Homocysteine Resist

Homocysteine Resist

Life Extension4.9 (6,300 ratings)
Format:Capsule Quantity: 60 Capsule(s) · 60 servings
Goals

Product analysis

70 out of 100

Homocysteine Resist supplies B vitamins involved in normal blood formation and homocysteine processing when nutritional intake is low.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality55

B6 is clearly identified as pyridoxal 5-phosphate, and riboflavin is also named. Folate source proportions remain unknown, and named forms do not establish added benefit from high amounts.

Ingredient Transparency80

The nutrient amounts and sources are stated. The folate declaration lacks source proportions, limiting a complete check of that part of the formula.

Value For Money64

B6 and riboflavin have favorable cost comparisons. Folate and B12 value remain uncertain, so the lower costs of those two B vitamins do not establish value for every contribution.

Customer Satisfaction93

Customer ratings are strongly positive across a substantial number of entries. The larger pool gives a broader view of satisfaction without demonstrating improved cognition or cardiovascular outcomes.

Product Focus73

The compact B-vitamin mix supports nutritional functions including blood formation and homocysteine processing. The 100 mg B6 serving raises a concrete concern about suitability for routine use, and larger amounts do not establish greater benefit.

Format
Capsule
Container
60 Capsule(s)
Per serving
$0.32
Customer rating
4.9 · 6,300 ratings
Report analysis

Goals

Impact
Highest effect
A Ingredient FitB+ PathwaysB+ EvidenceA Formulation Logic
Folate · 8500 mcg DFEVitamin B12 · 1000 mcg

Folate and B12 supply nutrients involved in one-carbon processes and blood formation, with riboflavin and B6 adding nutritional availability. Their large declared amounts do not establish improved energy, disease prevention or benefit beyond adequacy. The 100 mg vitamin B6 per serving triggers the supplied formulation concern; meeting amount references does not resolve that concern.

How this product is rated for Everyday Health

Ingredient fit91

The four B vitamins form a focused nutritional combination and meet the saved amount references.
Goal fit
The four B vitamins form a focused nutritional combination and meet the saved amount references.
Dose adequacy
The declared amounts meet the saved references; larger quantities do not establish extra benefit.

Pathways80

One-carbon metabolism and blood formation is the strongest represented area. The broader represented areas are energy metabolism cofactors; one-carbon metabolism and blood formation.
Depth
One-carbon metabolism and blood formation is the strongest represented area.
Breadth
The represented areas are energy metabolism cofactors; one-carbon metabolism and blood formation.

Evidence82

Folate provides the main evidence contribution. Folate provides a nutritional contribution, without proving general-health effects above adequate intake.
Evidence strength
Folate provides a nutritional contribution, without proving general-health effects above adequate intake.
Studied preparation
The ingredients meeting the amount threshold match the supplied preparation findings; this does not establish benefit beyond the stated scope.

Formulation logic93

Vitamin B6 at 100 mg per serving triggers the supplied high-amount formulation concern.
Partner coverage
The counted ingredients work independently or have their partner; no additional combination benefit is established.
Conflicts
Vitamin B6 at 100 mg per serving triggers the supplied high-amount formulation concern.
Effective doses
All counted ingredients meet the saved amount threshold; this does not make the amount a proven clinical dose.
Study evidence
Folate Supportive 80 studies
Hair Health
Impact
High effect
A Ingredient FitF PathwaysB EvidenceA+ Formulation Logic

Folate supports normal cell division, while vitamin B12 contributes to general nutrient adequacy. These roles and the saved amount findings do not establish independent hair regrowth. Higher amounts do not demonstrate stronger hair outcomes.

How this product is rated for Hair Health

Ingredient fit91

The relevant nutrient ingredients connect with hair mainly through nutritional sufficiency, with the selected serving determining the amount finding.
Goal fit
The included active ingredients are focused on the recognized hair-related nutrient contribution.
Dose adequacy
The recognized ingredients reach the saved amount anchors per selected serving; this does not establish additional benefit at higher intakes.

Pathways0

The saved result does not cover the specified hair mechanisms; nutritional relevance can still exist.
Depth
The saved findings identify nutrient support without coverage of the four specified hair mechanisms.
Breadth
None of the specified mechanisms reaches the saved coverage threshold.

Evidence78

The saved evidence finding recognizes individual ingredients and preparations, subject to their specific hair-outcome limitations.
Evidence strength
Vitamin B12 leads the saved evidence finding, although the supplied context limits how confidently routine hair benefits can be expected.
Studied preparation
The recognized preparations meet the saved preparation criteria; this does not mean the finished product has demonstrated regrowth.

Formulation logic100

The saved findings show no unmet partner requirement or configured conflict; amount recognition does not prove extra benefit from the combination.
Partner coverage
The recognized ingredients have no unmet partner requirement in the saved findings; this does not establish synergy.
Conflicts
No configured ingredient conflict was identified; this finding does not establish overall safety.
Effective doses
All ingredients counted here pass the saved minimum amount threshold, which is a comparison criterion rather than a proven treatment dose.
Study evidence
Folate Mixed 15 studies

Ingredients

IngredientAmount per servingScore
Riboflavin
25 mg 63
Vitamin B6 (Pyridoxal 5-Phosphate)
100 mg 72
Folate (L-5-Methyltetrahydrofolate, Calcium Salt)
8500 mcg DFE
Vitamin B12 (Methylcobalamin)
1000 mcg 90
Gluten Free Adults 18–50
Report overview
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value
A serving provides 1,000 mcg of B12 as methylcobalamin. The whole-product price works out to about $0.33 per 1,000 mcg of B12.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The B12 is methylcobalamin, a bioactive form.
Bioactive B12 Form Selection
The listed B12 form is methylcobalamin.

Dose, Safety & Label Transparency100

The label identifies the form and lists 1,000 mcg of B12 per serving.
Therapeutic Dosage Level
A serving contains 1,000 mcg of vitamin B12.
Label and Form Transparency
The label identifies methylcobalamin and specifies the B12 amount per serving.

Value50

The whole-product price works out to about $0.33 per 1,000 mcg of B12.
Price per 1,000 mcg B12
The whole-product price works out to about $0.33 per 1,000 mcg of B12.
A+ Ingredient Form & Label QualityF Dose, Safety & Label TransparencyA+ Value
The 100 mg of B6 per serving exceeds the European adult daily upper limit on its own. The identified B6 source is pyridoxal 5-phosphate.
How this ingredient is rated

Ingredient Form & Label Quality100

The B6 source is identified as pyridoxal 5-phosphate. No screened additives were flagged.
Vitamin B6 Form Identification
The identified vitamin B6 source is pyridoxal 5-phosphate.
Clean Label and Excipient Purity
No artificial colors, titanium dioxide or talc were flagged in the evaluation.

Dose, Safety & Label Transparency30

The 100 mg of B6 per serving exceeds the European adult daily upper limit on its own. The B6 source is disclosed.
Vitamin B6 Dose & Safety Policy
The 100 mg of B6 per serving exceeds the European adult daily upper limit on its own.
Label Transparency
The chemical source of the B6 is identified.

Value100

At about $0.0033 per mg of B6, based on the whole-product price, the B6 cost is low in the comparison.
Vitamin B6 Price Efficiency
At about $0.0033 per mg of B6, based on the whole-product price, the B6 cost is low in the comparison.
Riboflavin · 25 mg OverallScore63
F Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyB+ Value
A serving provides 25 mg of standard riboflavin, a moderate amount. The standard form needs conversion in the body to become active.
How this ingredient is rated

Active Ingredient Quality & Bioavailability30

The standard riboflavin form requires conversion in the body before it can become active.
Riboflavin Form Quality
The standard riboflavin form requires conversion in the body before it can become active.

Dose, Safety & Label Transparency88

The serving provides 25 mg of riboflavin, a moderate amount. No artificial additives were flagged.
Dosage for Energy & Metabolism
Each serving provides 25 mg of riboflavin, a moderate amount.
R5P Elemental Yield Transparency
The phosphate yield issue does not apply to standard riboflavin.
Additive Purity
No artificial additives were flagged in the available ingredient information.

Value80

A whole-product serving costs about $0.33.
Price per Serving Value
A whole-product serving costs about $0.33.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsEveryday Health forFolate
  2. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsEveryday Health forFolate
  3. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsEveryday Health forFolate
  4. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewEveryday Health forFolate
  5. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledEveryday Health forFolate
  6. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsEveryday Health forVitamin B12
  7. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsEveryday Health forVitamin B12
  8. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsEveryday Health forVitamin B12
  9. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsEveryday Health forVitamin B12
  10. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsEveryday Health forVitamin B12
  11. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  12. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  13. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  14. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  15. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  16. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  17. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  18. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  19. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12