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Megasorb CoQ-10 600 mg

Solgar
4.7
★ ★ ★ ★ ★
(876 ratings)
Coenzyme Q-10 600 mg
Product Image
Score75
600 mg of ubiquinone offers focused CoQ10 support with an appropriate fat-soluble delivery format. The large amount is more targeted than routine.
How scoring works
Quantity:30 Softgel(s) • (30 servings)
Goals:
Anti-Aging
Cardiovascular Support
Metabolism Boost
Energy
Heart Health
Anti-Inflammatory Support

Score 75

600 mg of ubiquinone offers focused CoQ10 support with an appropriate fat-soluble delivery format. The large amount is more targeted than routine.
How scoring works

Also available as

6 options
60.00mg • 120 Softgel(s) servings Coenzyme Q-10 60 mg • 120 Softgel(s) • 120 servings $23.99 ($0.19 per serving) 100.00mg • 90 Softgel(s) servings Coenzyme Q-10 100 mg • 90 Softgel(s) • 90 servings $29.62 ($0.32 per serving) 100.00mg • 60 Softgel(s) servings Coenzyme Q-10 100 mg • 60 Softgel(s) • 60 servings $22.12 ($0.36 per serving) 200.00mg • 60 Softgel(s) servings Coenzyme Q-10 200 mg • 60 Softgel(s) • 60 servings $35.99 ($0.59 per serving) 200.00mg • 30 Softgel(s) servings Coenzyme Q-10 200 mg • 30 Softgel(s) • 30 servings $19.49 ($0.64 per serving) 400.00mg • 60 Softgel(s) servings Coenzyme Q-10 400 mg • 60 Softgel(s) • 60 servings $57.74 ($0.96 per serving)
$36.04($1.20 per serving)
Daily Vita
$ 42.90
iHerb
$ 36.59
Pure Formulas
$ 38.99
Vitacost
$ 39.27
Amazon
$ 36.04
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Analysis

The serving supplies 600 mg of ubiquinone. CoQ10 supports mitochondrial energy production and acts as a fat-soluble antioxidant, with the clearest practical value when intake, synthesis, or status is inadequate.

Ubiquinone is an established form with broad use, although it relies more on conversion to ubiquinol after absorption. Softgel delivery is appropriate for a fat-soluble ingredient and generally supports better uptake than a dry powder capsule.

The amount is far above routine maintenance and is better suited to a specific, monitored reason than casual daily use. The single-active formula does not cover broader energy, lipid, inflammatory, or metabolic pathways, so it should be viewed as focused CoQ10 support.

Who is it for
  • Adults seeking higher targeted CoQ10 intake
  • People wanting a focused single-ingredient formula
Best for
  • Supporting mitochondrial energy production
  • Foundational cardiovascular nutrient support

Pros

  • Clearly identifies ubiquinone
  • Provides a clearly stated 600 mg amount
  • Uses a softgel suited to a fat-soluble ingredient

Cons

  • Single-ingredient design provides narrow pathway coverage
  • Amount is unusually high for routine use
  • Higher amount may be unnecessary for basic maintenance

Warnings

  • CoQ10 can reduce warfarin’s anticoagulant effect, so INR monitoring and prescriber coordination are important.
  • CoQ10 may add to the blood-pressure-lowering effect of antihypertensive medicines and can cause dizziness in susceptible users.
  • Digestive upset, headache, or sleep disturbance can occur; taking it earlier in the day with food may improve tolerance.
  • The 600 mg amount is high and should have a defined clinical or nutritional rationale rather than being used automatically.

Nutrient quality

79 High impact

Established ubiquinone and softgel delivery provide useful ingredient quality. The amount is very high and sits above the main researched range, while the very high amount is unnecessarily aggressive for routine general use.

.

Ingredient transparency

80 High impact

The ubiquinone form and active amount are clearly disclosed without a hidden blend. Serving directions and inactive ingredients are not supplied.

.

Customer satisfaction

67 High impact

The supplied average rating is strong and comes from a moderate rating pool. No firsthand experiences or recurring complaint details were provided, so consistency remains uncertain.

.

Value for money

72 High impact

The large amount is economical by ingredient weight, but it is more than many users need. The high serving cost and aggressive dose reduce practical value.

.
Report analysis

Goals

Anti-Aging
Anti-Aging
Impact
High effect
A- Goal FitB Strength of SupportC CoverageA- Formula Quality
Coenzyme Q-10 · 600 mg

CoQ10 directly supports mitochondrial energy and antioxidant defense, but the 600 mg serving is unusually large for routine healthy-aging support. Such a high amount may be more appropriate for a specific supervised use than for general maintenance.

Ubiquinone is clearly identified, yet it is less readily absorbed than ubiquinol for some users. The formula remains focused, but more CoQ10 does not add another aging pathway.

Study evidence
Coenzyme Q-10 Supportive 6 studies
Cardiovascular Support
Cardiovascular Support
Impact
High effect
A Goal FitB- Strength of SupportD CoverageA Formula Quality
Coenzyme Q-10 · 600 mg

CoQ10 directly supports cardiac energy production and antioxidant defense. The 600 mg serving is unusually high and is better suited to a deliberate, supervised use than routine maintenance.

Softgel delivery is appropriate for fat-soluble ubiquinone, although the carrier oil is not identified. CoQ10 may reduce warfarin’s anticoagulant effect, making medication review especially important at this amount.

Study evidence
Coenzyme Q-10 Supportive 89 studies
Metabolism Boost
Metabolism Boost
Impact
High effect
C+ Goal FitA- Strength of SupportC- CoverageA Formula Quality
Coenzyme Q-10 · 600 mg

CoQ10 directly supports mitochondrial energy production, making it relevant to metabolic efficiency. Human evidence supports energy-related benefits in some populations, but it does not consistently show a higher metabolic rate.

The 600 mg amount provides very strong pathway depth but may reduce warfarin's anticoagulant effect. Ubiquinone is clearly identified, and softgel delivery supports absorption of this fat-soluble active.

Study evidence
Coenzyme Q-10 Disputed 11 studies
Energy
Energy
Impact
High effect
A- Goal FitB- Strength of SupportD+ CoverageA Formula Quality
Coenzyme Q-10 · 600 mg

Ubiquinone directly supports mitochondrial energy production and antioxidant protection. The 600 mg serving provides a meaningful amount for a focused CoQ10 formula.

The softgel offers lipid-compatible delivery, although a carrier oil is not identified. CoQ10 may reduce warfarin's anticoagulant effect, making medication-specific review important at this high amount.

Study evidence
Coenzyme Q-10 Supportive 32 studies
Heart Health
Heart Health
Impact
High effect
A- Goal FitC+ Strength of SupportF CoverageA- Formula Quality
Coenzyme Q-10 · 600 mg

CoQ10 directly supports cardiac cellular energy, but the unusually large ubiquinone amount is beyond common maintenance use. The softgel format may help absorption, although the lipid carrier is not disclosed.

The high dose adds caution without broadening cardiovascular pathway coverage. People taking warfarin should discuss this dose with their prescriber because CoQ10 may reduce the anticoagulant effect.

Study evidence
Coenzyme Q-10 Supportive 114 studies
Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
High effect
C- Goal FitB Strength of SupportD+ CoverageA Formula Quality
Coenzyme Q-10 · 600 mg

CoQ10 supports mitochondrial antioxidant function and may modestly influence inflammatory markers. It is less directly aligned than curcumin, boswellia, bromelain, or omega-3 fatty acids.

Ubiquinone is established but requires conversion to the reduced form. The unusually high amount may reduce warfarin’s anticoagulant effect and requires specific monitoring.

Study evidence
Coenzyme Q-10 Supportive 46 studies

Ingredients

IngredientAmount per serving
Megasorb Coenzyme Q-10 (Ubiquinone)
 600 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Coenzyme Q-10 (Ubiquinone) · 600 mg OverallScore73
C Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyA+ Value

Ubiquinone is an established CoQ10 form but requires conversion to ubiquinol. The 600 mg ubiquinone serving sits above the main researched range but does not exceed the high-dose cutoff. The upper-end amount warrants extra care because CoQ10 may reduce warfarin’s anticoagulant effect.

View ingredientView products
Loading alternative details
87 Performance

Extra Strength Ubiquinol 200 mg

NOW
The reduced ubiquinol form at 200 mg supports absorption and keeps the formula closely aligned with CoQ10 use. The provided quality and goal assessments are stronger than the original, although the ingredient list still does not provide independent testing or certification details.
85 Performance

Mega Ubiquinol CoQ10 100 mg

Qunol
The reduced ubiquinol form at 100 mg supports absorption and keeps the formula closely aligned with CoQ10 use. The provided quality and goal assessments are stronger than the original, although the ingredient list still does not provide independent testing or certification details.
85 Performance

Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support 100 mg

Life Extension
The reduced ubiquinol form at 100 mg supports absorption and keeps the formula closely aligned with CoQ10 use. The provided quality and goal assessments are stronger than the original, although the added shilajit makes the formula less focused and may not suit people seeking CoQ10 alone.
87 Budget

Mega CoQ10 Ubiquinol 100 mg

Qunol
The reduced ubiquinol form at 100 mg supports absorption and keeps the formula closely aligned with CoQ10 use. Its lower serving cost improves routine value compared with the original; the ingredient list still does not provide independent testing or certification details.
86 Budget

Ubiquinol 100 mg

NOW
The reduced ubiquinol form at 100 mg supports absorption and keeps the formula closely aligned with CoQ10 use. Its lower serving cost improves routine value compared with the original; the ingredient list still does not provide independent testing or certification details.
87 Budget

QH-absorb 100 mg

Jarrow Formulas
The reduced ubiquinol form at 100 mg supports absorption and keeps the formula closely aligned with CoQ10 use. Its lower serving cost improves routine value compared with the original; the ingredient list still does not provide independent testing or certification details.
87 Value

CoQ10 200 mg

California Gold Nutrition
A clearly stated ubiquinone dose at 200 mg provides a focused CoQ10 formula without unrelated active ingredients. Strong provided quality and goal assessments combine with favorable serving economics, improving the balance of formulation and value; Ubiquinone is the oxidized form, so people specifically seeking ubiquinol may prefer another option.
84 Value

High Absorption CoQ10 200 mg

Doctor's Best
Ubiquinone at 200 mg is paired with black pepper extract to support absorption, adding a practical feature to a focused CoQ10 formula. Strong provided quality and goal assessments combine with favorable serving economics, improving the balance of formulation and value; Black pepper extract can affect how some medicines are handled, so medication users should check suitability.
79 Value

Ubiquinol 100 mg

Qunol
Named Kaneka ubiquinol at 100 mg gives clear disclosure of the reduced CoQ10 form, which is often chosen for easier absorption. Strong provided quality and goal assessments combine with favorable serving economics, improving the balance of formulation and value; the ingredient list still does not provide independent testing or certification details.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.
    Qu H; Guo M; Chai H; Wang WT; Gao ZY; Shi DZ · Journal of the American Heart Association · 2019
    Meta-analysis575 participants12 studies pooledEnergy forCoenzyme Q-10
  2. Coenzyme Q10 Supplementation in Athletes: A Systematic Review.
    Fernandes MSS; Fidelis DEDS; Aidar FJ; Badicu G; Greco G; Cataldi S; Santos GCJ; de Souza RF; Ardigò LP · Nutrients · 2026
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  3. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies.
    Mehrabani S; Askari G; Miraghajani M; Tavakoly R; Arab A · Complementary therapies in medicine · 2019
    Systematic review16 studies pooledEnergy forCoenzyme Q-10
  4. Coenzyme Q10 supplementation increases blood concentrations but shows limited and inconsistent effects on exercise performance: a systematic review and meta-analysis.
    Deng H; Song T; Yin M; Xu K; Zhong Y; Mohd NB; Naharudin MNB; Yusof A; Fan X · The British journal of nutrition · 2026
    Meta-analysis24 studies pooledEnergy forCoenzyme Q-10
  5. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer.
    Lesser GJ; Case D; Stark N; Williford S; Giguere J; Garino LA; Naughton MJ; Vitolins MZ; Lively MO; Shaw EG; Wake Forest University Community Clinical Oncology Program Research Base · The journal of supportive oncology · 2013
    Randomized trial236 participantsEnergy forCoenzyme Q-10
  6. Platelet mitochondrial function and endogenous coenzyme Q10 levels are reduced in patients after COVID-19.
    Sumbalova Z; Kucharska J; Palacka P; Rausova Z; Langsjoen PH; Langsjoen AM; Gvozdjakova A · Bratislavske lekarske listy · 2022
    Cross-sectional study25 participantsEnergy forCoenzyme Q-10
  7. Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview.
    Mantle D; Hargreaves I · Antioxidants (Basel, Switzerland) · 2020
    Narrative reviewAnti-Aging forCoenzyme Q-10
  8. Coenzyme Q10 Supplementation in Aging and Disease.
    Hernández-Camacho JD; Bernier M; López-Lluch G; Navas P · Frontiers in physiology · 2022
    Narrative reviewAnti-Aging forCoenzyme Q-10
  9. Coenzyme Q10, a cutaneous antioxidant and energizer.
    Hoppe U; Bergemann J; Diembeck W; Ennen J; Gohla S; Harris I; Jacob J; Kielholz J; Mei W; Pollet D; Schachtschabel D; Sauermann G; Schreiner V; Stäb F; Steckel F · BioFactors (Oxford, England) · 1999
    Clinical trialAnti-Aging forCoenzyme Q-10
  10. Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals.
    Pabis K; Wang W; Selvarajoo K; Budovskaya YV; Sorrentino V; Gruber J; Kennedy BK · Aging cell · 2026
    Cross-sectional study4,260 participantsAnti-Aging forCoenzyme Q-10
  11. Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults.
    Schmücker M; Tranberg C; Borch J; Kaae MK; Damgaard M; Flensted-Jensen M; Blom I; Morosetti M; Barbarossa S; Orlando P; Tiano L; Dela F; Helge JW; Larsen S · GeroScience · 2026
    Randomized trial40 participantsAnti-Aging forCoenzyme Q-10
  12. The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.
    Taghizadeh S; Izadi A; Shirazi S; Parizad M; Pourghassem Gargari B · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2021
    Randomized trial43 participantsAnti-Inflammatory Support forCoenzyme Q-10
  13. The effects of coenzyme Q10 supplementation on metabolic profiles and parameters of mental health in women with polycystic ovary syndrome.
    Karamali M; Gholizadeh M · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2022
    Randomized trial55 participantsAnti-Inflammatory Support forCoenzyme Q-10
  14. Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials.
    Hou S; Tian Z; Zhao D; Liang Y; Dai S; Ji Q; Fan Z; Liu Z; Liu M; Yang Y · Molecular nutrition & food research · 2023
    Meta-analysis1,517 participants31 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  15. Can coenzyme Q10 supplementation effectively reduce human tumor necrosis factor-α and interleukin-6 levels in chronic inflammatory diseases? A systematic review and meta-analysis of randomized controlled trials.
    Farsi F; Heshmati J; Keshtkar A; Irandoost P; Alamdari NM; Akbari A; Janani L; Morshedzadeh N; Vafa M · Pharmacological research · 2020
    Meta-analysis509 participants9 studies pooledAnti-Inflammatory Support forCoenzyme Q-10
  16. Promising efficacy of coenzyme Q10 supplementation as adjunctive therapy in juvenile idiopathic arthritis: a randomized-controlled pilot study.
    Elsherif N; Shousha G; Sabri NA; Shawki MA · Immunopharmacology and immunotoxicology · 2026
    Randomized trial58 participantsAnti-Inflammatory Support forCoenzyme Q-10
  17. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials.
    Liu Z; Tian Z; Zhao D; Liang Y; Dai S; Liu M; Hou S; Dong X; Zhaxinima; Yang Y · The Journal of clinical endocrinology and metabolism · 2022
    Meta-analysis2,794 participants50 studies pooledCardiovascular Support Heart Health forCoenzyme Q-10
  18. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
    Vrentzos E; Ikonomidis I; Pavlidis G; Katogiannis K; Korakas E; Kountouri A; Pliouta L; Michalopoulou E; Pelekanou E; Boumpas D; Lambadiari V · Cardiovascular diabetology · 2024
    Randomized trial60 participantsCardiovascular Support forCoenzyme Q-10
  19. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial.
    Mortensen SA; Rosenfeldt F; Kumar A; Dolliner P; Filipiak KJ; Pella D; Alehagen U; Steurer G; Littarru GP; Q-SYMBIO Study Investigators · JACC. Heart failure · 2015
    Randomized trial420 participantsCardiovascular Support forCoenzyme Q-10
  20. [Coenzyme Q-10 in the treatment of patients with chronic heart failure and reduced left ventricular ejection fraction: systematic review and meta-analysis].
    Mareev VY; Mareev YV; Begrambekova YL · Kardiologiia · 2022
    Meta-analysis1,139 participants6 studies pooledCardiovascular Support forCoenzyme Q-10
  21. Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.
    Mortensen AL; Rosenfeldt F; Filipiak KJ · Cardiology journal · 2020
    Randomized trialCardiovascular Support forCoenzyme Q-10
  22. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Tsai IC; Hsu CW; Chang CH; Tseng PT; Chang KV · Frontiers in pharmacology · 2024
    Meta-analysis1,126 participants13 studies pooledEnergy forCoenzyme Q-10
  23. Antifatigue effects of coenzyme Q10 during physical fatigue.
    Mizuno K; Tanaka M; Nozaki S; Mizuma H; Ataka S; Tahara T; Sugino T; Shirai T; Kajimoto Y; Kuratsune H; Kajimoto O; Watanabe Y · Nutrition (Burbank, Los Angeles County, Calif.) · 2008
    Randomized trial17 participantsEnergy forCoenzyme Q-10
  24. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial.
    Sabbatinelli J; Orlando P; Galeazzi R; Silvestri S; Cirilli I; Marcheggiani F; Dludla PV; Giuliani A; Bonfigli AR; Mazzanti L; Olivieri F; Antonicelli R; Tiano L · Nutrients · 2021
    Randomized trial51 participantsHeart Health forCoenzyme Q-10
  25. Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Zhao D; Liang Y; Dai S; Hou S; Liu Z; Liu M; Dong X; Zhan Y; Tian Z; Yang Y · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis1,831 participants26 studies pooledHeart Health forCoenzyme Q-10
  26. Effects of Coenzyme Q10 on Lipid, Glycemic, and Inflammatory Markers in Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Zhang Z; Liu Z; Geng Y; Huang Y; Hu R; Li F; Song Y; Zhang M · Journal of diabetes research · 2026
    Meta-analysis3,422 participants64 studies pooledHeart Health Metabolism Boost forCoenzyme Q-10
  27. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals.
    Zhang P; Yang C; Guo H; Wang J; Lin S; Li H; Yang Y; Ling W · Journal of clinical lipidology · 2019
    Randomized trial101 participantsHeart Health forCoenzyme Q-10
  28. Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial.
    Zhang P; Chen K; He T; Guo H; Chen X · Nutrition & metabolism · 2022
    Randomized trial101 participantsMetabolism Boost forCoenzyme Q-10
  29. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis.
    Hu X; Wang W; Su X; Peng H; Tan Z; Li Y; Huang Y · PeerJ · 2023
    Meta-analysis2,362 participants41 studies pooledMetabolism Boost forCoenzyme Q-10
  30. Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise.
    Diaz-Castro J; Mira-Rufino PJ; Moreno-Fernandez J; Chirosa I; Chirosa JL; Guisado R; Ochoa JJ · Food & function · 2021
    Randomized trial100 participantsMetabolism Boost forCoenzyme Q-10
  31. The effect of coenzyme Q10 intake on metabolic profiles in women candidates for in-vitro fertilization: a randomised trial.
    Ahmadi Asouri S; Asemi R; Aghadavod E; Jamilian M · Annals of medicine and surgery (2012) · 2024
    Randomized trial40 participantsMetabolism Boost forCoenzyme Q-10