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Collagen 5000 mg

4.2
★ ★ ★ ★ ★
(49 ratings)
Collagen 5000 mg
Product Image
Score68
The useful 5,000 mg collagen dose is the main strength, but fo-ti and a six-tablet serving create meaningful trade-offs. A simpler high-dose collagen formula would suit users who do not specifically want the added herb.
How scoring works
Tablet
Quantity:390 Tablet(s) • (65 servings)
Goals:
Nail Health
Skin Health
Joint Health
Bone Health
Anti-Aging
Hair Health
General Health

Score 68

The useful 5,000 mg collagen dose is the main strength, but fo-ti and a six-tablet serving create meaningful trade-offs. A simpler high-dose collagen formula would suit users who do not specifically want the added herb.
How scoring works
$23.00($0.35 per serving)
Walmart
$ 23.00
Report prices

Analysis

A 5,000 mg serving of hydrolyzed collagen peptides gives this formula enough quantity for a serious daily collagen routine. Vitamin C and biotin complement the skin, hair, and nail positioning, and the large bottle provides many servings.

The label does not state collagen source, type, protein matching, or an amino acid profile. Fo-ti adds complexity and a meaningful safety concern without being necessary to deliver collagen.

Six tablets per serving are less convenient than a powder and increase the daily pill burden. The collagen dose is attractive, but users should weigh it against the fo-ti ingredient and tablet count.

Who is it for
  • Adults seeking a multi-gram collagen tablet serving
  • People willing to take six tablets daily
Best for
  • Higher-dose collagen without a powder
  • A collagen formula with vitamin C and biotin

Pros

  • Provides 5,000 mg of hydrolyzed peptides
  • Includes vitamin C and biotin
  • Large bottle contains many servings

Cons

  • Requires six tablets per serving
  • Collagen source and type are not disclosed
  • Fo-ti adds avoidable formulation complexity

Warnings

  • Fo-ti root extract has a meaningful liver-injury concern; people with liver disease or who use medicines affecting the liver should avoid it unless a clinician specifically approves use.

Nutrient quality

71 High impact

Hydrolyzed collagen provides an absorbable form, though source, type, and standardization are not supplied. The collagen amount is meaningful, but fo-ti adds a serious formulation drawback.

Ingredient transparency

80 Highest impact

Every listed active has a specific amount and no proprietary blend hides the formula. Collagen source, type, protein matching, amino-acid data, full usage directions, and non-active ingredients are not supplied.

Customer satisfaction

52 Moderate impact

The aggregate rating is mixed, and the small review base limits confidence. No detailed feedback is supplied to assess recurring complaints or purpose-specific experiences.

Value for money

62 Moderate impact

The substantial collagen amount is cost-efficient. Fo-ti weakens quality and adds little value to an otherwise focused formula.

Report analysis

Goals

Nail Health
Nail Health
Impact
Highest effect
A Goal FitA- Strength of SupportA- CoverageB Formula Quality
Collagen · 5000 mgBiotin · 900 mcg

Five grams of hydrolyzed collagen peptides, vitamin C, and biotin create strong direct support for nail structure and growth. The collagen amount is meaningful, while vitamin C complements connective-tissue synthesis.

Source, collagen type, and amino-acid profile are not disclosed, and six tablets create a heavy daily serving. The fo-ti extract is unnecessary for nail support and has been linked to liver injury, especially in people with existing liver problems.

Study evidence
Biotin Supportive 8 studies
Collagen Supportive 4 studies
Vitamin C Supportive 1 study
Skin Health
Skin Health
Impact
Highest effect
A- Goal FitA Strength of SupportC+ CoverageB+ Formula Quality
Vitamin C · 60 mgCollagen · 5000 mg

Five grams of hydrolyzed collagen peptides directly support the skin protein matrix, with vitamin C as a synthesis cofactor. The focused structural strategy has good human evidence for selected elasticity and hydration outcomes.

The dose and hydrolyzed form are clearly disclosed, although the product lacks ceramides or a dedicated humectant. Fo-ti has been linked to liver injury, which is a notable safety drawback unrelated to collagen support.

Study evidence
Biotin Supportive 10 studies
Collagen Supportive 62 studies
Vitamin C Supportive 53 studies
Joint Health
Cartilage Support
Joint Health
Impact
Highest effect
A Goal FitA- Strength of SupportC+ CoverageB Formula Quality
Collagen · 5000 mg

Hydrolyzed collagen peptides at 5000 mg provide a meaningful structural dose, and vitamin C supports collagen synthesis. The formula is strongly aligned with cartilage and connective-tissue maintenance.

Collagen source, type, and amino acid profile are not disclosed, which limits product-level evidence matching. Fo-ti has been associated with liver injury and is an unnecessary safety concern in an otherwise focused collagen product.

Study evidence
Collagen Supportive 49 studies
Vitamin C Disputed 24 studies
Bone Health
Bone Health
Impact
High effect
B+ Goal FitB+ Strength of SupportC+ CoverageC+ Formula Quality
Vitamin C · 60 mgCollagen · 5000 mg

The collagen formula is well aligned with the flexible protein framework of bone. A substantial hydrolyzed collagen amount is paired with vitamin C to support collagen synthesis.

It does not disclose collagen type, source, or amino acid profile and provides no mineral or vitamin D support. Fo-ti has been associated with liver injury and warrants caution, particularly for people with existing liver problems.

Study evidence
Collagen Supportive 16 studies
Vitamin C Supportive 46 studies
Anti-Aging
Anti-Aging
Impact
High effect
B+ Goal FitB Strength of SupportC- CoverageB- Formula Quality
Collagen · 5000 mg

A useful hydrolyzed collagen amount directly supports structural tissues that change with age. The formula has a focused skin and joint rationale but little coverage of metabolic or cellular aging.

Collagen type, source, protein matching, and amino-acid profile are not disclosed, which limits quality assessment. The 420 mg fo-ti extract has been associated with liver injury and warrants caution, especially for people with existing liver problems.

Study evidence
Collagen Supportive 33 studies
Vitamin C Supportive 30 studies
Hair Health
Hair Health
Impact
High effect
B- Goal FitB- Strength of SupportB- CoverageB Formula Quality
Biotin · 900 mcgVitamin C · 60 mgCollagen · 5000 mg

Hydrolyzed collagen provides a substantial structural protein contribution, supported by vitamin C and biotin. Source, collagen type, and amino-acid profile are not disclosed, limiting product-specific evidence.

The combination covers structural support and a vitamin pathway with good dose depth. Fo-ti adds a significant liver safety concern and weakens the case for routine use.

Study evidence
Biotin Supportive 4 studies
Collagen Supportive 3 studies
Vitamin C Mixed 5 studies

Ingredients

IngredientAmount per serving
Vitamin C (Calcium Ascorbate)
 60 mg
Biotin
900 mcg
hydrolyzed Collagen Peptides
5000 mg
Fo-ti (root) extract
420 mg
Gluten Free Men 18–50 Dairy Free
Report overview
Collagen · 5000 mg OverallScore59
D+ Active Ingredient Quality & BioavailabilityD Dose, Safety & Label TransparencyA+ Value

A useful amount of hydrolyzed collagen peptides combines good dose strength with excellent cost efficiency. Source, collagen type, protein matching, and an amino-acid profile remain undisclosed. The 420 mg fo-ti extract has been associated with liver injury and warrants caution, especially with existing liver problems.

View ingredientView products
Loading alternative details
83 Performance

High Potency Maxi-Collagen 7000

Country Life
<p>Branded Verisol peptides and vitamin C give the formula a clear skin-support rationale. Its 7 g amount provides more collagen than the original's disclosed 5.06 g, while the named form and substantial peptide amount provide more complete general collagen coverage.</p>
85 Performance

Collagen 6000 mg

youtheory
<p>Hydrolyzed collagen is clearly identified for straightforward peptide delivery. Its 6.09 g amount provides more collagen than the original's disclosed 5.06 g, while the named form and substantial peptide amount provide more complete general collagen coverage.</p>
84 Performance

Super Collagen 6000 mg plus Vitamin C

21st Century
<p>Hydrolyzed collagen is clearly identified for straightforward peptide delivery. Its 6 g amount provides more collagen than the original's disclosed 5.06 g, while the named form and substantial peptide amount provide more complete general collagen coverage.</p>
72 Budget

Super Collagen

RejuviCare
<p>The 500 mg collagen serving comes at a lower serving cost than the original. It provides less collagen than the original's disclosed 5.06 g, which matters when total peptide intake is the priority, and the collagen amount is directly disclosed, although source and type details remain limited.</p>
73 Budget

Hydrolyzed Fish Collagen Type I 400 mg

Swanson Ultra
<p>The 800 mg collagen serving comes at a lower serving cost than the original. It provides less collagen than the original's disclosed 5.06 g, which matters when total peptide intake is the priority, and the fish source is identified, making the marine-collagen approach easier to assess.</p>
77 Budget

Advanced Collagen 1500 mg

AN Amazing Nutrition Amazing Formulas
<p>The 1.6 g collagen serving comes at a lower serving cost than the original. It provides less collagen than the original's disclosed 5.06 g, which matters when total peptide intake is the priority, and named collagen types make the source and intended coverage clearer.</p>
87 Value

Collagen + C 2500 mg

Spring Valley
<p>Clear active dosing and a favorable balance of collagen amount and serving economy make this a practical value option. Its 2.5 g collagen amount provides less collagen than the original's disclosed 5.06 g, which matters when total peptide intake is the priority.</p>
79 Value

Collagen 3000 mg Amino Acid Complex

Bronson
<p>Clear active dosing and a favorable balance of collagen amount and serving economy make this a practical value option. Its 3 g collagen amount provides less collagen than the original's disclosed 5.06 g, which matters when total peptide intake is the priority.</p>
85 Value

Collagen Skin Renewal

Natrol
<p>Clear active dosing and a favorable balance of collagen amount and serving economy make this a practical value option. Its 2.59 g collagen amount provides less collagen than the original's disclosed 5.06 g, which matters when total peptide intake is the priority.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study.
    Guadanhim LRS; Miot HA; Soares JLM; Silva SAM; Leonardi GR; Lopes RD; Bagatin E · Dermatology and therapy · 2023
    Randomized trial56 participantsSkin Health forCollagen
  2. Expanding the COL7A1 mutation database: novel and recurrent mutations and unusual genotype-phenotype constellations in 41 patients with dystrophic epidermolysis bullosa.
    Kern JS; Kohlhase J; Bruckner-Tuderman L; Has C · The Journal of investigative dermatology · 2006
    Observational study41 participantsNail Health forCollagen
  3. Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation.
    Hwang S; Won J; Kim S; Kang W; Park M · Journal of medicinal food · 2026
    Randomized trial114 participantsHair Health forCollagen
  4. The Sustained Effects of Bioactive Collagen Peptides on Skin Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Wang Y; Zhu W; Luo W; Ma Y; Zhou Y · Journal of cosmetic dermatology · 2025
    Randomized trial77 participantsSkin Health forCollagen
  5. Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study.
    Duangjai A; Srivilai J; Nangola S; Amornlerdpison D · Clinics and practice · 2025
    Randomized trialHair Health forCollagen
  6. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails.
    Hexsel D; Zague V; Schunck M; Siega C; Camozzato FO; Oesser S · Journal of cosmetic dermatology · 2018
    Single-arm trial25 participantsNail Health forCollagen
  7. Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.
    Dewi DAR; Arimuko A; Norawati L; Yenny SW; Setiasih NL; Perdiyana A; Arkania N; Nadhira F; Wiliantari N · Cureus · 2024
    Meta-analysis967 participants14 studies pooledSkin Health forCollagen
  8. Influence of collagen peptide supplementation on visible signs of skin and nail health and -aging in an East Asian population: A double blind, randomized, placebo-controlled trial.
    Vleminckx S; Virgilio N; Asserin J; Prawitt J; Silva CIF · Journal of cosmetic dermatology · 2024
    Randomized trial85 participantsNail Health forCollagen
  9. Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.
    Biełach-Bazyluk A; Jurga M; Flisiak I; Zbroch E · Nutrients · 2026
    Narrative reviewHair Health forCollagen
  10. Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
    Danessa G; Notario D; Regina R · Indian journal of dermatology, venereology and leprology · 2025
    Meta-analysis646 participants10 studies pooledSkin Health forCollagen
  11. Nail Supplements: When, How, and Why?
    Zaraa I; Richert B · Skin appendage disorders · 2026
    Narrative reviewNail Health forCollagen
  12. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.
    Proksch E; Schunck M; Zague V; Segger D; Degwert J; Oesser S · Skin pharmacology and physiology · 2014
    Randomized trial114 participantsSkin Health Anti-Aging forCollagen
  13. Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study.
    Kim J; Lee SG; Lee J; Choi S; Suk J; Lee JH; Yang JH; Yang JS; Kim J · Journal of medicinal food · 2022
    Randomized trial100 participantsSkin Health forCollagen
  14. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.
    Proksch E; Segger D; Degwert J; Schunck M; Zague V; Oesser S · Skin pharmacology and physiology · 2014
    Randomized trial69 participantsSkin Health Anti-Aging forCollagen
  15. Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
    Lee M; Kim E; Ahn H; Son S; Lee H · Food & function · 2023
    Randomized trial100 participantsSkin Health Anti-Aging forCollagen
  16. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
    Kim DU; Chung HC; Choi J; Sakai Y; Lee BY · Nutrients · 2018
    Randomized trial64 participantsSkin Health forCollagen
  17. Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis.
    Pu SY; Huang YL; Pu CM; Kang YN; Hoang KD; Chen KH; Chen C · Nutrients · 2023
    Meta-analysis1,721 participants26 studies pooledSkin Health forCollagen
  18. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
    de Miranda RB; Weimer P; Rossi RC · International journal of dermatology · 2021
    Meta-analysis1,125 participants19 studies pooledAnti-Aging Skin Health forCollagen
  19. Skin Anti-Aging and Moisturizing Effects of Low-Molecular-Weight Collagen Peptide Supplementation in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
    Lee E; Ahn DK; Kim JH; Lee S; Kim HJ; Lee HK; Shin JH · Journal of microbiology and biotechnology · 2025
    Randomized trial70 participantsAnti-Aging forCollagen
  20. Study on the Multiple Efficacies of Vitamin C Serum in Anti-Glycation, Anti-Carbonylation, Antioxidation, and Anti-Inflammation of Human Skin Based on In Vivo Tests.
    Zi Y; Liu J; Liu Q; Pan Y; Jiang X · Journal of cosmetic dermatology · 2026
    Randomized trial66 participantsAnti-Aging forVitamin C
  21. Evaluation of the anti-wrinkle effect of a lipophilic pro-vitamin C derivative, tetra-isopalmitoyl ascorbic acid.
    Yokota M; Yahagi S · Journal of cosmetic dermatology · 2022
    Randomized trial69 participantsAnti-Aging forVitamin C
  22. The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach.
    Crisan D; Roman I; Crisan M; Scharffetter-Kochanek K; Badea R · Clinical, cosmetic and investigational dermatology · 2015
    Clinical trial60 participantsAnti-Aging forVitamin C
  23. In vivo evaluation of topical ascorbic acid application on skin aging by 50 MHz ultrasound.
    Vergilio MM; Aiello LM; Furlan AS; Caritá AC; Azevedo JR; Bolzinger MA; Chevalier Y; Leonardi GR · Journal of cosmetic dermatology · 2022
    Randomized trial25 participantsAnti-Aging forVitamin C
  24. Clinical Applications of Vitamin C in Dermatology: A Systematic Review.
    Boghosian T; Mendez H; Boghosian N; Sayegh M; Beer J; Tosti A · The Journal of clinical and aesthetic dermatology · 2026
    Systematic review44 studies pooledAnti-Aging forVitamin C
  25. Undenatured type II collagen for knee osteoarthritis.
    Gupta A; Maffulli N · Annals of medicine · 2025
    Systematic review12 studies pooledAnti-Inflammatory Support forCollagen
  26. Anti-inflammatory effect of collagen tripeptide in atopic dermatitis.
    Hakuta A; Yamaguchi Y; Okawa T; Yamamoto S; Sakai Y; Aihara M · Journal of dermatological science · 2018
    Randomized trial17 participantsAnti-Inflammatory Support forCollagen
  27. [Points of undenatured type II collagen application in musculoskeletal pain syndromes treatment].
    Shavlovskaya OA; Gromova OA; Torshin IY · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2022
    Narrative reviewAnti-Inflammatory Support forCollagen
  28. Ultrasound Guided Injection of Collagen for Elbow Lateral Epicondylitis - A Pilot Study.
    Porta F; Filippucci E; Barni X; Dinescu SC; Vreju FA · Current health sciences journal · 2026
    Single-arm trial13 participantsAnti-Inflammatory Support forCollagen
  29. Effects of porcine-derived collagen hydrolysates on 24 h blood pressure profiles, markers for endothelial dysfunction and low-grade inflammation and the retinal vasculature in adults with overweight/obesity: a randomized, controlled trial.
    Chavez-Alfaro MA; Mensink RP; Joris PJ; Plat J · Food & function · 2025
    Randomized trial56 participantsAnti-Inflammatory Support forCollagen
  30. Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.
    Jiang W; Xu H; Jiang X; Zhan Y; Ju Y; Xie J; Huang Z; Huang Q; Pei F · The Journal of bone and joint surgery. American volume · 2025
    Randomized trial107 participantsAnti-Inflammatory Support Joint Health forVitamin C
  31. The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.
    Moftakhari Hajimirzaei S; Bagherzadeh Cham M; Dolikhani M; Tabatabaee SM; Ebrahimpour A · The archives of bone and joint surgery · 2026
    Meta-analysis1,162 participants10 studies pooledAnti-Inflammatory Support forVitamin C
  32. The impact of vitamin C supplementation on the perioperative outcomes after total hip and knee arthroplasty: a systematic review and meta-analysis.
    Liu X; Guo J; Li Y; Yang Y; Liu M; Gao Q; Yang Y; Wu X; Yue C · BMC musculoskeletal disorders · 2026
    Meta-analysis852 participants8 studies pooledAnti-Inflammatory Support forVitamin C
  33. Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review.
    Ruzijevaite G; Acaite E; Jagelaviciene E · Medicina (Kaunas, Lithuania) · 2025
    Systematic review811 participants17 studies pooledAnti-Inflammatory Support forVitamin C
  34. Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation.
    Korantzopoulos P; Kolettis TM; Kountouris E; Dimitroula V; Karanikis P; Pappa E; Siogas K; Goudevenos JA · International journal of cardiology · 2005
    Randomized trial44 participantsAnti-Inflammatory Support forVitamin C
  35. Effect of Calcium and Vitamin D Supplementation With and Without Collagen Peptides on Volumetric and Areal Bone Mineral Density, Bone Geometry and Bone Turnover in Postmenopausal Women With Osteopenia.
    Lampropoulou-Adamidou K; Karlafti E; Argyrou C; Makris K; Trovas G; Dontas IA; Tournis S; Triantafyllopoulos IK · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry · 2022
    Randomized trial51 participantsBone Health forCollagen
  36. Bone turnover and bone collagen maturation in osteoporosis: effects of antiresorptive therapies.
    Byrjalsen I; Leeming DJ; Qvist P; Christiansen C; Karsdal MA · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008
    Randomized trialBone Health forCollagen
  37. A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial.
    Elam ML; Johnson SA; Hooshmand S; Feresin RG; Payton ME; Gu J; Arjmandi BH · Journal of medicinal food · 2015
    Randomized trial39 participantsBone Health forCollagen
  38. Assessment of Osteoporosis in Lumbar Spine: In Vivo Quantitative MR Imaging of Collagen Bound Water in Trabecular Bone.
    Liu J; Liao JW; Li W; Chen XJ; Feng JX; Yao L; Huang PH; Su ZH; Lu H; Liao YT; Li SL; Ma YJ · Frontiers in endocrinology · 2022
    Methods validation study189 participantsBone Health forCollagen
  39. Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia.
    Argyrou C; Karlafti E; Lampropoulou-Adamidou K; Tournis S; Makris K; Trovas G; Dontas I; Triantafyllopoulos IK · Journal of musculoskeletal & neuronal interactions · 2021
    Randomized trial51 participantsBone Health forCollagen
  40. Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies.
    Zeng LF; Luo MH; Liang GH; Yang WY; Xiao X; Wei X; Yu J; Guo D; Chen HY; Pan JK; Huang HT; Liu Q; Guan ZT; Han YH; Zhao D; Zhao JL; Hou SR; Wu M; Lin JT; Li JH; Liang WX; Ou AH; Wang Q; Li ZP; Liu J · Frontiers in endocrinology · 2020
    Meta-analysis19,484 participants17 studies pooledBone Health forVitamin C
  41. Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis.
    Sun Y; Liu C; Bo Y; You J; Zhu Y; Duan D; Cui H; Lu Q · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Meta-analysis6 studies pooledBone Health forVitamin C
  42. Smoking, antioxidant vitamins, and the risk of hip fracture.
    Melhus H; Michaëlsson K; Holmberg L; Wolk A; Ljunghall S · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1999
    Cohort study66,651 participantsBone Health forVitamin C
  43. Micronutrients and the risk of hip fracture: Case-control study.
    Torbergsen AC; Watne LO; Wyller TB; Frihagen F; Strømsøe K; Bøhmer T; Mowe M · Clinical nutrition (Edinburgh, Scotland) · 2018
    Case-control study189 participantsBone Health forVitamin C
  44. Favorable effect of dietary vitamin C on bone mineral density in postmenopausal women (KNHANES IV, 2009): discrepancies regarding skeletal sites, age, and vitamin D status.
    Kim YA; Kim KM; Lim S; Choi SH; Moon JH; Kim JH; Kim SW; Jang HC; Shin CS · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Cross-sectional study1,196 participantsBone Health forVitamin C
  45. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis.
    Kumar S; Sugihara F; Suzuki K; Inoue N; Venkateswarathirukumara S · Journal of the science of food and agriculture · 2015
    Randomized trialGeneral Health forCollagen
  46. Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double-blind, placebo-controlled trial.
    Luo C; Su W; Song Y; Srivastava S · Journal of experimental orthopaedics · 2023
    Randomized trial101 participantsGeneral Health Joint Health forCollagen
  47. Healing Process, Pain, and Health-Related Quality of Life in Patients with Venous Leg Ulcers Treated with Fish Collagen Gel: A 12-Week Randomized Single-Center Study.
    Mościcka P; Cwajda-Białasik J; Szewczyk MT; Jawień A · International journal of environmental research and public health · 2022
    Randomized trial100 participantsGeneral Health forCollagen
  48. Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study.
    Shiojima Y; Takahashi M; Takahashi R; Maruyama K; Moriyama H; Bagchi D; Bagchi M; Akanuma M · Journal of the American Nutrition Association · 2023
    Randomized trial64 participantsGeneral Health forCollagen
  49. The use of a collagen matrix in hard-to-heal venous leg ulcers.
    Romanelli M; Mulder G; Paggi B; Macchia M; Panduri S; Dini V · Journal of wound care · 2016
    Randomized trial40 participantsGeneral Health forCollagen
  50. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies.
    Aune D; Keum N; Giovannucci E; Fadnes LT; Boffetta P; Greenwood DC; Tonstad S; Vatten LJ; Riboli E; Norat T · The American journal of clinical nutrition · 2019
    Meta-analysis69 studies pooledGeneral Health forVitamin C
  51. Scientific Opinion on the substantiation of a health claim related to vitamin C and increasing non haem iron absorption pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) · EFSA journal. European Food Safety Authority · 2026
    Guideline / consensusGeneral Health forVitamin C
  52. Vitamin C Depletion and All-Cause Mortality in Renal Transplant Recipients.
    Sotomayor CG; Eisenga MF; Gomes Neto AW; Ozyilmaz A; Gans ROB; Jong WHA; Zelle DM; Berger SP; Gaillard CAJM; Navis GJ; Bakker SJ · Nutrients · 2018
    Cohort study598 participantsGeneral Health forVitamin C
  53. Associations of Serum Biomarkers of Fruit and Vegetable Intake With the Risk of Cause-Specific Mortality and All-Cause Mortality: A National Prospective Cohort Study.
    Pu L; Zhang R; Wang X; Zhao T; Sun H; Han L · Frontiers in nutrition · 2022
    Cohort study12,530 participantsGeneral Health forVitamin C
  54. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition.
    Khaw KT; Bingham S; Welch A; Luben R; Wareham N; Oakes S; Day N · Lancet (London, England) · 2001
    Cohort study19,496 participantsGeneral Health forVitamin C
  55. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health Nail Health Skin Health forBiotin
  56. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health Skin Health forBiotin
  57. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  58. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  59. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  60. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  61. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  62. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  63. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
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    Case reportHair Health forVitamin C
  64. Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability.
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    Lugo JP; Saiyed ZM; Lane NE · Nutrition journal · 2016
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    Han G; Ye Y; Kang P · Drug design, development and therapy · 2025
    Randomized trial100 participantsJoint Health forVitamin C
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    Cross-sectional study4,733 participantsJoint Health forVitamin C
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    Ramón R; Holguín E; Chiriboga JD; Rubio N; Ballesteros C; Ezechieli M · Journal of personalized medicine · 2023
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    Fain O · Joint bone spine · 2005
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  72. Biotin for the treatment of nail disease: what is the evidence?
    Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
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  73. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
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  74. Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
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    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forBiotin
  76. Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
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  77. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
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  80. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
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  81. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  82. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
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    Randomized trial25 participantsSkin Health forVitamin C
  83. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
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    Cross-sectional study4,025 participantsSkin Health forVitamin C