5-HTP 100 mg Fast Dissolve Mixed Berry Natural Flavor

5-HTP 100 mg Fast Dissolve Mixed Berry Natural Flavor

Natrol4.4 (2,785 ratings)
Format:Tablet Quantity: 30 Tablet(s) · 30 servings
Goals
$14.00 $0.46 per serving
Pure FormulasLowest$14.00iHerb$15.59Vitacost$15.59Amazon$15.59

About this product

The 100 mg 5-HTP serving matches a conventional full amount and comes from named Griffonia simplicifolia. Fast-dissolve delivery may be convenient for users who have difficulty swallowing standard tablets or capsules.

The formula may support serotonin-related mood, stress, or sleep goals, but its weight-management role is indirect. Dissolving quickly does not broaden the mechanism or establish better absorption from the supplied data.

No extract standardization percentage or specific interaction warning is shown. The flavored delivery is a preference feature rather than a meaningful improvement in ingredient quality or safety.

Who is it for
  • People who dislike swallowing capsules
  • Users seeking a flavored 100 mg 5-HTP tablet
Best for
  • Convenient dissolvable dosing
  • Standard-strength serotonin-pathway support

Pros

  • Provides 100 mg of 5-HTP
  • Names Griffonia simplicifolia
  • Fast-dissolve format is easy to take

Cons

  • No stated extract standardization
  • No demonstrated release or absorption advantage
  • Covers only one pathway

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, triptans, or other serotonin-raising medicines without medical supervision.
  • 5-HTP may cause nausea, digestive discomfort, drowsiness, or vivid dreams.
  • Use care with other sedating products until tolerance is known.

Product analysis

76 out of 100
Fast-dissolve delivery makes a standard 5-HTP serving easier to take. It adds convenience but not broader support, better standardization, or clearer safety guidance.

AI assessment of the formula, label and price. How scoring works

Nutrient quality86

Griffonia simplicifolia is identified as the source, but the plant part and active standardization are not both clear. The 100 mg 5-HTP serving is well aligned with common supplemental use, while the focused design avoids unrelated actives.

.
Ingredient transparency82

All supplied active ingredients have specific amounts, and no proprietary blend hides key doses. Serving count is available, but full intake directions, excipients, and a serotonin-medication warning are absent from the supplied label details.

.
Customer satisfaction63

The supplied aggregate rating is mixed, which lowers confidence in consistent customer satisfaction. No review text is provided to identify repeated complaints or firsthand experiences tied to the intended uses.

.
Value for money66

Cost efficiency per equivalent active amount appears limited, with the standard dose shaping practical value. The single-active formula does not use decorative ingredients to justify its cost.

.
Format
Tablet
Container
30 Tablet(s)
Per serving
$0.46
Customer rating
4.4 · 2,785 ratings
Report analysis

Goals

Sleep Support
Sleep Support
Impact
Moderate effect
A Ingredient FitC PathwaysC- EvidenceA+ Formulation Logic

5-HTP may offer limited support through the serotonin–melatonin precursor route, with possible relevance mainly for poor sleepers. The supplied context doesn't establish a broad benefit across adults.

The product is labeled fast dissolve, but the ingredient facts don't establish a faster sleep effect from this form. The label's 100 mg is per serving, and its conflicting frequency details don't establish a daily total.

How this product is rated for Sleep Support

Ingredient fit95

5-HTP is the only ingredient with a described sleep role, and the amount is given per serving.
Goal fit
The product's only active with a specific sleep role is 5-HTP.
Dose adequacy
The label lists 100 mg 5-HTP per serving; directions allow up to two servings, but don't establish a required daily regimen.

Pathways60

5-HTP maps to the precursor route, without separate calming or sleep-timing coverage.
Depth
The product's possible support is concentrated in serotonin–melatonin precursor metabolism.
Breadth
Only the precursor route is represented, leaving other sleep processes outside the formula.

Evidence58

5-HTP's possible role is limited and context-specific, and the fast-dissolve label doesn't resolve that uncertainty.
Evidence strength
The supplied context points to possible benefit mainly for poor sleepers, not a broad adult effect.
Studied preparation
A distinct fast-dissolve 5-HTP preparation isn't identified in the ingredient facts.

Formulation logic100

5-HTP can stand alone, with no configured sleep conflict; the per-serving amount isn't a daily total.
Partner coverage
The 5-HTP contribution doesn't depend on a partner ingredient.
Conflicts
5-HTP is the only active listed, and it does not trigger a configured bedtime conflict.
Effective doses
The 100 mg amount is per serving; uncertain daily frequency doesn't change what one serving provides.
Study evidence
5-HTP Supportive 1 study
Stress Relief
Stress Relief
Impact
Moderate effect
A Ingredient FitD PathwaysC- EvidenceA+ Formulation Logic

5-HTP may help with anxiety or stress in some circumstances, but whether that translates into everyday stress relief is unclear. Its connection here is mainly to mood-related processes, with a smaller link to sleep recovery. The declared amount is known, though that alone cannot tell you how much calmer you might feel.

How this product is rated for Stress Relief

Ingredient fit95

5-HTP is the sole declared active relevant here. The serving supplies 100 mg of 5-HTP, matching the middle quantity reference of 100 mg.
Goal fit
5-HTP is the sole declared active relevant here.
Dose adequacy
The serving supplies 100 mg of 5-HTP, matching the middle quantity reference of 100 mg.

Pathways46

The main connection is to mood-related processes, with a smaller sleep-related contribution.
Depth
The main connection is to mood-related processes, with a smaller sleep-related contribution.
Breadth
Mood-related processes are the main connection, rather than broad coverage of several stress-related roles.

Evidence56

5-HTP’s possible stress benefit remains conditional, with uncertain everyday applicability.
Evidence strength
5-HTP’s possible stress benefit remains conditional, with uncertain everyday applicability.
Studied preparation
The identified relevant ingredients have preparation identities compatible with their possible roles; that does not guarantee a personal benefit.

Formulation logic100

The relevant ingredients can act individually without a required added partner. No particular ingredient conflict is identified.
Partner coverage
The relevant ingredients do not require an additional partner for their individual roles.
Conflicts
No particular ingredient conflict is identified.
Effective doses
The serving supplies 100 mg of 5-HTP, matching the middle quantity reference of 100 mg.
Study evidence
5-HTP Supportive 18 studies
Mood Support
Mood Support
Impact
Highest effect
A Ingredient FitC- PathwaysA EvidenceA+ Formulation Logic
5-HTP · 100 mg

5-HTP is a building block for serotonin, a chemical involved in mood signalling. That role doesn't tell us whether taking it will improve everyday mood. Its benefit for generally healthy adults remains unclear, and the declared amount alone cannot predict how you'll feel.

How this product is rated for Mood Support

Ingredient fit95

5-HTP relates to serotonin production, but that mechanism alone cannot predict improved mood.
Goal fit
5-HTP relates to serotonin production, but that mechanism alone cannot predict improved mood.
Dose adequacy
5-HTP supplies 100 mg per serving.

Pathways59

The main connection involves mood-related chemical signalling, but a mechanism alone cannot predict an emotional benefit.
Depth
The main connection involves mood-related chemical signalling, but a mechanism alone cannot predict an emotional benefit.
Breadth
The main connection involves mood-related chemical signalling, but a mechanism alone cannot predict an emotional benefit.

Evidence94

A serotonin-precursor role leaves the everyday mood benefit of 5-HTP uncertain.
Evidence strength
A serotonin-precursor role leaves the everyday mood benefit of 5-HTP uncertain.
Studied preparation
The named ingredients are identified; a matching ingredient identity alone does not guarantee the same mood benefit in every person.

Formulation logic100

No particular ingredient conflict or missing required partner is identified. Declared amounts describe one serving, not a confirmed daily regimen.
Partner coverage
No required ingredient partner is missing for the relevant ingredients.
Conflicts
No particular ingredient conflict is identified.
Effective doses
5-HTP supplies 100 mg per serving.
Study evidence
5-HTP Supportive 9 studies
Weight Loss
Weight Loss
Impact
Moderate effect
B- Ingredient FitF PathwaysC EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 5 studies

Ingredients

IngredientAmount per servingScore
5-HTP (Griffonia simplicifolia)
 100 mg 80
Adults 18–50 Dairy Free Vegetarian
Report overview
5-HTP (Griffonia simplicifolia) · 100 mg OverallScore80
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC Value
Each serving clearly provides 100 mg of 5-HTP, and the label names Griffonia simplicifolia. It doesn't state a standardization percentage, so the extract's strength is unclear. A specific warning about serotonin-modulating medicines is included, and the cost per 100 mg is moderate.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The listed ingredient has a named plant source, but the label leaves extract strength unspecified.
Botanical Source & Standardization
It names Griffonia simplicifolia but gives no percentage showing how much of the extract is 5-HTP.

Dose, Safety & Label Transparency100

The serving amount is clear, and the label includes a specific medicine warning.
Dosage Potency & Range
Each serving lists 100 mg of 5-HTP.
Safety Warnings & Label Clarity
A specific warning covers SSRIs, antidepressants, or other serotonin-modulating medicines.

Value60

The disclosed dose makes its cost easy to compare.
Price per 100mg 5-HTP
The cost per 100 mg of 5-HTP is moderate.
View ingredientView products
Loading alternative details
85 Performance

5-HTP 100 mg

NOW
Clearer botanical sourcing makes this a stronger quality alternative. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP 100 mg Extra Strength

Swanson
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
83 Performance

5-HTP Enhanced with Vitamins B6 and C

Doctor's Best
A more focused formula and stronger disclosed ingredient profile make this a better quality choice. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
84 Budget

5-HTP 50 mg

NOW
The lower recurring cost makes this a more economical eligible choice. Its 50 mg 5-HTP serving offers a more cautious starting option than the original’s 100 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
85 Budget

5-HTP 100 mg

Doctor's Best
The lower recurring cost makes this a more economical eligible choice. Its 100 mg 5-HTP serving matches the original amount while offering a different formula or package choice. The same serious interaction caution with serotonin-raising medicines applies.
82 Budget

5-HTP 50 mg

Swanson Premium Brand
The lower recurring cost makes this a more economical eligible choice. Its 50 mg 5-HTP serving offers a more cautious starting option than the original’s 100 mg amount. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP 200mg

Best Naturals
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
83 Value

5-HTP with Vitamin B6 & Vitamin C

Lake Avenue Nutrition
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. The active amount is disclosed, but botanical-source detail remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
82 Value

5-HTP 200 mg Maximum Strength

Swanson
Focused 5-HTP dosing and a lower recurring cost create a favorable quality-to-cost balance. A Griffonia source is identified, but active standardization remains incomplete. The same serious interaction caution with serotonin-raising medicines applies.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  2. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  3. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  4. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  5. Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients.
    Maes M; Vandewoude M; Schotte C; Maes L; Martin M; Blockx P · Acta psychiatrica Scandinavica · 1990
    Clinical trial120 participantsStress Relief for5-HTP
  6. Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).
    Bertolini F; Robertson L; Bisson JI; Meader N; Churchill R; Ostuzzi G; Stein DJ; Williams T; Barbui C · The Cochrane database of systematic reviews · 2022
    Systematic review2,023 participants13 studies pooledStress Relief for5-HTP
  7. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  8. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  9. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  10. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  11. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  12. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  13. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  14. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  15. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  16. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  17. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  18. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  19. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP