SuppHelper
search

Isoleucine

notesDescription

Isoleucine is one of three branched-chain amino acids (BCAAs), alongside Leucine and Valine, and is considered an essential amino acid, meaning the human body cannot synthesize it and must obtain it through diet or supplementation. It plays a critical role in numerous physiological processes, particularly in muscle metabolism, making it a popular supplement among athletes and those focused on fitness. Its unique branched structure is metabolized directly in muscle tissue rather than the liver, allowing for rapid use during exercise. Key functions of Isoleucine include assisting in muscle protein synthesis, which is vital for muscle growth and repair, and promoting muscle recovery after physical exertion. It also helps regulate blood sugar levels by facilitating glucose uptake into cells and supports energy production, especially during prolonged physical activity by serving as a fuel source. Furthermore, Isoleucine is involved in the formation of hemoglobin, the protein in red blood cells that carries oxygen throughout the body. Due to its importance in muscle development and energy metabolism, Isoleucine is frequently included in BCAA supplements to optimize athletic performance, reduce muscle soreness, and accelerate recovery times. It is particularly beneficial for individuals engaged in intense resistance training or endurance sports. Maintaining a balanced intake of all three BCAAs (Leucine, Isoleucine, and Valine) is generally recommended for optimal benefits, as they work synergistically.

ecoSources
Meat (beef, chicken, pork)FishEggsDairy products (milk, cheese, yogurt)Legumes (lentils, beans)Nuts (almonds, cashews)Seeds (sunflower seeds, pumpkin seeds)Whole grains (brown rice, quinoa)
Cheapest Isoleucine supplements
Discover the most affordable Isoleucine supplements to help you achieve your energy goals efficiently.
Best Isoleucine Supplements
Discover the best isoleucine supplements for boosting energy and supporting overall health and performance.
Value Isoleucine Supplements
Compare top-rated Isoleucine supplements for energy, focusing on the best value options to help you achieve your fitness goals efficiently and affordably.
check_circleOptimal Dosage
Minimum2000 mg
Maximum4000 mg
report_problemSafety & Toxicity
track_changesGoals
Energy
boltEnergy
Impact
Situational effect
Typical dose:500–2000 mg
Isoleucine can serve as an energy source for muscle tissue, sparing glycogen stores during intense physical activity. This makes it situationally useful for enhancing endurance and reducing exercise-induced fatigue in athletes.
View goal →
sync_altInteractions

add_circle_outlinePositive Interactions

add_circle
Leucine
Synergistic with Isoleucine as part of the BCAA trio, maximizing muscle protein synthesis and repair.
add_circle
Valine
Completes the BCAA combination with Isoleucine and Leucine, crucial for maintaining nitrogen balance and optimal muscle recovery.
add_circle
Vitamin B6
Acts as a vital co-factor for enzymes involved in the metabolism and utilization of amino acids, including Isoleucine.
add_circle
Creatine
Supports cellular energy production and muscle strength, complementing Isoleucine's role in muscle fuel and recovery.
add_circle
Glutamine
Often combined with BCAAs like Isoleucine to support muscle recovery, immune function, and gut health after intense exercise.
add_circle
L-Carnitine
Aids in fatty acid transport for energy production, which can support overall energy metabolism alongside Isoleucine during physical activity.

remove_circle_outlineNegative Interactions

remove_circle
Leucine
Extremely high, disproportionate doses of Leucine alone may compete with Isoleucine and Valine for absorption and transport, potentially leading to an imbalance in plasma BCAA levels.
inventory_2Recommended products
75 Budget Adreno Chelate

Adreno Chelate

Progressive Professional from Progressive Laboratories
5.0
★★★★★
(3 ratings)
Isoleucine: 10 mg
This supplement combines adrenal concentrate with electrolytes and essential amino acids, crafted to help support daily energy and the body's adaptive responses.
Buy for $25(from Pure Formulas)
Other sellers
83 Budget Essential Aminos

Essential Aminos

Pure Encapsulations
4.9
★★★★★
(22 ratings)
Isoleucine: 79 mg
This product offers all nine essential amino acids in capsule form, supporting fundamental bodily functions and overall protein synthesis for general well-being.
Buy for $55(from Pure Formulas)
Other sellers
88 Value BCAA 3200 mg

BCAA 3200 mg

Best Naturals
4.8
★★★★★
(47 ratings)
Isoleucine: 800 mg
An exceptionally high-dose BCAA product with a classic 2:1:1 ratio, offering outstanding value per serving.
Buy for $18.85(from iHerb)
Other sellers
76 Budget Branched-Chain Amino Acids

Branched-Chain Amino Acids

Lake Avenue Nutrition
4.7
★★★★★
(1343 ratings)
Isoleucine: 650 mg
A well-priced BCAA capsule providing a solid dose with a slightly leucine-heavy ratio.
Buy for $23(from iHerb)
Other sellers
70 Budget BCAA Plus Branched Chain Amino Acids

BCAA Plus Branched Chain Amino Acids

Solgar
4.8
★★★★★
(252 ratings)
Isoleucine: 360 mg
This supplement offers a basic dose of branched-chain amino acids, enhanced with Vitamin B6 for metabolic support, suitable for general daily intake or light exercise support.
Buy for $22.78(from iHerb)
Other sellers
85 Budget Amino-9 Essentials Powder

Amino-9 Essentials Powder

NOW Sports
4.4
★★★★★
(1471 ratings)
Isoleucine: 442 mg
This powder delivers all nine essential amino acids, making it a versatile supplement for daily support of muscle, energy, and overall bodily functions.
Buy for $25.69(from Vitacost)
Other sellers (4)
72 Budget Branched Chain Amino Acids

Branched Chain Amino Acids

NOW Sports
4.6
★★★★★
(2876 ratings)
Isoleucine: 650 mg
A solid BCAA supplement offering a good dose per serving with a slightly elevated leucine ratio in capsule form.
Buy for $14.89(from Vitacost)
Other sellers (5)
85 Best The Original Watermelon Explosion

The Original Watermelon Explosion

XTEND
4.5
★★★★★
(52231 ratings)
Isoleucine: 1750 mg
This is a comprehensive BCAA supplement with added glutamine, electrolytes, and citrulline malate, designed to support muscle recovery, hydration, and performance during workouts.
Buy for $24.97(from Amazon)
Other sellers (3)
85 Best The Original Blue Raspberry Ice

The Original Blue Raspberry Ice

XTEND
4.6
★★★★★
(12359 ratings)
Isoleucine: 1750 mg
This is a comprehensive BCAA supplement with added glutamine, electrolytes, and citrulline malate, designed to support muscle recovery, hydration, and performance during workouts.
Buy for $24.92(from Amazon)
Other sellers (3)
85 Best The Original Glacial Grape

The Original Glacial Grape

XTEND
4.5
★★★★★
(50928 ratings)
Isoleucine: 1750 mg
This is a comprehensive BCAA supplement with added glutamine, electrolytes, and citrulline malate, designed to support muscle recovery, hydration, and performance during workouts.
Buy for $27.99(from iHerb)
Other sellers (2)
85 Best The Original Knockout Fruit Punch

The Original Knockout Fruit Punch

XTEND
4.5
★★★★★
(47968 ratings)
Isoleucine: 1750 mg
This is a comprehensive BCAA supplement with added glutamine, electrolytes, and citrulline malate, designed to support muscle recovery, hydration, and performance during workouts.
Buy for $27.74(from Amazon)
Other sellers (2)
85 Best The Original Smash Apple

The Original Smash Apple

XTEND
4.4
★★★★★
(3740 ratings)
Isoleucine: 1750 mg
This is a comprehensive BCAA supplement with added glutamine, electrolytes, and citrulline malate, designed to support muscle recovery, hydration, and performance during workouts.
Buy for $24.99(from iHerb)
Other sellers (1)
85 Best The Original Strawberry Kiwi Splash

The Original Strawberry Kiwi Splash

XTEND
4.5
★★★★★
(49517 ratings)
Isoleucine: 1750 mg
This is a comprehensive BCAA supplement with added glutamine, electrolytes, and citrulline malate, designed to support muscle recovery, hydration, and performance during workouts.
Buy for $27.99(from Amazon)
Other sellers (2)
78 Best Ripped Blueberry Lemonade

Ripped Blueberry Lemonade

XTEND
4.4
★★★★★
(3488 ratings)
Isoleucine: 1750 mg
This product combines muscle-supporting BCAAs and L-Glutamine with electrolytes for hydration, plus ingredients like CLA, L-Carnitine, and Capsimax to support metabolic goals and energy for fitness-minded individuals.
Buy for $35.94(from Amazon)
Other sellers (1)
78 Best Ripped Strawberry Kiwi Splash

Ripped Strawberry Kiwi Splash

XTEND
4.4
★★★★★
(3440 ratings)
Isoleucine: 1750 mg
This product combines muscle-supporting BCAAs and L-Glutamine with electrolytes for hydration, alongside ingredients like CLA, L-Carnitine, and Capsimax designed to contribute to metabolic goals and energy for fitness enthusiasts.
Buy for $37.99(from Amazon)
Other sellers (1)
85 Best The Original Italian Blood Orange

The Original Italian Blood Orange

XTEND
4.5
★★★★★
(52478 ratings)
Isoleucine: 1750 mg
This is a comprehensive BCAA supplement with added glutamine, electrolytes, and citrulline malate, designed to support muscle recovery, hydration, and performance during workouts.
Buy for $27.99(from iHerb)
Other sellers (2)
60 Budget Daily Amino Acid

Daily Amino Acid

21st Century
4.7
★★★★★
(8613 ratings)
Isoleucine: 63 mg
This supplement offers a broad mix of amino acids and a daily dose of calcium in an economical tablet form, intended for general wellness support.
Buy for $9.99(from iHerb)
Other sellers (1)
78 Budget Mega-Size BCAA 1000 Caps

Mega-Size BCAA 1000 Caps

Optimum Nutrition
4.6
★★★★★
(25872 ratings)
Isoleucine: 250 mg
A very affordable BCAA capsule with a classic 2:1:1 ratio, though it provides a lower dose per serving.
Buy for $18.99(from Supplement City Usa)
Other sellers (3)
90 Value The Original Knockout Fruit Punch

The Original Knockout Fruit Punch

XTEND
4.5
★★★★★
(47940 ratings)
Isoleucine: 1750 mg
This large-format BCAA supplement combines glutamine, electrolytes, and citrulline malate to effectively support muscle recovery, hydration, and workout performance at a great value.
Buy for $54.99(from Amazon)
Other sellers (2)
82 Best Muscle BCAA Tropical Punch

Muscle BCAA Tropical Punch

ZHOU
4.6
★★★★★
(110 ratings)
Isoleucine: 2500 mg
A comprehensive blend that combines essential BCAAs and Glutamine with Vitamin C, performance support, and a probiotic, making it a versatile option for fitness and general well-being.
Buy for $24.49(from Vitacost)
Other sellers (1)
90 Value The Original Blue Raspberry Ice

The Original Blue Raspberry Ice

XTEND
4.5
★★★★★
(53228 ratings)
Isoleucine: 1750 mg
This large-format BCAA supplement combines glutamine, electrolytes, and citrulline malate to effectively support muscle recovery, hydration, and workout performance at a great value.
Buy for $55.94(from Amazon)
Other sellers (2)
82 Value The Original Smash Apple

The Original Smash Apple

XTEND
4.5
★★★★★
(2652 ratings)
Isoleucine: 1750 mg
This XTEND product offers a comprehensive mix of BCAAs, glutamine, electrolytes, and citrulline malate to support muscle recovery, hydration, and exercise performance during and after workouts.
Buy for $43.99(from Amazon)
Other sellers (1)
80 Value The Original Tropic Thunder

The Original Tropic Thunder

XTEND
4.5
★★★★★
(56887 ratings)
Isoleucine: 1750 mg
This XTEND product offers a comprehensive mix of BCAAs, glutamine, electrolytes, and citrulline malate to support muscle recovery, hydration, and exercise performance during and after workouts.
Buy for $57.2(from Amazon)
Other sellers (2)
80 Value The Original Strawberry Kiwi Splash

The Original Strawberry Kiwi Splash

XTEND
4.5
★★★★★
(49510 ratings)
Isoleucine: 1750 mg
This XTEND product offers a comprehensive mix of BCAAs, glutamine, electrolytes, and citrulline malate to support muscle recovery, hydration, and exercise performance during and after workouts.
Buy for $54.99(from Amazon)
Other sellers (2)
80 Value The Original Watermelon Explosion

The Original Watermelon Explosion

XTEND
4.5
★★★★★
(52224 ratings)
Isoleucine: 1750 mg
This XTEND product offers a comprehensive mix of BCAAs, glutamine, electrolytes, and citrulline malate to support muscle recovery, hydration, and exercise performance during and after workouts.
Buy for $54.99(from Amazon)
Other sellers (2)
79 Value The Original Glacial Grape

The Original Glacial Grape

XTEND
4.5
★★★★★
(50928 ratings)
Isoleucine: 1750 mg
This XTEND product offers a comprehensive mix of BCAAs, glutamine, electrolytes, and citrulline malate to support muscle recovery, hydration, and exercise performance during and after workouts.
Buy for $64.99(from iHerb)
Other sellers (2)
82 Value The Original Mango Madness

The Original Mango Madness

XTEND
4.5
★★★★★
(61804 ratings)
Isoleucine: 1750 mg
This XTEND product offers a comprehensive mix of BCAAs, glutamine, electrolytes, and citrulline malate to support muscle recovery, hydration, and exercise performance during and after workouts.
Buy for $53(from Amazon)
Other sellers (2)
82 Value The Original Lemon-Lime Squeeze

The Original Lemon-Lime Squeeze

XTEND
4.5
★★★★★
(56351 ratings)
Isoleucine: 1750 mg
This XTEND product offers a comprehensive mix of BCAAs, glutamine, electrolytes, and citrulline malate to support muscle recovery, hydration, and exercise performance during and after workouts.
Buy for $49.6(from Amazon)
Other sellers (2)
analyticsProduct stats
sellPrice per product
Average$36.41
Median$29.99
restaurantPrice per serving
Average$1.14
Median$0.87
sciencePrice per 1000 mg
Average$1.52
Median$0.72
bar_chartPrice distribution
bar_chartPrice per serving distribution
bar_chartPrice per 1000 mg
Reference amount: 1000 mg
bar_chartPaired ingredients

SuppHelper

Compare supplements smarter. Science-backed, user-rated, updated daily.

Explore

  • Compare Supplements
  • Health Goals
  • Stacks

Legal

  • Privacy Policy
  • Terms of Use
  • Medical Disclaimer

Stay in the Loop

© 2025 SuppHelper. All rights reserved.