Valerian

Description

Valerian is a perennial flowering plant native to Europe and Asia, whose roots have been utilized for centuries as a traditional herbal remedy. It is predominantly known for its mild sedative effects, making it a popular natural choice for individuals seeking to enhance sleep onset and duration, as well as manage occasional feelings of nervousness or mild stress. The therapeutic actions of Valerian are believed to stem from its diverse array of bioactive compounds, including valerenic acid, iridoids (like valepotriates), and various flavonoids. These constituents are thought to interact with gamma-aminobutyric acid (GABA) receptors in the brain, a key neurotransmitter that helps to regulate nerve impulses. This interaction facilitates a calming effect on the central nervous system, often compared to the action of some conventional anxiolytic medications but typically with a milder impact. Historically, Valerian was applied to a range of conditions, from insomnia to digestive discomfort. In contemporary practice, its primary applications are centered on its anxiolytic (anxiety-reducing) and hypnotic (sleep-inducing) properties. It is frequently employed as a sleep aid or to mitigate symptoms of daily stress, contributing to overall mental relaxation without commonly leading to residual drowsiness upon waking when used as directed.

Sources
Valerian plant (Valeriana officinalis) root
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Timing & Intake
Pre BedTake with Water, preferably 30 minutes to 2 hours before bedtime for sleep support.
Often taken in the evening or shortly before bedtime for its calming and sleep-inducing effects. For general anxiety, it can be taken during the day, though potential drowsiness should be considered.
Optimal Dosage
Minimum400 mg
Maximum900 mg
Safety & Toxicity
Price per product
Average$17.65
Median$16.87
Price per serving
Average$0.44
Median$0.36
Price per 100 mg
Average$0.36
Median$0.21
Price distribution
Price per serving distribution
Price per 100 mg
Reference amount: 100 mg
Forms
Paired ingredients
Valerenic Acid (11)90
Valerenic acids represent a class of sesquiterpenoids found in Valeriana officinalis, crucial for the plant's anxiolytic and sedative effects. Extracts are often standardized to contain a certain percentage of these compounds, indicating potency. They are thought to modulate GABA-A receptors, contributing to their calming properties.
Pros
  • Represents a standardized active complex for Valerian extracts
  • Well-recognized markers for product quality and potency
  • Associated with the main pharmacological effects of Valerian
Cons
  • Focuses only on one class of compounds, potentially overlooking other beneficial constituents in whole Valerian
  • Specific individual roles of each valerenic acid are still being researched
Per product
Avg$33.21
Med$34.49
Per serving
Avg$0.86
Med$0.66
Per 100 mg
Avg$0.49
Med$0.27
Price distribution
Valerenic Acids (6)90
Valerenic acids represent a class of sesquiterpenoids found in Valeriana officinalis, crucial for the plant's anxiolytic and sedative effects. Extracts are often standardized to contain a certain percentage of these compounds, indicating potency. They are thought to modulate GABA-A receptors, contributing to their calming properties.
Pros
  • Represents a standardized active complex for Valerian extracts
  • Well-recognized markers for product quality and potency
  • Associated with the main pharmacological effects of Valerian
Cons
  • Focuses only on one class of compounds, potentially overlooking other beneficial constituents in whole Valerian
  • Specific individual roles of each valerenic acid are still being researched
Per product
Avg$20.49
Med$16.68
Per serving
Avg$0.41
Med$0.41
Per 100 mg
Avg$0.17
Med$0.16
Price distribution
Valeric Acid (1)35
Valeric acid (pentanoic acid) is a saturated fatty acid found in Valerian root, particularly in the essential oil. While historically thought to contribute to Valerian's calming effects, modern research suggests its primary role is in giving Valerian its characteristic strong smell. Its direct pharmacological activity as a primary mediator of sleep and stress relief is not as well-supported as that of the valerenic acids.
Pros
  • Contributes to the characteristic aroma of Valerian, a traditional marker
  • May have some minor synergistic effects within the whole plant extract
Cons
  • Not considered a primary active compound for Valerian's sedative or anxiolytic effects
  • Its direct therapeutic impact is less understood compared to valerenic acids
  • Responsible for the unpleasant odor sometimes associated with Valerian
Per product
Avg$18.26
Med$18.26
Per serving
Avg$0.60
Med$0.60
Per 100 mg
Avg$0.30
Med$0.30
Price distribution