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Ester-C Plus 1000 mg Vitamin C

4.6
★ ★ ★ ★ ★
(303 ratings)
Vitamin C 1000 mg
Rutin 25 mg
Acerola 25 mg
Flavonoid (mixture) 200 mg
Product Image
Score81
A well-formed high-dose buffered vitamin C product whose main value lies in Ester-C and bioflavonoids, not its small botanical extras.
How scoring works
Tablet
Quantity:90 Tablet(s) • (90 servings)
Goals:
Immunity
General Health
Skin Health
Anti-Inflammatory Support

Score 81

A well-formed high-dose buffered vitamin C product whose main value lies in Ester-C and bioflavonoids, not its small botanical extras.
How scoring works
$14.29($0.15 per serving)
Vitacost
$ 14.29
Daily Vita
$ 18.14
iHerb
$ 0.00
Report prices

Analysis

A substantial amount of buffered Ester-C supports antioxidant defenses, collagen production, and normal immune function. Calcium ascorbate should be easier on the stomach than an equivalent amount of ordinary ascorbic acid.

The bioflavonoid complex is a logical companion to the main nutrient, and all supporting amounts are stated. Acerola, rose hips, and rutin are small additions with limited value for shoppers seeking those ingredients specifically.

The formula is well suited to focused high-potency vitamin C use and offers good practical value. It does not provide the carotenoids, minerals, lipids, or structural ingredients needed for broad vision or skin coverage.

Who is it for
  • Adults seeking high-potency buffered vitamin C
  • People sensitive to acidic forms
  • Users wanting focused antioxidant support
Best for
  • Vitamin C repletion
  • Collagen cofactor support
  • Immune and antioxidant nutrition

Pros

  • Buffered branded vitamin C
  • Substantial active amount
  • Coherent bioflavonoid support

Cons

  • Small acerola and rutin amounts
  • Incomplete inactive-ingredient context
  • Limited support outside antioxidant pathways

Warnings

  • The large vitamin C amount may cause diarrhea or stomach discomfort
  • People prone to oxalate kidney stones should seek guidance before long-term high intake
  • Account for other vitamin C sources before combining supplements

Nutrient quality

88 Highest impact

Branded buffered calcium ascorbate provides a well-regarded delivery form. Vitamin C is substantial, while bioflavonoids are useful and the fruit additions remain small.

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Ingredient transparency

78 High impact

Every listed active has a specific amount. The supplied data does not include a complete inactive ingredient list.

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Customer satisfaction

65 High impact

The aggregate satisfaction measure is strong enough to support a favorable first impression. Missing feedback themes leave repeat complaints and purpose fit uncertain despite adequate volume.

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Value for money

89 Highest impact

The low price strongly supports the premium buffered form. Each serving provides substantial vitamin C at an economical cost.

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Report analysis

Goals

Immunity
Immunity
Impact
Highest effect
A Goal FitA+ Strength of SupportB- CoverageA Formula Quality
Vitamin C · 1000 mg

Buffered vitamin C provides strong support for immune-cell function, epithelial barriers, and oxidative-stress control. Quantified bioflavonoids and related plant compounds modestly extend the antioxidant strategy.

The 1,000 mg Ester-C serving is clearly disclosed and uses a stomach-friendly calcium ascorbate form. Supporting ingredients remain logically related, although the smaller fruit extracts add less certain immune value.

Study evidence
Vitamin C Supportive 53 studies
General Health
General Health
Impact
Highest effect
A- Goal FitA Strength of SupportB- CoverageA Formula Quality
Vitamin C · 1000 mg

Buffered vitamin C and quantified bioflavonoids provide strong antioxidant and connective-tissue support. The formula remains focused, yet its supporting ingredients give it more functional range than plain vitamin C alone.

The 1,000 mg Ester-C amount is clearly disclosed and uses a stomach-friendly calcium ascorbate form. Bioflavonoids, acerola, rose hips, and rutin form a coherent antioxidant combination without obscuring the primary active.

Study evidence
Vitamin C Supportive 56 studies
Skin Health
Skin Health
Impact
Highest effect
B Goal FitA Strength of SupportC+ CoverageB+ Formula Quality
Vitamin C · 1000 mg

Buffered vitamin C provides strong support for collagen formation and antioxidant defense. Bioflavonoids add complementary antioxidant activity, although the formula does not target skin hydration or barrier lipids directly.

The branded calcium ascorbate form is clearly disclosed and should be gentler than plain ascorbic acid. The large serving may cause digestive discomfort in sensitive users, especially when combined with other vitamin C sources.

Study evidence
Vitamin C Supportive 53 studies
Anti-Inflammatory Support
Cellular Defense
Anti-Inflammatory Support
Impact
High effect
B- Goal FitA Strength of SupportC CoverageA- Formula Quality
Vitamin C · 1000 mg

Buffered Ester-C provides a strong antioxidant dose with good gastric tolerance. Bioflavonoids broaden antioxidant support, although rutin and the botanical additions are present in modest amounts.

Clear disclosure and a branded vitamin C form strengthen confidence in the main active. The formula remains more supportive of oxidative balance than directly targeted to inflammatory enzymes.

Study evidence
Rutin Supportive 6 studies
Vitamin C Supportive 50 studies
Vision Support
Macular and Blue Light Defense
Vision Support
Impact
Moderate effect
D- Goal FitA+ Strength of SupportD- CoverageC Formula Quality
Vitamin C · 1000 mg

Vitamin C provides antioxidant support relevant to ocular tissues, but no macular carotenoid, zinc, or retinal lipid is included. A 1,000 mg serving provides a meaningful vitamin C amount, but it does not supply the core carotenoids or structural lipids used for targeted vision support.

The product addresses only water-soluble antioxidant defense and does not cover macular pigment or retinal lipid pathways. The simple vitamin C design is internally coherent for antioxidant supplementation.

Study evidence
Vitamin C Disputed 24 studies

Ingredients

IngredientAmount per serving
Calories
5 Calorie(s)
Total Carbohydrates
1 Gram(s)
Vitamin C (Ester-C Calcium Ascorbate)
 1000 mg
Calcium (Ester-C Calcium Ascorbate)
 100 mg
Citrus Bioflavonoid Complex
200 mg
Acerola extract
25 mg
Rose Hips
25 mg
Rutin
25 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Halal Vegetarian
Report overview
Vitamin C (Ester-C Calcium Ascorbate) · 1000 mg OverallScore92
A- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA+ Value

Patented Ester-C supplies a well-targeted 1,000 mg dose in a buffered and stomach-friendly form. Separate calcium disclosure and quantified bioflavonoids make the active profile easy to assess. Excellent cost efficiency for a premium form strengthens the practical value, though full tablet excipients are not shown.

View ingredientView products
Rutin · 25 mg OverallScore40
F Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyD+ Value

The 25 mg rutin amount is clearly disclosed but too low for targeted use. Missing source, form, purity, and standardization details weaken ingredient-quality confidence. Average cost efficiency does little to distinguish it for rutin-focused use.

View ingredientView products
Acerola · 25 mg OverallScore25
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyD+ Value
Synthetic or buffered vitamin C dominates while acerola contributes only 25 mg. No vitamin C yield, standardization percentage, or concentration ratio is disclosed for the acerola. 25 mg is a token acerola amount below the minimum potency tier. The high vitamin C amount may cause stomach upset or diarrhea in sensitive users.
View ingredientView products
Loading alternative details
86 Performance

C

Swanson
Fully buffered calcium ascorbate with citrus bioflavonoids provides a clear, well-dosed core with good stomach-comfort potential. The focused formula is easier to evaluate than the original’s bioflavonoids and small fruit additions, although it offers less ingredient variety.
86 Performance

Ester-C Plus 1000 mg Vitamin C

Solgar
High-potency buffered vitamin C and a meaningful citrus bioflavonoid amount improve form quality and formula focus. It addresses the original’s weakly characterized fruit additions, but complete excipient and usage details remain unavailable.
87 Performance

Ester-C with Citrus Bioflavonoids

American Health
Buffered Ester-C and a substantial citrus bioflavonoid amount create a more coherent antioxidant formula. The long supply strengthens practicality compared with Ester-C Plus 1000 mg Vitamin C, while inactive ingredients and full directions are not shown.
80 Budget

Ultra C Formula

Swanson Premium Brand
A very low serving cost makes a practical ascorbic acid amount a more economical option than Ester-C Plus 1000 mg Vitamin C. It is less gentle than the original buffered form, and its tiny botanical additions add little.
84 Budget

Ester-C 500 mg With Citrus Bioflavoinds

American Health
Low serving cost combines buffered Ester-C with citrus bioflavonoids, offering stronger value than Ester-C Plus 1000 mg Vitamin C. Buffered delivery preserves the original’s stomach-comfort advantage while keeping the formula focused.
84 Budget

Ester-C 24 Hour Immune Support 1000 mg

NatureSmart
A low-cost serving provides substantial buffered Ester-C with a compatible citrus bioflavonoid complex. It offers clearer core value than the original’s weakly characterized fruit additions, though complete excipient details are not supplied.
82 Value

Buffered C-1000 Complex

NOW
A substantial buffered vitamin C amount and meaningful citrus bioflavonoids provide stronger ingredient depth at favorable serving value. Acerola and rutin remain secondary, and the high vitamin C amount may cause digestive upset in sensitive users.
83 Value

Ester-C plus 500 mg Vitamin C

Solgar
Buffered Ester-C offers a practical daily amount with small, clearly disclosed botanical and flavonoid additions at strong value. The lower vitamin C amount is a trade-off, but the active and supporting amounts are clearly disclosed.
79 Value

Buffered Vitamin C 500 mg

Bluebonnet
Buffered calcium ascorbate and a meaningful citrus bioflavonoid amount offer a balanced combination of comfort, disclosure, and value. Its vitamin C amount is lower than the original’s, and rutin remains a minor addition.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusImmunity forVitamin C
  2. Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic Review and Meta-Analysis.
    Keya TA; Leela A; Fernandez K; Habib N; Rashid M · Current reviews in clinical and experimental pharmacology · 2022
    Meta-analysis10 studies pooledImmunity forVitamin C
  3. Vitamin C supplementation and salivary immune function following exercise-heat stress.
    Carrillo AE; Murphy RJ; Cheung SS · International journal of sports physiology and performance · 2009
    Randomized trial12 participantsImmunity forVitamin C
  4. Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults.
    Calder PC; Kreider RB; McKay DL · Nutrients · 2025
    Systematic review13 studies pooledImmunity forVitamin C
  5. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  6. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage.
    Fitzpatrick RE; Rostan EF · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2002
    Non-randomized trial10 participantsSkin Health forVitamin C
  7. Vitamin C and postoperative outcomes following mandibular third molar extraction: a randomized split-mouth study.
    Demirel M; Aktas A; Kizil M; Yalcin N · Oral surgery, oral medicine, oral pathology and oral radiology · 2026
    Randomized trial56 participantsSkin Health forVitamin C
  8. The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial.
    Bazyar H; Moradi L; Zaman F; Zare Javid A · Phytotherapy research : PTR · 2023
    Randomized trial50 participantsAnti-Inflammatory Support forRutin
  9. Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature.
    Muvhulawa N; Dludla PV; Ziqubu K; Mthembu SXH; Mthiyane F; Nkambule BB; Mazibuko-Mbeje SE · Pharmacological research · 2022
    Systematic reviewAnti-Inflammatory Support forRutin
  10. Rutin-loaded chitosan microspheres: Characterization and evaluation of the anti-inflammatory activity.
    Cosco D; Failla P; Costa N; Pullano S; Fiorillo A; Mollace V; Fresta M; Paolino D · Carbohydrate polymers · 2018
    OtherAnti-Inflammatory Support forRutin
  11. Oral enzyme combination therapy reduces systemic inflammation, urinary CTXII and pain in knee osteoarthritis: a proof-of-mechanism, randomised, crossover, double-blind, placebo-controlled trial.
    Henrotin Y; Pap T; Lieten S; Badot V; Dubuc JE; Urbin-Choffray D; von Eynatten M; Johansen OE; Rau S; Brabants K · RMD open · 2025
    Randomized trial45 participantsAnti-Inflammatory Support forRutin
  12. The Impact of the Combination of Proteolytic Enzyme and Rutin on the Post-operative Management of Inflammation: A Randomized, Controlled, Double-Blind, Comparative Clinical Trial
    Rathi PC, Rathi CL, Risbud SP, Ganu GP · Cureus · 2024
    Randomized trial65 participantsAnti-Inflammatory Support forRutin
  13. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support forVitamin C
  14. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  15. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  16. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  17. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  18. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  19. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  20. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  21. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  22. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  23. Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis.
    Sun L; Zhao JH; Fan WY; Feng B; Liu WW; Chen RQ; Ban C; Dang AG; Wang M; Luo KT; Zhou GY; Yu FF; Ba Y · Nutrition reviews · 2024
    Meta-analysis2,334 participants14 studies pooledImmunity forVitamin C
  24. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.
    Abioye AI; Bromage S; Fawzi W · BMJ global health · 2021
    Meta-analysisImmunity forVitamin C
  25. New evidence for antioxidant properties of vitamin C.
    Vojdani A; Bazargan M; Vojdani E; Wright J · Cancer detection and prevention · 2001
    Randomized trial20 participantsImmunity forVitamin C
  26. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  27. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  28. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  29. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  30. Role of Oral Vitamin 'C' on Astigmatic Errors in Phacoemulsification.
    Mohan S; Sah K; Khattri M; Ahmad L; Sachan SK · Current eye research · 2021
    Randomized trial400 participantsVision Support forVitamin C
  31. Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
    Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJ · Redox biology · 2019
    Observational studyVision Support forVitamin C
  32. Nutritional modulation of cataract.
    Weikel KA; Garber C; Baburins A; Taylor A · Nutrition reviews · 2014
    Narrative reviewVision Support forVitamin C
  33. Dietary n-3 Fatty Acid, α-Tocopherol, Zinc, vitamin D, vitamin C, and β-carotene are Associated with Age-Related Macular Degeneration in Japan.
    Aoki A; Inoue M; Nguyen E; Obata R; Kadonosono K; Shinkai S; Hashimoto H; Sasaki S; Yanagi Y · Scientific reports · 2017
    Case-control study530 participantsVision Support forVitamin C
  34. Adherence to a Mediterranean diet, lifestyle and age-related macular degeneration: the Coimbra Eye Study - report 3.
    Raimundo M; Mira F; Cachulo MDL; Barreto P; Ribeiro L; Farinha C; Laíns I; Nunes S; Alves D; Figueira J; Merle BM; Delcourt C; Santos L; Silva R · Acta ophthalmologica · 2019
    Case-control study883 participantsVision Support forVitamin C