Product Image

Anti-Alcohol HepatoProtection Complex

Life Extension
4.7
★ ★ ★ ★ ★
(3571 ratings)
Thiamin 100 mg
Vitamin C 1000 mg
Glutathione 50 mg
Product Image
Score66
Strong NAC and benfotiamine doses stand out, but weak forms, incomplete complex disclosure, and a costly five-capsule serving undermine the formula.
How scoring works
Quantity:60 Capsule(s) • (12 servings)
Goals:
Anti-Inflammatory Support
Immunity
General Health
Skin Health

Score 66

Strong NAC and benfotiamine doses stand out, but weak forms, incomplete complex disclosure, and a costly five-capsule serving undermine the formula.
How scoring works
$16.50($1.37 per serving)
Pure Formulas
$ 16.50
iHerb
$ 16.50
Vitacost
$ 16.50
Amazon
$ 27.97
Report prices

Analysis

NAC at 1,200 mg and benfotiamine at 600 mg are the strongest parts of the formula, with vitamin C adding further antioxidant support. Vitamin E, zinc, selenium, clove, grape, milk thistle, and glutathione broaden the coverage but vary greatly in dose and likely contribution.

Zinc oxide and sodium selenite are less appealing forms than several common alternatives. A HepatoProtection Complex is listed without a meaningful amount, which prevents a complete assessment of the formula.

The five-capsule serving and limited number of servings reduce convenience and value. The product may support antioxidant defenses, but it should never be viewed as offsetting or making alcohol use safe.

Who is it for
  • Adults seeking a broad antioxidant supplement
  • People specifically interested in NAC and benfotiamine together
Best for
  • High-dose NAC supplementation
  • Short-term antioxidant nutrient support

Pros

  • Provides 1,200 mg of NAC
  • Includes a substantial benfotiamine amount
  • Combines several complementary antioxidant nutrients

Cons

  • HepatoProtection Complex is poorly defined
  • Uses zinc oxide and sodium selenite
  • Five-capsule serving is costly and inconvenient

Warnings

  • Do not use the supplement as protection from alcohol-related harm or as a reason to drink more
  • The 1,000 mg vitamin C and 1,200 mg NAC amounts may cause nausea, stomach upset, or loose stools
  • NAC may intensify headache or blood-pressure effects when combined with nitroglycerin

Nutrient quality

69 High impact

Several forms are well specified, although zinc oxide and sodium selenite are less desirable choices. N-acetyl-L-cysteine, benfotiamine, and vitamin C are provided in substantial amounts.

Ingredient transparency

71 High impact

Most active ingredients have amounts, but the named complex is recorded without a meaningful dose. Inactive capsule ingredients are not included in the supplied label data.

Customer satisfaction

72 High impact

The supplied average and volume indicate strong aggregate satisfaction. No detailed experience reports are available to identify repeated complaints or confirm perceived benefits.

Value for money

48 Lower impact

The main doses are substantial, but the short package life weakens the price-to-quality balance. Few servings are provided, making routine use comparatively costly.

Report analysis

Goals

Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Highest effect
B+ Goal FitB+ Strength of SupportA- CoverageB- Formula Quality
Vitamin E · 33.5 mgVitamin C · 1000 mgGlutathione · 50 mg

NAC, vitamin C, vitamin E, and clove polyphenols create a strong antioxidant core that may reduce inflammation-related oxidative stress. Smaller amounts of glutathione, silymarin, grape proanthocyanidins, and resveratrol broaden the protective concept.

NAC is supplied at a substantial amount, but several label additions are too small to provide comparable depth. NAC can intensify headache or low blood pressure from nitrate medicines such as nitroglycerin.

Study evidence
Glutathione Disputed 2 studies
Resveratrol Supportive 34 studies
Vitamin C Supportive 50 studies
Vitamin E Supportive 20 studies
Zinc Supportive 64 studies
Immunity
Immunity
Impact
High effect
A Goal FitB- Strength of SupportC CoverageB+ Formula Quality
Vitamin C · 1000 mgZinc · 8 mgSelenium · 25 mcg

Vitamin C supports foundational antioxidant defenses, collagen formation, and normal immune function. The formula supports antioxidant, collagen, and immune pathways but does not fill a broad range of nutrient gaps.

The label presents a substantial 1,000 mg vitamin C serving suited to focused antioxidant support. The label clearly identifies ascorbic acid, but the unbuffered form offers no absorption or stomach-comfort advantage.

Study evidence
Vitamin C Supportive 53 studies
General Health
General Health
Impact
Moderate effect
C- Goal FitB- Strength of SupportC CoverageC- Formula Quality
Selenium · 25 mcgZinc · 8 mgVitamin C · 1000 mg

Vitamin C, vitamin E, thiamine forms, zinc, selenium, and N-acetyl-L-cysteine provide substantial antioxidant and nutrient support. The combination is coherent for oxidative stress associated with alcohol exposure, but that is a specialized use rather than a general daily foundation.

Several smaller botanical and antioxidant additions are unlikely to contribute as strongly as the main actives. N-acetyl-L-cysteine at 1200 mg may cause nausea or digestive upset in sensitive users, and the broad formula is less efficient when judged only for general wellness.

Study evidence
Selenium Supportive 70 studies
Vitamin C Supportive 56 studies
Zinc Supportive 60 studies
Skin Health
Skin Health
Impact
Moderate effect
D Goal FitC+ Strength of SupportD+ CoverageF Formula Quality
Zinc · 8 mgVitamin C · 1000 mgResveratrol · 5 mgSelenium · 25 mcgVitamin E · 33.5 mg

Vitamin C, vitamin E, zinc, N-acetyl-L-cysteine, and plant antioxidants provide several ingredients with possible skin relevance. The formula is designed for alcohol-related liver support, so most of its structure is not directed at skin outcomes.

Vitamin C is substantial, but zinc oxide is a less preferred form and several antioxidants appear at small amounts. The crowded formula offers nominal breadth without collagen peptides, ceramides, or hyaluronic acid.

Study evidence
Resveratrol Supportive 7 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Zinc Supportive 66 studies

Ingredients

IngredientAmount per serving
Vitamin C (Ascorbic Acid)
 1000 mg
Vitamin E (D-Alpha-Tocopheryl Succinate)
 33.5 mg
Thiamine (Thiamine Hydrochloride, Vitamin B1)
 100 mg
Zinc (Zinc Oxide)
 8 mg
Selenium (Sodium Selenite)
 25 mcg
N-Acetyl-L-Cysteine
1200 mg
Benfotiamine
600 mg
Clovinol Clove extract (Polyphenols)
 250 mg
Glutathione
50 mg
HepatoProtection Complex
0 NP
Leucoselect Grape extract (Proanthocyanidins)
 20 mg
Silymarin (Milk Thistle extract)
 20 mg
Barley grass whole powder
15 mg
Trans-Resveratrol (Japanese Knotweed (root) extract, Red Grape (fruit) extract)
 5 mg
Adults 18–50
Report overview
Thiamin (Thiamine Hydrochloride, Vitamin B1) · 100 mg OverallScore79
A Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyB- Value

Benfotiamine and thiamine hydrochloride provide strong form quality, but the listed thiamine entries total about 700 mg. That amount exceeds the collection maximum and may be more than needed for general metabolic support. Cost efficiency is moderate for the premium active delivered, while the high dose limits broad suitability.

View ingredientView products
Vitamin C (Ascorbic Acid) · 1000 mg OverallScore52
F Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyF Value

The formula includes a well-targeted amount of plain ascorbic acid within a much broader antioxidant and botanical blend. It is not buffered and the high N-acetyl-L-cysteine amount may cause nausea or digestive upset in some users. Although the Vitamin C amount is transparent, the product is costly when judged only as a Vitamin C source.

View ingredientView products
Glutathione · 50 mg OverallScore24
F Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyF Value

The glutathione state and source are not specified, leaving absorption and purity uncertain. The amount is clearly disclosed in a convenient single capsule but is low for a standard oral form. A high serving cost makes the glutathione component poor value despite the broader antioxidant formula.

View ingredientView products
Loading alternative details
66 Performance

Complete Liver Cleanse

Nature's Way
<p>Standardized milk thistle and a larger stated glutathione amount create more direct liver-support coverage than the original’s small milk thistle and glutathione amounts. The trade-off is an undisclosed amino-acid blend and no stated NAC or benfotiamine.</p>
76 Performance

B-Complex with Vitamin C Stress Formula

Solgar
<p>A broad vitamin profile offers more balanced daily nutrient coverage and avoids the original’s short supply and narrow liver-protection positioning. It lacks NAC, benfotiamine, glutathione, and meaningful liver-focused botanicals, so it is a general nutritional alternative rather than a close targeted replacement.</p>
75 Performance

Stress B-Complex Caps

Twinlab
<p>The full vitamin C amount and broad B-vitamin profile provide clearer everyday nutrient support than the original’s mix of large core doses and many small extras. It removes NAC, glutathione, and milk thistle, and its elevated pyridoxine remains a long-term-use concern.</p>
77 Budget

Stress B with Zinc

21st Century
<p>The much lower serving cost retains vitamin C, thiamin, zinc, and a broad B-vitamin base. It does not provide the original’s NAC, benfotiamine, glutathione, or milk thistle, and its high zinc, niacin, and copper amounts reduce balance.</p>
75 Budget

Stress B-Complex Caps

Twinlab
<p>Vitamin C and broad B-vitamin coverage support a similar antioxidant and energy-oriented foundation at a lower serving cost. It omits NAC, glutathione, and the liver-focused botanicals, while elevated pyridoxine makes prolonged routine use less appealing.</p>
66 Budget

Complete Liver Cleanse

Nature's Way
<p>Milk thistle, glutathione, selenium, calcium D-glucarate, turmeric, dandelion, and artichoke preserve the liver-support focus at a lower serving cost. A hidden amino-acid blend and a large plant-sterol portion reduce transparency and make the formula less focused than it first appears.</p>
77 Value

Stress B with Zinc

21st Century
<p>Vitamin C and core B vitamins are delivered at strong serving value with clearly listed amounts. It is less aligned with liver support because it lacks NAC, benfotiamine, glutathione, and milk thistle, while its mineral doses require care.</p>
75 Value

B-Complex with Vitamin C Stress Formula

Solgar
<p>The broad vitamin C and B-complex profile offers a longer, more economical supply for general antioxidant and energy support. Standard nutrient forms and an undefined herbal blend limit quality, and none of the original’s main liver-focused actives are present.</p>
75 Value

Stress B-Complex Caps

Twinlab
<p>High vitamin C plus a complete B-vitamin base provide good practical coverage at a lower serving cost. The formula gives up the original’s NAC, benfotiamine, glutathione, and milk thistle, and the pyridoxine amount is still fairly high.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  2. Serum vitamin C and spinal pain: a nationwide study.
    Dionne CE; Laurin D; Desrosiers T; Abdous B; Le Sage N; Frenette J; Mondor M; Pelletier S · Pain · 2017
    Cross-sectional study4,742 participantsGeneral Health forVitamin C
  3. Serum type III procollagen, procollagen V, tumour necrosis factor-a, interleukin-6 in liver cirrhosis after antiviral treatment.
    Li W; Liu X; Bi F · Journal of medical biochemistry · 2025
    Randomized trial92 participantsAnti-Inflammatory Support forGlutathione
  4. Evaluation of the antioxidant and anti-inflammatory effect of sublingual glutathione on COPD patients.
    Farag A; Abass W; Qassem H · Journal of medicine and life · 2024
    Cohort study50 participantsAnti-Inflammatory Support forGlutathione
  5. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial.
    Mahjabeen W; Khan DA; Mirza SA · Complementary therapies in medicine · 2022
    Randomized trial110 participantsAnti-Inflammatory Support forResveratrol
  6. Resveratrol decreases local inflammatory markers and systemic endotoxin in patients with aggressive periodontitis.
    Zhang Q; Xu S; Xu W; Zhou Y; Luan H; Wang D · Medicine · 2022
    Randomized trial160 participantsAnti-Inflammatory Support forResveratrol
  7. Effects of resveratrol supplementation on inflammatory markers, fatigue scale, fasting blood sugar and lipid profile in relapsing-remitting multiple sclerosis patients: a double-blind, randomized placebo-controlled trial.
    Keramatzadeh S; Hosseini SA; Majdinasab N; Cheraghian B; Zilaee M · Nutritional neuroscience · 2025
    Randomized trial55 participantsAnti-Inflammatory Support forResveratrol
  8. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease.
    Tomé-Carneiro J; Gonzálvez M; Larrosa M; Yáñez-Gascón MJ; García-Almagro FJ; Ruiz-Ros JA; García-Conesa MT; Tomás-Barberán FA; Espín JC · The American journal of cardiology · 2012
    Randomized trial75 participantsAnti-Inflammatory Support forResveratrol
  9. Effects of resveratrol supplementation on risk factors of non-communicable diseases: A meta-analysis of randomized controlled trials.
    Guo XF; Li JM; Tang J; Li D · Critical reviews in food science and nutrition · 2019
    Meta-analysis1,069 participants29 studies pooledAnti-Inflammatory Support forResveratrol
  10. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  11. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  12. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  13. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  14. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  15. Effects of delta-tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial.
    Mahjabeen W; Khan DA; Mirza SA; Pervez MA · Phytotherapy research : PTR · 2021
    Randomized trial110 participantsAnti-Inflammatory Support forVitamin E
  16. Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials.
    Saboori S; Shab-Bidar S; Speakman JR; Yousefi Rad E; Djafarian K · European journal of clinical nutrition · 2016
    Meta-analysis495 participants12 studies pooledAnti-Inflammatory Support forVitamin E
  17. Efficacy of Nutritional Interventions on Inflammatory Markers in Haemodialysis Patients: A Systematic Review and Limited Meta-Analysis.
    Khor BH; Narayanan SS; Sahathevan S; Gafor AHA; Daud ZAM; Khosla P; Sabatino A; Fiaccadori E; Chinna K; Karupaiah T · Nutrients · 2018
    Meta-analysis46 studies pooledAnti-Inflammatory Support forVitamin E
  18. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.
    Chee NM; Sinnanaidu RP; Chan WK · Journal of gastroenterology and hepatology · 2024
    Meta-analysis8 studies pooledAnti-Inflammatory Support forVitamin E
  19. Delta-tocotrienol supplementation improves biochemical markers of hepatocellular injury and steatosis in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled trial.
    Pervez MA; Khan DA; Slehria AUR; Ijaz A · Complementary therapies in medicine · 2021
    Randomized trial71 participantsAnti-Inflammatory Support forVitamin E
  20. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent.
    Bao B; Prasad AS; Beck FW; Fitzgerald JT; Snell D; Bao GW; Singh T; Cardozo LJ · The American journal of clinical nutrition · 2010
    Randomized trial40 participantsAnti-Inflammatory Support forZinc
  21. Zinc Supplementation in Individuals with Prediabetes and type 2 Diabetes: a GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.
    Nazari M; Nikbaf-Shandiz M; Pashayee-Khamene F; Bagheri R; Goudarzi K; Hosseinnia NV; Dolatshahi S; Omran HS; Amirani N; Ashtary-Larky D; Asbaghi O; Ghanavati M · Biological trace element research · 2024
    Meta-analysis23 studies pooledAnti-Inflammatory Support forZinc
  22. The Effects of Zinc Supplementation on C-Reactive Protein and Inflammatory Cytokines: A Meta-Analysis and Systematical Review.
    Ceylan MN; Akdas S; Yazihan N · Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Meta-analysis73 studies pooledAnti-Inflammatory Support forZinc
  23. The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Hosseini R; Montazerifar F; Shahraki E; Karajibani M; Mokhtari AM; Dashipour AR; Ferns GA; Jalali M · Biological trace element research · 2021
    Randomized trial46 participantsAnti-Inflammatory Support forZinc
  24. Zinc supplementation and cardiovascular disease risk factors: A GRADE-assessed systematic review and dose-response meta-analysis.
    Nazari M; Ashtary-Larky D; Nikbaf-Shandiz M; Goudarzi K; Bagheri R; Dolatshahi S; Omran HS; Amirani N; Ghanavati M; Asbaghi O · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
    Meta-analysis75 studies pooledAnti-Inflammatory Support forZinc
  25. Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
    Cui Z; Xie R; Lu X; Schomburg L; Brenner H; Schöttker B · Redox biology · 2025
    Meta-analysis95 participants20 studies pooledGeneral Health forSelenium
  26. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies.
    Jayedi A; Rashidy-Pour A; Parohan M; Zargar MS; Shab-Bidar S · Advances in nutrition (Bethesda, Md.) · 2019
    Meta-analysis507,251 participants41 studies pooledGeneral Health forSelenium
  27. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
    Sharabati I; Qafesha RM; Hindawi MD; Amro S; Ayesh BM · Clinical endocrinology · 2024
    Meta-analysis4 studies pooledGeneral Health forSelenium
  28. Associations of plasma metal concentrations with the risks of all-cause and cardiovascular disease mortality in Chinese adults.
    Shi L; Yuan Y; Xiao Y; Long P; Li W; Yu Y; Liu Y; Liu K; Wang H; Zhou L; Yang H; Li X; He M; Wu T · Environment international · 2021
    Cohort study6,155 participantsGeneral Health forSelenium
  29. Updates on clinical studies of selenium supplementation in radiotherapy.
    Puspitasari IM; Abdulah R; Yamazaki C; Kameo S; Nakano T; Koyama H · Radiation oncology (London, England) · 2015
    Systematic review16 studies pooledGeneral Health forSelenium
  30. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  31. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  32. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  33. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  34. Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.
    Mohammadi F; Oshvandi K; Kamallan SR; Khazaei S; Ranjbar H; Ahmadi-Motamayel F; Gillespie M; Jenabi E; Vafaei SY · Nursing open · 2022
    Randomized trial144 participantsGeneral Health forZinc
  35. Zinc supplementation in young children with acute diarrhea in India.
    Sazawal S; Black RE; Bhan MK; Bhandari N; Sinha A; Jalla S · The New England journal of medicine · 1995
    Randomized trial937 participantsGeneral Health forZinc
  36. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13.
    Clemons TE; Kurinij N; Sperduto RD; AREDS Research Group · Archives of ophthalmology (Chicago, Ill. : 1960) · 2004
    Randomized trial4,753 participantsGeneral Health forZinc
  37. Effects of zinc and probiotic co-supplementation on inflammation, gastrointestinal symptoms, quality of life, and mood in irritable bowel syndrome patients.
    Rezazadegan M; Soheilipour M; Amani R · Scientific reports · 2026
    Randomized trial84 participantsGeneral Health forZinc
  38. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial.
    Siahbazi S; Behboudi-Gandevani S; Moghaddam-Banaem L; Montazeri A · The journal of obstetrics and gynaecology research · 2018
    Randomized trial142 participantsGeneral Health forZinc
  39. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  40. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  41. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  42. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  43. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  44. Efficacy and safety of Resveratrol combined with Ablative Fractional CO2 laser system in the treatment of skin photoaging.
    Du YM; Zeng J; Li M; Wang YB; Wu Y; Qi RQ; Gao XH; Chen HD · Journal of cosmetic dermatology · 2021
    Non-randomized trial32 participantsSkin Health forResveratrol
  45. Exploring resveratrol-enriched collagen dressings for diabetic foot ulcers: A retrospective study of wound healing outcomes.
    Sezikli İ; Kendirci M · Journal of tissue viability · 2025
    Cohort study41 participantsSkin Health forResveratrol
  46. Enhanced antioxidant effect of trans-resveratrol: potential of binary systems with polyethylene glycol and cyclodextrin.
    Moyano-Mendez JR; Fabbrocini G; De Stefano D; Mazzella C; Mayol L; Scognamiglio I; Carnuccio R; Ayala F; La Rotonda MI; De Rosa G · Drug development and industrial pharmacy · 2016
    Clinical trialSkin Health forResveratrol
  47. Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.
    Rao A; Briskey D; Roche G; Tremblay A; Da Silva Pinto M; Tompkins TA · Frontiers in aging · 2026
    Randomized trial134 participantsSkin Health forResveratrol
  48. Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect.
    Montenegro L; Parenti C; Turnaturi R; Pasquinucci L · Pharmaceutics · 2020
    Clinical trial12 participantsSkin Health forResveratrol
  49. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  50. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  51. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  52. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  53. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  54. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
    Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
    Randomized trial45 participantsSkin Health forVitamin E
  55. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
    Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
    Meta-analysis20 studies pooledSkin Health forVitamin E
  56. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forVitamin E Skin Health forZinc
  57. Effects of tocotrienol on aging skin: A systematic review.
    Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
    Systematic reviewSkin Health forVitamin E
  58. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
    Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
    Randomized trialSkin Health forVitamin E
  59. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  60. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  61. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  62. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc