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5-HTP 100 mg

Solgar
4.7
★ ★ ★ ★ ★
(1934 ratings)
5-HTP 100 mg
Valerian 100 mg
Product Image
Score75
A practical 100 mg 5-HTP serving gains useful sleep support from valerian and magnesium. Serotonin interactions and incomplete valerian or mineral-form detail are important limitations.
How scoring works
Quantity:90 Capsule(s) • (90 servings)
Goals:
Stress Relief
Sleep Support
Mood Support
Weight Loss

Score 75

A practical 100 mg 5-HTP serving gains useful sleep support from valerian and magnesium. Serotonin interactions and incomplete valerian or mineral-form detail are important limitations.
How scoring works
$25.49($0.28 per serving)
Vitacost
$ 26.59
Daily Vita
$ 29.70
Vitacost
$ 26.99
iHerb
$ 25.49
Amazon
$ 27.99
Pure Formulas
$ 26.99
Report prices

Analysis

One capsule supplies 100 mg 5-HTP from Griffonia seed, 100 mg valerian extract, 10 mg vitamin B6, and 50 mg magnesium. The 5-HTP amount fits a common supplemental serving, and pyridoxal 5-phosphate is a useful B6 form.

5-HTP is the main mood and sleep-related active, while valerian and magnesium add calming support. Valerian lacks an extract ratio or valerenic-acid percentage, and the label does not clarify how the listed B6 and magnesium forms divide their totals.

Ninety servings and one-capsule dosing provide good convenience. It is unsuitable for unsupervised use with serotonin-modulating medicine and should be reserved for times when drowsiness is acceptable.

Who is it for
  • Adults seeking a 5-HTP sleep-and-mood capsules
  • Users whose needs match the disclosed ingredient amounts
  • People who can screen ingredient-specific medication and tolerance concerns
Best for
  • Comparing form, dose, and practical value
  • Goal-aligned supplement selection
  • Users who prefer a 5-HTP sleep-and-mood capsules

Pros

  • Provides 100 mg 5-HTP
  • Uses Griffonia seed extract
  • Includes active-form vitamin B6
  • One capsule with 90 servings

Cons

  • Valerian is not standardized
  • Magnesium includes oxide
  • Form totals are not clearly divided
  • Weight-loss relevance is modest

Warnings

  • Do not combine 5-HTP with SSRIs, SNRIs, MAO inhibitors, tramadol, triptans, or other serotonin-modulating medicines because serotonin toxicity can occur
  • Valerian and 5-HTP may cause drowsiness, so avoid driving after use
  • 5-HTP may cause nausea or vivid dreams, especially when first used

Nutrient quality

77 High impact

Griffonia-derived 5-HTP and active vitamin B6 are strong form choices, while magnesium combines glycinate with oxide. The 5-HTP amount is meaningful, but valerian and magnesium are modest and duplicate entries reduce dose clarity.

Ingredient transparency

75 High impact

Listed active ingredients have specific weights and no proprietary blend hides their doses. Complete use directions and a full other-ingredients list are not included in the supplied facts.

Customer satisfaction

71 High impact

The supplied average rating is strong, and review volume provides a stable broad signal. No detailed comments are provided to assess repeated complaints or whether experiences match the intended use.

Value for money

76 High impact

Meaningful core dosing and favorable recurring cost support good practical value. Incomplete form, activity, or use details remain the main value trade-off.

Report analysis

Goals

Stress Relief
Stress Relief
Impact
High effect
B+ Goal FitC+ Strength of SupportB CoverageB- Formula Quality
Magnesium · 50 mgVitamin B6 · 10 mg

The 100 mg 5-HTP amount directly supports serotonin synthesis, while valerian, magnesium, and vitamin B6 add calming or cofactor roles. The combination covers mood, sleep, and nervous-system support more broadly than a single active.

Valerian and magnesium are included below their associated preferred ranges, and oxide plus missing botanical standardization reduce form quality. Do not combine 5-HTP with SSRIs, MAO inhibitors, or other serotonin-raising medicines because the combination may cause serotonin toxicity.

Study evidence
5-HTP Supportive 18 studies
Magnesium Supportive 13 studies
Valerian Supportive 18 studies
Vitamin B6 Supportive 10 studies
Sleep Support
Sleep Support
Impact
High effect
B Goal FitB- Strength of SupportB CoverageB- Formula Quality
Magnesium · 50 mg

The formula addresses serotonin and melatonin precursor support through 5-HTP while adding magnesium and valerian for relaxation. Several secondary actives are modestly dosed, so the broad pathway coverage is stronger than the depth in each pathway.

Amounts and forms are clearly listed, including some magnesium glycinate and active vitamin B6, but magnesium oxide and an unstandardized low valerian amount limit quality. The 5-HTP can interact with serotonin-raising medicines such as antidepressants and may increase the risk of excessive serotonin.

Study evidence
5-HTP Supportive 1 study
Magnesium Supportive 23 studies
Valerian Supportive 31 studies
Vitamin B6 Disputed 7 studies
Mood Support
Mood Support
Impact
High effect
B Goal FitB Strength of SupportC- CoverageB Formula Quality
Vitamin B6 · 10 mgMagnesium · 50 mg5-HTP · 100 mg

5-HTP directly supports serotonin synthesis, and P-5-P provides a relevant conversion cofactor. Magnesium and valerian add calming support, although both are modestly dosed.

The combination covers more than one mood pathway but has uneven depth. Combining 5-HTP with serotonergic drugs can raise serotonin-syndrome risk, while valerian may add sedation with alcohol or sedatives.

Study evidence
5-HTP Supportive 9 studies
Magnesium Supportive 60 studies
Valerian Supportive 17 studies
Vitamin B6 Supportive 19 studies
Weight Loss
Weight Loss
Impact
High effect
D Goal FitA- Strength of SupportC CoverageB Formula Quality
Magnesium · 50 mg

The 100 mg 5-HTP amount may support appetite control for people whose eating is tied to cravings or low satiety. Evidence is situational, and it does not directly increase metabolic rate or preserve muscle.

Vitamin B6 supports serotonin synthesis, while magnesium and valerian add a calming emphasis that may suit evening use. Combining 5-HTP with serotonergic medicines such as SSRIs or MAO inhibitors can raise serotonin-related risk, and valerian may add sedation.

Study evidence
5-HTP Supportive 5 studies
Magnesium Supportive 17 studies

Ingredients

IngredientAmount per serving
Vitamin B6 (Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride)
 10 mg
Magnesium (Magnesium Glycinate, Magnesium Oxide)
 50 mg
5-HTP (Griffonia simplicifolia Seed Extract)
 100 mg
Valerian extract
100 mg
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Halal Vegetarian
Report overview
5-HTP (Griffonia simplicifolia Seed Extract) · 100 mg OverallScore75
B- Active Ingredient Quality & BioavailabilityB- Dose, Safety & Label TransparencyA- Value

The 100 mg 5-HTP dose comes from Griffonia seed extract and matches the collection's standard amount. A vegetable capsule supports straightforward use, though no 5-HTP standardization percentage is stated. The supplied label details also lack a warning about SSRIs and other serotonin-modulating medicines, whose combination with 5-HTP may raise the risk of serotonin toxicity.

View ingredientView products
Valerian · 100 mg OverallScore66
C- Active Ingredient Quality & BioavailabilityC- Dose, Safety & Label TransparencyA+ Value

The 100 mg valerian extract is clearly disclosed but lacks an extract ratio or valerenic acid standardization. Its dose falls below the preferred extract range, making it a secondary part of this multi-ingredient formula rather than a focused valerian option. One capsule contains the odor well and the serving cost is favorable for the collection.

View ingredientView products
Loading alternative details
81 Performance

5-HTP Plus+ 200 mg

NatureWise
<p>The Griffonia source and pyridoxal 5-phosphate are useful forms, though extract standardization is absent. Compared with the original, the 5-HTP profile keeps the ingredient match close while the more coherent or clearly disclosed formula provides the main quality advantage.</p>
82 Performance

Valerian Root 200 mg

Swanson Superior Herbs
<p>Valerenic-acid-standardized extract plus valerian herb provides a substantial and well-specified sleep-support formula. Compared with the original, the Valerian profile keeps the ingredient match close while the more coherent or clearly disclosed formula provides the main quality advantage.</p>
85 Performance

5-HTP 100 mg

Doctor's Best
<p>The 100 mg 5-HTP serving provides standard support for serotonin-related mood, stress, or sleep needs. Compared with the original, the 5-HTP profile keeps the ingredient match close while the more coherent or clearly disclosed formula provides the main quality advantage.</p>
82 Budget

Valerian

Nature's Way
<p>Whole valerian plus valerenic-acid-standardized extract provides a substantial and well-specified sleep formula. Compared with the original, its Valerian overlap preserves the intended ingredient focus at a lower serving cost, although the stated limitations still matter.</p>
80 Budget

5-HTP 100 mg Time Release

Natrol
<p>The 100 mg 5-HTP serving provides standard support for serotonin-related mood, stress, or sleep needs. Compared with the original, its 5-HTP overlap preserves the intended ingredient focus at a lower serving cost, although the stated limitations still matter.</p>
78 Budget

Valerian Alcohol-Free

Herb Pharm
<p>A concentrated alcohol-free liquid provides a substantial valerian amount and flexible use. Compared with the original, its Valerian overlap preserves the intended ingredient focus at a lower serving cost, although the stated limitations still matter.</p>
85 Value

5-HTP 100 mg

NOW
<p>The 100 mg 5-HTP serving provides standard support for serotonin-related mood, stress, or sleep needs. Compared with the original, the 5-HTP alignment and practical serving economics create a more balanced value trade-off, with the stated caveats in mind.</p>
80 Value

Valerian Root 475 mg

Swanson
<p>A substantial single-herb valerian dose provides focused sleep support with exceptional serving value. Compared with the original, the Valerian alignment and practical serving economics create a more balanced value trade-off, with the stated caveats in mind.</p>
83 Value

5-HTP 200mg

Best Naturals
<p>Griffonia simplicifolia identifies the botanical source, but no active standardization percentage is supplied. Compared with the original, the 5-HTP alignment and practical serving economics create a more balanced value trade-off, with the stated caveats in mind.</p>
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study.
    Farah GJ; Ferreira GZ; Danieletto-Zanna CF; Luppi CR; Jacomacci WP · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020
    Randomized trial20 participantsMood Support Stress Relief forValerian
  2. Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
    Truyens M; Lobatón T; Ferrante M; Bossuyt P; Vermeire S; Pouillon L; Dewint P; Cremer A; Peeters H; Lambrecht G; Louis E; Rahier JF; Dewit O; Muls V; Holvoet T; Vandermeulen L; Peeters A; Gonzales GB; Bos S; Laukens D; De Vos M · Gastroenterology · 2022
    Randomized trial166 participantsMood Support for5-HTP
  3. Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials.
    Fernández-San-Martín MI; Masa-Font R; Palacios-Soler L; Sancho-Gómez P; Calbó-Caldentey C; Flores-Mateo G · Sleep medicine · 2010
    Meta-analysis18 studies pooledSleep Support forValerian
  4. Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
    Zhang W; Yan Y; Wu Y; Yang H; Zhu P; Yan F; Zhao R; Tian P; Wang T; Fan Q; Su Z · Pharmacological research · 2022
    Meta-analysis29 participants29 studies pooledStress Relief Mood Support forValerian
  5. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
    Sutanto CN; Xia X; Heng CW; Tan YS; Lee DPS; Fam J; Kim JE · Clinical nutrition (Edinburgh, Scotland) · 2024
    Randomized trial30 participantsSleep Support for5-HTP
  6. Complementary and alternative treatments for insomnia disorder: a systematic umbrella review.
    Ell J; Schmid SR; Benz F; Spille L · Journal of sleep research · 2024
    Systematic review15 studies pooledSleep Support forValerian
  7. Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study.
    Andreatini R; Sartori VA; Seabra ML; Leite JR · Phytotherapy research : PTR · 2003
    Randomized trial36 participantsMood Support forValerian
  8. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  9. Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study.
    Chandra Shekhar H; Joshua L; Thomas JV · Advances in therapy · 2024
    Randomized trial80 participantsMood Support Sleep Support Stress Relief forValerian
  10. Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial.
    Velasquez ACA; Tsuji M; Dos Santos Cordeiro L; Petinati MFP; Rebellato NLB; Sebastiani AM; da Costa DJ; Scariot R · Oral and maxillofacial surgery · 2024
    Randomized trial54 participantsStress Relief forValerian
  11. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial.
    Hajizadeh I; Jamshidi M; Kazemi M; Kargar H; Sadeghi T · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2023
    Randomized trial40 participantsSleep Support forValerian
  12. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  13. Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
    Shinjyo N; Waddell G; Green J · Journal of evidence-based integrative medicine · 2021
    Meta-analysis6,894 participants60 studies pooledMood Support forValerian
  14. Valerian for sleep: a systematic review and meta-analysis.
    Bent S; Padula A; Moore D; Patterson M; Mehling W · The American journal of medicine · 2006
    Meta-analysis1,093 participants16 studies pooledSleep Support forValerian
  15. Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions.
    Cropley M; Cave Z; Ellis J; Middleton RW · Phytotherapy research : PTR · 2002
    Non-randomized trial54 participantsStress Relief forValerian
  16. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  17. Does valerian work for insomnia? An umbrella review of the evidence.
    Valente V; Machado D; Jorge S; Drake CL; Marques DR · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024
    Systematic review8 studies pooledSleep Support forValerian
  18. An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia.
    Jacobs BP; Bent S; Tice JA; Blackwell T; Cummings SR · Medicine · 2005
    Randomized trial391 participantsMood Support forValerian
  19. Valerian for anxiety disorders.
    Miyasaka LS; Atallah AN; Soares BG · The Cochrane database of systematic reviews · 2007
    Systematic review36 participants1 studies pooledMood Support Stress Relief forValerian
  20. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  21. Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.
    Sateia MJ; Buysse DJ; Krystal AD; Neubauer DN; Heald JL · Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017
    Guideline / consensusSleep Support forValerian
  22. Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: a systematic review.
    Araújo JO; Bergamaschi CC; Lopes LC; Guimarães CC; de Andrade NK; Ramacciato JC; Motta RHL · BMJ open · 2021
    Systematic review327 participants12 studies pooledStress Relief Mood Support forValerian
  23. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  24. Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia--a randomized, double-blind, comparative clinical study.
    Ziegler G; Ploch M; Miettinen-Baumann A; Collet W · European journal of medical research · 2003
    Randomized trial202 participantsSleep Support forValerian
  25. Stress-induced insomnia treated with kava and valerian: singly and in combination.
    Wheatley D · Human psychopharmacology · 2019
    Single-arm trial24 participantsStress Relief forValerian
  26. Symptomatic treatment of interferon-α-induced depression in hepatitis C: a systematic review.
    Baraldi S; Hepgul N; Mondelli V; Pariante CM · Journal of clinical psychopharmacology · 2012
    Systematic review64 studies pooledMood Support for5-HTP
  27. Herbal medicine for insomnia: A systematic review and meta-analysis.
    Leach MJ; Page AT · Sleep medicine reviews · 2016
    Meta-analysis1,602 participants14 studies pooledSleep Support forValerian
  28. Chemotypic diversity and neuroactive potential of Valeriana jatamansi Jones: a systematic review on phytochemistry, pharmacology and standardisation challenges.
    Nisar S; Jan N; Hassan I; Andleeb L; Shabir PA · Natural product research · 2026
    Meta-analysis12 studies pooledMood Support forValerian
  29. [Use of valerian in anxiety and sleep disorders: what is the best evidence?].
    Nunes A; Sousa M · Acta medica portuguesa · 2012
    Systematic review4 studies pooledStress Relief forValerian
  30. Serotonin precursors in the treatment of depression.
    van Praag HM · Advances in biochemical psychopharmacology · 1982
    Narrative reviewMood Support for5-HTP
  31. Valerian for insomnia: a systematic review of randomized clinical trials.
    Stevinson C; Ernst E · Sleep medicine · 2019
    Systematic review9 studies pooledSleep Support forValerian
  32. Valerian extract alters functional brain connectivity: A randomized double-blind placebo-controlled trial.
    Roh D; Jung JH; Yoon KH; Lee CH; Kang LY; Lee SK; Shin K; Kim DH · Phytotherapy research : PTR · 2019
    Randomized trial64 participantsMood Support forValerian
  33. GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence.
    Savage K; Firth J; Stough C; Sarris J · Phytotherapy research : PTR · 2018
    Systematic review10 studies pooledStress Relief forValerian
  34. Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
    Takahashi S; Takahashi R; Masumura I; Miike A · Folia psychiatrica et neurologica japonica · 1977
    Single-arm trial14 participantsMood Support for5-HTP
  35. A systematic review of insomnia and complementary medicine.
    Sarris J; Byrne GJ · Sleep medicine reviews · 2011
    Systematic review20 studies pooledSleep Support forValerian
  36. Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.
    Borrás S; Martínez-Solís I; Ríos JL · Planta medica · 2021
    Systematic reviewStress Relief forValerian
  37. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.
    Wang H; Jin M; Xie M; Yang Y; Xue F; Li W; Zhang M; Li Z; Li X; Jia N; Liu Y; Cui X; Hu G; Dong L; Wang G; Yu Q · Journal of affective disorders · 2023
    Meta-analysis4,049 participants52 studies pooledMood Support forMagnesium
  38. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.
    Tarleton EK; Littenberg B; MacLean CD; Kennedy AG; Daley C · PloS one · 2017
    Randomized trial126 participantsMood Support Stress Relief forMagnesium
  39. Magnesium supplementation as an adjunct to fluoxetine therapy for depression.
    Walyddaini AS; Lisal ST; Ilhamuddin; Zainuddin AA; Tanra AJ; Widianingsih Y; Syamsuddin S · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan · 2026
    Randomized trial40 participantsMood Support forMagnesium
  40. The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression.
    Afsharfar M; Shahraki M; Shakiba M; Asbaghi O; Dashipour A · Clinical nutrition ESPEN · 2021
    Randomized trial46 participantsMood Support forMagnesium
  41. Dietary magnesium intake and risk of depression.
    Sun C; Wang R; Li Z; Zhang D · Journal of affective disorders · 2019
    Cross-sectional study17,730 participantsMood Support forMagnesium
  42. High Dose Vitamin B6 Reduces Depression Symptoms.
    Field DT; Cracknell R; Biagi N · Depression and anxiety · 2026
    Randomized trial267 participantsMood Support forVitamin B6
  43. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
    Khodadad M; Bahadoran P; Kheirabadi GR; Sabzghabaee AM · International journal of preventive medicine · 2022
    Randomized trial81 participantsMood Support Stress Relief forVitamin B6
  44. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010.
    Lu J; Mao H; Tan Y; Luo G · Brain and behavior · 2024
    Cross-sectional study24,683 participantsMood Support forVitamin B6
  45. Associations of dietary B vitamins intakes with depression in adults.
    Wu Y; Li S; Wang W; Zhang D · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2023
    Observational study17,732 participantsMood Support forVitamin B6
  46. Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.
    Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK · International journal of psychiatry in medicine · 1995
    Cohort study88 participantsMood Support forVitamin B6
  47. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus.
    Khalid S; Bashir S; Mehboob R; Anwar T; Ali M; Hashim M; Waseem H; Basharat S · Frontiers in endocrinology · 2024
    Randomized trial320 participantsSleep Support forMagnesium
  48. Association of magnesium intake with sleep duration and sleep quality: findings from the CARDIA study.
    Zhang Y; Chen C; Lu L; Knutson KL; Carnethon MR; Fly AD; Luo J; Haas DM; Shikany JM; Kahe K · Sleep · 2022
    Cohort study3,964 participantsSleep Support forMagnesium
  49. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy.
    Saadawy IM; Kaki AM; Abd El Latif AA; Abd-Elmaksoud AM; Tolba OM · Acta anaesthesiologica Scandinavica · 2010
    Randomized trial120 participantsSleep Support forMagnesium
  50. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.
    Abbasi B; Kimiagar M; Sadeghniiat K; Shirazi MM; Hedayati M; Rashidkhani B · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013
    Randomized trial46 participantsSleep Support forMagnesium
  51. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.
    Barna O; Lohoida P; Holovchenko Y; Bazylevych A; Velychko V; Hovbakh I; Bula L; Shechter M · Nutrition journal · 2021
    Randomized trial175 participantsSleep Support forMagnesium
  52. Effects of a Valerian-Hops Extract Combination (Ze 91019) on Sleep Duration and Daytime Cognitive and Psychological Parameters in Occasional Insomnia: A Randomized Controlled Feasibility Trial.
    Schicktanz N; Gerhards C; Schlitt T; Aerni A; Müggler E; de Quervain D; Papassotiropoulos A; Boonen G; Drewe J; Butterweck V · Brain and behavior · 2025
    Randomized trial40 participantsSleep Support forValerian
  53. Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial.
    Zandifar A; Mousavi S; Schmidt NB; Badrfam R; Seif E; Qorbani M; Mehrabani Natanzi M · Journal of affective disorders · 2023
    Randomized trial66 participantsSleep Support forVitamin B6
  54. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.
    Jadidi A; Rezaei Ashtiani A; Khanmohamadi Hezaveh A; Aghaepour SM · BMC complementary medicine and therapies · 2023
    Randomized trial75 participantsSleep Support forVitamin B6
  55. Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study.
    García-García C; Baik I · Nutrition research and practice · 2022
    Randomized trial47 participantsSleep Support forVitamin B6
  56. Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep.
    Adventure-Heart DJ; Madden NA; Delfabbro P · Perceptual and motor skills · 2018
    Randomized trial100 participantsSleep Support forVitamin B6
  57. The effect of pyridoxine administration on melatonin secretion in normal men.
    Luboshitzky R; Ophir U; Nave R; Epstein R; Shen-Orr Z; Herer P · Neuro endocrinology letters · 2003
    Randomized trial12 participantsSleep Support forVitamin B6
  58. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
    Kahn RS; Westenberg HG; Verhoeven WM; Gispen-de Wied CC; Kamerbeek WD · International clinical psychopharmacology · 1987
    Randomized trial45 participantsStress Relief for5-HTP
  59. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
    Schruers K; van Diest R; Overbeek T; Griez E · Psychiatry research · 2003
    Randomized trial48 participantsStress Relief for5-HTP
  60. Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
    Smarius LJ; Jacobs GE; Hoeberechts-Lefrandt DH; de Kam ML; van der Post JP; de Rijk R; van Pelt J; Schoemaker RC; Zitman FG; van Gerven JM; Gijsman HJ · Journal of psychopharmacology (Oxford, England) · 2008
    Randomized trialStress Relief for5-HTP
  61. Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
    Jacobs GE; Kamerling IM; de Kam ML; Derijk RH; van Pelt J; Zitman FG; van Gerven JM · Journal of psychopharmacology (Oxford, England) · 2010
    Randomized trialStress Relief for5-HTP
  62. An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress.
    Emanuele E; Bertona M; Minoretti P; Geroldi D · Neuro endocrinology letters · 2011
    Single-arm trial15 participantsStress Relief for5-HTP
  63. Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.
    Wang L; Zhou J; Liu Q; Qian K; Wang L; Xie C · Therapeutics and clinical risk management · 2026
    Randomized trial137 participantsStress Relief forMagnesium
  64. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.
    Saba S; Faizi F; Sepandi M; Nehrir B · Magnesium research · 2022
    Non-randomized trial60 participantsStress Relief forMagnesium
  65. Effects of dry needling compared to magnesium infiltration in trigger points for patients with myofascial pain syndrome: a randomized controlled study in Tunisia.
    Dhouibi J; Moncer R; Kalbousi N; Gaddour M; Laayouni S; Ouanes W; Kacem B; Jemni S · Korean journal of family medicine · 2026
    Randomized trial45 participantsStress Relief forMagnesium
  66. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
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