Extra Strength Tranquil Sleep

Extra Strength Tranquil Sleep

Natural Factors Stress-Relax4.5 (2,452 ratings)
Format:Tablet Quantity: 60 Tablet(s) · 60 servings
Goals
$34.97 $0.58 per serving

Product analysis

52 out of 100

Extra Strength Tranquil Sleep combines melatonin for sleep timing and onset with theanine that may support calm and reported sleep quality. Melatonin can cause drowsiness and slower reactions, which matters if you need to stay alert after taking it.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality24

The theanine and melatonin forms are not clearly disclosed. The plant source for 5-HTP is named, but its relative form quality remains uncertain.

Ingredient Transparency70

Ingredient amounts are stated, making the serving quantities clear. Unspecified forms limit comparison with more clearly described preparations.

Value For Money45

The theanine comparison suggests favorable value, while melatonin and 5-HTP are less economical. The mixed comparisons leave the combination less compelling than its theanine component alone.

Customer Satisfaction80

Customer feedback is favorable across a substantial number of ratings. Specific experiences and health benefits cannot be inferred from the ratings.

Product Focus65

Sleep timing and relaxation are the clearest purposes, with limited evidence for broader mood or thinking benefits. Melatonin may impair alertness after intake, and the small 5-HTP amount adds no clear benefit.

Format
Tablet
Container
60 Tablet(s)
Per serving
$0.58
Customer rating
4.5 · 2,452 ratings
Report analysis

Goals

Sleep Support
Impact
Highest effect
A Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Melatonin · 6 mgTheanine · 200 mg
Study evidence
5-HTP Supportive 1 study
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Stress Relief
Impact
High effect
A Ingredient FitB+ PathwaysB EvidenceA+ Formulation Logic
Theanine · 200 mg
Study evidence
5-HTP Supportive 18 studies
Melatonin Supportive 21 studies
Theanine Supportive 16 studies
Mood Support
Impact
Moderate effect
B Ingredient FitD- PathwaysC EvidenceA+ Formulation Logic
5-HTP · 15 mg
Study evidence
5-HTP Supportive 9 studies
Theanine Supportive 12 studies
Brain Health
Impact
High effect
B+ Ingredient FitC- PathwaysB EvidenceA+ Formulation Logic
Study evidence
Melatonin Supportive 29 studies
Theanine Supportive 17 studies
Productivity Boost
Impact
Lower effect
B- Ingredient FitC PathwaysB- EvidenceA+ Formulation Logic
Theanine · 200 mg
Study evidence
Theanine Supportive 5 studies
Cognitive Support
Impact
High effect
B- Ingredient FitD+ PathwaysB+ EvidenceB+ Formulation Logic
Theanine · 200 mg
Study evidence
Theanine Supportive 25 studies
Mental Focus
Impact
Lower effect
B- Ingredient FitC PathwaysB EvidenceB+ Formulation Logic
Theanine · 200 mg
Study evidence
Theanine Supportive 19 studies

Ingredients

IngredientAmount per servingScore
Calories
10 Calorie(s)
Total Carbohydrates
2 Gram(s)
Suntheanine L-Theanine
200 mg 96
5-HTP (Griffonia simplicifolia)
15 mg 60
Melatonin
6 mg 46
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
Theanine · 200 mg OverallScore96
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value
The serving provides 200 mg of L-Theanine, with a relatively low cost per 100 mg. The amount falls in a range associated with relaxation and focus. A branded form is indicated, though its name is unclear.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

The form is L-Theanine, the form associated with calming and focus. A branded form is indicated, though its name is unclear.
Isomer Specificity (L-Theanine)
The form is L-Theanine, the form associated with calming and focus.
Branded Forms & Purity Standards
A branded form is indicated, though its name is unclear.

Dose, Safety & Label Transparency100

The amount is clearly stated. 200 mg per serving falls in the range associated with relaxation and focus.
Theanine Dosage Efficacy
200 mg per serving falls in the range associated with relaxation and focus.
Label Transparency & Blends
The label states 200 mg of L-Theanine per serving.

Value80

The cost per 100 mg of theanine is relatively low.
Price per 100mg L-Theanine
The cost per 100 mg of theanine is relatively low.
Melatonin · 6 mg OverallScore46
C Active Ingredient Quality & BioavailabilityD- Dose, Safety & Label TransparencyF Value
A serving provides 6 mg of melatonin at a high cost per serving. It comes as a chewable tablet; its melatonin source is unclear. A third-party laboratory claim is present, but it has not been independently confirmed.
How this ingredient is rated

Active Ingredient Quality & Bioavailability60

It comes as a chewable tablet, but the melatonin source is unclear. A third-party laboratory claim is present, but it has not been independently confirmed.
Third-Party Purity Verification
A third-party laboratory claim is present, but it has not been independently confirmed.

Dose, Safety & Label Transparency40

A serving provides 6 mg of melatonin.
Physiological Dosing Alignment
A serving provides 6 mg of melatonin.

Value30

The cost per serving is high.
Price Per Serving Efficiency
The cost per serving is high.
B- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value
A serving provides 15 mg of 5-HTP, at a very high cost per 100 mg. The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated. The label includes a warning about serotonin-related medication interactions. The serving also contains 200 mg of L-theanine and 6 mg of melatonin.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated.
Botanical Source & Standardization
The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated.

Dose, Safety & Label Transparency79

The serving contains 15 mg of 5-HTP. The serving also contains 200 mg of L-theanine and 6 mg of melatonin. The label includes a warning about serotonin-related medication interactions.
Dosage Potency & Range
The serving provides 15 mg of 5-HTP. The serving also contains 200 mg of L-theanine and 6 mg of melatonin.
Safety Warnings & Label Clarity
The label includes a warning about serotonin-related medication interactions.

Value0

The cost per 100 mg of 5-HTP is very high.
Price per 100mg 5-HTP
The cost per 100 mg of 5-HTP is very high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  2. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  3. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  4. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  5. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  6. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  7. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  8. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  9. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  10. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  11. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  12. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  13. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Productivity Boost Stress Relief forTheanine
  14. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  15. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  16. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  17. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  18. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  19. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  20. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine