Product Image

Melatonin Activated Micro-Soluble Spray W/Bioavailability Enhancing Cofactors Natural Peppermint

Natures Plus
4.6
★ ★ ★ ★ ★
(1246 ratings)
Melatonin 1.5 mg
Product Image
Score79
A convenient 1.5 mg peppermint spray fits lower-dose sleep-onset use. Tiny cofactors add little, and accurate spray measurement matters.
How scoring works
Quantity:2 Liquid(s) • (80 servings)
Goals:
Sleep Support

Score 79

A convenient 1.5 mg peppermint spray fits lower-dose sleep-onset use. Tiny cofactors add little, and accurate spray measurement matters.
How scoring works
$18.66($0.23 per serving)
iHerb
$ 18.66
iHerb
$ 18.66
Vitacost
$ 18.99
Walmart
$ 18.66
Report prices

Analysis

The peppermint spray delivers 1.5 mg melatonin, a cautious-to-moderate amount for sleep onset. Oral spray delivery may be convenient for users who avoid tablets.

Vitamin B6 and vitamin E are small supporting additions, while GABA is present at only 2.5 mg. Those cofactors are unlikely to drive the sleep result.

Eighty servings support reasonable bottle life, though the routine cost exceeds many tablets. Accurate use depends on consistent spray volume and following the supplied pump directions.

Who is it for
  • Adults preferring oral sprays
  • People seeking a lower melatonin amount
  • Users who like peppermint flavor
Best for
  • Fast bedtime administration
  • Pill-free sleep support
  • Travel-friendly use

Pros

  • Low-to-moderate 1.5 mg amount
  • Convenient spray format
  • Includes 80 servings
  • Clear active amounts

Cons

  • GABA amount is negligible
  • Cofactors add little direct value
  • Spray consistency affects dosing
  • Costs more than basic tablets

Warnings

  • Use the stated number of sprays to avoid dosing errors
  • Melatonin can impair alertness after use

Nutrient quality

91 Highest impact

Micro-soluble spray delivery supports rapid sleep-onset use. The low melatonin amount closely fits physiological sleep signaling.

Ingredient transparency

78 High impact

The melatonin and any listed supporting nutrients have specific amounts. The provided facts omit the complete inactive-ingredient and flavoring list.

Customer satisfaction

71 High impact

The supplied aggregate rating is strong. No specific review comments are provided to assess whether negative complaints repeat.

Value for money

71 High impact

The formula quality is reasonable for its simple sleep-support role. The recurring cost is reasonable for the delivery format.

Report analysis

Goals

Sleep Support
Sleep Support
Impact
Highest effect
A+ Goal FitA Strength of SupportC+ CoverageB+ Formula Quality
Melatonin · 1.5 mg

Melatonin supports sleep timing, and the 1.5 mg amount is well suited with a lower-dose approach. The oral spray may act conveniently around bedtime, while the tiny GABA amount is unlikely to add much.

Melatonin, GABA, and vitamin B6 doses are clear. The main limitation is that it relies almost entirely on melatonin despite presenting several cofactors.

Study evidence
GABA Supportive 4 studies
Melatonin Supportive 181 studies
Vitamin B6 Disputed 7 studies

Ingredients

IngredientAmount per serving
Vitamin E (D-Alpha-Tocopheryl Acetate)
 1 IU
Vitamin B6 (Pyridoxine Hydrochloride)
 2.5 mg
Melatonin
1.5 mg
GABA
2500 mcg
Gluten Free Adults 18–50
Report overview
Melatonin · 1.5 mg OverallScore68
F Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC Value

A one-spray serving delivers a physiological 1.5 mg dose through a rapid-onset format. The spray lacks stated sustained-release technology, so it is oriented toward sleep initiation. Its above-median cost reflects the specialized delivery, but no independent purity certification is disclosed.

View ingredientView products
Loading alternative details
88 Performance

Melatonin 1.0 mg Orange Flavor

Source Naturals Sleep Science
<p>A clearly disclosed 1 mg melatonin amount is lower than the original's 1.5 mg amount and may suit more conservative dosing. The focused formula and stronger supplied quality profile make it a better-supported option, although the different dose or delivery format may change how it fits individual use.</p>
87 Performance

Melatonin 1 mg

Nature's Bounty
<p>A clearly disclosed 1 mg melatonin amount is lower than the original's 1.5 mg amount and may suit more conservative dosing. The focused formula and stronger supplied quality profile make it a better-supported option, although the different dose or delivery format may change how it fits individual use.</p>
87 Performance

Melatonin Lozenges 3 mg

Life Extension
<p>A clearly disclosed 3 mg melatonin amount is higher than the original's 1.5 mg amount and may not suit people who prefer lower exposure. The focused formula and stronger supplied quality profile make it a better-supported option, although the different dose or delivery format may change how it fits individual use.</p>
84 Budget

Melatonin 1 mg

Spring Valley
<p>The 1 mg amount is lower than the original's 1.5 mg amount and may suit more conservative dosing while lowering the serving cost. The supplied active list stays focused on melatonin without another active ingredient.</p>
83 Budget

Melatonin 3 mg

Nature Made
<p>The 3 mg amount is higher than the original's 1.5 mg amount and may not suit people who prefer lower exposure while lowering the serving cost. The added calcium is not central to the sleep-timing goal.</p>
85 Budget

Melatonin 1 mg

Swanson Premium Brand
<p>The 1 mg amount is lower than the original's 1.5 mg amount and may suit more conservative dosing while lowering the serving cost. The supplied active list stays focused on melatonin without another active ingredient.</p>
88 Value

Melatonin 1.0 mg Peppermint Flavor

Source Naturals Sleep Science
<p>The 1 mg melatonin serving combines clear active disclosure with favorable value in the supplied data. It is lower than the original's 1.5 mg amount and may suit more conservative dosing, so dose fit matters alongside the cost advantage.</p>
83 Value

Melatonin 3 mg

NOW
<p>The 3 mg melatonin serving combines clear active disclosure with favorable value in the supplied data. It is higher than the original's 1.5 mg amount and may not suit people who prefer lower exposure, so dose fit matters alongside the cost advantage.</p>
83 Value

Melatonin 3 mg

21st Century
<p>The 3 mg melatonin serving combines clear active disclosure with favorable value in the supplied data. It is higher than the original's 1.5 mg amount and may not suit people who prefer lower exposure, so dose fit matters alongside the cost advantage.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Meta-analysis: melatonin for the treatment of primary sleep disorders.
    Ferracioli-Oda E; Qawasmi A; Bloch MH · PloS one · 2013
    Meta-analysis1,683 participants19 studies pooledSleep Support forMelatonin
  2. Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis.
    Salanitro M; Wrigley T; Ghabra H; de Haan E; Hill CM; Solmi M; Cortese S · Neuroscience and biobehavioral reviews · 2022
    Meta-analysis1,998 participants34 studies pooledSleep Support forMelatonin
  3. Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis.
    Li T; Jiang S; Han M; Yang Z; Lv J; Deng C; Reiter RJ; Yang Y · Frontiers in neuroendocrinology · 2019
    Meta-analysis205 participants7 studies pooledSleep Support forMelatonin
  4. Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial.
    Sletten TL; Magee M; Murray JM; Gordon CJ; Lovato N; Kennaway DJ; Gwini SM; Bartlett DJ; Lockley SW; Lack LC; Grunstein RR; Rajaratnam SMW; Delayed Sleep on Melatonin (DelSoM) Study Group · PLoS medicine · 2019
    Randomized trial116 participantsSleep Support forMelatonin
  5. Melatonin treatment for age-related insomnia.
    Zhdanova IV; Wurtman RJ; Regan MM; Taylor JA; Shi JP; Leclair OU · The Journal of clinical endocrinology and metabolism · 2001
    Randomized trial30 participantsSleep Support forMelatonin
  6. Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis.
    Tsukinaga A; Mihara T; Takeshima T; Tomita M; Goto T · Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023
    Meta-analysis516 participants8 studies pooledSleep Support forMelatonin
  7. Unintended consequences: college students' melatonin usage, sleep disturbance, and depressive symptoms.
    Peltz JS; Rogge R · Sleep and biological rhythms · 2025
    Cohort study331 participantsSleep Support forMelatonin
  8. The Effectiveness of Melatonin for Sleep Disturbances in Parkinson' Disease: Systematic Review and Meta-Analysis.
    Yousef O; Abouelmagd ME; Khaddam H; Shbani A; Yousef R; Meshref M; Hanafi I · Journal of sleep research · 2026
    Meta-analysis409 participants8 studies pooledSleep Support forMelatonin
  9. Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial.
    Byun JI; Shin YY; Chung SE; Shin WC · Journal of clinical neurology (Seoul, Korea) · 2020
    Randomized trial40 participantsSleep Support forGABA
  10. Analysis of the Effects of Known Sleep-Support Supplements in Relation to Life Habits, Sleep Conditions, and Sleep Problems.
    Imafuku F; Yamamoto K; Tanaka E; Aoki R; Nishino S · Nutrients · 2023
    Randomized trial160 participantsSleep Support forGABA
  11. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
    Plante DT; Jensen JE; Schoerning L; Winkelman JW · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012
    Case-control study40 participantsSleep Support forGABA
  12. GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial.
    Guimarães AP; Seidel H; Pires LVM; Trindade CO; Baleeiro RDS; Souza PM; Silva FGDE; Coelho DB; Becker LK; Oliveira EC · Journal of dietary supplements · 2024
    Randomized trial30 participantsSleep Support forGABA
  13. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety.
    Wade AG; Ford I; Crawford G; McConnachie A; Nir T; Laudon M; Zisapel N · BMC medicine · 2010
    Randomized trial791 participantsSleep Support forMelatonin
  14. Effects of exogenous melatonin on sleep: a meta-analysis.
    Brzezinski A; Vangel MG; Wurtman RJ; Norrie G; Zhdanova I; Ben-Shushan A; Ford I · Sleep medicine reviews · 2005
    Meta-analysis284 participants8 studies pooledSleep Support forMelatonin
  15. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  16. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  17. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  18. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  19. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6