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D3 1000 IU

Nature Made
4.6
★ ★ ★ ★ ★
(83 ratings)
Vitamin D 1000 IU
Product Image
Score85
Best suited to immunity, with the clearest benefits coming from the disclosed active ingredients. Its single-nutrient design offers strong depth for Vitamin D but does not address other immune pathways.
How scoring works
Quantity:180 Softgel(s) • (180 servings)
Goals:
Immunity
General Health
Anti-Inflammatory Support
Energy
Anti-Aging
Testosterone Support

Score 85

Best suited to immunity, with the clearest benefits coming from the disclosed active ingredients. Its single-nutrient design offers strong depth for Vitamin D but does not address other immune pathways.
How scoring works
$8.23($0.04 per serving)
Walmart
$ 9.38
Vitacost
$ 8.23
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Analysis

Vitamin D3 directly supports immune-cell development and communication. The 1,000 IU amount is suitable for routine maintenance rather than correction of a known deficiency. The softgel provides a lipid-based format that suits this fat-soluble vitamin.

Vitamin D3 supports a foundational endocrine pathway and the softgel format aids absorption. The amount is suitable for routine maintenance but remains below a more targeted daily range for many adults. Benefits for testosterone are most likely when vitamin D status is low, and a blood test can guide need.

Cholecalciferol provides the preferred vitamin D form. Its lipid-based format supports absorption of this fat-soluble vitamin. The 1,000 IU serving is suitable for routine maintenance, and cost efficiency is favorable for the amount supplied.

Who is it for
  • People seeking immunity support
  • People seeking general health support
  • People seeking anti-inflammatory support support
Best for
  • Immunity
  • General Health
  • Anti-Inflammatory Support

Pros

  • Vitamin D3 directly supports immune-cell development and communication.
  • The 1,000 IU amount is suitable for routine maintenance rather than correction of a known deficiency.
  • The softgel provides a lipid-based format that suits this fat-soluble vitamin.
  • Vitamin D3 provides focused support for calcium absorption, immune function, and maintenance of normal bone health.
  • The softgel format suits this fat-soluble vitamin and the cholecalciferol form is clearly identified.

Cons

  • Its single-nutrient design offers strong depth for Vitamin D but does not address other immune pathways.
  • The daily amount is useful for routine maintenance, particularly when sun exposure or dietary intake is limited.
  • The narrow formula does not address other nutritional gaps, but it delivers its single purpose cleanly.
  • The formula is lean and transparent, but it covers only one anti-inflammatory pathway.
  • Vitamin D can improve fatigue when low status is a contributing factor, but it is not a direct acute energy enhancer.

Warnings

  • Benefits for testosterone are most likely when vitamin D status is low, and a blood test can guide need.

Nutrient quality

96 Highest impact

Cholecalciferol in a softgel is a well-absorbed form and suitable delivery format. The vitamin D3 amount is suitable for routine maintenance use.

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Ingredient transparency

85 Highest impact

The single active ingredient has a specific amount. A complete oil carrier and inactive ingredient list was not supplied.

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Customer satisfaction

59 Moderate impact

The available aggregate rating is strong for this category. No firsthand outcome details were supplied, so alignment with the intended use is uncertain.

.

Value for money

95 Highest impact

The preferred D3 form and softgel delivery provide strong quality for the serving cost. The product is highly competitive among basic vitamin D softgels.

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Report analysis

Goals

Immunity
Immunity
Impact
Highest effect
A- Goal FitA- Strength of SupportC CoverageA+ Formula Quality
Vitamin D · 1000 IU

Vitamin D3 directly supports immune-cell development and communication. The 1,000 IU amount is suitable for routine maintenance rather than correction of a known deficiency.

The softgel provides a lipid-based format that suits this fat-soluble vitamin. Its single-nutrient design offers strong depth for Vitamin D but does not address other immune pathways.

Study evidence
Vitamin D Supportive 85 studies
General Health
General Health
Impact
Highest effect
A Goal FitA- Strength of SupportD+ CoverageA+ Formula Quality
Vitamin D · 1000 IU

Vitamin D3 provides focused support for calcium absorption, immune function, and maintenance of normal bone health. The daily amount is useful for routine maintenance, particularly when sun exposure or dietary intake is limited.

The softgel format suits this fat-soluble vitamin and the cholecalciferol form is clearly identified. The narrow formula does not address other nutritional gaps, but it delivers its single purpose cleanly.

Study evidence
Vitamin D Supportive 115 studies
Anti-Inflammatory Support
Systemic Inflammatory Balance
Anti-Inflammatory Support
Impact
High effect
B Goal FitB+ Strength of SupportD- CoverageA+ Formula Quality
Vitamin D · 1000 IU

Vitamin D3 offers focused immune modulation that may help maintain a balanced inflammatory baseline. The amount is suitable for routine maintenance rather than intensive correction.

Cholecalciferol and softgel delivery support good absorption. The formula is lean and transparent, but it covers only one anti-inflammatory pathway.

Study evidence
Vitamin D Supportive 101 studies
Energy
Energy
Impact
High effect
C+ Goal FitB+ Strength of SupportD CoverageA Formula Quality
Vitamin D · 1000 IU

Vitamin D can improve fatigue when low status is a contributing factor, but it is not a direct acute energy enhancer. Human evidence supports correcting vitamin D deficiency to improve related fatigue, while benefit in replete users is less consistent.

The 1000 IU amount supports routine vitamin D maintenance rather than providing a token dose. Cholecalciferol is clearly disclosed in a lipid softgel appropriate for fat-soluble absorption.

Study evidence
Vitamin D Supportive 32 studies
Anti-Aging
Anti-Aging
Impact
High effect
C+ Goal FitB+ Strength of SupportD+ CoverageA Formula Quality
Vitamin D · 1000 IU

Vitamin D3 supports bone, muscle, and immune function at a practical maintenance amount. Softgel delivery is well suited to absorption of this fat-soluble nutrient.

A single vitamin cannot address mitochondrial decline, oxidative stress, or structural aging broadly. The focused and transparent formula works best as one foundation within a wider plan.

Study evidence
Vitamin D Supportive 50 studies
Testosterone Support
Testosterone Support
Impact
High effect
B- Goal FitB Strength of SupportD- CoverageA+ Formula Quality
Vitamin D · 1000 IU

Vitamin D3 supports a foundational endocrine pathway and the softgel format aids absorption. The amount is suitable for routine maintenance but remains below a more targeted daily range for many adults.

Benefits for testosterone are most likely when vitamin D status is low, and a blood test can guide need. The single-nutrient design provides useful depth without covering zinc, magnesium, boron, or stress pathways.

Study evidence
Vitamin D Supportive 56 studies

Ingredients

IngredientAmount per serving
Vitamin D3 (Cholecalciferol)
 1000 IU
Gluten Free Adults 18–50
Report overview
Vitamin D (Cholecalciferol) · 1000 IU OverallScore78
A Active Ingredient Quality & BioavailabilityC Dose, Safety & Label TransparencyB+ Value

Cholecalciferol provides the preferred vitamin D form. Its lipid-based format supports absorption of this fat-soluble vitamin. The 1,000 IU serving is suitable for routine maintenance, and cost efficiency is favorable for the amount supplied.

View ingredientView products
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<p>A focused formula supplies 2000 IU of cholecalciferol without unrelated active ingredients. Its focused formula and dose alignment support practical value, although it does not undercut the original’s serving cost and uses a higher vitamin D amount, so suitability depends more heavily on measured status and professional guidance.</p>
86 Value

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<p>A focused formula supplies 2000 IU of cholecalciferol without unrelated active ingredients. Its focused formula and dose alignment support practical value, although it does not undercut the original’s serving cost and uses a higher vitamin D amount, so suitability depends more heavily on measured status and professional guidance.</p>
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Vitamin D-3 2000 IU

Source Naturals
<p>A focused formula supplies 2000 IU of cholecalciferol without unrelated active ingredients. Its focused formula and dose alignment support practical value, although it does not undercut the original’s serving cost and uses a higher vitamin D amount, so suitability depends more heavily on measured status and professional guidance.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Current opinion on the role of vitamin D supplementation in respiratory infections and asthma/COPD exacerbations: A need to establish publication guidelines for overcoming the unpublished data.
    Anitua E; Tierno R; Alkhraisat MH · Clinical nutrition (Edinburgh, Scotland) · 2022
    Meta-analysis50,554 participants65 studies pooledImmunity forVitamin D
  2. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
    Zhu Z; Zhu X; Gu L; Zhan Y; Chen L; Li X · Frontiers in nutrition · 2022
    Meta-analysis4,859 participants10 studies pooledImmunity forVitamin D
  3. Vitamin D supplementation and hospitalization for infection in older adults: A post-hoc analysis of data from the Australian D-Health Trial.
    Pham H; Waterhouse M; Baxter C; Romero BD; McLeod DS; Armstrong BK; Ebeling PR; English DR; Hartel G; O'Connell RL; van der Pols JC; Venn AJ; Webb PM; Whiteman DC; Neale RE · The American journal of clinical nutrition · 2023
    Randomized trial21,315 participantsImmunity forVitamin D
  4. Effect of vitamin D status and vitamin D supplementation on immune function and prevention of acute respiratory tract infections in dark-skinned individuals: a systematic review and meta-analysis.
    Bournot AR; Darling AL; Givens ID; Lovegrove JA; Lanham-New SA; Hart KH · Public health nutrition · 2024
    Meta-analysis36,707 participants18 studies pooledImmunity forVitamin D
  5. Effect of moderate or high versus low dose daily vitamin D on COVID-19 incidence: A double-blind, parallel-group randomized clinical trial.
    Meltzer DO; Moy JN; Schram AW; Tate A; Hyman MJ; Cursio JF; Vokes T; Yeo KJ; Prochaska M; Jacobs JJ; Solway J · Clinical nutrition (Edinburgh, Scotland) · 2026
    Randomized trial955 participantsImmunity forVitamin D
  6. Effect of Vitamin D Supplementation on Fatigue in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
    López-Muñoz P; Torres-Costoso AI; Fernández-Rodríguez R; Guzmán-Pavón MJ; de Arenas-Arroyo SN; Basco-López JÁ; Reina-Gutiérrez S · Nutrients · 2023
    Meta-analysis345 participants5 studies pooledEnergy forVitamin D
  7. Vitamin D for the management of multiple sclerosis.
    Jagannath VA; Filippini G; Di Pietrantonj C; Asokan GV; Robak EW; Whamond L; Robinson SA · The Cochrane database of systematic reviews · 2018
    Meta-analysis933 participants12 studies pooledEnergy forVitamin D
  8. Vitamin D levels and menopause-related symptoms.
    LeBlanc ES; Desai M; Perrin N; Wactawski-Wende J; Manson JE; Cauley JA; Michael YL; Tang J; Womack C; Song Y; Johnson KC; O'Sullivan MJ; Woods N; Stefanick ML · Menopause (New York, N.Y.) · 2015
    Cross-sectional study530 participantsEnergy forVitamin D
  9. Fatigue and Vitamin D Status in Frail Elderly with and without Cancer, and Healthy Controls of Different Ages: Results from the IMAGE Study.
    Dahlén E; Hedman C; Mily A; Alisjahbana A; Spulber G; Holmström-Edstedt J; Bergman P; Buggert M; Björkhem-Bergman L · Gerontology · 2025
    Cohort study273 participantsEnergy forVitamin D
  10. Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trials.
    Serag I; Abouzid M; Alsaadany KR; Hendawy M; Ali HT; Yaseen Y; Moawad MHED · European journal of medical research · 2025
    Meta-analysis1,903 participants21 studies pooledEnergy forVitamin D
  11. Supplementation with vitamin D does not increase serum testosterone levels in healthy males.
    Jorde R; Grimnes G; Hutchinson MS; Kjærgaard M; Kamycheva E; Svartberg J · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2014
    Randomized trialTestosterone Support forVitamin D
  12. Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized control trial.
    Saha S; Goswami R; Ramakrishnan L; Vishnubhatla S; Mahtab S; Kar P; Srinivasan S; Singh N; Singh U · Clinical endocrinology · 2019
    Randomized trial228 participantsTestosterone Support forVitamin D
  13. Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
    Rafiq R; van Schoor NM; Sohl E; Zillikens MC; Oosterwerff MM; Schaap L; Lips P; de Jongh RT · The Journal of steroid biochemistry and molecular biology · 2017
    Cohort study643 participantsTestosterone Support forVitamin D
  14. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial.
    Al-Bayyari N; Al-Domi H; Zayed F; Hailat R; Eaton A · Clinical nutrition (Edinburgh, Scotland) · 2021
    Randomized trial60 participantsTestosterone Support forVitamin D
  15. Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism.
    Guo S; Tal R; Jiang H; Yuan T; Liu Y · International journal of endocrinology · 2022
    Meta-analysis824 participants13 studies pooledTestosterone Support forVitamin D
  16. Joint association of serum 25-hydroxyvitamin D concentration and body mass index on the acceleration of clinical biomarker-based biological aging.
    Pan Z; Zeng J; Chen Z; Chen S; Yang J; Li H; Wang S; Wang J; Li N; Gong Y; Liu M; Li C · The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Cohort study389,217 participantsAnti-Aging forVitamin D
  17. Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels.
    Schöttker B; Hagen L; Zhang Y; Gào X; Holleczek B; Gao X; Brenner H · The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Cohort study9,940 participantsAnti-Aging forVitamin D
  18. Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study.
    Song S; Lim JY; Kim M; Won CW; Park HY · The journal of nutrition, health & aging · 2025
    Cohort study1,292 participantsAnti-Aging forVitamin D
  19. Vitamin D deficit is associated with accelerated brain aging in the general population.
    Terock J; Bonk S; Frenzel S; Wittfeld K; Garvert L; Hosten N; Nauck M; Völzke H; Van der Auwera S; Grabe HJ · Psychiatry research. Neuroimaging · 2022
    Cross-sectional study1,865 participantsAnti-Aging forVitamin D
  20. Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP).
    Zhao C; Tsapanou A; Manly J; Schupf N; Brickman AM; Gu Y · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Cohort study1,759 participantsAnti-Aging forVitamin D
  21. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
    Zhou A; Hyppönen E · International journal of epidemiology · 2023
    Observational study294,970 participantsAnti-Inflammatory Support forVitamin D
  22. Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial.
    El Amrousy D; El Ashry H; Hodeib H; Hassan S · Journal of clinical gastroenterology · 2021
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  23. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
    Gao YQ; Gao YH; Xing JH · World journal of diabetes · 2025
    Randomized trial120 participantsAnti-Inflammatory Support forVitamin D
  24. Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.
    Yang F; Sun M; Sun C; Li J; Yang X; Bi C; Wang M; Pu L; Wang J; Wang C; Xie M; Yao Y; Jin L · Scientific reports · 2020
    Cross-sectional study9,809 participantsAnti-Inflammatory Support forVitamin D
  25. Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.
    Zhang C; Cui J; Li S; Shen J; Luo X; Yao Y; Shi H · BMC geriatrics · 2024
    Cohort study3,072 participantsAnti-Inflammatory Support forVitamin D
  26. Vitamin D Supplementation in Adolescents and Young Adults With Juvenile Systemic Lupus Erythematosus for Improvement in Disease Activity and Fatigue Scores: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Lima GL; Paupitz J; Aikawa NE; Takayama L; Bonfa E; Pereira RM · Arthritis care & research · 2016
    Randomized trial40 participantsEnergy forVitamin D
  27. Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Randomized Controlled Trial.
    Kodama S; Nakata M; Konishi N; Yoshino M; Fujisawa A; Naganuma M; Kobayashi Y; Hirai Y; Kitagawa A; Miyokawa M; Mishima R; Teramukai S; Fukushima M · Nutrients · 2026
    Randomized trial91 participantsEnergy forVitamin D
  28. The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
    Elfituri S · Reumatologia · 2024
    Randomized trial68 participantsEnergy forVitamin D
  29. The effect of home-based aerobic training and vitamin D supplementation on fatigue and quality of life in patients with multiple sclerosis during COVID-19 outbreak.
    Bahmani E; Hoseini R; Amiri E · Science & sports · 2022
    Randomized trial40 participantsEnergy forVitamin D
  30. Vitamin D supplementation for prevention of mortality in adults.
    Bjelakovic G; Gluud LL; Nikolova D; Whitfield K; Wetterslev J; Simonetti RG; Bjelakovic M; Gluud C · The Cochrane database of systematic reviews · 2014
    Meta-analysis95,286 participants159 studies pooledGeneral Health forVitamin D
  31. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial.
    Abbasnezhad A; Amani R; Hajiani E; Alavinejad P; Cheraghian B; Ghadiri A · Neurogastroenterology and motility · 2018
    Randomized trial90 participantsGeneral Health forVitamin D
  32. The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials.
    Kow CS; Ramachandram DS; Hasan SS; Wong Z; Thiruchelvam K · Inflammopharmacology · 2024
    Meta-analysis2,495 participants19 studies pooledGeneral Health forVitamin D
  33. Vitamin D Status and Mortality: A Systematic Review of Observational Studies.
    Heath AK; Kim IY; Hodge AM; English DR; Muller DC · International journal of environmental research and public health · 2019
    Systematic review84 studies pooledGeneral Health forVitamin D
  34. Meta-analysis of long-term vitamin D supplementation on overall mortality.
    Zheng Y; Zhu J; Zhou M; Cui L; Yao W; Liu Y · PloS one · 2014
    Meta-analysis42 studies pooledGeneral Health forVitamin D
  35. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
    Martineau AR; Jolliffe DA; Greenberg L; Aloia JF; Bergman P; Dubnov-Raz G; Esposito S; Ganmaa D; Ginde AA; Goodall EC; Grant CC; Janssens W; Jensen ME; Kerley CP; Laaksi I; Manaseki-Holland S; Mauger D; Murdoch DR; Neale R; Rees JR; Simpson S; Stelmach I; Trilok Kumar G; Urashima M; Camargo CA; Griffiths CJ; Hooper RL · Health technology assessment (Winchester, England) · 2020
    Meta-analysis11,321 participants25 studies pooledImmunity forVitamin D
  36. Vitamin D3 and deconvoluting a rash.
    Ernst MK; Evans ST; Techner JM; Rothbaum RM; Christensen LF; Onay UV; Biyashev D; Demczuk MM; Nguyen CV; Honda KS; McCormick TS; Tsoi LC; Gudjonsson JE; Cooper KD; Lu KQ · JCI insight · 2023
    Randomized trial28 participantsImmunity forVitamin D
  37. Effect of vitamin D3 supplementation on cellular immunity and inflammatory markers in COVID-19 patients admitted to the ICU.
    Bychinin MV; Klypa TV; Mandel IA; Yusubalieva GM; Baklaushev VP; Kolyshkina NA; Troitsky AV · Scientific reports · 2022
    Randomized trial110 participantsImmunity forVitamin D
  38. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
    Jamilian M; Foroozanfard F; Rahmani E; Talebi M; Bahmani F; Asemi Z · Nutrients · 2018
    Randomized trial90 participantsTestosterone Support forVitamin D
  39. Association between plasma 25-OH vitamin D and testosterone levels in men.
    Nimptsch K; Platz EA; Willett WC; Giovannucci E · Clinical endocrinology · 2012
    Case-control study1,362 participantsTestosterone Support forVitamin D
  40. Causal Link Between Vitamin D and Total Testosterone in Men: A Mendelian Randomization Analysis.
    Chen C; Zhai H; Cheng J; Weng P; Chen Y; Li Q; Wang C; Xia F; Wang N; Lu Y · The Journal of clinical endocrinology and metabolism · 2020
    Other4,254 participantsTestosterone Support forVitamin D