Ultra Strength One-per-Day RxOmega-3 with Vitamin D3 25 mcg (1000IU)

Ultra Strength One-per-Day RxOmega-3 with Vitamin D3 25 mcg (1000IU)

Natural Factors4.9 (1,724 ratings)
Format:Softgel Quantity: 150 Softgel(s) · 150 servings
Goals
$49.67 $0.33 per serving

Product analysis

51 out of 100

Ultra Strength One-per-Day RxOmega-3 with Vitamin D3 25 mcg (1000IU) offers a daily option whose DHA may help lower triglycerides, a type of blood fat. Its EPA amount remains unclear, limiting a complete omega-3 comparison.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality21

Several source names are given, but the precise DHA form is not clearly disclosed. That limits a confident comparison of absorption quality.

Ingredient Transparency60

The DHA amount is declared, while the EPA amount remains unresolved. Some other composition and form details are also uncertain, limiting a full omega-3 comparison.

Value For Money40

Value cannot be determined reliably from the available price and DHA amount information. The unresolved EPA amount also limits a complete comparison.

Customer Satisfaction89

Customer feedback is very positive. A large number of ratings gives that view a broader base, though reviews do not establish effectiveness.

Product Focus76

DHA provides the clearest connection to lowering blood fats and to inflammation-related pathways. The unresolved EPA amount limits confidence in the full contribution.

Format
Softgel
Container
150 Softgel(s)
Per serving
$0.33
Customer rating
4.9 · 1,724 ratings
Report analysis

Goals

Inflammation
Impact
Moderate effect
C- Ingredient FitF PathwaysA EvidenceA- Formulation Logic
Vitamin D · 25 mcgFish Oil · 1407 mg
Study evidence
Fish Oil Supportive 68 studies
Vitamin D Supportive 101 studies
Skin Health
Impact
High effect
B- Ingredient FitD PathwaysB EvidenceA+ Formulation Logic
Omega-3 · 900 mg
Study evidence
Omega-3 Supportive 35 studies
Cardiovascular Support
Impact
High effect
C- Ingredient FitD- PathwaysB+ EvidenceA Formulation Logic
Vitamin D · 25 mcgFish Oil · 1407 mg
Study evidence
Fish Oil Supportive 185 studies
Vitamin D Mixed 170 studies

Ingredients

IngredientAmount per servingScore
Calories
15 Calorie(s)
Total Fat
1.5 Gram(s)
Cholesterol
5 mg
Vitamin D3 (Cholecalciferol, Lanolin)
25 mcg
pharmaceutical grade Fish Oil concentrate (Anchovy, Mackerel, Sardine)
1407 mg 44
Omega-3 Fatty Acids
900 mg 54
Eicosapentaenoic Acid Ethyl Ester
600 mg
Docosahexaenoic Acid Ethyl Ester
300 mg 74
Gluten Free Adults 18–50 Dairy Free Sugar Free
Report overview
DHA · 300 mg OverallScore74
B- Active Ingredient Quality & BioavailabilityB+ Dose, Safety & Label TransparencyC Value
A serving provides 300 mg of DHA. The cost per gram of DHA is moderate. DHA is in ethyl ester form. A purity certification or pharmaceutical-grade claim is indicated, but the specific claim is not identified here.
How this ingredient is rated

Active Ingredient Quality & Bioavailability72

DHA is in ethyl ester form. The declared omega-3 content is about 64% of the oil.
DHA Chemical Form & Bioavailability
DHA is in ethyl ester form.
Oxidation Protection & Stability
An antioxidant is indicated, though its identity is not available here.
Oil Concentration & Purity
The declared omega-3 content is about 64% of the oil.

Dose, Safety & Label Transparency83

A serving provides 300 mg of DHA. A purity certification or pharmaceutical-grade claim is indicated, but the specific claim is not identified here.
DHA Absolute Dosage
A serving provides 300 mg of DHA.
Purity & Heavy Metal Verification
A purity certification or pharmaceutical-grade claim is indicated, but the specific claim is not identified here.
Ingredient Source Transparency
The source includes small fish or krill, though the specific source is not identified here.

Value60

The cost per gram of DHA is moderate.
Price per Gram of DHA
The cost per gram of DHA is moderate.
C Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyA+ Value
The serving contains 1407 mg of fish oil, but its EPA and DHA amounts remain unclear. The estimated cost per gram of EPA and DHA is low. The oil is described as ethyl ester form.
How this ingredient is rated

Active Ingredient Quality & Bioavailability60

The oil is described as ethyl ester form. A specific purification method is claimed, but its name is not available here. The available information does not mention independent testing.
Omega-3 Molecular Form
The oil is described as ethyl ester form.
Purification & Filtration Method
A specific purification method is claimed, but its name is not available here.
Third-Party Purity & Potency Verification
The available information does not mention independent testing.
Source & Sustainability
A fish source is indicated, but the species is not clear in the available information.

Dose, Safety & Label Transparency0

The combined EPA and DHA amount and their share of the oil are unclear. A qualifying antioxidant is not established in the available information.
Total Active Omega-3 Dose (EPA + DHA)
The combined EPA and DHA amount is unknown from the available information.
Omega-3 Potency & Concentration
The proportion of the oil supplied as EPA and DHA cannot be established.
EPA & DHA Individual Disclosure
Separate EPA and DHA amounts are not established in the available information.
Oxidation Protection (Stabilizers)
A qualifying antioxidant is not established in the available information.

Value100

The estimated cost per gram of EPA and DHA is low.
Cost Per Gram of Active EPA + DHA
The estimated cost per gram of EPA and DHA is low.
Omega-3 · 900 mg OverallScore54
B- Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyA+ Value
The serving provides 900 mg of total omega-3. Its estimated EPA and DHA cost is low. Separate EPA and DHA amounts are incomplete, so their concentration is unknown. It uses ethyl esters.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The omega-3s are in ethyl ester form. The source and antioxidant information indicate antioxidant inclusion.
Molecular Form & Absorption Potential
The omega-3s are in ethyl ester form.
Source Purity & Oxidative Protection
The source and antioxidant information indicate antioxidant inclusion.

Dose, Safety & Label Transparency15

The total omega-3 amount is available, but separate EPA and DHA amounts are not both available. No qualifying independent purity certification or testing claim is available.
EPA & DHA Label Specificity
The total omega-3 amount is available, but separate EPA and DHA amounts are not both available.
Active Ingredient Concentration
The EPA and DHA share of the oil is unknown because the required amounts are incomplete.
Third-Party Purity Verification
No qualifying independent purity certification or testing claim is available.

Value100

The estimated cost per gram of EPA and DHA is low.
Price per 1000mg of EPA+DHA
The estimated cost per gram of EPA and DHA is low.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.
    Hu Y; Hu FB; Manson JE · Journal of the American Heart Association · 2020
    Meta-analysis127,477 participants13 studies pooledCardiovascular Support forFish Oil
  2. Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
    Lu J; Liu R; Ren H; Wang S; Hu C; Shi Z; Li M; Liu W; Wan Q; Su Q; Li Q; Zheng H; Qu S; Yang F; Ji H; Lin H; Qi H; Wu X; Wu K; Chen Y; Xu Y; Xu M; Wang T; Zheng J; Ning G; Zheng R; Bi Y; Zhong H; Wang W · Med (New York, N.Y.) · 2025
    Randomized trial309 participantsCardiovascular Support forFish Oil
  3. A systematic review of fish-oil supplements for the prevention and treatment of hypertension.
    Campbell F; Dickinson HO; Critchley JA; Ford GA; Bradburn M · European journal of preventive cardiology · 2013
    Meta-analysis1,524 participants17 studies pooledCardiovascular Support forFish Oil
  4. Effects of fish oil-derived fatty acids on suboptimal cardiovascular health: A multicenter, randomized, double-blind, placebo-controlled trial.
    Zeng Q; Dong SY; Liu YP; Fu J; Shuai P; Zhao ZM; Li TX · Nutrition, metabolism, and cardiovascular diseases : NMCD · 2017
    Randomized trial422 participantsCardiovascular Support forFish Oil
  5. Effect of High-Dose Marine Omega-3 Fatty Acids on Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
    Sekikawa A; Cui C; Sugiyama D; Fabio A; Harris WS; Zhang X · Nutrients · 2020
    Meta-analysis6 studies pooledCardiovascular Support forFish Oil
  6. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis.
    Norouzzadeh M; Rashedi MH; Mahdavi-Mazdeh G; Kosari A; Shahinfar H · Current atherosclerosis reports · 2026
    Meta-analysisCardiovascular Support forVitamin D
  7. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.
    Kumar V; Yadav AK; Lal A; Kumar V; Singhal M; Billot L; Gupta KL; Banerjee D; Jha V · Journal of the American Society of Nephrology : JASN · 2017
    Randomized trial120 participantsCardiovascular Support forVitamin D
  8. Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk.
    Porto C; Petribu K; Barbosa N; Magalhães R; Lira C; Porto AB; Markman-Filho B; Lordsleem A; Calado E; Magalhães J; Sougey E; Silva T; Junio A; Bandeira F; Leão R · American heart journal plus : cardiology research and practice · 2025
    Randomized trial224 participantsCardiovascular Support forVitamin D
  9. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
    Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y · PloS one · 2017
    Randomized trial70 participantsCardiovascular Support forVitamin D
  10. Paricalcitol and endothelial function in chronic kidney disease trial.
    Zoccali C; Curatola G; Panuccio V; Tripepi R; Pizzini P; Versace M; Bolignano D; Cutrupi S; Politi R; Tripepi G; Ghiadoni L; Thadhani R; Mallamaci F · Hypertension (Dallas, Tex. : 1979) · 2015
    Randomized trial88 participantsCardiovascular Support forVitamin D
  11. Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial.
    Song J; Hu M; Li C; Yang B; Ding Q; Wang C; Mao L · Food & function · 2018
    Randomized trial201 participantsInflammation forFish Oil
  12. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.
    Lin YL; Wang CL; Chiang TI · Frontiers in nephrology · 2024
    Randomized trial60 participantsInflammation forFish Oil
  13. Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized controlled trial.
    Yang B; Ren XL; Li ZH; Shi MQ; Ding F; Su KP; Guo XJ; Li D · Food & function · 2020
    Randomized trial77 participantsInflammation forFish Oil
  14. The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning.
    Meng Z; Dong Y; Gao H; Yao D; Gong Y; Meng Q; Zheng T; Cui X; Su X; Tian Y · The Journal of international medical research · 2019
    Randomized trial174 participantsInflammation forFish Oil
  15. Effects of Omega-3 Fatty Acid Intake in Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Liu R; Jiang J; Fu Z; Liu C; Yao L; Quan H · Journal of the American Nutrition Association · 2022
    Meta-analysis49 studies pooledInflammation forFish Oil
  16. Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study.
    Zhou A; Hyppönen E · International journal of epidemiology · 2023
    Observational study294,970 participantsInflammation forVitamin D
  17. Vitamin D in Children With Inflammatory Bowel Disease: A Randomized Controlled Clinical Trial.
    El Amrousy D; El Ashry H; Hodeib H; Hassan S · Journal of clinical gastroenterology · 2021
    Randomized trial120 participantsInflammation forVitamin D
  18. Vitamin D supplementation reduces infection rate and promotes wound healing in patients with diabetic foot ulcers.
    Gao YQ; Gao YH; Xing JH · World journal of diabetes · 2025
    Randomized trial120 participantsInflammation forVitamin D
  19. Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES.
    Yang F; Sun M; Sun C; Li J; Yang X; Bi C; Wang M; Pu L; Wang J; Wang C; Xie M; Yao Y; Jin L · Scientific reports · 2020
    Cross-sectional study9,809 participantsInflammation forVitamin D
  20. Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.
    Zhang C; Cui J; Li S; Shen J; Luo X; Yao Y; Shi H · BMC geriatrics · 2024
    Cohort study3,072 participantsInflammation forVitamin D