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Extra Strength Hair Skin & Nails

Nature's Bounty Optimal Solutions
4.7
★ ★ ★ ★ ★
(69 ratings)
Biotin 5000 mcg
Niacin 25 mg
Manganese 5 mg
Vitamin A 5000 IU
PABA 10 mg
Vitamin D 800 IU
Vitamin E 15 IU
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Score65
The beauty-focused formula has a useful core built around high-dose biotin, vitamin C, zinc, vitamin D3, and hyaluronic acid. Collagen, argan oil, horsetail, choline, PABA, and alpha-lipoic acid appear in small amounts that are unlikely to add much depth.
How scoring works
Quantity:30 Softgel(s) • (10 servings)
Goals:
Nail Health
Hair Health
Skin Health

Score 65

The beauty-focused formula has a useful core built around high-dose biotin, vitamin C, zinc, vitamin D3, and hyaluronic acid. Collagen, argan oil, horsetail, choline, PABA, and alpha-lipoic acid appear in small amounts that are unlikely to add much depth.
How scoring works
$5.73($0.57 per serving)
iHerb
$ 5.73
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Analysis

The beauty-focused formula has a useful core built around high-dose biotin, vitamin C, zinc, vitamin D3, and hyaluronic acid. A lipid-based softgel suits the fat-soluble vitamins, while the disclosed amounts make the principal nutrients easy to judge.

Collagen, argan oil, horsetail, choline, PABA, and alpha-lipoic acid appear in small amounts that are unlikely to add much depth. It fits adults seeking targeted hair, skin, and nail nutrient coverage better than anyone expecting a meaningful collagen serving.

The 5,000 mcg biotin amount can interfere with thyroid, hormone, and cardiac troponin blood tests. The short ten-serving package is convenient for a trial but creates more frequent repurchasing.

Who is it for
  • Adults seeking hair, skin, and nail nutrient support
  • People who prefer softgels
  • Users who want high-dose biotin with zinc and vitamin C
Best for
  • High-biotin beauty support
  • A short trial-size supply
  • Combining micronutrients with hyaluronic acid

Pros

  • Provides 5,000 mcg of disclosed biotin
  • Includes vitamin C, zinc, vitamin D3, and hyaluronic acid
  • Softgel format suits the fat-soluble vitamins

Cons

  • Only ten servings are supplied
  • Collagen is limited to 50 mg
  • Several specialty ingredients are present in token amounts

Warnings

  • The 5,000 mcg biotin dose can distort thyroid, hormone, and cardiac troponin test results; disclose use before blood testing.
  • Preformed vitamin A from retinyl palmitate warrants care when stacking other retinol-containing supplements, especially during pregnancy.
  • The 5 mg manganese amount adds to intake from food and other supplements, so repeated stacking is unnecessary.

Nutrient quality

62 Moderate impact

Vitamin D3, natural vitamin E, and several gluconate minerals are useful forms, though folic acid and cyanocobalamin are less preferred, and biotin is substantial, but collagen, horsetail, choline, selenium, and several specialty ingredients are modest. The very high biotin amount may interfere with some thyroid, hormone, and cardiac laboratory tests, while several low-dose additions lengthen the formula without adding much likely benefit.

Ingredient transparency

76 High impact

Specific amounts are listed for the active vitamins, minerals, and specialty ingredients. No proprietary blend hides the amounts of key active ingredients, while excipients and softgel materials are not included in the supplied label details.

Customer satisfaction

65 Moderate impact

The supplied aggregate satisfaction metric is strong, and the feedback volume offers some support but remains less robust than heavily reviewed alternatives. No review excerpts were provided, so recurring complaints and purpose-specific experiences cannot be checked.

Value for money

55 Moderate impact

The useful biotin and broad nutrient base partly support the cost, but many specialty ingredients are lightly dosed. Each serving offers broad coverage, though the meaningful contribution is concentrated in a few nutrients, while low-dose oils, herbs, and structural ingredients add limited practical value.

Report analysis

Goals

Nail Health
Nail Strength and ResilienceHealthy Nail Growth
Nail Health
Impact
Highest effect
A+ Goal FitA Strength of SupportA- CoverageA- Formula Quality
Collagen · 50 mgBiotin · 5000 mcgHorsetail · 3 mg

High-dose d-biotin leads a focused hair, skin, and nail formula with vitamin C and zinc support. Horsetail is present only at a very small amount, so silica support is limited.

The formula provides strong biotin depth with several sensible secondary cofactors. High-dose biotin can distort thyroid, hormone, and cardiac laboratory tests, so users should disclose it before blood work.

Study evidence
Biotin Supportive 8 studies
Horsetail Not classified

No linked studies yet.

Vitamin C Supportive 1 study
Zinc No effect 1 study
Hair Health
Healthy Hair Growth Cycle
Hair Health
Impact
High effect
B+ Goal FitC Strength of SupportB- CoverageC Formula Quality
Biotin · 5000 mcgVitamin D · 800 IUZinc · 7.5 mgIron · 3 mgVitamin C · 60 mgCollagen · 50 mg

High-dose biotin, vitamin D3, zinc, iron, collagen, hyaluronic acid, and several cofactors give the formula direct hair-health intent. Biotin is the strongest contribution, while iron and vitamin D may help mainly when an underlying deficiency is present.

Collagen, horsetail, and iron are far below targeted amounts, so the long ingredient list overstates its functional breadth. High-dose biotin can distort thyroid, hormone, and cardiac laboratory tests, so users should disclose it before blood work.

Study evidence
Biotin Supportive 4 studies
Collagen Supportive 3 studies
Horsetail Not classified

No linked studies yet.

Iron Disputed 25 studies
Selenium Disputed 7 studies
Vitamin C Mixed 5 studies
Vitamin D Disputed 34 studies
Zinc Supportive 22 studies
Skin Health
Clear and Even Tone
Skin Health
Impact
High effect
B Goal FitC Strength of SupportC+ CoverageC+ Formula Quality
Hyaluronic Acid · 30 mgZinc · 7.5 mgVitamin C · 60 mgCollagen · 50 mgSelenium · 12.5 mcgVitamin E · 15 IU

Collagen, hyaluronic acid, vitamin C, zinc, and antioxidant vitamins create clear skin-health relevance. The main limitation is that the headline collagen amount is far below typical gram-level peptide servings.

Softgel delivery and clear active amounts make the formula easy to assess, while its hyaluronic acid contribution is modest. High-dose biotin can interfere with some thyroid, hormone, and cardiac laboratory tests, so users should disclose it before blood testing.

Study evidence
Biotin Supportive 10 studies
Collagen Supportive 62 studies
Vitamin A Supportive 106 studies
Vitamin C Supportive 53 studies
Vitamin E Supportive 38 studies
Zinc Supportive 66 studies

Ingredients

IngredientAmount per serving
Calories
15 Calorie(s)
Total Fat
1 Gram(s)
Vitamin A (Retinyl Palmitate)
 5000 IU
Vitamin C (Ascorbic Acid)
 60 mg
Vitamin D (Cholecalciferol, Vitamin D3)
 800 IU
Vitamin E (D-Alpha-Tocopheryl Acetate)
 15 IU
Thiamine (Thiamine Mononitrate, Vitamin B1)
 5 mg
Riboflavin (Vitamin B2)
 5 mg
Niacin (Niacinamide)
 25 mg
Vitamin B6 (Pyridoxine Hydrochloride)
 5 mg
Folic Acid
200 mcg
Vitamin B12 (Cyanocobalamin)
 8 mcg
Biotin (D-Biotin)
 5000 mcg
Pantothenic Acid (D-Calcium Pantothenate)
 15 mg
Iron (Ferrous Gluconate)
 3 mg
Zinc (Zinc Gluconate)
 7.5 mg
Selenium (Selenium Yeast)
 12.5 mcg
Manganese (Manganese Gluconate)
 5 mg
Argan Oil
25 mg
PABA
10 mg
Choline Bitartrate
10 mg
Alpha Lipoic Acid
10 mg
Horsetail
3 mg
hydrolyzed Collagen
50 mg
Hyaluronic Acid (Sodium Hyaluronate)
 30 mg
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
Biotin (D-Biotin) · 5000 mcg OverallScore92
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyC Value

The label identifies d-Biotin and provides a high dose aligned with hair and nail support. The amount is disclosed outside any proprietary blend, and the supplied softgel ingredients show no penalized additives. High-dose biotin can distort some thyroid, hormone, and cardiac laboratory results, so users should disclose it before blood tests.

View ingredientView products
Niacin (Niacinamide) · 25 mg OverallScore84
A Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyC Value

Niacinamide fits the skin-focused goal and appears at a suitable multinutrient amount. Rapid-release softgels provide convenient immediate delivery, while the chemical form carries little flush risk. A moderate serving cost supports fair value across the broader beauty formula.

View ingredientView products
Manganese (Manganese Gluconate) · 5 mg OverallScore82
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value

Manganese gluconate supplies a soluble organic form at an amount suited to targeted support. The elemental dose is clearly disclosed and remains below the adult upper limit. Cost per serving is moderate, but the small package and beauty-focused blend reduce its efficiency as a dedicated manganese option.

View ingredientView products
Loading alternative details
68 Performance

Hair Vitamins

SugarBearHair
A potentially better match in selected areas comes from 5,000 mcg of biotin with vitamin D3, vitamin C, zinc citrate, and pantothenic acid. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 3 mg of horsetail, the ingredient focus is directly aligned with hair and nail support, although the supporting nutrient amounts are modest and high-dose biotin can distort some laboratory tests.
71 Performance

Extra Strength Hair Skin & Nails

Spring Valley
A potentially better match in selected areas comes from 5,000 mcg of D-biotin with 2,000 IU of vitamin D3, 90 mg of vitamin C, zinc, and 60 mg of collagen. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 3 mg of horsetail, the beauty-support core is broader while staying relatively economical, although collagen, hyaluronic acid, horsetail, and oils are still modest and the high biotin amount can affect laboratory tests.
55 Performance

Enzyme Nutrition Multi-Vitamin Two Daily

Enzymedica
A potentially better match in selected areas comes from vitamin D3, natural mixed vitamin E, beta-carotene, folate, and a broad vitamin-and-mineral base. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 3 mg of horsetail, the natural vitamin E forms and broad coverage improve several nutrient-quality details, although enzyme, probiotic, ATP, and botanical entries lack measurable amounts.
72 Budget

One Daily Women's Adult Gummy

Equate
A lower serving cost comes with vitamin D, vitamin E, folic acid, biotin, calcium, and zinc in a women’s adult gummy. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 3 mg of horsetail, it provides broad basic coverage without the original formula’s very high biotin exposure, although many forms are unspecified and mineral amounts are light.
73 Budget

Muti Vitamin Raspberry Flavor

Yum-V's Complete
A lower serving cost comes with vitamin D3, vitamin C, folic acid, biotin, and several B vitamins in an adult gummy. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 3 mg of horsetail, it supplies basic adult nutrient coverage without extremely high biotin, although synthetic vitamin E, basic B-vitamin forms, and very little choline limit formulation depth.
75 Budget

Flintstones Complete

Bayer
A lower serving cost comes with beta-carotene, vitamin C, vitamin D, iron, zinc, and broad basic vitamin coverage. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 3 mg of horsetail, it supplies a wide maintenance base at low serving cost, although the child-focused amounts and many unspecified forms do not match every adult.
70 Value

Hair Skin & Nails

Nature's Bounty Optimal Solutions
A useful quality-to-cost balance comes from 3,000 mcg of biotin with vitamin D3, vitamin C, zinc, 50 mg of collagen, and 30 mg of inositol. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 3 mg of horsetail, the targeted beauty formula remains economical and lowers biotin exposure relative to the extra-strength version, although collagen and horsetail are too lightly dosed to add much structural support.
75 Value

Multi Adult Gummies

Nature Made
A useful quality-to-cost balance comes from vitamin D3, vitamin C, folic acid, biotin, and zinc in an adult gummy. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 3 mg of horsetail, it provides inexpensive broad vitamin coverage in a simpler serving, although mineral coverage is thin and several nutrient forms are basic.
78 Value

Children's Chewable

Thompson
A useful quality-to-cost balance comes from vitamin D3, natural-form vitamin E, beta-carotene, iron, and clearly named minerals. Compared with the original formula with 5,000 mcg of biotin, 50 mg of collagen, 30 mg of hyaluronic acid, and 3 mg of horsetail, the formula offers broad maintenance coverage with several useful forms, although it is designed for children and calcium, magnesium, and zinc are lightly dosed.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin, and Nail Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Study.
    Patel MN; Maheshvari J; Patel N · Cureus · 2025
    Randomized trial105 participantsHair Health Nail Health Skin Health forBiotin
  2. Low serum biotinidase activity in children with valproic acid monotherapy.
    Schulpis KH; Karikas GA; Tjamouranis J; Regoutas S; Tsakiris S · Epilepsia · 2001
    Clinical trial125 participantsHair Health Skin Health forBiotin
  3. Vitamins A, B, C, and D: A Short Review for the Dermatologist.
    Coerdt KM; Goggins CA; Khachemoune A · Alternative therapies in health and medicine · 2021
    Narrative reviewHair Health forBiotin
  4. The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.
    Soleymani T; Lo Sicco K; Shapiro J · Journal of drugs in dermatology : JDD · 2018
    Narrative reviewHair Health forBiotin
  5. Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation.
    Hwang S; Won J; Kim S; Kang W; Park M · Journal of medicinal food · 2026
    Randomized trial114 participantsHair Health forCollagen
  6. Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study.
    Duangjai A; Srivilai J; Nangola S; Amornlerdpison D · Clinics and practice · 2025
    Randomized trialHair Health forCollagen
  7. Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing.
    Biełach-Bazyluk A; Jurga M; Flisiak I; Zbroch E · Nutrients · 2026
    Narrative reviewHair Health forCollagen
  8. The Association Between Alopecia Areata and Iron Deficiency Anemia: A Large-Scale Population-Based Case-Control Study.
    Davidovici B; Drutin Y; Ben-Tov A; Mimouni D; Wohl Y · Journal of personalized medicine · 2026
    Case-control study100,203 participantsHair Health forIron
  9. Iron Deficiency and Nonscarring Alopecia in Women: Systematic Review and Meta-Analysis.
    Treister-Goltzman Y; Yarza S; Peleg R · Skin appendage disorders · 2022
    Meta-analysis10,029 participants36 studies pooledHair Health forIron
  10. Comparative Analysis of Postoperative Hair Loss and Micronutrient Deficiencies After One-Anastomosis Gastric Bypass Versus Sleeve Gastrectomy.
    Chinisaz F; Maleki T; Najjari K; Miratashi Yazdi SA · Obesity surgery · 2026
    Cohort study261 participantsHair Health forIron
  11. Assessment of Serum Ferritin Levels in Female Patients With Telogen Effluvium.
    Thamotharan N; Harikumar MV; Sundaram M; Swaminathan A; Rangarajan S · Cureus · 2026
    Cross-sectional study100 participantsHair Health forIron
  12. Diagnosis and treatment of female alopecia: Focusing on the iron deficiency-related alopecia.
    Lin CS; Chan LY; Wang JH; Chang CH · Tzu chi medical journal · 2023
    Cohort study155 participantsHair Health forIron
  13. Beyond Efficacy: 0.6% Selenium Disulfide Shampoo Matches 2% Ketoconazole for Seborrheic Dermatitis with Superior Cosmesis.
    Farris PK; Barbosa V; Houshman EB; Kovylkina N · Journal of drugs in dermatology : JDD · 2026
    Randomized trial87 participantsHair Health forSelenium
  14. Selenium Disulfide-based shampoo applied for 4 weeks significantly improves dandruff and seborrheic dermatitis.
    Turcu G; Artenie C; Nowicka D; Arenbergerová M; Lazaridou E; Khobzei K; Ataseven A; Part M; Leclerc-Mercier S · European journal of dermatology : EJD · 2023
    Observational study1,407 participantsHair Health forSelenium
  15. A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.
    Barbosa V; Melo DF; Vañó-Galván S; Lutchmanen-Kolanthan V; Sant'Anna B; Leclerc-Mercier S; Reygagne P · Skin appendage disorders · 2025
    Randomized trial64 participantsHair Health forSelenium
  16. Changes of serum trace elements level in patients with alopecia areata: A meta-analysis.
    Jin W; Zheng H; Shan B; Wu Y · The Journal of dermatology · 2018
    Meta-analysis764 participantsHair Health forSelenium
  17. Scientific opinion on the tolerable upper intake level for selenium.
    EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA); Turck D; Bohn T; Castenmiller J; de Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Peláez C; Pentieva K; Siani A; Thies F; Tsabouri S; Vinceti M; Aggett P; Crous Bou M; Cubadda F; Ciccolallo L; de Sesmaisons Lecarré A; Fabiani L; Titz A; Naska A · EFSA journal. European Food Safety Authority · 2023
    Systematic reviewHair Health forSelenium
  18. Management of hair loss associated with endocrine therapy in patients with breast cancer: an overview.
    Karatas F; Sahin S; Sever AR; Altundag K · SpringerPlus · 2016
    Narrative reviewHair Health forVitamin C
  19. Elucidating causal relationships of diet-derived circulating antioxidants and the risk of non-scarring alopecia: A Mendelian randomization study.
    Ba Y; Shen L; Peng X; Zhang Y; Wang J · Medicine · 2024
    Methods validation study201,019 participantsHair Health forVitamin C
  20. Alterations of plasma antioxidants and mitochondrial DNA mutation in hair follicles of smokers.
    Liu CS; Chen HW; Lii CK; Tsai CS; Kuo CL; Wei YH · Environmental and molecular mutagenesis · 2002
    Observational studyHair Health forVitamin C
  21. Removal of synthetic hair dye using formamidine sulfinic acid and other sulfinate precursors.
    Hawkes JA; Lewis DM; Mama J; Murray J · International journal of cosmetic science · 2026
    Methods validation studyHair Health forVitamin C
  22. A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene.
    Kilic M; Taskesen M; Coskun T; Gürakan F; Tokatli A; Sivri HS; Dursun A; Schmitt S; Küry S · JIMD reports · 2013
    Case reportHair Health forVitamin C
  23. Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis.
    Lee S; Kim BJ; Lee CH; Lee WS · Journal of the European Academy of Dermatology and Venereology : JEADV · 2018
    Meta-analysis2,039 participants14 studies pooledHair Health forVitamin D
  24. Intralesional vitamin D3 in treatment of alopecia areata: A randomized controlled clinical trial.
    Rashad AF; Elgamal E; Fouda I · Journal of cosmetic dermatology · 2022
    Randomized trial60 participantsHair Health forVitamin D
  25. Vitamin D and its Analogs in Treatment of Mild to Moderate Alopecia Areata: Systematic Review and Meta-Analysis.
    Alsaati AA; Kaliyadan F; Alsaadoun D; Alzakry LM; Alzabadin RA; Hakami TH; Rubaian NFB · Indian dermatology online journal · 2025
    Meta-analysisHair Health forVitamin D
  26. Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial.
    El Taieb MA; Hegazy EM; Ibrahim HM; Osman AB; Abualhamd M · Archives of dermatological research · 2020
    Randomized trial60 participantsHair Health forVitamin D
  27. Serum 25 hydroxyvitamin D in non-scarring alopecia: A systematic review and meta-analysis.
    Chen Y; Dong X; Wang Y; Li Y; Xiong L; Li L · Journal of cosmetic dermatology · 2024
    Meta-analysis10,670 participants23 studies pooledHair Health forVitamin D
  28. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
    Berger RS; Fu JL; Smiles KA; Turner CB; Schnell BM; Werchowski KM; Lammers KM · The British journal of dermatology · 2003
    Randomized trial200 participantsHair Health forZinc
  29. Incubatory environment of the scalp impacts pre-emergent hair to affect post-emergent hair cuticle integrity.
    Schwartz JR; Henry JP; Kerr KM; Flagler MJ; Page SH; Redman-Furey N · Journal of cosmetic dermatology · 2018
    Randomized trialHair Health forZinc
  30. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
    Draelos ZD; Kenneally DC; Hodges LT; Billhimer W; Copas M; Margraf C · The journal of investigative dermatology. Symposium proceedings · 2006
    Randomized trial40 participantsHair Health forZinc
  31. BMI and levels of zinc, copper in hair, serum and urine of Turkish male patients with androgenetic alopecia.
    Ozturk P; Kurutas E; Ataseven A; Dokur N; Gumusalan Y; Gorur A; Tamer L; Inaloz S · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015
    Case-control study216 participantsHair Health forZinc
  32. Analysis of serum zinc and copper concentrations in hair loss.
    Kil MS; Kim CW; Kim SS · Annals of dermatology · 2013
    Case-control study342 participantsHair Health forZinc
  33. Biotin for the treatment of nail disease: what is the evidence?
    Lipner SR; Scher RK · The Journal of dermatological treatment · 2018
    Narrative reviewNail Health forBiotin
  34. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy.
    Colombo VE; Gerber F; Bronhofer M; Floersheim GL · Journal of the American Academy of Dermatology · 1991
    Other32 participantsNail Health forBiotin
  35. Treatment of brittle nail with a hydroxypropyl chitosan-based lacquer, alone or in combination with oral biotin: A randomized, assessor-blinded trial.
    Chiavetta A; Mazzurco S; Secolo MP; Tomarchio G; Milani M · Dermatologic therapy · 2020
    Randomized trial50 participantsNail Health forBiotin
  36. Vitamins and minerals: their role in nail health and disease.
    Scheinfeld N; Dahdah MJ; Scher R · Journal of drugs in dermatology : JDD · 2007
    Narrative reviewNail Health forBiotin Nail Health forZinc
  37. Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient.
    Dunleavy KA; Ungaro RC; Manning L; Gold S; Novak J; Colombel JF · Crohn's & colitis 360 · 2023
    Other20 participantsNail Health forVitamin C
  38. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters.
    Aksac SE; Bilgili SG; Yavuz GO; Yavuz IH; Aksac M; Karadag AS · International journal of dermatology · 2021
    Non-randomized trial60 participantsSkin Health forBiotin
  39. Generalized seborrhoeic dermatitis. Clinical and therapeutic data of 25 patients.
    Messaritakis J; Kattamis C; Karabula C; Matsaniotis N · Archives of disease in childhood · 1976
    Non-randomized trial25 participantsSkin Health forBiotin
  40. Holocarboxylase synthetase deficiency: novel clinical and molecular findings.
    Tammachote R; Janklat S; Tongkobpetch S; Suphapeetiporn K; Shotelersuk V · Clinical genetics · 2010
    Case series4 participantsSkin Health forBiotin
  41. Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis.
    Dewi DAR; Arimuko A; Norawati L; Yenny SW; Setiasih NL; Perdiyana A; Arkania N; Nadhira F; Wiliantari N · Cureus · 2024
    Meta-analysis967 participants14 studies pooledSkin Health forCollagen
  42. Effects of collagen-based supplements on skin's hydration and elasticity: A systematic review and meta-analysis.
    Danessa G; Notario D; Regina R · Indian journal of dermatology, venereology and leprology · 2025
    Meta-analysis646 participants10 studies pooledSkin Health forCollagen
  43. Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
    Lee M; Kim E; Ahn H; Son S; Lee H · Food & function · 2023
    Randomized trial100 participantsSkin Health forCollagen
  44. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study.
    Kim DU; Chung HC; Choi J; Sakai Y; Lee BY · Nutrients · 2018
    Randomized trial64 participantsSkin Health forCollagen
  45. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
    de Miranda RB; Weimer P; Rossi RC · International journal of dermatology · 2021
    Meta-analysis1,125 participants19 studies pooledSkin Health forCollagen
  46. Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.
    Farris P; Berson D; Bhatia N; Goldberg D; Lain E; Mariwalla K; Zeichner J; Miller D; McGuire T; Kizoulis M · Journal of drugs in dermatology : JDD · 2024
    Meta-analysis471 participants6 studies pooledSkin Health forVitamin A
  47. Tensile properties and contours of aging facial skin. A controlled double-blind comparative study of the effects of retinol, melibiose-lactose and their association.
    Piérard-Franchimont C; Castelli D; Cromphaut IV; Bertin C; Ries G; Cauwenbergh G; Piérard GE · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2016
    Randomized trial120 participantsSkin Health forVitamin A
  48. Antiaging action of retinol: from molecular to clinical.
    Bellemère G; Stamatas GN; Bruère V; Bertin C; Issachar N; Oddos T · Skin pharmacology and physiology · 2009
    Randomized trial48 participantsSkin Health forVitamin A
  49. An Updated Review of Topical Tretinoin in Dermatology: From Acne and Photoaging to Skin Cancer.
    Balado-Simó P; Morgado-Carrasco D; Gómez-Armayones S; López-Ferrer A; Barco D; Ferrándiz-Pulido C; Podlipnik S · Journal of clinical medicine · 2025
    Narrative reviewSkin Health forVitamin A
  50. Novel Cyclized Hexapeptide-9 Outperforms Retinol Against Skin Aging: A Randomized, Double-Blinded, Active- and Vehicle-Controlled Clinical Trial.
    Chang H; Tao K; Yang Y; Wang Y; Ge M; Wang X; Tang S; Yu H · Journal of cosmetic dermatology · 2025
    Randomized trialSkin Health forVitamin A
  51. Evaluation of the anti-wrinkle effect of an ascorbic acid-loaded dissolving microneedle patch via a double-blind, placebo-controlled clinical study.
    Lee C; Yang H; Kim S; Kim M; Kang H; Kim N; An S; Koh J; Jung H · International journal of cosmetic science · 2017
    Randomized trial23 participantsSkin Health forVitamin C
  52. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial.
    Machado BHB; Frame J; Zhang J; Najlah M · Aesthetic plastic surgery · 2021
    Randomized trial149 participantsSkin Health forVitamin C
  53. Randomized trial of topical ascorbic acid in DMSO versus imiquimod for the treatment of basal cell carcinoma.
    Burke B; Bailie JE · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Randomized trial25 participantsSkin Health forVitamin C
  54. Vitamin C improves healing of foot ulcers: a randomised, double-blind, placebo-controlled trial.
    Gunton JE; Girgis CM; Lau T; Vicaretti M; Begg L; Flood V · The British journal of nutrition · 2022
    Randomized trial16 participantsSkin Health forVitamin C
  55. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.
    Cosgrove MC; Franco OH; Granger SP; Murray PG; Mayes AE · The American journal of clinical nutrition · 2007
    Cross-sectional study4,025 participantsSkin Health forVitamin C
  56. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.
    Javanbakht MH; Keshavarz SA; Djalali M; Siassi F; Eshraghian MR; Firooz A; Seirafi H; Ehsani AH; Chamari M; Mirshafiey A · The Journal of dermatological treatment · 2011
    Randomized trial45 participantsSkin Health forVitamin E
  57. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
    Liu X; Yang G; Luo M; Lan Q; Shi X; Deng H; Wang N; Xu X; Zhang C · PloS one · 2022
    Meta-analysis20 studies pooledSkin Health forVitamin E
  58. Evidence-Based Nutritional Interventions in Wound Care.
    Saeg F; Orazi R; Bowers GM; Janis JE · Plastic and reconstructive surgery · 2021
    Systematic review2,339 participants36 studies pooledSkin Health forVitamin E Skin Health forZinc
  59. Effects of tocotrienol on aging skin: A systematic review.
    Ghazali NI; Mohd Rais RZ; Makpol S; Chin KY; Yap WN; Goon JA · Frontiers in pharmacology · 2022
    Systematic reviewSkin Health forVitamin E
  60. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
    Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H · The American journal of clinical nutrition · 2000
    Randomized trialSkin Health forVitamin E
  61. Sex-related differences in response to zinc pyrithione shampoo vs. non-anti-dandruff shampoo.
    Collins LZ; Baines FL; Matheson JR; Turner GA; Diao Y; Li Y; Pi Y · International journal of cosmetic science · 2019
    Meta-analysis2,088 participants20 studies pooledSkin Health forZinc
  62. Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.
    Andrew PV; Pinnock A; Poyner A; Brown K; Chittock J; Kay LJ; Cork MJ; Danby SG · Dermatology and therapy · 2024
    Cohort study23 participantsSkin Health forZinc
  63. Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial.
    Ågren MS; Chafranska L; Eriksen JO; Forman JL; Bjerrum MJ; Schjerling P; Larsen HF; Cottarelli E; Jorgensen LN; Gjerdrum LMR · European journal of cell biology · 2021
    Randomized trial30 participantsSkin Health forZinc
  64. A pilot trial using topical regular crystalline insulin vs. aqueous zinc solution for uncomplicated cutaneous wound healing: Impact on quality of life.
    Attia EA; Belal DM; El Samahy MH; El Hamamsy MH · Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2014
    Randomized trial90 participantsSkin Health forZinc