Apigenin

Description

Apigenin is a bioactive plant flavonoid abundantly present in various fruits, vegetables, and herbs, notably parsley and chamomile. As a member of the flavone subclass, it possesses a distinct chemical structure that allows it to interact with diverse cellular pathways within the body. This interaction contributes to its wide array of biological activities, including its notable antioxidant, anti-inflammatory, and potential anticancer effects. Research indicates that Apigenin operates through multiple mechanisms. These include the modulation of enzyme activities, the inhibition of inflammatory signaling pathways such as NF-κB, and the influence on other cellular cascades. These actions are fundamental to its ability to combat oxidative stress, reduce inflammation, and potentially offer protective benefits to various tissues and organs, including the brain. Given its broad spectrum of beneficial activities, Apigenin is increasingly incorporated into dietary supplements. It is often sought for its potential roles in supporting cognitive function, promoting cardiovascular health, aiding in relaxation, and maintaining overall cellular integrity against damage and dysfunction.

Sources
ParsleyChamomileCelerySpinachArtichokesOrangesSpearmintBasilOreganoCoriander
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Optimal Dosage
Minimum10 mg
Maximum50 mg
Safety & Toxicity
Toxicity Threshold50 mg
Toxicity EffectStomach irritation, nausea
Goals
Anti-Aging
Anti-Aging
Impact
Moderate effect
Typical dose:50–200 mg
Apigenin has been shown to inhibit the enzyme CD38, which is a primary consumer of NAD+, thereby helping to preserve NAD+ levels essential for mitochondrial function and DNA repair. It also shows promise in helping the body clear senescent 'zombie' cells that contribute to aging. Additionally, it binds to GABA receptors in the brain, promoting relaxation and deeper sleep.
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Sleep Support
Sleep Support
Impact
Moderate effect
Typical dose:50–200 mg
Apigenin is a bioactive flavonoid that acts on the central nervous system to produce a calming effect. It binds to specific brain receptors (benzodiazepine receptors) that decrease anxiety and initiate sleep. It is a gentle, non-habit-forming option for promoting relaxation before bed.
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Anti-Inflammatory Support
Anti-Inflammatory Support
Impact
Situational effect
Typical dose:50–200 mg
Apigenin is a natural compound found in plants like chamomile that modulates the body's inflammatory response at a molecular level. It helps downregulate the production of inflammatory cytokines and enzymes, making it a valuable situational tool for managing chronic, low-grade inflammation.
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Stress Relief
Stress Relief
Impact
Situational effect
Typical dose:25–100 mg
Apigenin acts as a mild sedative by binding to specific receptors in the brain (benzodiazepine receptors), which reduces anxiety without the side effects of stronger medications. It is particularly effective for unwinding from stress in the evening.
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Interactions

Positive Interactions

Vitamin C
May enhance overall antioxidant capacity due to synergistic effects with Apigenin.
Vitamin E
May contribute to a stronger antioxidant defense system when combined with Apigenin.
Selenium
May provide synergistic antioxidant protection alongside Apigenin.
Turmeric
Apigenin and Curcumin (from Turmeric) both possess anti-inflammatory and antioxidant properties, potentially leading to enhanced effects.
Curcumin
Apigenin and Curcumin both possess anti-inflammatory and antioxidant properties, potentially leading to enhanced effects.
Green Tea
May offer synergistic antioxidant benefits as both contain various flavonoids.
Coenzyme Q-10
May provide enhanced antioxidant and cellular energy support in conjunction with Apigenin.
Astaxanthin
May amplify antioxidant protection due to complementary mechanisms of action.
Lycopene
May contribute to stronger antioxidant effects, particularly against lipid peroxidation.
Gluthathione
May support the body's natural antioxidant system through synergistic action.
Glutathione
May support the body's natural antioxidant system through synergistic action.
Rutin
As both are flavonoids, they may exert synergistic antioxidant and anti-inflammatory benefits.
Resveratrol
Both Apigenin and Resveratrol are polyphenols with overlapping antioxidant and anti-inflammatory properties, potentially enhancing their overall effects.
Bacopa
May enhance neuroprotective and cognitive support benefits.
Ashwagandha
May offer complementary adaptogenic and anti-inflammatory benefits.
Ginkgo
May enhance neuroprotective and antioxidant support for brain health.
Melatonin
May complement Melatonin's effects in promoting relaxation and sleep due to Apigenin's presence in chamomile.
Price per product
Average$31.39
Median$22.47
Price per serving
Average$0.34
Median$0.32
Price distribution
Price per serving distribution
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Paired ingredients