(s)
Total Carbohydrates
2 Gram(s)
Protein
1 Gram(s)
Vitamin A (Beta-Carotene)
 3000 mcg RAE
Vitamin C (Calcium Ascorbate)
 1000 mg
Vitamin E (D-Alpha-Tocopherol)
 268 mg
Calcium (Calcium Ascorbate, Dicalcium Phosphate)
 110 mg
Selenium (L-Selenomethionine)
 100 mcg
Gluten Free Adults 18–50 Dairy Free
Report overview
Selenium (L-Selenomethionine) · 100 mcg OverallScore79
A+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyF Value

L-selenomethionine provides a well-disclosed organic source at a maintenance-level dose. The amount leaves ample room below the upper intake limit. Selenium-specific value is weak, though the serving also supplies other nutrients.

View ingredientView products
Vitamin C (Calcium Ascorbate) · 1000 mg OverallScore73
B+ Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyF Value

Buffered calcium ascorbate provides an efficient 1,000 mg dose with less acidity than plain ascorbic acid. Separate vitamin C and calcium disclosure is a meaningful label strength. Vitamin C value remains poor in this smaller antioxidant-combination package.

View ingredientView products
Loading alternative details
89 Performance

C-500 Calcium Ascorbate-C

NOW
<p>Buffered calcium ascorbate provides a practical 500 mg vitamin C amount without the original blend's high vitamin E and beta-carotene exposure. The small bioflavonoid addition is unlikely to add much, and selenium would need to come from elsewhere if required.</p>
87 Performance

Se-Methyl L-Selenocysteine 200 mcg

Life Extension
<p>A precisely named organic selenium form makes targeted selenium intake easier to assess than the original multi-antioxidant formula. It avoids high fat-soluble vitamin amounts, although 200 mcg still warrants care when combined with other selenium sources.</p>
86 Performance

Ester-C Plus 1000 mg Vitamin C

Solgar
<p>Buffered Ester-C and 200 mg of citrus bioflavonoids provide focused vitamin C support with a gentler formulation than plain ascorbic acid. It avoids the original's aggressive fat-soluble nutrients, but it supplies no selenium.</p>
85 Budget

C-500 With Rose Hips

NOW
<p>A focused 500 mg vitamin C serving costs less to use and avoids the original blend's high vitamin E and beta-carotene exposure. Plain ascorbic acid may be harder on a sensitive stomach, and the product does not replace selenium.</p>
87 Budget

Selenium 100 mcg

Swanson
<p>A maintenance-oriented amount of trademarked L-selenomethionine offers a less costly way to retain selenium support. The single-nutrient design avoids the original formula's fat-soluble vitamin burden but gives up vitamin C and broader antioxidant coverage.</p>
87 Budget

Selenium 200 mcg

California Gold Nutrition
<p>Well-identified L-selenomethionine provides targeted selenium support at much better serving value. Its 200 mcg amount is higher than the original selenium serving, so combined intake needs care, and vitamin C is absent.</p>
89 Value

Pure Buffered Calcium Ascorbate

NOW
<p>Buffered calcium ascorbate supplies 890 mg of clearly disclosed vitamin C with strong serving value and less formula complexity. The narrower design avoids high vitamin E and beta-carotene but does not cover selenium.</p>
87 Value

Selenium 200 mcg

Nature's Way
<p>L-selenomethionine offers a well-defined, absorbed selenium form in a simple long-supply product. Value is strong for targeted selenium use, though 200 mcg requires attention to food and other supplements and leaves vitamin C uncovered.</p>
87 Value

100% Pure Vitamin C Powder

Swanson Premium Brand
<p>A flexible 1000 mg vitamin C powder gives concentrated antioxidant support with very strong serving value and no active padding. Plain ascorbic acid is acidic, and the formula omits selenium and the original product's broader nutrients.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic Review and Meta-Analysis.
    Keya TA; Leela A; Fernandez K; Habib N; Rashid M · Current reviews in clinical and experimental pharmacology · 2022
    Meta-analysis10 studies pooledImmunity forVitamin C
  2. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  3. Vitamin C for the management of COVID-19: a systematic review and meta-analysis of randomized controlled trials.
    Abid H; Mushtaq I; Munir ABI; Shakil J; Vinjamuri S; Tadasare N; Kiran F; Muhammad Wali Mirza A; Fatima Khidri F; Shahid A; Ayyan M; Ehsan M; Cheema HA; Alsubari AMA; Sahra S; Siddiqi NI · Annals of medicine and surgery (2012) · 2026
    Meta-analysis9 studies pooledImmunity forVitamin C
  4. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  5. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage.
    Fitzpatrick RE; Rostan EF · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2002
    Non-randomized trial10 participantsSkin Health forVitamin C
  6. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  7. What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review.
    Pameijer EM; Heus P; Damen JAA; Spijker R; Hooft L; Ringens PJ; Imhof SM; van Leeuwen R · Acta ophthalmologica · 2023
    Systematic review27 studies pooledVision Support forVitamin C
  8. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration.
    Evans JR; Lawrenson JG · The Cochrane database of systematic reviews · 2018
    Meta-analysis55,614 participants4 studies pooledVision Support forVitamin C Vision Support forVitamin E
  9. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  10. Selenium and the course of mild Graves' orbitopathy.
    Marcocci C; Kahaly GJ; Krassas GE; Bartalena L; Prummel M; Stahl M; Altea MA; Nardi M; Pitz S; Boboridis K; Sivelli P; von Arx G; Mourits MP; Baldeschi L; Bencivelli W; Wiersinga W; European Group on Graves' Orbitopathy · The New England journal of medicine · 2011
    Randomized trial159 participantsAnti-Inflammatory Support forSelenium
  11. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial.
    Asemi Z; Jamilian M; Mesdaghinia E; Esmaillzadeh A · Nutrition (Burbank, Los Angeles County, Calif.) · 2016
    Randomized trial70 participantsAnti-Inflammatory Support forSelenium
  12. Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease.
    Farrokhian A; Bahmani F; Taghizadeh M; Mirhashemi SM; Aarabi MH; Raygan F; Aghadavod E; Asemi Z · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2017
    Randomized trial60 participantsAnti-Inflammatory Support forSelenium
  13. The effects of selenium supplementation on cardiovascular risk factors in patients with metabolic diseases ‒ A systematic review and meta-analysis of randomized controlled trials.
    Qiu W; Huang N; Zhang K; Qiu H; Guo Z; Han F; Sun X; Hou N; Kan C · Nutricion hospitalaria · 2026
    Meta-analysis656 participants11 studies pooledAnti-Inflammatory Support forSelenium
  14. Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Kamali A; Amirani E; Asemi Z · Biological trace element research · 2020
    Randomized trial33 participantsAnti-Inflammatory Support forSelenium
  15. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  16. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  17. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  18. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  19. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  20. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  21. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  22. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  23. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  24. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  25. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  26. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  27. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health Vision Support forSelenium
  28. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  29. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledGeneral Health forSelenium
  30. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  31. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  32. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  33. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  34. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  35. Effects of selenium supplementation on selenoprotein gene expression and response to influenza vaccine challenge: a randomised controlled trial.
    Goldson AJ; Fairweather-Tait SJ; Armah CN; Bao Y; Broadley MR; Dainty JR; Furniss C; Hart DJ; Teucher B; Hurst R · PloS one · 2011
    Randomized trial119 participantsImmunity forSelenium
  36. Effect of selenium on immune response against hepatitis B vaccine with accelerated method in insulin-dependent diabetes mellitus patients.
    Janbakhsh A; Mansouri F; Vaziri S; Sayad B; Afsharian M; Rahimi M; Shahebrahimi K; Salari F · Caspian journal of internal medicine · 2013
    Randomized trial62 participantsImmunity forSelenium
  37. Chemoprevention trial of human hepatitis with selenium supplementation in China.
    Yu SY; Li WG; Zhu YJ; Yu WP; Hou C · Biological trace element research · 1990
    Non-randomized trial20,847 participantsImmunity forSelenium
  38. Selenium nanoparticles as adjunctive therapy in sepsis: A pilot randomized clinical trial.
    Gu WJ; Huang W; Zhao FZ; Yuan XK; Jin K; Chen JL; Zhang CY; Huang Y; He L; Zhuang H; Yin HY; Chen T · Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2026
    Randomized trial70 participantsImmunity forSelenium
  39. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations.
    Gärtner R; Gasnier BC; Dietrich JW; Krebs B; Angstwurm MW · The Journal of clinical endocrinology and metabolism · 2002
    Randomized trial70 participantsImmunity forSelenium
  40. Depressed immune response to tetanus in children with vitamin A deficiency.
    Semba RD; Muhilal; Scott AL; Natadisastra G; Wirasasmita S; Mele L; Ridwan E; West KP; Sommer A · The Journal of nutrition · 1992
    Randomized trial236 participantsImmunity forVitamin A
  41. Impact of a single megadose of vitamin A at delivery on breastmilk of mothers and morbidity of their infants.
    Roy SK; Islam A; Molla A; Akramuzzaman SM; Jahan F; Fuchs G · European journal of clinical nutrition · 1997
    Randomized trial50 participantsImmunity forVitamin A
  42. Vitamin A supplementation reduces measles morbidity in young African children: a randomized, placebo-controlled, double-blind trial.
    Coutsoudis A; Broughton M; Coovadia HM · The American journal of clinical nutrition · 1991
    Randomized trial60 participantsImmunity forVitamin A
  43. Vitamin A supplementation enhances specific IgG antibody levels and total lymphocyte numbers while improving morbidity in measles.
    Coutsoudis A; Kiepiela P; Coovadia HM; Broughton M · The Pediatric infectious disease journal · 1992
    Randomized trial60 participantsImmunity forVitamin A
  44. Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children.
    Long KZ; Santos JI; Estrada Garcia T; Haas M; Firestone M; Bhagwat J; Dupont HL; Hertzmark E; Rosado JL; Nanthakumar NN · The Journal of nutrition · 2006
    Randomized trial127 participantsImmunity forVitamin A
  45. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  46. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  47. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  48. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects.
    Meydani SN; Barklund MP; Liu S; Meydani M; Miller RA; Cannon JG; Morrow FD; Rocklin R; Blumberg JB · The American journal of clinical nutrition · 1990
    Randomized trial32 participantsImmunity forVitamin E
  49. Immunomodulatory effects of palm-derived tocotrienol-rich fraction in healthy volunteers following influenza vaccination: A randomised clinical trial.
    Chen S; Ahmad B; Palanisamy UD; Hafid SRA; Selvaduray KR; Radhakrishnan AK · Nutrition research (New York, N.Y.) · 2026
    Randomized trial150 participantsImmunity forVitamin E
  50. Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers.
    Mahalingam D; Radhakrishnan AK; Amom Z; Ibrahim N; Nesaretnam K · European journal of clinical nutrition · 2011
    Randomized trialImmunity forVitamin E
  51. Vitamin E and beta-carotene supplementation and hospital-treated pneumonia incidence in male smokers.
    Hemilä H; Virtamo J; Albanes D; Kaprio J · Chest · 2004
    Randomized trial29,133 participantsImmunity forVitamin E
  52. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial.
    Meydani SN; Meydani M; Blumberg JB; Leka LS; Siber G; Loszewski R; Thompson C; Pedrosa MC; Diamond RD; Stollar BD · JAMA · 1997
    Randomized trial88 participantsImmunity forVitamin E
  53. Acute selenium toxicity associated with a dietary supplement.
    MacFarquhar JK; Broussard DL; Melstrom P; Hutchinson R; Wolkin A; Martin C; Burk RF; Dunn JR; Green AL; Hammond R; Schaffner W; Jones TF · Archives of internal medicine · 2010
    Observational study201 participantsNail Health forSelenium
  54. Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
    Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
    Other20 participantsNail Health forVitamin C
  55. Dermatologic signs in patients with eating disorders.
    Strumia R · American journal of clinical dermatology · 2005
    Narrative reviewNail Health forVitamin E
  56. Yellow nail syndrome: clinical experience in a series of 21 patients.
    Piraccini BM; Urciuoli B; Starace M; Tosti A; Balestri R · Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2014
    Case series20 participantsNail Health forVitamin E
  57. Why don't we use vitamin E in dermatology?
    Pehr K; Forsey RR · CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1993
    Systematic reviewNail Health forVitamin E
  58. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forVitamin E
  59. Diagnosis and management of yellow nail syndrome: An international multi-institutional retrospective cohort study of 111 cases by an expert panel.
    Curtis KL; Piraccini BM; Starace M; Rapparini L; Richert B; Rubin AI; Jellinek NJ; Tosti A; Di Chiacchio NG; Di Chiacchio N; Iorizzo M; Grover C; Hinshaw MA; Vlahovic TC; Bellet JS; Rigopoulos D; Lipner SR · Journal of the American Academy of Dermatology · 2025
    Cohort study111 participantsNail Health forVitamin E
  60. Comparative clinical trial of bifonazole solution versus selenium sulphide shampoo in the treatment of pityriasis versicolor.
    Chu AC · Dermatologica · 1985
    Randomized trial38 participantsSkin Health forSelenium
  61. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial.
    Duffield-Lillico AJ; Slate EH; Reid ME; Turnbull BW; Wilkins PA; Combs GF; Park HK; Gross EG; Graham GF; Stratton MS; Marshall JR; Clark LC; Nutritional Prevention of Cancer Study Group · Journal of the National Cancer Institute · 2003
    Randomized trial1,312 participantsSkin Health forSelenium
  62. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forSelenium Skin Health forVitamin E
  63. A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh.
    Verret WJ; Chen Y; Ahmed A; Islam T; Parvez F; Kibriya MG; Graziano JH; Ahsan H · Journal of occupational and environmental medicine · 2006
    Randomized trial121 participantsSkin Health forSelenium
  64. The Whitening, Moisturizing, Anti-aging Activities, and Skincare Evaluation of Selenium-Enriched Mung Bean Fermentation Broth.
    Wei K; Guo C; Zhu J; Wei Y; Wu M; Huang X; Zhang M; Li J; Wang X; Wang Y; Wei X · Frontiers in nutrition · 2022
    Clinical trial31 participantsSkin Health forSelenium
  65. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  66. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  67. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  68. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  69. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
    Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
    Randomized trial45 participantsSkin Health forVitamin E
  70. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
    Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
    Meta-analysis20 studies pooledSkin Health forVitamin E
  71. Effects of tocotrienol on aging skin: A systematic review.
    Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
    Systematic reviewSkin Health forVitamin E
  72. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
    Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
    Randomized trialSkin Health forVitamin E
  73. Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction: A vehicle-controlled, randomized clinical trial.
    Watson SL; Jones LW; Stapleton F; Hinds M; Ng A; Tan J; Alster Y; Bosworth C; Rafaeli O; DePuy V; CELESTIAL STUDY Group · The ocular surface · 2026
    Randomized trial245 participantsVision Support forSelenium
  74. Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction over six months of treatment: A Phase 2, vehicle-controlled, randomized extension trial.
    Downie LE; Craig JP; Stapleton F; Tan J; Jones LW; Ng A; Hinds M; Bosworth C; Alster Y · The ocular surface · 2025
    Randomized trial245 participantsVision Support forSelenium
  75. AZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial.
    Stapleton F; Hinds M; Tan J; Jones L; Chalmers R; Bosworth C; Alster Y · The ocular surface · 2025
    Randomized trial67 participantsVision Support forSelenium
  76. The effect of a biweekly novel selenium sulfide-containing topical treatment in symptomatic contact lens wearers: An exploratory study.
    Stapleton F; Jia T; DePuy V; Bosworth C; Gleeson M; Tan J · The ocular surface · 2025
    Randomized trial14 participantsVision Support forSelenium
  77. A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa.
    Berson EL; Rosner B; Sandberg MA; Hayes KC; Nicholson BW; Weigel-DiFranco C; Willett W · Archives of ophthalmology (Chicago, Ill. : 1960) · 1993
    Randomized trial601 participantsVision Support forVitamin A
  78. Efficacy and safety of retinol palmitate ophthalmic solution in the treatment of dry eye: a Japanese Phase II clinical trial.
    Toshida H; Funaki T; Ono K; Tabuchi N; Watanabe S; Seki T; Otake H; Kato T; Ebihara N; Murakami A · Drug design, development and therapy · 2018
    Randomized trial66 participantsVision Support forVitamin A
  79. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.
    Imdad A; Mayo-Wilson E; Haykal MR; Regan A; Sidhu J; Smith A; Bhutta ZA · The Cochrane database of systematic reviews · 2022
    Meta-analysis1,223,856 participants47 studies pooledVision Support forVitamin A
  80. Vitamin A supplementation improves retinal function in infants at risk of retinopathy of prematurity.
    Mactier H; McCulloch DL; Hamilton R; Galloway P; Bradnam MS; Young D; Lavy T; Farrell L; Weaver LT · The Journal of pediatrics · 2012
    Randomized trial89 participantsVision Support forVitamin A
  81. Effect of short-term, high-dose retinol on dark adaptation in aging and early age-related maculopathy.
    Owsley C; McGwin G; Jackson GR; Heimburger DC; Piyathilake CJ; Klein R; White MF; Kallies K · Investigative ophthalmology & visual science · 2006
    Randomized trial104 participantsVision Support forVitamin A
  82. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  83. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  84. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C Vision Support forVitamin E
  85. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C
  86. Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study.
    Christen WG; Liu S; Glynn RJ; Gaziano JM; Buring JE · Archives of ophthalmology (Chicago, Ill. : 1960) · 2008
    Cohort study35,551 participantsVision Support forVitamin E
  87. Long-term nutrient intake and 5-year change in nuclear lens opacities.
    Jacques PF; Taylor A; Moeller S; Hankinson SE; Rogers G; Tung W; Ludovico J; Willett WC; Chylack LT · Archives of ophthalmology (Chicago, Ill. : 1960) · 2005
    Cohort study408 participantsVision Support forVitamin E
  88. Dietary intake of antioxidants and risk of age-related macular degeneration.
    van Leeuwen R; Boekhoorn S; Vingerling JR; Witteman JC; Klaver CC; Hofman A; de Jong PT · JAMA · 2005
    Cohort study4,765 participantsVision Support forVitamin E