Tranquil Sleep

Tranquil Sleep

Natural Factors Stress-Relax4.5 (3,294 ratings)
Format:Tablet Quantity: 120 Tablet(s) · 60 servings
Goals
$41.97 $0.69 per serving

Product analysis

53 out of 100

Tranquil Sleep combines melatonin for sleep timing and falling asleep with theanine that may help you relax. Melatonin can cause sleepiness and slower reactions for hours, which limits its suitability for daytime focus.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality24

Ingredient quality is difficult to compare because most forms are not disclosed. The identified 5-HTP source does not establish the quality of the full mixture.

Ingredient Transparency70

All listed amounts are disclosed, making serving sizes easier to compare. Only the 5-HTP source is identified by form, leaving the rest less clear.

Value For Money44

Theanine offers favourable value, but the 5-HTP and melatonin portions compare poorly on cost. Paying for the combination therefore offers less convincing value than theanine alone suggests.

Customer Satisfaction82

Customers give consistently positive ratings, with a sizeable number of responses behind them. Ratings describe satisfaction and do not establish effectiveness or safety.

Product Focus66

Sleep timing, falling asleep and relaxation are the clearest uses. Wider mood and cognitive benefits are less certain, and melatonin-related sleepiness works against daytime attention.

Format
Tablet
Container
120 Tablet(s)
Per serving
$0.69
Customer rating
4.5 · 3,294 ratings
Report analysis

Goals

Sleep Support
Impact
Highest effect
A- Ingredient FitA+ PathwaysA+ EvidenceA+ Formulation Logic
Melatonin · 3 mgTheanine · 200 mg
Study evidence
5-HTP Supportive 1 study
Melatonin Supportive 181 studies
Theanine Supportive 8 studies
Stress Relief
Impact
High effect
B+ Ingredient FitB+ PathwaysB EvidenceA+ Formulation Logic
Theanine · 200 mg
Study evidence
5-HTP Supportive 18 studies
Melatonin Supportive 21 studies
Theanine Supportive 16 studies
Mood Support
Impact
High effect
C+ Ingredient FitD- PathwaysA EvidenceA+ Formulation Logic
5-HTP · 30 mg
Study evidence
5-HTP Supportive 9 studies
Theanine Supportive 12 studies
Brain Health
Impact
High effect
B+ Ingredient FitC- PathwaysB EvidenceA+ Formulation Logic
Study evidence
Melatonin Supportive 29 studies
Theanine Supportive 17 studies
Productivity Boost
Impact
Lower effect
B- Ingredient FitC PathwaysB- EvidenceA+ Formulation Logic
Theanine · 200 mg
Study evidence
Theanine Supportive 5 studies
Cognitive Support
Impact
High effect
B- Ingredient FitD+ PathwaysB+ EvidenceB+ Formulation Logic
Theanine · 200 mg
Study evidence
Theanine Supportive 25 studies
Mental Focus
Impact
Lower effect
B- Ingredient FitC PathwaysB EvidenceB+ Formulation Logic
Theanine · 200 mg
Study evidence
Theanine Supportive 19 studies

Ingredients

IngredientAmount per servingScore
Calories
15 Calorie(s)
Total Carbohydrates
3 Gram(s)
Suntheanine L-Theanine
200 mg 96
5-HTP (Griffonia simplicifolia)
30 mg 60
Melatonin
3 mg 70
Gluten Free Adults 18–50 Vegan Dairy Free Vegetarian
Report overview
Theanine · 200 mg OverallScore96
A+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyB+ Value
200 mg of L-theanine per serving comes at a competitive cost per 100 mg. That amount is within the range associated with relaxation and focus. A branded source is indicated, though its name is not specified.
How this ingredient is rated

Active Ingredient Quality & Bioavailability100

It uses L-theanine, the form associated with calming and focus. A branded source is indicated, though its name is not specified.
Isomer Specificity (L-Theanine)
It uses L-theanine, the form associated with calming and focus.
Branded Forms & Purity Standards
A branded source is indicated, though its name is not specified.

Dose, Safety & Label Transparency100

A serving provides 200 mg of L-theanine. That amount is within the range associated with relaxation and focus. The amount and source are individually stated.
Theanine Dosage Efficacy
A serving provides 200 mg of L-theanine. That amount is within the range associated with relaxation and focus.
Label Transparency & Blends
The amount and source are individually stated.

Value80

The cost per 100 mg of theanine is competitive.
Price per 100mg L-Theanine
The cost per 100 mg of theanine is competitive.
Melatonin · 3 mg OverallScore70
C Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
A serving provides 3 mg of melatonin at a high cost per serving. It comes as a chewable tablet; its melatonin source is unclear. A third-party laboratory claim is present, but it has not been independently confirmed.
How this ingredient is rated

Active Ingredient Quality & Bioavailability60

It comes as a chewable tablet, but the melatonin source is unclear. A third-party laboratory claim is present, but it has not been independently confirmed.
Third-Party Purity Verification
A third-party laboratory claim is present, but it has not been independently confirmed.

Dose, Safety & Label Transparency100

A serving provides 3 mg of melatonin.
Physiological Dosing Alignment
A serving provides 3 mg of melatonin.

Value30

The cost per serving is high.
Price Per Serving Efficiency
The cost per serving is high.
B- Active Ingredient Quality & BioavailabilityB Dose, Safety & Label TransparencyF Value
A serving provides 30 mg of 5-HTP, at a very high cost per 100 mg. The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated. The label includes a warning about serotonin-related medication interactions. The serving also contains 200 mg of L-theanine and 3 mg of melatonin.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated.
Botanical Source & Standardization
The 5-HTP comes from Griffonia simplicifolia, with no 5-HTP standardization percentage stated.

Dose, Safety & Label Transparency79

The serving contains 30 mg of 5-HTP. The serving also contains 200 mg of L-theanine and 3 mg of melatonin. The label includes a warning about serotonin-related medication interactions.
Dosage Potency & Range
The serving provides 30 mg of 5-HTP. The serving also contains 200 mg of L-theanine and 3 mg of melatonin.
Safety Warnings & Label Clarity
The label includes a warning about serotonin-related medication interactions.

Value0

The cost per 100 mg of 5-HTP is very high.
Price per 100mg 5-HTP
The cost per 100 mg of 5-HTP is very high.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Comparative Efficacy, Tolerability, and Acceptability of Donanemab, Lecanemab, Aducanumab, Melatonin, and Aerobic Exercise for a Short Time on Cognitive Function in Mild Cognitive Impairment and Mild Alzheimer's Disease: A Systematic Review and Network Meta-Analysis.
    Terao I; Kodama W · Journal of Alzheimer's disease : JAD · 2024
    Meta-analysis4,599 participants10 studies pooledBrain Health forMelatonin
  2. Melatonin for sleep and cognitive outcomes in older adults with cognitive impairment: a meta-analysis of randomised controlled trials.
    Mdluli NT; Banda KJ; Chang YC · Age and ageing · 2025
    Meta-analysis516 participants10 studies pooledBrain Health forMelatonin
  3. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial.
    Wade AG; Farmer M; Harari G; Fund N; Laudon M; Nir T; Frydman-Marom A; Zisapel N · Clinical interventions in aging · 2015
    Randomized trial80 participantsBrain Health forMelatonin
  4. Early Oral Melatonin Supplementation Supports White Matter Maturation in Preterm Infants: Neuroprotective Insights of an Antioxidant Molecule.
    Garofoli F; Asteggiano C; Minniti ML; Accorsi P; Albertini R; Angelini M; Aversa S; Ballante E; Cabini RF; Caporali C; Cociglio S; Franco V; Longo S; Malerba L; Materia V; Mazzocchi L; Naboni C; Palmisani M; Pullega C; Pisoni C; Preda L; Riboli A; Risso FM; Rognone E; Savini G; Simoncelli AM; Villani P; Tzialla C; Pinelli L; Fazzi E; Chiapparini L; Borgatti R; Ghirardello S; Pichiecchio A; Orcesi S · Journal of pineal research · 2026
    Randomized trial54 participantsBrain Health forMelatonin
  5. Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Abouelmagd ME; Aldemerdash MA; Khatatbeh AA; Osman ASA; Abbas A; Allam S; AlEdani EM; Aldemerdash A; Monteith TS · Current pain and headache reports · 2026
    Meta-analysis788 participants9 studies pooledBrain Health forMelatonin
  6. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  7. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  8. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  9. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  10. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  11. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control: a double-blind, placebo-controlled, crossover study.
    Dassanayake TL; Wijesundara D; Kahathuduwa CN; Weerasinghe VS · Nutritional neuroscience · 2023
    Randomized trial32 participantsCognitive Support forTheanine
  12. Acute effects of theanine, caffeine and theanine-caffeine combination on attention.
    Kahathuduwa CN; Dassanayake TL; Amarakoon AMT; Weerasinghe VS · Nutritional neuroscience · 2018
    Clinical trial20 participantsCognitive Support Mental Focus forTheanine
  13. Safety and Efficacy of AlphaWave® L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.
    Moulin M; Crowley DC; Xiong L; Guthrie N; Lewis ED · Neurology and therapy · 2024
    Randomized trial30 participantsMental Focus Productivity Boost Stress Relief forTheanine
  14. Effect of L-theanine on selective attention in a traffic-related reaction task in sleep-deprived young adults: a double-blind placebo-controlled, crossover study.
    Karunaratne UW; Dassanayake TL · Nutritional neuroscience · 2025
    Randomized trial24 participantsMental Focus forTheanine
  15. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode.
    Jangid P; Malik P; Singh P; Sharma M; Gulia AK · Asian journal of psychiatry · 2013
    Randomized trial70 participantsMood Support for5-HTP
  16. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.
    Li S; Sutanto CN; Xia X; Kim JE · Nutrients · 2025
    Randomized trial30 participantsMood Support for5-HTP
  17. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Javelle F; Lampit A; Bloch W; Häussermann P; Johnson SL; Zimmer P · Nutrition reviews · 2020
    Meta-analysis13 studies pooledMood Support for5-HTP
  18. Tryptophan and 5-hydroxytryptophan for depression.
    Shaw K; Turner J; Del Mar C · The Cochrane database of systematic reviews · 2002
    Systematic review64 participants2 studies pooledMood Support for5-HTP
  19. 5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    Aliño JJ; Gutierrez JL; Iglesias ML · International pharmacopsychiatry · 1976
    Non-randomized trial30 participantsMood Support for5-HTP
  20. l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
    Shamabadi A; Kafi F; Arab Bafrani M; Asadigandomani H; A Basti F; Akhondzadeh S · Journal of affective disorders · 2023
    Randomized trial60 participantsMood Support forTheanine