Double Potency 5-HTP Extra

Double Potency 5-HTP Extra

Irwin Naturals4.6 (578 ratings)
Format:Softgel Quantity: 60 Softgel(s) · 30 servings
Goals

Product analysis

43 out of 100

Double Potency 5-HTP Extra combines ingredients aimed at relaxation, sleep and calmer attention, although the expected effects remain uncertain. Several preparations are unspecified, making it harder to connect the full mixture with findings for particular ingredients.

AI assessment of the formula, label and price. How scoring works

Nutrient Quality20

Most ingredient forms are unspecified, and part of the mixture cannot be assessed confidently. The quality of the combination therefore remains uncertain.

Ingredient Transparency56

Most amounts are stated, but one is omitted and most forms are unspecified. Disclosure of the combined entry’s contents cannot be established confidently.

Value For Money30

The theanine is relatively expensive for the amount provided. Value for the other relevant ingredients remains uncertain, so the full combination is difficult to justify on value alone.

Customer Satisfaction76

Customer feedback is positive across several hundred ratings. The review volume gives context to satisfaction without proving sleep or mood effects.

Product Focus58

The ingredients have overlapping relaxation, sleep and attention purposes. Evidence is limited, and some amounts are below those used in the relevant trials.

Format
Softgel
Container
60 Softgel(s)
Per serving
$0.66
Customer rating
4.6 · 578 ratings
Report analysis

Goals

Mood Support
Impact
High effect
C+ Ingredient FitC PathwaysA+ EvidenceA+ Formulation Logic
Vitamin B6 · 10 mgMagnesium · 50 mgVitamin D · 12.5 mcg5-HTP · 100 mg
Study evidence
5-HTP Supportive 9 studies
Magnesium Supportive 60 studies
Theanine Supportive 12 studies
Vitamin B6 Supportive 19 studies
Vitamin D Supportive 163 studies
Impact
High effect
C- Ingredient FitB+ PathwaysB+ EvidenceA+ Formulation Logic
Magnesium · 50 mgTheanine · 100 mg
Study evidence
5-HTP Supportive 1 study
Magnesium Supportive 23 studies
Omega-3 Mixed 20 studies
Theanine Supportive 8 studies
Vitamin D Supportive 55 studies
Stress Relief
Impact
High effect
C- Ingredient FitC+ PathwaysB- EvidenceA+ Formulation Logic
Vitamin D · 12.5 mcgMagnesium · 50 mgVitamin B6 · 10 mgTheanine · 100 mg
Study evidence
5-HTP Supportive 18 studies
Magnesium Supportive 13 studies
Theanine Supportive 16 studies
Vitamin D Supportive 41 studies
Cognitive Support
Impact
Moderate effect
C- Ingredient FitF PathwaysA+ EvidenceA+ Formulation Logic
Vitamin B6 · 10 mgMagnesium · 50 mgVitamin D · 12.5 mcgTheanine · 100 mg
Study evidence
Magnesium Supportive 24 studies
Theanine Supportive 25 studies
Vitamin B6 Supportive 17 studies
Vitamin D Supportive 118 studies
Impact
Moderate effect
D Ingredient FitF PathwaysB- EvidenceA Formulation Logic
Vitamin D · 12.5 mcgMagnesium · 50 mg
Study evidence
5-HTP Supportive 5 studies
Fish Oil Disputed 30 studies
Ginger Supportive 15 studies
Magnesium Supportive 17 studies
Theanine Not classified

No linked studies yet.

Vitamin D Disputed 80 studies
Productivity Boost
Impact
Moderate effect
D- Ingredient FitD- PathwaysB- EvidenceA+ Formulation Logic
Vitamin B6 · 10 mgMagnesium · 50 mgTheanine · 100 mg
Study evidence
Magnesium Supportive 10 studies
Theanine Supportive 5 studies

Ingredients

IngredientAmount per servingScore
Calories
15 Calorie(s)
Total Fat
1 Gram(s)
Cholesterol
5 mg
Total Carbohydrates
1 Gram(s)
Protein
1 Gram(s)
Vitamin D (Cholecalciferol)
12.5 mcg
Vitamin B6 (Pyridoxine Hydrochloride)
10 mg
Magnesium (Magnesium Citrate)
50 mg
Fish Oil (DHA, EPA)
800 mg 12
5-HTP (Griffonia simplicifolia)
100 mg 74
Lemon Balm extract
100 mg
L-Theanine
100 mg 76
Damiana extract
75 mg
Holy Basil extract (Ursolic Acid)
75 mg
Saffr'active Saffron extract (Saffranal)
5 mg
BioPerine Complex
3 mg
Bioperine Black Pepper extract (Piperine)
0 NP
Ginger extract (Gingerols)
0 NP
Adults 18–50 Women
Report overview
Theanine · 100 mg OverallScore76
B+ Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
Each serving provides 100 mg of L-theanine, with a high cost per 100 mg. No branded source or additional purity claim is recorded.
How this ingredient is rated

Active Ingredient Quality & Bioavailability80

The ingredient is L-theanine. No branded source or additional purity claim is recorded.
Isomer Specificity (L-Theanine)
The form is L-theanine.
Branded Forms & Purity Standards
No branded source or additional purity claim is recorded.

Dose, Safety & Label Transparency100

Each serving provides 100 mg of L-theanine.
Theanine Dosage Efficacy
Each serving provides 100 mg of L-theanine.
Label Transparency & Blends
The L-theanine amount is stated separately.

Value20

The cost per 100 mg of theanine is high.
Price per 100mg L-Theanine
The cost per 100 mg of theanine is high.
B- Active Ingredient Quality & BioavailabilityA+ Dose, Safety & Label TransparencyF Value
Each serving supplies 100 mg of 5-HTP; its estimated cost per 100 mg is high. The Griffonia simplicifolia source is named, but its standardization percentage is unclear. The label includes a medication interaction warning. It also contains 100 mg of L-theanine.
How this ingredient is rated

Active Ingredient Quality & Bioavailability70

The 5-HTP comes from Griffonia simplicifolia, but its standardization percentage is not given.
Botanical Source & Standardization
The 5-HTP comes from Griffonia simplicifolia, but its standardization percentage is not given.

Dose, Safety & Label Transparency100

Each serving provides 100 mg of 5-HTP. The label includes a warning about serotonin-related medication interactions. It also contains 100 mg of L-theanine.
Dosage Potency & Range
Each serving provides 100 mg of 5-HTP.
Safety Warnings & Label Clarity
The label includes a warning about serotonin-related medication interactions.

Value30

The estimated cost per 100 mg of 5-HTP is high. The estimate assigns the full product cost to 5-HTP and may overstate its cost.
Price per 100mg 5-HTP
The estimated cost per 100 mg of 5-HTP is high. The estimate assigns the full product cost to 5-HTP and may overstate its cost.
F Active Ingredient Quality & BioavailabilityF Dose, Safety & Label TransparencyF Value
The estimated combined EPA and DHA is 240 mg per serving; their individual amounts are not listed. The estimated cost per gram of EPA and DHA is high, but the actual amounts are uncertain. The oil’s molecular form is not specified.
How this ingredient is rated

Active Ingredient Quality & Bioavailability14

The oil’s molecular form is not specified. No purification method is specified in the available details. Independent testing is not specified in the available details.
Omega-3 Molecular Form
The oil’s molecular form is not specified.
Purification & Filtration Method
No purification method is specified in the available details.
Third-Party Purity & Potency Verification
Independent testing is not specified in the available details.
Source & Sustainability
A qualifying fish source is indicated, but its species is not named in the available details.

Dose, Safety & Label Transparency6

The estimated combined EPA and DHA is 240 mg per serving; their individual amounts are not listed. The estimated EPA and DHA share 30% of the fish oil, with the actual share uncertain.
Total Active Omega-3 Dose (EPA + DHA)
The estimated combined EPA and DHA is 240 mg per serving; their individual amounts are not listed.
Omega-3 Potency & Concentration
The estimated EPA and DHA share 30% of the fish oil, with the actual share uncertain.
EPA & DHA Individual Disclosure
EPA and DHA amounts are not individually listed.
Oxidation Protection (Stabilizers)
A qualifying antioxidant for oil protection is not specified in the available details.

Value20

The estimated cost per gram of EPA and DHA is high, but the actual amounts are uncertain.
Cost Per Gram of Active EPA + DHA
The estimated cost per gram of EPA and DHA is high, but the actual amounts are uncertain.
Report alternatives

Sources

Published studies used for the product analysis and the top-ranked studies for each ingredient and goal.

  1. Antenatal magnesium sulfate and neuroprotection.
    Doyle LW · Current opinion in pediatrics · 2012
    Meta-analysis6,145 participants5 studies pooledBrain Health forMagnesium
  2. No. 376-Magnesium Sulphate for Fetal Neuroprotection.
    Magee LA; De Silva DA; Sawchuck D; Synnes A; von Dadelszen P · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2020
    Guideline / consensus4,446 participantsBrain Health forMagnesium
  3. Magnesium Sulfate Before Preterm Birth for Neuroprotection: An Updated Cochrane Systematic Review.
    Shepherd ES; Goldsmith S; Doyle LW; Middleton P; Marret S; Rouse DJ; Pryde P; Wolf HT; Crowther CA · Obstetrics and gynecology · 2024
    Systematic review5,917 participants6 studies pooledBrain Health forMagnesium
  4. Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery: a systematic review with meta-analysis and trial sequential analysis.
    Wolf HT; Huusom LD; Henriksen TB; Hegaard HK; Brok J; Pinborg A · BJOG : an international journal of obstetrics and gynaecology · 2020
    Meta-analysis5,917 participants6 studies pooledBrain Health forMagnesium
  5. Magnesium sulfate and fetal neuroprotection: overview of clinical evidence.
    Chollat C; Marret S · Neural regeneration research · 2020
    Narrative reviewBrain Health forMagnesium
  6. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
    Hidese S; Ogawa S; Ota M; Ishida I; Yasukawa Z; Ozeki M; Kunugi H · Nutrients · 2020
    Randomized trial30 participantsBrain Health Cognitive Support Sleep Support forTheanine
  7. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave® L-Theanine on Stress in a Healthy Adult Population.
    Evans M; McDonald AC; Xiong L; Crowley DC; Guthrie N · Neurology and therapy · 2021
    Randomized trialBrain Health Stress Relief forTheanine
  8. Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Payne ER; Aceves-Martins M; Dubost J; Greyling A; de Roos B · Nutrition reviews · 2025
    Meta-analysis50 studies pooledBrain Health Cognitive Support Mental Focus forTheanine
  9. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
    Foxe JJ; Morie KP; Laud PJ; Rowson MJ; de Bruin EA; Kelly SP · Neuropharmacology · 2012
    Randomized trial27 participantsBrain Health Cognitive Support forTheanine
  10. Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.
    Baba Y; Inagaki S; Nakagawa S; Kaneko T; Kobayashi M; Takihara T · Journal of medicinal food · 2021
    Randomized trialBrain Health Mental Focus Productivity Boost forTheanine
  11. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
    Zhang C; Luo J; Yuan C; Ding D · Journal of Alzheimer's disease : JAD · 2021
    Meta-analysis21 studies pooledBrain Health forVitamin B6
  12. Relationship between serum pyridoxal 5'-phosphate concentration and cognitive function in older Japanese.
    Itoh K; Kuwabara A; Otsuka R; Sugimoto T; Sakurai T; Niida S; Ao M; Tanaka K; Takenaka S; Kanouchi H · Journal of clinical biochemistry and nutrition · 2025
    Cross-sectional study266 participantsBrain Health forVitamin B6
  13. A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women.
    Dhivya K; Sarumathy S; Manigandan G · Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Randomized trial180 participantsBrain Health forVitamin B6
  14. Lower Plasma Vitamin B-6 is Associated with 2-Year Cognitive Decline in the Boston Puerto Rican Health Study.
    Palacios N; Scott T; Sahasrabudhe N; Gao X; Tucker KL · The Journal of nutrition · 2020
    Cohort study949 participantsBrain Health Cognitive Support forVitamin B6
  15. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review.
    Iolascon G; Gimigliano R; Bianco M; De Sire A; Moretti A; Giusti A; Malavolta N; Migliaccio S; Migliore A; Napoli N; Piscitelli P; Resmini G; Tarantino U; Gimigliano F · The journal of nutrition, health & aging · 2017
    Scoping review12 studies pooledBrain Health forVitamin B6
  16. Vitamin D and brain health: an observational and Mendelian randomization study.
    Navale SS; Mulugeta A; Zhou A; Llewellyn DJ; Hyppönen E · The American journal of clinical nutrition · 2022
    Cohort study427,690 participantsBrain Health forVitamin D
  17. The association between vitamin D and cognition: a systematic review.
    van der Schaft J; Koek HL; Dijkstra E; Verhaar HJ; van der Schouw YT; Emmelot-Vonk MH · Ageing research reviews · 2014
    Systematic review28 studies pooledBrain Health forVitamin D
  18. Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults.
    Miller JW; Harvey DJ; Beckett LA; Green R; Farias ST; Reed BR; Olichney JM; Mungas DM; DeCarli C · JAMA neurology · 2016
    Cohort study382 participantsBrain Health forVitamin D
  19. Vitamin D insufficiency and cognitive impairment in Asians: a multi-ethnic population-based study and meta-analysis.
    Annweiler C; Milea D; Whitson HE; Cheng CY; Wong TY; Ikram MK; Lamoureux EL; Sabanayagam C · Journal of internal medicine · 2017
    Meta-analysis2,273 participants7 studies pooledBrain Health forVitamin D
  20. Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis.
    Mowry EM; Waubant E; McCulloch CE; Okuda DT; Evangelista AA; Lincoln RR; Gourraud PA; Brenneman D; Owen MC; Qualley P; Bucci M; Hauser SL; Pelletier D · Annals of neurology · 2012
    Cohort study469 participantsBrain Health forVitamin D