Lipotropic Factors

Lipotropic Factors

Solgar4.6 (2,245 ratings)
Format:Tablet Quantity: 100 Tablet(s) · 33 servings
Goals

Product analysis

64 out of 100

Lipotropic Factors provides choline to support normal liver function, including how the liver moves fat. Its clearest value is nutritional, particularly when choline intake is low.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality56

Choline bitartrate provides a reasonable, clearly identified choline form. The other ingredients lack specific form descriptions, leaving their quality harder to judge.

Ingredient Transparency72

All declared ingredient amounts are disclosed. Only the choline form is specified, limiting comparisons of the other preparations.

Value For Money48

The choline contribution offers moderate value for the full serving cost. Value for the other assessed contributions remains uncertain.

Customer Satisfaction83

Customer feedback is very positive. Thousands of ratings provide a broad picture of buyer satisfaction, without establishing liver or cognitive effects.

Product Focus73

A compact ingredient mix gives the formula a clear central role in choline nutrition. Its focus-related uses have less support than its normal nutritional liver role.

Format
Tablet
Container
100 Tablet(s)
Per serving
$0.51
Customer rating
4.6 · 2,245 ratings
Report analysis

Goals

Liver & Detox
Impact
High effect
B- Ingredient FitD+ PathwaysA- EvidenceA+ Formulation Logic
Choline · 410 mg

Choline helps the liver maintain cell integrity and export fat. Its clearest relevance is nutritional: restoring choline after depletion can reverse related liver dysfunction. The declared 410 mg per serving partly meets the saved amount comparison, but it does not establish extra toxin clearance when nutrient intake is adequate. Methionine's precursor role adds no demonstrated independent detoxification benefit.

How this product is rated for Liver & Detox

Ingredient fit75

Declared choline provides a nutritional liver-function connection.
Goal fit
Declared choline provides a nutritional liver-function connection.
Dose adequacy
Choline provides a partial nutritional amount comparison per serving.

Pathways52

Liver cell integrity and fat export is the main route in the saved findings.
Depth
Liver cell integrity and fat export is the main route in the saved findings.
Breadth
One route reaches substantial coverage; other routes are limited.

Evidence86

Choline depletion and repletion support a nutritional liver role, rather than extra toxin clearance.
Evidence strength
Choline depletion and repletion support a nutritional liver role, rather than extra toxin clearance.
Studied preparation
The declared choline amount is recognized directly, without converting carrier or phospholipid mass.

Formulation logic100

No required partner is missing and no configured ingredient conflict was found.
Partner coverage
The included ingredients work independently or have their required partner.
Conflicts
No configured ingredient conflict was found.
Effective doses
All included ingredients meet the saved minimum amount comparison; this does not establish a clinically effective toxin-clearance dose.
Study evidence
Choline Supportive 6 studies
Cognitive Support
Impact
High effect
C+ Ingredient FitD+ PathwaysA- EvidenceA+ Formulation Logic
Choline · 410 mg

Choline is a precursor of acetylcholine, which participates in memory and attention. The 410 mg serving makes a substantial but partial contribution in the saved amount comparison. Generic choline trials in healthy young adults were null, so this biological role and amount do not establish routine memory enhancement.

How this product is rated for Cognitive Support

Ingredient fit68

The counted amounts provide a partial comparison with the reviewed exposures; lower amounts do not establish benefit below studied doses.
Goal fit
Relevant ingredients sit within a broader formula that also contains ingredients without an established contribution to this goal.
Dose adequacy
The counted amounts provide a partial comparison with the reviewed exposures; lower amounts do not establish benefit below studied doses.

Pathways52

The strongest represented area is acetylcholine signalling; this describes the ingredient roles rather than a demonstrated cognitive effect.
Depth
The strongest represented area is acetylcholine signalling; this describes the ingredient roles rather than a demonstrated cognitive effect.
Breadth
The represented areas are acetylcholine signalling. Broader cognitive improvements do not follow automatically from those roles.

Evidence89

The saved preparation comparison is met for the counted ingredients; it does not establish benefits beyond their specific evidence.
Evidence strength
Vitamin B4 (Choline) provides the strongest represented evidence contribution, within the population and outcome limitations described for that ingredient.
Studied preparation
The saved preparation comparison is met for the counted ingredients; it does not establish benefits beyond their specific evidence.

Formulation logic100

No configured conflict was identified among the assessed ingredients; this does not assess every possible interaction.
Partner coverage
The counted ingredients have no unmet partner requirement in these findings; this does not demonstrate an added benefit from combining them.
Conflicts
No configured conflict was identified among the assessed ingredients; this does not assess every possible interaction.
Effective doses
The counted ingredients pass the saved minimum amount threshold; passing it does not prove efficacy at each serving amount.
Study evidence
Choline Supportive 76 studies
Mental Focus
Impact
High effect
C+ Ingredient FitD+ PathwaysB- EvidenceA+ Formulation Logic
Choline · 410 mg

Choline is a precursor for acetylcholine, a messenger involved in attention. That normal role does not establish extra focus in adults with adequate intake, and the supplied healthy-adult choline-bitartrate trial did not show acute memory improvement. The declared bitartrate material should not be assumed equivalent to an amount of nutrient choline.

How this product is rated for Mental Focus

Ingredient fit68

Vitamin B4 (Choline) underpin this product’s connection to focus. Some amounts provide only a partial match to the saved comparison ranges.
Goal fit
The formula includes ingredients aimed at other purposes, so its focus connection is less concentrated.
Dose adequacy
The included amounts only partly meet the saved reference ranges for the relevant ingredients.

Pathways53

The main mapped contribution is cholinergic signalling. The mechanism alone does not establish an acute focus benefit.
Depth
Cholinergic signalling is the strongest mapped route, with partial coverage. That biological connection does not itself demonstrate acute focus improvement.
Breadth
The meaningful mapped contribution is concentrated in one route, with limited breadth across other aspects of focus.

Evidence74

The supplied evidence is limited for immediate everyday focus, despite the biological roles reflected in the saved findings.
Evidence strength
The leading ingredient supplies the evidence finding, but the supplied science does not establish routine acute focus enhancement.
Studied preparation
The included preparations match those accepted in the saved comparison; this does not extend the trials to different outcomes or populations.

Formulation logic100

The included ingredients have no identified configured conflict. No required partner is missing.
Partner coverage
No required partner is missing for the included ingredients.
Conflicts
No configured ingredient conflict was identified in the supplied findings.
Effective doses
The included ingredients meet the saved minimum amount threshold; that threshold is not a demonstrated effective dose for acute focus.
Study evidence
Choline Supportive 22 studies

Ingredients

IngredientAmount per servingScore
Total Carbohydrates
1 Gram(s)
Choline (Choline Bitartrate)
410 mg 71
Inositol
1 Gram(s)
L-Methionine
1 Gram(s)
Gluten Free Adults 18–50 Vegan Kosher Dairy Free Sugar Free Vegetarian
Report overview
D+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyD+ Value
Each serving provides 410 mg of choline from choline bitartrate, a larger amount. The available ingredient information also flags additives.
How this ingredient is rated

Active Ingredient Quality & Bioavailability53

The identified source is choline bitartrate, a standard choline form.
Choline Form Efficacy & Bioavailability
The identified source is choline bitartrate, a standard choline form.
Formula Purity & Excipient Quality
The available ingredient information flags additives.

Dose, Safety & Label Transparency100

The stated amount is 410 mg of choline per serving.
Choline Dose by Declared Basis
A serving supplies 410 mg of choline, a larger amount.
Elemental Yield Transparency
The choline amount and its choline bitartrate source are identified.

Value50

At the whole-product price, the cost is about $0.12 per 100 mg of choline.
Price per 100 mg of Declared Choline Basis
The whole-product price corresponds to about $0.12 per 100 mg of choline.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial.
    De Jesus Moreno Moreno M · Clinical therapeutics · 2003
    Randomized trial261 participantsCognitive Support forCholine
  2. Association of dietary choline intake with incidence of dementia, Alzheimer disease, and mild cognitive impairment: a large population-based prospective cohort study.
    Niu YY; Yan HY; Zhong JF; Diao ZQ; Li J; Li CP; Chen LH; Huang WQ; Xu M; Xu ZT; Liang XF; Li ZH; Liu D · The American journal of clinical nutrition · 2025
    Cohort study125,594 participantsCognitive Support forCholine
  3. Choline intake during pregnancy and child cognition at age 7 years.
    Boeke CE; Gillman MW; Hughes MD; Rifas-Shiman SL; Villamor E; Oken E · American journal of epidemiology · 2013
    Cohort study895 participantsCognitive Support forCholine
  4. Effects of choline alfoscerate on cognitive function and quality of life in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
    Sohn M; Park YH; Lim S · Diabetes, obesity & metabolism · 2025
    Randomized trial36 participantsCognitive Support forCholine
  5. Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.
    Warton FL; Molteno CD; Warton CMR; Wintermark P; Lindinger NM; Dodge NC; Zöllei L; van der Kouwe AJW; Carter RC; Jacobson JL; Jacobson SW; Meintjes EM · Alcoholism, clinical and experimental research · 2022
    Randomized trial52 participantsCognitive Support forCholine
  6. Choline and contribution to normal liver function of the foetus and exclusively breastfed infants: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006.
    EFSA Panel on Nutrition, Novel Foods and Food allergens (NDA); Turck D; Bohn T; Castenmiller J; De Henauw S; Hirsch-Ernst KI; Knutsen HK; Maciuk A; Mangelsdorf I; McArdle HJ; Naska A; Pentieva K; Thies F; Tsabouri S; Vinceti M; Bresson JL; Fiolet T; Siani A · EFSA journal. European Food Safety Authority · 2024
    Guideline / consensusLiver & Detox forCholine
  7. Adiposity May Moderate the Link Between Choline Intake and Non-alcoholic Fatty Liver Disease.
    Mazidi M; Katsiki N; Mikhailidis DP; Banach M · Journal of the American College of Nutrition · 2020
    Cross-sectional study20,643 participantsLiver & Detox forCholine
  8. Choline and Choline-Related Metabolites in Pediatric Short Bowel Syndrome.
    Hilberath J; Shunova A; Heister L; Poets CF; Bernhard W · Nutrients · 2026
    Observational study80 participantsLiver & Detox forCholine
  9. Choline Supplementation in Cystic Fibrosis-The Metabolic and Clinical Impact.
    Bernhard W; Lange R; Graepler-Mainka U; Engel C; Machann J; Hund V; Shunova A; Hector A; Riethmüller J · Nutrients · 2019
    Single-arm trial10 participantsLiver & Detox forCholine
  10. 1H MR Spectroscopy at 3T for Hepatic Choline Quantification in Healthy Young Women: A Translational Imaging Study with Dietary Correlation.
    Hawesa H; Alghamdi R; Allam H; Alfaifi B; Alrabiah N; Alghumaiz M; Shanawani M; Alshegri H; Hassan MG · Current medical imaging · 2026
    Cohort study88 participantsLiver & Detox forCholine
  11. Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.
    Wozniak JR; Fink BA; Fuglestad AJ; Eckerle JK; Boys CJ; Sandness KE; Radke JP; Miller NC; Lindgren C; Brearley AM; Zeisel SH; Georgieff MK · Journal of neurodevelopmental disorders · 2021
    Randomized trial31 participantsMental Focus forCholine
  12. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort.
    Poly C; Massaro JM; Seshadri S; Wolf PA; Cho E; Krall E; Jacques PF; Au R · The American journal of clinical nutrition · 2012
    Cohort study1,391 participantsMental Focus forCholine
  13. Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.
    Obeid R; Derbyshire E; Schön C · Advances in nutrition (Bethesda, Md.) · 2022
    Meta-analysis30 studies pooledMental Focus forCholine
  14. Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies.
    Akison LK; Kuo J; Reid N; Boyd RN; Moritz KM · Alcoholism, clinical and experimental research · 2019
    Systematic reviewMental Focus forCholine
  15. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk.
    Ross RG; Hunter SK; McCarthy L; Beuler J; Hutchison AK; Wagner BD; Leonard S; Stevens KE; Freedman R · The American journal of psychiatry · 2013
    Randomized trialMental Focus forCholine