5-HTP 100 mg

5-HTP 100 mg

Spring Valley4.3 (285 ratings)
Format:Capsule Quantity: 30 Capsule(s) · 15 servings
Goals
$4.90 $0.32 per serving

About this product

The ingredient data show 200 mg of 5-HTP per serving from Griffonia simplicifolia seed extract. That is a high-strength amount delivered through two capsules, so the title may not communicate the full serving exposure clearly.

5-HTP may support mood or sleep through serotonin production, while its role in weight management is indirect and less reliable. The formula does not provide broader stress, circadian, or appetite-support pathways.

Extract standardization is not supplied, and the label data show no targeted serotonin-medication warning. A higher serving gives sensitive users less room to assess tolerance unless they deliberately use fewer capsules than the stated serving.

Who is it for
  • Experienced 5-HTP users who want a high-strength serving
  • People who can adjust a two-capsule serving carefully
Best for
  • High-potency serotonin-pathway support
  • Split-capsule dose adjustment

Pros

  • Identifies Griffonia seed extract
  • Provides a substantial active amount
  • Two capsules allow partial-serving use

Cons

  • Full serving amount differs from the title emphasis
  • High dose may be excessive for new users
  • Extract standardization is not disclosed

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, triptans, or other serotonin-raising medicines without medical supervision.
  • The 200 mg serving may increase nausea, digestive discomfort, drowsiness, or vivid dreams.
  • Check the two-capsule serving carefully to avoid unintentionally taking more 5-HTP than expected.

Product analysis

75 out of 100
The full serving supplies a potent 200 mg amount rather than the 100 mg highlighted in the name. It may suit experienced users, but dose clarity and safety labeling need more care.

AI assessment of the formula, label and price. How scoring works

Nutrient quality75

The named Griffonia seed extract gives the active a clear botanical source, although no standardization percentage is supplied. The 200 mg 5-HTP serving is meaningful but aggressive for general use, and added nutrients do not remove that dosing concern.

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Ingredient transparency84

All supplied active ingredients have specific amounts, and no proprietary blend hides key doses. Serving count is available, but full intake directions, excipients, and a serotonin-medication warning are absent from the supplied label details.

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Customer satisfaction58

The supplied aggregate rating is mixed, which lowers confidence in consistent customer satisfaction. No review text is provided to identify repeated complaints or firsthand experiences tied to the intended uses.

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Value for money80

Cost efficiency per equivalent active amount appears good, with the high-strength dose shaping practical value. The calcium addition contributes little to the core serotonin-precursor purpose.

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Format
Capsule
Container
30 Capsule(s)
Per serving
$0.32
Customer rating
4.3 · 285 ratings
Report analysis

Goals

Sleep Support
Impact
Moderate effect
B+ Ingredient FitC PathwaysC- EvidenceA+ Formulation Logic

5-HTP may offer a connection to sleep through the serotonin-melatonin precursor pathway, but its contribution to better sleep is uncertain. This formula centers on that one route, without a separate ingredient for sleep timing or relaxation.

The per-serving amount is 200 mg, and calcium is also listed without an established sleep role. The product's potential contribution therefore comes mainly from a single precursor ingredient rather than a broader sleep-focused combination.

How this product is rated for Sleep Support

Ingredient fit81

5-HTP is the sole ingredient with a sleep-related role; calcium is listed separately without an established sleep contribution.
Goal fit
5-HTP is the only sleep-related ingredient; calcium doesn't add an established sleep role.
Dose adequacy
The serving contains 200 mg of 5-HTP; calcium's amount and sleep role aren't established here.

Pathways60

The formula focuses on the serotonin-melatonin precursor route and leaves timing and calming routes uncovered.
Depth
The main route is precursor support for serotonin and melatonin, not direct sleep timing.
Breadth
Only the precursor route is covered; separate timing and calming routes are absent.

Evidence58

5-HTP has a limited, uncertain sleep connection, rather than a broadly established role across adults.
Evidence strength
5-HTP's possible sleep contribution is limited and doesn't establish a general benefit.
Studied preparation
The product names 5-HTP but provides no separate preparation identity for it.

Formulation logic100

5-HTP is included on its own, with no listed conflict or missing partner.
Partner coverage
5-HTP is included alone; no required partner is missing.
Conflicts
No caffeine or other specific activating ingredient is listed.
Effective doses
The 200 mg amount is per serving, but quantity alone doesn't establish a stronger sleep effect.
Study evidence
5-HTP Supportive 1 study
Mood Support
Impact
Highest effect
B+ Ingredient FitC- PathwaysA EvidenceA+ Formulation Logic
5-HTP · 200 mg

5-HTP is a building block for serotonin, a chemical involved in mood. That role alone doesn't tell you whether taking it will make you feel better. A routine mood benefit for generally healthy adults remains unclear, so its presence shouldn't be taken as a promise of better emotional well-being.

How this product is rated for Mood Support

Ingredient fit81

The ingredient choice relates to mood, although the practical benefit depends on the ingredient and preparation.
Goal fit
5-HTP is the main relevant ingredient here.
Dose adequacy
5-HTP provides 200 mg per serving. This amount alone does not predict mood improvement.

Pathways59

The main connection involves chemical signals associated with mood; that role alone does not guarantee a mood improvement.
Depth
The main connection involves chemical signals associated with mood; that role alone does not guarantee a mood improvement.
Breadth
Connections with mood-related processes do not predict how much your emotional well-being will change.

Evidence94

5-HTP is a serotonin precursor, but its everyday mood benefit remains unclear.
Evidence strength
5-HTP is a serotonin precursor, but its everyday mood benefit remains unclear.
Studied preparation
Ingredient identity alone does not remove the limitations on who may benefit.

Formulation logic100

No particular ingredient conflict is identified. The combination itself does not show how much your mood will change.
Partner coverage
No additional partner is required by the ingredient relationships described here.
Conflicts
No particular conflict between the declared ingredients is identified.
Effective doses
The relevant amounts are declared, but they do not guarantee an individual mood benefit.
Study evidence
5-HTP Supportive 9 studies
Weight Loss
Impact
Moderate effect
B- Ingredient FitF PathwaysC EvidenceA+ Formulation Logic
Study evidence
5-HTP Supportive 5 studies
Stress Relief
Impact
Moderate effect
B+ Ingredient FitD PathwaysC- EvidenceA+ Formulation Logic

5-HTP may help with some anxiety and stress-related symptoms, but how well that translates to everyday stress relief remains uncertain. The serving provides 200 mg, at the upper end of the comparison range. That amount alone doesn't make the benefit more predictable, and the possible effects remain specific to the circumstances in which 5-HTP helps.

How this product is rated for Stress Relief

Ingredient fit81

5-HTP may help with selected anxiety and stress-related symptoms; everyday applicability remains uncertain.
Goal fit
5-HTP is the stress-related ingredient, alongside calcium.
Dose adequacy
The 200 mg serving is at the upper comparison amount for 5-HTP; that is not proof of greater benefit.

Pathways46

5-HTP relates chiefly to mood-related chemical processes, while its practical stress benefit remains conditional.
Depth
5-HTP relates chiefly to mood-related chemical processes, while its practical stress benefit remains conditional.
Breadth
The connection is concentrated in mood-related processes rather than a broad range of stress effects.

Evidence56

5-HTP may help with selected anxiety and stress-related symptoms; everyday applicability remains uncertain.
Evidence strength
5-HTP may help with selected anxiety and stress-related symptoms; everyday applicability remains uncertain.
Studied preparation
The declared ingredient can be related to its stress context, while the stated limits on benefit still apply.

Formulation logic100

No particular ingredient conflict or missing required companion is identified. The declared amounts do not guarantee a stress benefit.
Partner coverage
The relevant ingredient does not require a missing companion for this use.
Conflicts
No particular ingredient conflict is identified.
Effective doses
The 200 mg serving is at the upper comparison amount for 5-HTP; that is not proof of greater benefit.
Study evidence
5-HTP Supportive 18 studies

Ingredients

IngredientAmount per servingScore
Calcium
128 mg
5-HTP (Griffonia simplicifolia Seed Extract)
200 mg 82
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
B- Active Ingredient Quality & BioavailabilityA Dose, Safety & Label TransparencyA- Value
The selected two-capsule serving provides 200 mg of 5-HTP from Griffonia simplicifolia, though no standardization percentage is given. The label includes a specific warning about interactions with serotonin medicines. Its cost per 100 mg is below the collection's typical price, so the larger serving remains relatively economical.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The label names a botanical source but doesn't state how much of the extract is 5-HTP.
Botanical Source & Standardization
Griffonia simplicifolia is identified, but the label doesn't give a 5-HTP standardization percentage.

Dose, Safety & Label Transparency93

A two-capsule serving supplies 200 mg and comes with a specific drug-interaction warning.
Dosage Potency & Range
The selected serving provides 200 mg of 5-HTP.
Safety Warnings & Label Clarity
The label specifically warns about use with SSRIs or other serotonin-modulating medicines.

Value85

The cost for a standard 100 mg amount is below the collection's typical price.
Price per 100mg 5-HTP
Its cost per 100 mg is below the collection's typical price.
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Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients.
    Cangiano C; Laviano A; Del Ben M; Preziosa I; Angelico F; Cascino A; Rossi-Fanelli F · International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity · 1998
    Randomized trial25 participantsWeight Loss for5-HTP
  2. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
    Cangiano C; Ceci F; Cascino A; Del Ben M; Laviano A; Muscaritoli M; Antonucci F; Rossi-Fanelli F · The American journal of clinical nutrition · 1992
    Randomized trial20 participantsWeight Loss for5-HTP
  3. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity.
    Halford JC; Harrold JA; Boyland EJ; Lawton CL; Blundell JE · Drugs · 2007
    Narrative reviewWeight Loss for5-HTP
  4. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.
    Evans C; Mekhail V; Curtis J; Czartoryski P; Kaminski J; Ellerbroek A; Bustillo E; Jiannine L; Santana JC; Antonio J · Journal of dietary supplements · 2023
    Randomized trial48 participantsWeight Loss for5-HTP
  5. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects.
    Ceci F; Cangiano C; Cairella M; Cascino A; Del Ben M; Muscaritoli M; Sibilia L; Rossi Fanelli F · Journal of neural transmission · 1989
    Clinical trial19 participantsWeight Loss for5-HTP
  6. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  7. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  8. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  9. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  10. Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients.
    Maes M; Vandewoude M; Schotte C; Maes L; Martin M; Blockx P · Acta psychiatrica Scandinavica · 1990
    Clinical trial120 participantsStress Relief for5-HTP
  11. Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).
    Bertolini F; Robertson L; Bisson JI; Meader N; Churchill R; Ostuzzi G; Stein DJ; Williams T; Barbui C · The Cochrane database of systematic reviews · 2022
    Systematic review2,023 participants13 studies pooledStress Relief for5-HTP
  12. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  13. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  14. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  15. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  16. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  17. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  18. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  19. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP