Methylfolate B Complex

Methylfolate B Complex

Codeage4.8 (894 ratings)
Format:Capsule Quantity: 120 Capsule(s) · 60 servings
Goals

Product analysis

71 out of 100

Methylfolate B Complex provides B vitamins that support normal blood formation and energy use, especially when dietary intake is low. Their clearest role is meeting nutritional needs rather than enhancing how you feel once those needs are met.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality65

Riboflavin uses a favorable phosphate form, and the vitamin B6 form is clearly identified. Folate, B12 and betaine quality cannot be compared confidently from the available information.

Ingredient Transparency100

Amounts and forms are disclosed for every listed ingredient, making serving comparisons straightforward. No mixed-form proportions are needed for these entries.

Value For Money43

Riboflavin has a middle-range value comparison, while B6 is somewhat less favorable. Folate and B12 cost comparisons remain unresolved, limiting a judgment about the combination.

Customer Satisfaction82

Customer ratings are positive. The size of the review pool helps put that satisfaction in context, without proving effectiveness or safety.

Product Focus70

The B vitamins mainly support normal nutrient functions when intake is low. The wide range of mood, brain and heart aims does not establish additional benefits from methylated or activated form names.

Format
Capsule
Container
120 Capsule(s)
Per serving
$0.59
Customer rating
4.8 · 894 ratings
Report analysis

Goals

Impact
Highest effect
A- Ingredient FitB+ PathwaysB+ EvidenceA+ Formulation Logic
Folate · 1360 mcg DFEVitamin B12 · 1000 mcg

Folate, vitamin B12, riboflavin and vitamin B6 provide a focused contribution to B-vitamin nutrition when intake is low. Folate and B12 address related nutritional needs, but the combination does not establish an additional general health effect. The generous amounts and methylated forms do not demonstrate better outcomes than adequate ordinary nutrient intake.

How this product is rated for Everyday Health

Ingredient fit87

The relevant nutrients are supplied in amounts that reach the saved comparison endpoints. Extra amounts do not establish extra nutritional benefit.
Goal fit
Relevant nutrients provide the main general health contribution, while additional active ingredients make the formula less focused on this goal.
Dose adequacy
The relevant declared amounts reach the saved comparison endpoints; those endpoints do not establish extra benefit above nutritional adequacy.

Pathways80

The strongest contribution concerns nutrients associated with blood formation. Other nutrient functions also receive substantial coverage.
Depth
The strongest finding concerns nutrients associated with blood formation, reflecting the relevant nutrient amounts in this serving.
Breadth
Two areas reach substantial coverage, providing some breadth across nutritional functions.

Evidence82

Vitamin B9 (Folate) leads the supported nutritional contribution. The relevant preparations meet the supplied criteria, without establishing extra benefits for adults with adequate intake.
Evidence strength
Vitamin B9 (Folate) supplies the strongest supported contribution here, with routine usefulness limited to nutritional availability when intake is low.
Studied preparation
The relevant nutrient preparations meet the saved preparation criteria; this does not establish superiority of a particular form or delivery method.

Formulation logic100

The relevant nutrients can contribute independently or have their required partners, and no configured conflict is reported.
Partner coverage
The relevant ingredients can contribute independently or have their required partners present; an additional combination benefit is not established.
Conflicts
No configured ingredient conflict was identified in the supplied findings; this does not establish overall safety.
Effective doses
All ingredients included in this finding meet the saved minimum amount requirement; this is not a proven clinical benefit threshold.
Study evidence
Folate Supportive 80 studies
Hair Health
Impact
High effect
B+ Ingredient FitF PathwaysB EvidenceA+ Formulation Logic

Folate supports cell division and B12 supplies a B-complex cofactor, connecting this formula to general nutrient adequacy. Their amounts reach the upper end of the saved comparison, but this does not establish an independent hair-regrowth effect. The additional B vitamins have no established standalone hair-growth benefit in the supplied context.

How this product is rated for Hair Health

Ingredient fit83

The formula contains nutrients connected to hair or nutrient adequacy, with their amounts recognized to differing degrees.
Goal fit
Relevant nutrients share the formula with ingredients serving broader purposes, so its focus on hair is limited.
Dose adequacy
The included amounts reach the saved comparison's upper range; this does not show that larger amounts improve hair outcomes.

Pathways0

The included nutrients connect primarily to nutrient adequacy, with no assigned coverage of the four separately evaluated hair-related routes.
Depth
No contribution was assigned to the evaluated androgen, hair-fibre, antioxidant or stress-related routes.
Breadth
None of the evaluated routes reached the saved coverage threshold.

Evidence78

B12 leads the saved evidence comparison, while its supplied context does not establish standalone hair growth.
Evidence strength
B12 leads the saved evidence comparison, while its supplied context does not establish standalone hair growth.
Studied preparation
The included preparations match those recognized in the saved comparison, without proving that the complete product improves hair outcomes.

Formulation logic100

Required partners are accounted for and no configured conflict was found. Included contributions meet the saved minimum amount threshold.
Partner coverage
No required ingredient partner is missing among the included contributions.
Conflicts
No configured ingredient conflict was identified; this finding does not establish overall product safety.
Effective doses
All included contributions clear the saved minimum amount threshold, which is not a clinically proven hair-treatment dose.
Study evidence
Folate Mixed 15 studies

Ingredients

IngredientAmount per servingScore
Riboflavin (Riboflavin 5-Phosphate)
30 mg 85
Vitamin B6 (Pyridoxal 5-Phosphate)
15 mg 77
Folate (Quatrefolic)
1360 mcg DFE
Vitamin B12 (Methylcobalamin)
1000 mcg 84
Betaine (Trimethylglycine)
600 mg
Gluten Free Adults 18–50 Dairy Free
Report overview
A+ Ingredient Form & Label QualityC+ Dose, Safety & Label TransparencyD Value
A serving provides 15 mg of vitamin B6 as pyridoxal 5-phosphate, exceeding the European adult daily upper limit before food or other supplements are counted. The whole-product price works out to about $0.04 per mg of B6, a high cost in this ingredient comparison.
How this ingredient is rated

Ingredient Form & Label Quality100

The identified B6 source is pyridoxal 5-phosphate. The evaluated ingredient information flags no artificial dyes, titanium dioxide or talc.
Vitamin B6 Form Identification
The identified B6 source is pyridoxal 5-phosphate.
Clean Label and Excipient Purity
The evaluated ingredient information flags no artificial dyes, titanium dioxide or talc.

Dose, Safety & Label Transparency69

The 15 mg of B6 per serving exceeds the European adult daily upper limit before food or other supplements are counted. The chemical source is identified as pyridoxal 5-phosphate.
Vitamin B6 Dose & Safety Policy
The 15 mg of B6 per serving exceeds the European adult daily upper limit before food or other supplements are counted.
Label Transparency
The chemical source is identified as pyridoxal 5-phosphate.

Value46

The whole-product price works out to about $0.04 per mg of B6, a high cost in this ingredient comparison.
Vitamin B6 Price Efficiency
The whole-product price works out to about $0.04 per mg of B6, a high cost in this ingredient comparison.
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
A serving lists 1,000 mcg of vitamin B12 as methylcobalamin. The whole-product price corresponds to about $0.60 per 1,000 mcg of B12.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The named form is methylcobalamin.
Bioactive B12 Form Selection
The named form is methylcobalamin.

Dose, Safety & Label Transparency100

The serving lists 1,000 mcg of vitamin B12. The B12 amount and its specific form are both identified.
Therapeutic Dosage Level
The stated serving provides 1,000 mcg of vitamin B12.
Label and Form Transparency
The B12 amount and its specific form are both identified.

Value20

Based on the whole-product price, the cost corresponds to about $0.60 per 1,000 mcg of B12.
Price per 1,000 mcg B12
Based on the whole-product price, the cost corresponds to about $0.60 per 1,000 mcg of B12.
A+ Active Ingredient Quality & BioavailabilityA- Dose, Safety & Label TransparencyD+ Value
A serving provides 30 mg riboflavin, a moderate amount, from riboflavin 5'-phosphate. The label states the riboflavin amount itself.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The ingredient is riboflavin 5'-phosphate, an active coenzyme form.
Riboflavin Form Quality
The ingredient is riboflavin 5'-phosphate, an active coenzyme form.

Dose, Safety & Label Transparency88

A serving provides 30 mg riboflavin, a moderate amount. No artificial colors or synthetic sweeteners were flagged in the available ingredient information.
Dosage for Energy & Metabolism
A serving provides 30 mg riboflavin, a moderate amount.
R5P Elemental Yield Transparency
The declared 30 mg is the riboflavin amount, not just the weight of the phosphate compound.
Additive Purity
No artificial colors or synthetic sweeteners were flagged in the available ingredient information.

Value50

The whole-product serving costs about $0.60.
Price per Serving Value
The whole-product serving costs about $0.60.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort.
    Bo Y; Xu H; Zhang H; Zhang J; Wan Z; Zhao X; Yu Z · Nutrients · 2022
    Cohort study55,569 participantsEveryday Health forFolate
  2. The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study.
    Schorah CJ; Devitt H; Lucock M; Dowell AC · European journal of clinical nutrition · 1998
    Randomized trial119 participantsEveryday Health forFolate
  3. Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study.
    Song S; Song BM; Park HY · The Journal of nutrition · 2023
    Cohort study21,260 participantsEveryday Health forFolate
  4. The concept of folic acid supplementation and its role in prevention of neural tube defect among pregnant women: PRISMA.
    Seyoum Tola F · Medicine · 2024
    Systematic reviewEveryday Health forFolate
  5. Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations.
    Colapinto CK; O'Connor DL; Sampson M; Williams B; Tremblay MS · Journal of public health (Oxford, England) · 2017
    Systematic review71,847 participants46 studies pooledEveryday Health forFolate
  6. Oral Vitamin B12 versus Placebo for the Prevention of Chemotherapy-Induced Peripheral Neuropathy in Gynecological Cancer Patients: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Insin P; Chaiwongsa T; Prueksaritanond N · Asian Pacific journal of cancer prevention : APJCP · 2026
    Randomized trial40 participantsEveryday Health forVitamin B12
  7. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
    Didangelos T; Karlafti E; Kotzakioulafi E; Margariti E; Giannoulaki P; Batanis G; Tesfaye S; Kantartzis K · Nutrients · 2021
    Randomized trial90 participantsEveryday Health forVitamin B12
  8. A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia.
    Xu G; Lv ZW; Feng Y; Tang WZ; Xu GX · Pain medicine (Malden, Mass.) · 2014
    Randomized trial98 participantsEveryday Health forVitamin B12
  9. Local Injection of Methylcobalamin Combined with Lidocaine for Acute Herpetic Neuralgia.
    Xǔ G; Xu S; Tang WZ; Xú G; Cheng C; Xu J · Pain medicine (Malden, Mass.) · 2017
    Randomized trial204 participantsEveryday Health forVitamin B12
  10. The Effect of Vitamin B12 and Folic Acid Supplementation on Serum Homocysteine, Anemia Status and Quality of Life of Patients with Multiple Sclerosis.
    Nozari E; Ghavamzadeh S; Razazian N · Clinical nutrition research · 2022
    Clinical trial50 participantsEveryday Health forVitamin B12
  11. Hair Loss After Metabolic and Bariatric Surgery: a Systematic Review and Meta-analysis.
    Zhang W; Fan M; Wang C; Mahawar K; Parmar C; Chen W; Yang W; Global Bariatric Research Collaborative · Obesity surgery · 2021
    Meta-analysis2,538 participants18 studies pooledHair Health forFolate
  12. Quantitative Analysis of Selected Circulating Hematological Biomarkers, Essential Minerals, Vitamins, and Thyroid Hormones in Females Affected by Hair Loss.
    Al-Fawaeir S; Al-Odat I · Diseases (Basel, Switzerland) · 2025
    Case-control study200 participantsHair Health forFolate Hair Health forVitamin B12
  13. Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
    Saini A; Norman AR; Cunningham D; Chau I; Hill M; Tait D; Hickish T; Iveson T; Lofts F; Jodrell D; Ross PJ; Oates J · British journal of cancer · 2003
    Randomized trialHair Health forFolate
  14. Role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first- and second-line treatment of advanced colorectal cancer.
    Jonker D; Rumble RB; Maroun J; Gastrointestinal Cancer Disease Site Groupof Cancer Care Ontario’s Program in Evidence-Based Care · Current oncology (Toronto, Ont.) · 2012
    Randomized trialHair Health forFolate
  15. Phase I-II study of vinorelbine in combination with 5-fluorouracil and folinic acid as first-line chemotherapy in metastatic breast cancer: a regimen with a low subjective toxic burden.
    Nolè F; de Braud F; Aapro M; Minchella I; De Pas TM; Zampino MG; Monti S; Andreoni G; Goldhirsch A · Annals of oncology : official journal of the European Society for Medical Oncology · 1997
    Randomized trialHair Health forFolate
  16. Factors Associated with Premature Hair Graying in a Young Indian Population.
    Chakrabarty S; Krishnappa PG; Gowda DG; Hiremath J · International journal of trichology · 2016
    Case-control study74 participantsHair Health forVitamin B12
  17. Risk Factors for Pediatric Alopecia Areata: Clinical and Biochemical Findings from a Case - Control Study.
    İritaş SY · Dermatology practical & conceptual · 2026
    Case-control study600 participantsHair Health forVitamin B12
  18. Hair Loss After Laparoscopic Sleeve Gastrectomy.
    Katsogridaki G; Tzovaras G; Sioka E; Perivoliotis K; Zachari E; Magouliotis D; Tasiopoulou V; Chatedaki C; Zacharoulis D · Obesity surgery · 2019
    Cohort study50 participantsHair Health forVitamin B12
  19. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases.
    Sonthalia S; Priya A; Tobin DJ · Indian journal of dermatology · 2022
    Cross-sectional study71 participantsHair Health forVitamin B12